This takes the uncertainty in the model parameter estimates and to simulate a number of theoretical studies. Each study simulates a realization of the parameters from the uncertainty in the fixed parameter estimates. In addition the omega and sigma matrices are simulated from the uncertainty in the Omega/Sigma matrices based on the number of subjects and observations the model was based on.
nlmixrSim(object, ...)
# S3 method for nlmixrFitData
rxSolve(
object,
params = NULL,
events = NULL,
inits = NULL,
scale = NULL,
method = c("liblsoda", "lsoda", "dop853", "indLin"),
transitAbs = NULL,
atol = 1e08,
rtol = 1e06,
maxsteps = 70000L,
hmin = 0,
hmax = NA_real_,
hmaxSd = 0,
hini = 0,
maxordn = 12L,
maxords = 5L,
...,
cores,
covsInterpolation = c("locf", "linear", "nocb", "midpoint"),
addCov = FALSE,
matrix = FALSE,
sigma = NULL,
sigmaDf = NULL,
sigmaLower = Inf,
sigmaUpper = Inf,
nCoresRV = 1L,
sigmaIsChol = FALSE,
sigmaSeparation = c("auto", "lkj", "separation"),
sigmaXform = c("identity", "variance", "log", "nlmixrSqrt", "nlmixrLog",
"nlmixrIdentity"),
nDisplayProgress = 10000L,
amountUnits = NA_character_,
timeUnits = "hours",
stiff,
theta = NULL,
thetaLower = Inf,
thetaUpper = Inf,
eta = NULL,
addDosing = FALSE,
stateTrim = Inf,
updateObject = FALSE,
omega = NULL,
omegaDf = NULL,
omegaIsChol = FALSE,
omegaSeparation = c("auto", "lkj", "separation"),
omegaXform = c("variance", "identity", "log", "nlmixrSqrt", "nlmixrLog",
"nlmixrIdentity"),
omegaLower = Inf,
omegaUpper = Inf,
nSub = 1L,
thetaMat = NULL,
thetaDf = NULL,
thetaIsChol = FALSE,
nStud = 1L,
dfSub = 0,
dfObs = 0,
returnType = c("rxSolve", "matrix", "data.frame", "data.frame.TBS", "data.table",
"tbl", "tibble"),
seed = NULL,
nsim = NULL,
minSS = 10L,
maxSS = 1000L,
infSSstep = 12,
strictSS = TRUE,
istateReset = TRUE,
subsetNonmem = TRUE,
maxAtolRtolFactor = 0.1,
from = NULL,
to = NULL,
by = NULL,
length.out = NULL,
iCov = NULL,
keep = NULL,
indLinPhiTol = 1e07,
indLinPhiM = 0L,
indLinMatExpType = c("expokit", "AlMohy", "arma"),
indLinMatExpOrder = 6L,
drop = NULL,
idFactor = TRUE,
mxhnil = 0,
hmxi = 0,
warnIdSort = TRUE,
warnDrop = TRUE,
ssAtol = 1e08,
ssRtol = 1e06,
safeZero = TRUE,
sumType = c("pairwise", "fsum", "kahan", "neumaier", "c"),
prodType = c("long double", "double", "logify"),
sensType = c("advan", "autodiff", "forward", "central"),
linDiff = c(tlag = 1.5e05, f = 1.5e05, rate = 1.5e05, dur = 1.5e05, tlag2 =
1.5e05, f2 = 1.5e05, rate2 = 1.5e05, dur2 = 1.5e05),
linDiffCentral = c(tlag = TRUE, f = TRUE, rate = TRUE, dur = TRUE, tlag2 = TRUE, f2 =
TRUE, rate2 = TRUE, dur2 = TRUE),
resample = NULL,
resampleID = TRUE
)
# S3 method for nlmixrFitData
simulate(object, nsim = 1, seed = NULL, ...)
# S3 method for nlmixrFitData
solve(a, b, ...)
object  nlmixr object 

