Simulate Parameters from a Theta/Omega specification

rxSimThetaOmega(
  params = NULL,
  omega = NULL,
  omegaDf = NULL,
  omegaLower = as.numeric(c(R_NegInf)),
  omegaUpper = as.numeric(c(R_PosInf)),
  omegaIsChol = FALSE,
  omegaSeparation = "auto",
  omegaXform = 1L,
  nSub = 1L,
  thetaMat = NULL,
  thetaLower = as.numeric(c(R_NegInf)),
  thetaUpper = as.numeric(c(R_PosInf)),
  thetaDf = NULL,
  thetaIsChol = FALSE,
  nStud = 1L,
  sigma = NULL,
  sigmaLower = as.numeric(c(R_NegInf)),
  sigmaUpper = as.numeric(c(R_PosInf)),
  sigmaDf = NULL,
  sigmaIsChol = FALSE,
  sigmaSeparation = "auto",
  sigmaXform = 1L,
  nCoresRV = 1L,
  nObs = 1L,
  dfSub = 0,
  dfObs = 0,
  simSubjects = TRUE
)

Arguments

params	Named Vector of RxODE model parameters
omega	Estimate of Covariance matrix. When omega is a list, assume it is a block matrix and convert it to a full matrix for simulations.
omegaDf	The degrees of freedom of a t-distribution for simulation. By default this is `NULL` which is equivalent to `Inf` degrees, or to simulate from a normal distribution instead of a t-distribution.
omegaLower	Lower bounds for simulated ETAs (by default -Inf)
omegaUpper	Upper bounds for simulated ETAs (by default Inf)
omegaIsChol	Indicates if the `omega` supplied is a Cholesky decomposed matrix instead of the traditional symmetric matrix.
omegaSeparation	Omega separation strategy Tells the type of separation strategy when simulating covariance with parameter uncertainty with standard deviations modeled in the `thetaMat` matrix. `"lkj"` simulates the correlation matrix from the `rLKJ1` matrix with the distribution parameter `eta` equal to the degrees of freedom `nu` by `(nu-1)/2` `"separation"` simulates from the identity inverse Wishart covariance matrix with `nu` degrees of freedom. This is then converted to a covariance matrix and augmented with the modeled standard deviations. While computationally more complex than the `"lkj"` prior, it performs better when the covariance matrix size is greater or equal to 10 `"auto"` chooses `"lkj"` when the dimension of the matrix is less than 10 and `"separation"` when greater than equal to 10.
omegaXform	When taking `omega` values from the `thetaMat` simulations (using the separation strategy for covariance simulation), how should the `thetaMat` values be turned int standard deviation values: `identity` This is when standard deviation values are directly modeled by the `params` and `thetaMat` matrix `variance` This is when the `params` and `thetaMat` simulates the variance that are directly modeled by the `thetaMat` matrix `log` This is when the `params` and `thetaMat` simulates `log(sd)` `nlmixrSqrt` This is when the `params` and `thetaMat` simulates the inverse cholesky decomposed matrix with the `x^2` modeled along the diagonal. This only works with a diagonal matrix. `nlmixrLog` This is when the `params` and `thetaMat` simulates the inverse cholesky decomposed matrix with the `exp(x^2)` along the diagonal. This only works with a diagonal matrix. `nlmixrIdentity` This is when the `params` and `thetaMat` simulates the inverse cholesky decomposed matrix. This only works with a diagonal matrix.
nSub	Number between subject variabilities (`ETAs`) simulated for every realization of the parameters.
thetaMat	Named theta matrix.
thetaLower	Lower bounds for simulated population parameter variability (by default `-Inf`)
thetaUpper	Upper bounds for simulated population unexplained variability (by default `Inf`)
thetaDf	The degrees of freedom of a t-distribution for simulation. By default this is `NULL` which is equivalent to `Inf` degrees, or to simulate from a normal distribution instead of a `t`-distribution.
thetaIsChol	Indicates if the `theta` supplied is a Cholesky decomposed matrix instead of the traditional symmetric matrix.
nStud	Number virtual studies to characterize uncertainty in estimated parameters.
sigma	Named sigma covariance or Cholesky decomposition of a covariance matrix. The names of the columns indicate parameters that are simulated. These are simulated for every observation in the solved system.
sigmaLower	Lower bounds for simulated unexplained variability (by default -Inf)
sigmaUpper	Upper bounds for simulated unexplained variability (by default Inf)
sigmaDf	Degrees of freedom of the sigma t-distribution. By default it is equivalent to `Inf`, or a normal distribution.
sigmaIsChol	Boolean indicating if the sigma is in the Cholesky decomposition instead of a symmetric covariance
sigmaSeparation	separation strategy for sigma; Tells the type of separation strategy when simulating covariance with parameter uncertainty with standard deviations modeled in the `thetaMat` matrix. `"lkj"` simulates the correlation matrix from the `rLKJ1` matrix with the distribution parameter `eta` equal to the degrees of freedom `nu` by `(nu-1)/2` `"separation"` simulates from the identity inverse Wishart covariance matrix with `nu` degrees of freedom. This is then converted to a covariance matrix and augmented with the modeled standard deviations. While computationally more complex than the `"lkj"` prior, it performs better when the covariance matrix size is greater or equal to 10 `"auto"` chooses `"lkj"` when the dimension of the matrix is less than 10 and `"separation"` when greater than equal to 10.
sigmaXform	When taking `sigma` values from the `thetaMat` simulations (using the separation strategy for covariance simulation), how should the `thetaMat` values be turned int standard deviation values: `identity` This is when standard deviation values are directly modeled by the `params` and `thetaMat` matrix `variance` This is when the `params` and `thetaMat` simulates the variance that are directly modeled by the `thetaMat` matrix `log` This is when the `params` and `thetaMat` simulates `log(sd)` `nlmixrSqrt` This is when the `params` and `thetaMat` simulates the inverse cholesky decomposed matrix with the `x^2` modeled along the diagonal. This only works with a diagonal matrix. `nlmixrLog` This is when the `params` and `thetaMat` simulates the inverse cholesky decomposed matrix with the `exp(x^2)` along the diagonal. This only works with a diagonal matrix. `nlmixrIdentity` This is when the `params` and `thetaMat` simulates the inverse cholesky decomposed matrix. This only works with a diagonal matrix.
nCoresRV	Number of cores used for the simulation of the sigma variables. By default this is 1. To reproduce the results you need to run on the same platform with the same number of cores. This is the reason this is set to be one, regardless of what the number of cores are used in threaded ODE solving.
nObs	Number of observations to simulate (with `sigma` matrix)
dfSub	Degrees of freedom to sample the between subject variability matrix from the inverse Wishart distribution (scaled) or scaled inverse chi squared distribution.
dfObs	Degrees of freedom to sample the unexplained variability matrix from the inverse Wishart distribution (scaled) or scaled inverse chi squared distribution.
simSubjects	boolean indicated RxODE should simulate subjects in studies (`TRUE`, default) or studies (`FALSE`)

Value

a data frame with the simulated subjects

Author

Matthew L.Fidler