Fidler M, Hallow M, Wilkins J, Wang W (2020). RxODE: Facilities for Simulating from ODE-Based Models. R package version 0.9.2-0,

  title = {{RxODE}: Facilities for Simulating from ODE-Based Models},
  author = {Matthew L.  Fidler and Melissa Hallow and Justin Wilkins and Wenping Wang},
  year = {2020},
  note = {R package version 0.9.2-0},
  url = {},

Wang W, Hallow K, James D (2015). “A Tutorial on RxODE: Simulating Differential Equation Pharmacometric Models in R.” CPT: Pharmacometrics \& Systems Pharmacology, 5(1), 3–10. ISSN 2163-8306,

  title = {A Tutorial on RxODE: Simulating Differential Equation Pharmacometric Models in R},
  author = {Wenping Wang and K Melissa Hallow and David A James},
  journal = {CPT: Pharmacometrics \& Systems Pharmacology},
  year = {2015},
  volume = {5},
  pages = {3--10},
  number = {1},
  month = {nov},
  abstract = {This tutorial presents the application of an R package, RxODE, that facilitates quick, efficient simulations of ordinary differential equation models completely within R. Its application is illustrated through simulation of design decision effects on an adaptive dosing regimen. The package provides an efficient, versatile way to specify dosing scenarios and to perform simulation with variability with minimal custom coding. Models can be directly translated to Rshiny applications to facilitate interactive, real-time evaluation/iteration on simulation scenarios.},
  address = {Hoboken},
  issn = {2163-8306},
  publisher = {John Wiley and Sons Inc.},
  url = {},
  • Matthew L. Fidler. Author. ORCID

  • Melissa Hallow. Author.

  • Wenping Wang. Author, maintainer.

  • Zufar Mulyukov. Contributor.

  • Justin Wilkins. Contributor. ORCID

  • Simon Frost. Contributor.

  • Goro Fuji. Contributor.

  • Morwenn. Contributor.

  • Heng Li. Contributor.

  • Yu Feng. Contributor.

  • Alan Hindmarsh. Contributor.

  • Linda Petzold. Contributor.

  • Ernst Hairer. Contributor.

  • Gerhard Wanner. Contributor.

  • J Colinge. Contributor.

  • Hadley Wickham. Contributor.

  • G Grothendieck. Contributor.

  • Robert Gentleman. Contributor.

  • Daniel C. Dillon. Contributor.

  • Ross Ihaka. Contributor.

  • Cleve Moler. Contributor.

  • Jack Dongarra. Contributor.

  • R core team. Copyright holder.