...  Other arguments sent to 
params  a numeric named vector with values for every parameter in the ODE system; the names must correspond to the parameter identifiers used in the ODE specification; 
events  an 
inits  a vector of initial values of the state variables (e.g., amounts in each compartment), and the order in this vector must be the same as the state variables (e.g., PK/PD compartments); 
scale  a numeric named vector with scaling for ode
parameters of the system. The names must correspond to the
parameter identifiers in the ODE specification. Each of the
ODE variables will be divided by the scaling factor. For
example 
method  The method for solving ODEs. Currently this supports:

transitAbs  boolean indicating if this is a transit compartment absorption 
atol  a numeric absolute tolerance (1e8 by default) used by the ODE solver to determine if a good solution has been achieved; This is also used in the solved linear model to check if prior doses do not add anything to the solution. 
rtol  a numeric relative tolerance ( 
maxsteps  maximum number of (internally defined) steps allowed during one call to the solver. (5000 by default) 
hmin  The minimum absolute step size allowed. The default value is 0. 
hmax  The maximum absolute step size allowed. When

hmaxSd  The number of standard deviations of the time difference to add to hmax. The default is 0 
hini  The step size to be attempted on the first step. The
default value is determined by the solver (when 
maxordn  The maximum order to be allowed for the nonstiff (Adams) method. The default is 12. It can be between 1 and 12. 
maxords  The maximum order to be allowed for the stiff (BDF) method. The default value is 5. This can be between 1 and 5. 
cores  Number of cores used in parallel ODE solving. This
is equivalent to calling 
covsInterpolation  specifies the interpolation method for
timevarying covariates. When solving ODEs it often samples
times outside the sampling time specified in

addCov  A boolean indicating if covariates should be added to the output matrix or data frame. By default this is disabled. 
matrix  A boolean indicating if a matrix should be returned instead of the RxODE's solved object. 
sigma  Named sigma covariance or Cholesky decomposition of a covariance matrix. The names of the columns indicate parameters that are simulated. These are simulated for every observation in the solved system. 
sigmaDf  Degrees of freedom of the sigma tdistribution. By
default it is equivalent to 
sigmaLower  Lower bounds for simulated unexplained variability (by default Inf) 
sigmaUpper  Upper bounds for simulated unexplained variability (by default Inf) 
nCoresRV  Number of cores used for the simulation of the sigma variables. By default this is 1. To reproduce the results you need to run on the same platform with the same number of cores. This is the reason this is set to be one, regardless of what the number of cores are used in threaded ODE solving. 
sigmaIsChol  Boolean indicating if the sigma is in the Cholesky decomposition instead of a symmetric covariance 
sigmaSeparation  separation strategy for sigma; Tells the type of separation strategy when
simulating covariance with parameter uncertainty with standard
deviations modeled in the

sigmaXform  When taking

nDisplayProgress  An integer indicating the minimum number of cbased solves before a progress bar is shown. By default this is 10,000. 
amountUnits  This supplies the dose units of a data frame supplied instead of an event table. This is for importing the data as an RxODE event table. 
timeUnits  This supplies the time units of a data frame supplied instead of an event table. This is for importing the data as an RxODE event table. 
stiff  a logical (

theta  A vector of parameters that will be named 
thetaLower  Lower bounds for simulated population parameter
variability (by default 
thetaUpper  Upper bounds for simulated population unexplained
variability (by default 
eta  A vector of parameters that will be named 
addDosing  Boolean indicating if the solve should add RxODE
EVID and related columns. This will also include dosing
information and estimates at the doses. Be default, RxODE
only includes estimates at the observations. (default

