Generate the d(err)/d(eta) values for FO related methods

Source: R/rxJacobian.R

Generate the d(err)/d(eta) values for FO related methods

.rxGenHdEta(
  obj,
  predfn,
  pkpars = NULL,
  errfn = NULL,
  init = NULL,
  pred.minus.dv = TRUE,
  promoteLinSens = TRUE,
  theta = FALSE,
  addProp = c("combined2", "combined1")
)

Arguments

obj

RxODE object
predfn

Prediction function
pkpars

Pk Pars function
errfn

Error function
init

Initialization parameters for scaling.
pred.minus.dv

Boolean stating if the FOCEi objective function is based on PRED-DV (like NONMEM). Default TRUE.
promoteLinSens

Promote solved linear compartment systems to sensitivity-based solutions.
theta

Calculate THETA derivatives instead of ETA derivatives. By default FALSE
addProp

one of "combined1" and "combined2"; These are the two forms of additive+proportional errors supported by monolix/nonmem:

combined1: transform(y)=transform(f)+(a+b*f^c)*eps

combined2: transform(y)=transform(f)+(a^2+b^2*f^(2c))*eps

Value

RxODE/symengine environment

Author

Matthew L. Fidler