Warfarin PK/PD data
warfarinA data frame with 519 rows and 9 columns
Patient identifier (n=32)
Time [h]
Total drug administered [mg]
Warfarin concentrations [mg/L] or PCA measurement
Dependent identifier Information (cp: Dose or PK, pca: PCA, factor)
Event identifier
Weight [kg]
Age [yr]
Gender (male or female, factor)
Funaki T, Holford N, Fujita S (2018). Population PKPD analysis using nlmixr and NONMEM. PAGJA 2018
O'Reilly RA, Aggeler PM, Leong LS. Studies of the coumarin anticoagulant drugs: The pharmacodynamics of warfarin in man. Journal of Clinical Investigation 1963; 42(10): 1542-1551
O'Reilly RA, Aggeler PM. Studies on coumarin anticoagulant drugs Initiation of warfarin therapy without a loading dose. Circulation 1968; 38: 169-177.
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