stateTrim  When amounts/concentrations in one of the states
are above this value, trim them to be this value. By default
Inf. Also trims to stateTrim for large negative
amounts/concentrations. If you want to trim between a range
say 
updateObject  This is an internally used flag to update the
RxODE solved object (when supplying an RxODE solved object) as
well as returning a new object. You probably should not
modify it's 
omega  Estimate of Covariance matrix. When omega is a list, assume it is a block matrix and convert it to a full matrix for simulations. 
omegaDf  The degrees of freedom of a tdistribution for
simulation. By default this is 
omegaIsChol  Indicates if the 
omegaSeparation  Omega separation strategy Tells the type of separation strategy when
simulating covariance with parameter uncertainty with standard
deviations modeled in the

omegaXform  When taking

omegaLower  Lower bounds for simulated ETAs (by default Inf) 
omegaUpper  Upper bounds for simulated ETAs (by default Inf) 
nSub  Number between subject variabilities ( 
thetaMat  Named theta matrix. 
thetaDf  The degrees of freedom of a tdistribution for
simulation. By default this is 
thetaIsChol  Indicates if the 
nStud  Number virtual studies to characterize uncertainty in estimated parameters. 
dfSub  Degrees of freedom to sample the between subject variability matrix from the inverse Wishart distribution (scaled) or scaled inverse chi squared distribution. 
dfObs  Degrees of freedom to sample the unexplained variability matrix from the inverse Wishart distribution (scaled) or scaled inverse chi squared distribution. 
returnType  This tells what type of object is returned. The currently supported types are:

seed  an object specifying if and how the random number generator should be initialized 
nsim  represents the number of simulations. For RxODE, if
you supply single subject event tables (created with

minSS  Minimum number of iterations for a steadystate dose 
maxSS  Maximum number of iterations for a steadystate dose 
infSSstep  Step size for determining if a constant infusion has reached steady state. By default this is large value, 420. 
strictSS  Boolean indicating if a strict steadystate is
required. If a strict steadystate is ( 
istateReset  When 
subsetNonmem  subset to NONMEM compatible EVIDs only. By
default 
maxAtolRtolFactor  The maximum 
from  When there is no observations in the event table, start observations at this value. By default this is zero. 
to  When there is no observations in the event table, end observations at this value. By default this is 24 + maximum dose time. 
by  When there are no observations in the event table, this
is the amount to increment for the observations between 
length.out  The number of observations to create if there isn't any observations in the event table. By default this is 200. 
iCov  A data frame of individual nontime varying covariates
to combine with the 
keep  Columns to keep from either the input dataset or the

indLinPhiTol  the requested accuracy tolerance on exponential matrix. 
indLinPhiM  the maximum size for the Krylov basis 
indLinMatExpType  This is them matrix exponential type that is use for RxODE. Currently the following are supported:

indLinMatExpOrder  an integer, the order of approximation to
be used, for the 
drop  Columns to drop from the output 
idFactor  This boolean indicates if original ID values should be maintained. This changes the default sequentially ordered ID to a factor with the original ID values in the original dataset. By default this is enabled. 
mxhnil  maximum number of messages printed (per problem)
warning that 
hmxi  inverse of the maximum absolute value of 
warnIdSort  Warn if the ID is not present and RxODE assumes the order of the parameters/iCov are the same as the order of the parameters in the input dataset. 
warnDrop  Warn if column(s) were supposed to be dropped, but were not present. 
ssAtol  Steady state atol convergence factor. Can be a vector based on each state. 
ssRtol  Steady state rtol convergence factor. Can be a vector based on each state. 
safeZero  Use safe zero divide and log routines. By default this is turned on but you may turn it off if you wish. 
sumType  Sum type to use for

prodType  Product to use for

sensType  Sensitivity type for

linDiff  This gives the linear difference amount for all the types of linear compartment model parameters where sensitivities are not calculated. The named components of this numeric vector are:

linDiffCentral  This gives the which parameters use central
differences for the linear compartment model parameters. The
are the same components as 
resample  A character vector of model variables to resample
from the input dataset; This sampling is done with replacement.
When 
resampleID  boolean representing if the resampling should be
done on an individual basis 
a  when using 
b  when using 
A RxODE solved object