FOCEi fit
foceiFit(data, ...)
focei.fit(data, ...)
# S3 method for data.frame
foceiFit(data, ...)
# S3 method for data.frame0
foceiFit(
data,
inits,
PKpars,
model = NULL,
pred = NULL,
err = NULL,
lower = -Inf,
upper = Inf,
fixed = NULL,
skipCov = NULL,
control = foceiControl(),
thetaNames = NULL,
etaNames = NULL,
etaMat = NULL,
...,
env = NULL,
keep = NULL,
drop = NULL
)Data to fit; Needs to be RxODE compatible and have
DV, AMT, EVID in the dataset.
Ignored parameters
Initialization list
Pk Parameters function
The RxODE model to use
The Prediction function
The Error function
Lower bounds
Upper Bounds
Boolean vector indicating what parameters should be fixed.
Boolean vector indicating what parameters should be fixed when calculating covariances
FOCEi options Control list. See
foceiControl
Names of the thetas to be used in the final object.
Eta names to be used in the final object.
Eta matrix for initial estimates or final estimates of the ETAs.
An environment used to build the FOCEi or nlmixr object.
Columns to keep from either the input dataset. For the input dataset, if any records are added to the data LOCF (Last Observation Carried forward) imputation is performed.
Columns to drop from the output
A focei fit or nlmixr fit object FOCEi fit object
# \donttest{
## Comparison to Wang2007 objective functions
mypar2 = function ()
{
k = theta[1] * exp(eta[1]);
}
mod <- RxODE({
ipre = 10 * exp(-k * t)
})
#>
pred <- function() ipre
errProp <- function(){
return(prop(0.1))
}
inits <- list(THTA=c(0.5),
OMGA=list(ETA[1] ~ 0.04));
w7 <- Wang2007
w7$DV <- w7$Y
w7$EVID <- 0
w7$AMT <- 0
## Wang2007 prop error OBF 39.458 for NONMEM FOCEi, nlmixr matches.
fitPi <- foceiFit(w7, inits, mypar2,mod,pred,errProp,
control=foceiControl(maxOuterIterations=0,covMethod=""))
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → calculate jacobian
#>
#> → calculate ∂(f)/∂(η)
#>
#> → calculate ∂(R²)/∂(η)
#>
#> → finding duplicate expressions in inner model...
#>
#> → optimizing duplicate expressions in inner model...
#>
#> → finding duplicate expressions in EBE model...
#>
#> → optimizing duplicate expressions in EBE model...
#>
#> → compiling inner model...
#>
#> ✔ done
#> → finding duplicate expressions in FD model...
#>
#> → optimizing duplicate expressions in FD model...
#>
#> → compiling EBE model...
#>
#> ✔ done
#> → compiling events FD model...
#>
#> ✔ done
#> Calculating residuals/tables
#> done
#> Warning: initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))
print(fitPi$objective)
#> [1] 39.45755
## Wang2007 prop error OBF 39.207 for NONMEM FOCE; nlmixr matches.
fitP <- foceiFit(w7, inits, mypar2,mod,pred,errProp,
control=foceiControl(maxOuterIterations=0,covMethod="",
interaction=FALSE))
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → calculate jacobian
#>
#> → calculate ∂(f)/∂(η)
#>
#> → finding duplicate expressions in inner model...
#>
#> → optimizing duplicate expressions in inner model...
#>
#> → finding duplicate expressions in EBE model...
#>
#> → optimizing duplicate expressions in EBE model...
#>
#> → compiling inner model...
#>
#> ✔ done
#> → finding duplicate expressions in FD model...
#>
#> → compiling EBE model...
#>
#> ✔ done
#> → compiling events FD model...
#>
#> ✔ done
#> Calculating residuals/tables
#> done
#> Warning: initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))
print(fitP$objective)
#> [1] 39.20672
## Wang 2007 prop error OBF 39.213 for NONMEM FO; nlmixr matches
fitPfo <- foceiFit(w7, inits, mypar2,mod,pred,errProp,
control=foceiControl(maxOuterIterations=0,covMethod="",
fo=TRUE))
#> Calculating residuals/tables
#> done
print(fitPfo$objective)
#> [1] 39.21322
## Note if you have the etas you can evaluate the likelihood
## of an arbitrary model. It doesn't have to be solved by
## FOCEi
etaMat <- matrix(fitPi$eta[,-1])
fitP2 <- foceiFit(w7, inits, mypar2,mod,pred,errProp, etaMat=etaMat,
control=foceiControl(maxOuterIterations=0,maxInnerIterations=0,
covMethod=""))
#> Calculating residuals/tables
#> done
errAdd <- function(){
return(add(0.1))
