Generate the ETA sensitivities for FO related methods

Source: R/rxJacobian.R

Generate the ETA sensitivities for FO related methods

.rxGenEtaS(
  obj,
  predfn,
  pkpars = NULL,
  errfn = NULL,
  init = NULL,
  promoteLinSens = TRUE,
  theta = FALSE,
  addProp = c("combined2", "combined1")
)

Arguments

obj

RxODE object
predfn

Prediction function
pkpars

Pk Pars function
errfn

Error function
init

Initialization parameters for scaling.
promoteLinSens

Promote solved linear compartment systems to sensitivity-based solutions.
theta

Calculate THETA derivatives instead of ETA derivatives. By default FALSE
addProp

one of "combined1" and "combined2"; These are the two forms of additive+proportional errors supported by monolix/nonmem:

combined1: transform(y)=transform(f)+(a+b*f^c)*eps

combined2: transform(y)=transform(f)+(a^2+b^2*f^(2c))*eps

Value

RxODE/symengine environment

Author

Matthew L. Fidler