This is from a PK study in neonatal infants. They received multiple doses of phenobarbital for seizure prevention.

pheno_sd

Format

A data frame with 744 rows and 8 columns

ID

Infant ID

TIME

Time of (hr)

AMT

Dose in (ug/kg)

WT

Weight in kg

APGR

A 5-minute Apgar score to measure infant health

DV

The concentration of phenobarbitol in the serum (ug/mL)

MDV

If the dependent variable (DV) is missing; 0 for observations, 1 for doses

EVID

Event ID

Source

Pinheiro, J. C. and Bates, D. M. (2000), Mixed-Effects Models in S and S-PLUS, Springer, New York. (Appendix A.23)

Davidian, M. and Giltinan, D. M. (1995), Nonlinear Models for Repeated Measurement Data, Chapman and Hall, London. (section 6.6)

Grasela and Donn (1985), Neonatal population pharmacokinetics of phenobarbital derived from routine clinical data, Developmental Pharmacology and Therapeutics, 8, 374-383.

Boeckmann, A. J., Sheiner, L. B., and Beal, S. L. (1994), NONMEM Users Guide: Part V, University of California, San Francisco.

Littell, R. C., Milliken, G. A., Stroup, W. W. and Wolfinger, R. D. (1996), SAS System for Mixed Models, SAS Institute, Cary, NC.

Details

The data were originally given in Grasela and Donn(1985) and are analyzed in Boeckmann, Sheiner and Beal (1994), in Davidian and Giltinan (1995), and in Littell et al. (1996).

See also