}
## Wang2007 add error of -2.059 for NONMEM FOCE=NONMEM FOCEi;
## nlmixr matches.
fitA <- foceiFit(w7, inits, mypar2,mod,pred,errAdd,
control=foceiControl(maxOuterIterations=0,covMethod=""))
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → calculate jacobian
#>
#> → calculate ∂(f)/∂(η)
#>
#> → calculate ∂(R²)/∂(η)
#>
#> → finding duplicate expressions in inner model...
#>
#> → optimizing duplicate expressions in inner model...
#>
#> → finding duplicate expressions in EBE model...
#>
#> → optimizing duplicate expressions in EBE model...
#>
#> → compiling inner model...
#>
#> ✔ done
#> → finding duplicate expressions in FD model...
#>
#> → compiling EBE model...
#>
#> ✔ done
#> → compiling events FD model...
#>
#> ✔ done
#> Calculating residuals/tables
#> done
#> Warning: initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))
## Wang2007 add error of 0.026 for NONMEM FO; nlmixr matches
fitAfo <- foceiFit(w7, inits, mypar2,mod,pred,errAdd,
control=foceiControl(maxOuterIterations=0,fo=TRUE,covMethod=""))
#> Calculating residuals/tables
#> done
## Extending Wang2007 to add+prop with same dataset
errAddProp <- function(){
return(add(0.1) + prop(0.1));
}
fitAP <- foceiFit(w7, inits, mypar2,mod,pred,errAddProp,
control=foceiControl(maxOuterIterations=0,covMethod=""))
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → calculate jacobian
#>
#> → calculate ∂(f)/∂(η)
#>
#> → calculate ∂(R²)/∂(η)
#>
#> → finding duplicate expressions in inner model...
#>
#> → optimizing duplicate expressions in inner model...
#>
#> → finding duplicate expressions in EBE model...
#>
#> → optimizing duplicate expressions in EBE model...
#>
#> → compiling inner model...
#>
#> ✔ done
#> → finding duplicate expressions in FD model...
#>
#> → optimizing duplicate expressions in FD model...
#>
#> → compiling EBE model...
#>
#> ✔ done
#> → compiling events FD model...
#>
#> ✔ done
#> Calculating residuals/tables
#> done
#> Warning: initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))
## Checking lognormal
errLogn <- function(){
return(lnorm(0.1));
}
## First run the fit with the nlmixr lnorm error
fitLN <- foceiFit(w7, inits, mypar2,mod,pred,errLogn,
control=foceiControl(maxOuterIterations=0,covMethod=""))
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → calculate jacobian
#>
#> → calculate ∂(f)/∂(η)
#>
#> → calculate ∂(R²)/∂(η)
#>
#> → finding duplicate expressions in inner model...
#>
#> → optimizing duplicate expressions in inner model...
#>
#> → finding duplicate expressions in EBE model...
#>
#> → optimizing duplicate expressions in EBE model...
#>
#> → compiling inner model...
#>
#> ✔ done
#> → finding duplicate expressions in FD model...
#>
#> → compiling EBE model...
#>
#> ✔ done
#> → compiling events FD model...
#>
#> ✔ done
#> Calculating residuals/tables
#> done
#> Warning: initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))
## Next run on the log-transformed space
w72 <- w7; w72$DV <- log(w72$DV)
predL <- function() log(ipre)
fitLN2 <- foceiFit(w72, inits, mypar2,mod,predL,errAdd,
control=foceiControl(maxOuterIterations=0,covMethod=""))
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → calculate jacobian
#>
#> → calculate ∂(f)/∂(η)
#>
#> → calculate ∂(R²)/∂(η)
#>
#> → finding duplicate expressions in inner model...
#>
#> → optimizing duplicate expressions in inner model...
#>
#> → finding duplicate expressions in EBE model...
#>
#> → optimizing duplicate expressions in EBE model...
#>
#> → compiling inner model...
#>
#> ✔ done
#> → finding duplicate expressions in FD model...
#>
#> → compiling EBE model...
#>
#> ✔ done
#> → compiling events FD model...
#>
#> ✔ done
#> Calculating residuals/tables
#> done
#> Warning: initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))
## Correct the fitLN2's objective function to be on the normal scale
print(fitLN2$objective + 2*sum(w72$DV))
#> [1] 40.03872
## Note the objective function of the lognormal error is on the normal scale.
print(fitLN$objective)
#> [1] 40.03872
mypar2 <- function ()
{
ka <- exp(THETA[1] + ETA[1])
cl <- exp(THETA[2] + ETA[2])
v <- exp(THETA[3] + ETA[3])
}
mod <- RxODE({
d/dt(depot) <- -ka * depot
d/dt(center) <- ka * depot - cl / v * center
cp <- center / v
})
#>
pred <- function() cp
err <- function(){
return(add(0.1))
}
inits <- list(THTA=c(0.5, -3.2, -1),
OMGA=list(ETA[1] ~ 1, ETA[2] ~ 2, ETA[3] ~ 1));
## Remove 0 concentrations (should be lloq)
d <- theo_sd[theo_sd$EVID==0 & theo_sd$DV>0 | theo_sd$EVID>0,];
fit1 <- foceiFit(d, inits, mypar2,mod,pred,err)
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → calculate jacobian
#>
#> → calculate sensitivities
#>
#> → calculate ∂(f)/∂(η)
#>
#> → calculate ∂(R²)/∂(η)
#>
#> → finding duplicate expressions in inner model...
#>
#> → optimizing duplicate expressions in inner model...
#>
#> → finding duplicate expressions in EBE model...
#>
#> → optimizing duplicate expressions in EBE model...
#>
#> → compiling inner model...
#>
#> ✔ done
#> → finding duplicate expressions in FD model...
#>
#> → optimizing duplicate expressions in FD model...
#>
#> → compiling EBE model...
#>
#> ✔ done
#> → compiling events FD model...
#>
#> ✔ done
#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
#> F: Forward difference gradient approximation
#> C: Central difference gradient approximation
#> M: Mixed forward and central difference gradient approximation
#> Unscaled parameters for Omegas=chol(solve(omega));
#> Diagonals are transformed, as specified by foceiControl(diagXform=)
#> |-----+---------------+-----------+-----------+-----------+-----------|
#> | #| Objective Fun | THETA[1] | THETA[2] | THETA[3] | ERR[1] |
#> |.....................| o1 | o2 | o3 |...........|
#> | 1| 16296.646 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9242 | 1.000 |...........|
#> | U| 16296.646 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | X| 16296.646 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | G| Gill Diff. |-3.331e+06 |-3.184e+06 |-1.769e+08 |-5.812e+08 |
#> |.....................|-2.612e+09 |-1.269e+10 |-4.292e+10 |...........|
#> | 2| 28017.197 | 0.7620 | -0.9999 | 0.05156 | 0.6874 |
#> |.....................| 1.058 | 1.207 | 1.957 |...........|
#> | U| 28017.197 | 0.5001 | -3.200 | -0.9961 | 0.3203 |
#> |.....................| 1.058 | 1.079 | 1.957 |...........|
#> | X| 28017.197 | 1.649 | 0.04077 | 0.3693 | 0.3203 |
#> |.....................| 1.058 | 1.079 | 1.957 |...........|
#> | 3| 26434.007 | 0.7619 | -1.000 | 0.04959 | 0.6809 |
#> |.....................| 1.029 | 1.066 | 1.479 |...........|
#> | U| 26434.007 | 0.5000 | -3.200 | -0.9980 | 0.3183 |
#> |.....................| 1.029 | 0.9599 | 1.479 |...........|
#> | X| 26434.007 | 1.649 | 0.04076 | 0.3686 | 0.3183 |
#> |.....................| 1.029 | 0.9599 | 1.479 |...........|
#> | 4| 26020.091 | 0.7619 | -1.000 | 0.04861 | 0.6776 |
#> |.....................| 1.015 | 0.9950 | 1.239 |...........|
#> | U| 26020.091 | 0.5000 | -3.200 | -0.9990 | 0.3173 |
#> |.....................| 1.015 | 0.9004 | 1.239 |...........|
#> | X| 26020.091 | 1.649 | 0.04076 | 0.3682 | 0.3173 |
#> |.....................| 1.015 | 0.9004 | 1.239 |...........|
#> | 5| 25877.965 | 0.7619 | -1.000 | 0.04811 | 0.6760 |
#> |.....................| 1.007 | 0.9596 | 1.120 |...........|
#> | U| 25877.965 | 0.5000 | -3.200 | -0.9995 | 0.3167 |
#> |.....................| 1.007 | 0.8706 | 1.120 |...........|
#> | X| 25877.965 | 1.649 | 0.04076 | 0.3681 | 0.3167 |
#> |.....................| 1.007 | 0.8706 | 1.120 |...........|
#> | 6| 25817.252 | 0.7619 | -1.000 | 0.04787 | 0.6752 |
#> |.....................| 1.004 | 0.9419 | 1.060 |...........|
#> | U| 25817.252 | 0.5000 | -3.200 | -0.9998 | 0.3165 |
#> |.....................| 1.004 | 0.8558 | 1.060 |...........|
#> | X| 25817.252 | 1.649 | 0.04076 | 0.3680 | 0.3165 |
#> |.....................| 1.004 | 0.8558 | 1.060 |...........|
#> | 7| 25786.482 | 0.7619 | -1.000 | 0.04774 | 0.6748 |
#> |.....................| 1.002 | 0.9331 | 1.030 |...........|
#> | U| 25786.482 | 0.5000 | -3.200 | -0.9999 | 0.3164 |
#> |.....................| 1.002 | 0.8483 | 1.030 |...........|
#> | X| 25786.482 | 1.649 | 0.04076 | 0.3679 | 0.3164 |
#> |.....................| 1.002 | 0.8483 | 1.030 |...........|
#> | 8| 25768.221 | 0.7619 | -1.000 | 0.04768 | 0.6746 |
#> |.....................| 1.001 | 0.9287 | 1.015 |...........|
#> | U| 25768.221 | 0.5000 | -3.200 | -0.9999 | 0.3163 |
#> |.....................| 1.001 | 0.8446 | 1.015 |...........|
#> | X| 25768.221 | 1.649 | 0.04076 | 0.3679 | 0.3163 |
#> |.....................| 1.001 | 0.8446 | 1.015 |...........|
#> | 9| 25755.637 | 0.7619 | -1.000 | 0.04765 | 0.6745 |
#> |.....................| 1.000 | 0.9264 | 1.007 |...........|
#> | U| 25755.637 | 0.5000 | -3.200 | -1.000 | 0.3163 |
#> |.....................| 1.000 | 0.8428 | 1.007 |...........|
#> | X| 25755.637 | 1.649 | 0.04076 | 0.3679 | 0.3163 |
#> |.....................| 1.000 | 0.8428 | 1.007 |...........|
#> | 10| 25746.091 | 0.7619 | -1.000 | 0.04763 | 0.6744 |
#> |.....................| 1.000 | 0.9253 | 1.004 |...........|
#> | U| 25746.091 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8418 | 1.004 |...........|
#> | X| 25746.091 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8418 | 1.004 |...........|
#> | 11| 25737.929 | 0.7619 | -1.000 | 0.04763 | 0.6744 |
#> |.....................| 1.000 | 0.9248 | 1.002 |...........|
#> | U| 25737.929 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8414 | 1.002 |...........|
#> | X| 25737.929 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8414 | 1.002 |...........|
#> | 12| 25730.735 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9245 | 1.001 |...........|
#> | U| 25730.735 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8411 | 1.001 |...........|
#> | X| 25730.735 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8411 | 1.001 |...........|
#> | 13| 25723.922 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9244 | 1.000 |...........|
#> | U| 25723.922 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8410 | 1.000 |...........|
#> | X| 25723.922 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8410 | 1.000 |...........|
#> | 14| 25717.623 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9243 | 1.000 |...........|
#> | U| 25717.623 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8410 | 1.000 |...........|
#> | X| 25717.623 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8410 | 1.000 |...........|
#> | 15| 25711.474 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9243 | 1.000 |...........|
#> | U| 25711.474 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | X| 25711.474 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | 16| 25705.505 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9243 | 1.000 |...........|
#> | U| 25705.505 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | X| 25705.505 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | 17| 25699.753 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9242 | 1.000 |...........|
#> | U| 25699.753 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | X| 25699.753 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | 18| 25694.433 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9242 | 1.000 |...........|
#> | U| 25694.433 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | X| 25694.433 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | 19| 25689.271 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9242 | 1.000 |...........|
#> | U| 25689.271 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | X| 25689.271 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | 20| 25684.245 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9242 | 1.000 |...........|
#> | U| 25684.245 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | X| 25684.245 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | 21| 25679.428 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9242 | 1.000 |...........|
#> | U| 25679.428 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | X| 25679.428 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | 22| 25674.815 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9242 | 1.000 |...........|
#> | U| 25674.815 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | X| 25674.815 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | 23| 25670.503 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9242 | 1.000 |...........|
#> | U| 25670.503 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | X| 25670.503 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | 24| 25666.420 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9242 | 1.000 |...........|
#> | U| 25666.42 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | X| 25666.42 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | 25| 25662.449 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9242 | 1.000 |...........|
#> | U| 25662.449 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | X| 25662.449 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | 26| 25658.655 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9242 | 1.000 |...........|
#> | U| 25658.655 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | X| 25658.655 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | 27| 25655.138 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9242 | 1.000 |...........|
#> | U| 25655.138 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | X| 25655.138 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | 28| 25651.776 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9242 | 1.000 |...........|
#> | U| 25651.776 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | X| 25651.776 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | 29| 25647.392 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9242 | 1.000 |...........|
#> | U| 25647.392 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | X| 25647.392 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | 30| 25644.458 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9242 | 1.000 |...........|
#> | U| 25644.458 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | X| 25644.458 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | 31| 25641.733 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9242 | 1.000 |...........|
#> | U| 25641.733 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | X| 25641.733 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | 32| 25639.141 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9242 | 1.000 |...........|
#> | U| 25639.141 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | X| 25639.141 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> calculating covariance matrix
#>
S matrix calculation failed; Switch to R-matrix covariance.
#> done
#> Calculating residuals/tables
#> done
#> Warning: tolerances (atol/rtol) were temporarily increased for some difficult ODE solving during the optimization.
#> consider increasing sigdig/atol/rtol changing initial estimates or changing the structural model
#> Warning: gradient problems with initial estimate and covariance; see $scaleInfo
#> Warning: numerical difficulties solving forward sensitivity inner problem, tried approximating with more inaccurate numeric differences
#> Warning: using R matrix to calculate covariance
#> Warning: bad solve during optimization
#> Warning: last objective function was not at minimum, possible problems in optimization
#> Warning: tolerances were reduced during Gill Gradient, so it was repeated 1/3 times
#> You can control this with foceiControl(repeatGillMax=.)
#> Warning: initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))
#> Warning: Hessian reset during optimization; (can control by foceiControl(resetHessianAndEta=.))
## you can also fit lognormal data with the objective function on the same scale
errl <- function(){
return(lnorm(0.1))
}
fit2 <- foceiFit(d, inits, mypar2,mod,pred,errl)
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → calculate jacobian
#>
#> → calculate sensitivities
#>
#> → calculate ∂(f)/∂(η)
#>
#> → calculate ∂(R²)/∂(η)
#>
#> → finding duplicate expressions in inner model...
#>
#> → optimizing duplicate expressions in inner model...
#>
#> → finding duplicate expressions in EBE model...
#>
#> → optimizing duplicate expressions in EBE model...
#>
#> → compiling inner model...
#>
#> ✔ done
#> → finding duplicate expressions in FD model...
#>
#> → optimizing duplicate expressions in FD model...
#>
#> → compiling EBE model...
#>
#> ✔ done
#> → compiling events FD model...
#>
#> ✔ done
#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
#> F: Forward difference gradient approximation
#> C: Central difference gradient approximation
#> M: Mixed forward and central difference gradient approximation
#> Unscaled parameters for Omegas=chol(solve(omega));
#> Diagonals are transformed, as specified by foceiControl(diagXform=)
#> |-----+---------------+-----------+-----------+-----------+-----------|
#> | #| Objective Fun | THETA[1] | THETA[2] | THETA[3] | ERR[1] |
#> |.....................| o1 | o2 | o3 |...........|
#> | 1| 39934.019 | 0.7619 | -1.000 | 0.04762 | 0.6744 |
#> |.....................| 1.000 | 0.9242 | 1.000 |...........|
#> | U| 39934.019 | 0.5000 | -3.200 | -1.000 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | X| 39934.019 | 1.649 | 0.04076 | 0.3679 | 0.3162 |
#> |.....................| 1.000 | 0.8409 | 1.000 |...........|
#> | G| Gill Diff. | 907.7 | -734.6 | -754.0 |-7.853e+04 |
#> |.....................| 180.7 | 281.1 | 562.7 |...........|
#> | 2| 10452.292 | 0.7503 | -0.9906 | 0.05722 | 1.674 |
#> |.....................| 0.9977 | 0.9207 | 0.9928 |...........|
#> | U| 10452.292 | 0.4884 | -3.191 | -0.9904 | 0.6324 |
#> |.....................| 0.9977 | 0.8379 | 0.9928 |...........|
#> | X| 10452.292 | 1.630 | 0.04115 | 0.3714 | 0.6324 |
#> |.....................| 0.9977 | 0.8379 | 0.9928 |...........|
#> | M| Mixed Diff. | 110.4 | -215.6 | -225.8 | -9762. |
#> |.....................| -1766. | -1796. | -1612. |...........|
#> | 3| 9501.1243 | 0.7487 | -0.9490 | 0.1014 | 1.882 |
#> |.....................| 1.568 | 1.505 | 1.528 |...........|
#> | U| 9501.1243 | 0.4868 | -3.149 | -0.9462 | 0.6981 |
#> |.....................| 1.568 | 1.329 | 1.528 |...........|
#> | X| 9501.1243 | 1.627 | 0.04289 | 0.3882 | 0.6981 |
#> |.....................| 1.568 | 1.329 | 1.528 |...........|
#> | F| Forward Diff. | 316.0 | -362.1 | -303.1 | -7470. |
#> |.....................| 842.5 | 869.9 | 309.7 |...........|
#> | 4| 4988.0442 | 0.7071 | -0.9013 | 0.1413 | 2.866 |
#> |.....................| 1.457 | 1.390 | 1.488 |...........|
#> | U| 4988.0442 | 0.4452 | -3.101 | -0.9063 | 1.009 |
#> |.....................| 1.457 | 1.233 | 1.488 |...........|
#> | X| 4988.0442 | 1.561 | 0.04499 | 0.4040 | 1.009 |
#> |.....................| 1.457 | 1.233 | 1.488 |...........|
#> | M| Mixed Diff. | 150.4 | -204.6 | -198.6 | -7321. |
#> |.....................| -7286. | -7256. | -7130. |...........|
#> | 5| 3460.3162 | 0.4168 | -0.6925 | 0.2697 | 3.506 |
#> |.....................| 1.393 | 1.235 | 2.133 |...........|
#> | U| 3460.3162 | 0.1549 | -2.892 | -0.7779 | 1.212 |
#> |.....................| 1.393 | 1.102 | 2.133 |...........|
#> | X| 3460.3162 | 1.167 | 0.05544 | 0.4593 | 1.212 |
#> |.....................| 1.393 | 1.102 | 2.133 |...........|
#> | M| Mixed Diff. | 168.7 | -139.4 | -40.96 | -4780. |
#> |.....................| -5994. | -6491. | -4966. |...........|
#> | 6| 2908.7479 | 0.3867 | -0.6676 | 0.2770 | 4.359 |
#> |.....................| 2.462 | 2.393 | 3.019 |...........|
#> | U| 2908.7479 | 0.1248 | -2.868 | -0.7706 | 1.481 |
#> |.....................| 2.462 | 2.076 | 3.019 |...........|
#> | X| 2908.7479 | 1.133 | 0.05684 | 0.4627 | 1.481 |
#> |.....................| 2.462 | 2.076 | 3.019 |...........|
#> | F| Forward Diff. | -3393. | -3181. | -3815. | -1839. |
#> |.....................| -1382. | -1261. | -304.4 |...........|
#> | 7| 2546.9141 | 0.9032 | -0.1834 | 0.8577 | 4.639 |
#> |.....................| 2.673 | 2.585 | 3.066 |...........|
#> | U| 2546.9141 | 0.6413 | -2.383 | -0.1899 | 1.570 |
#> |.....................| 2.673 | 2.238 | 3.066 |...........|
#> | X| 2546.9141 | 1.899 | 0.09223 | 0.8270 | 1.570 |
#> |.....................| 2.673 | 2.238 | 3.066 |...........|
#> | F| Forward Diff. | 48.65 | -236.5 | -84.70 | -767.4 |
#> |.....................| 1.138 | 54.81 | 2.055 |...........|
#> | 8| 2195.3155 | 0.8732 | -0.03761 | 0.9099 | 5.112 |
#> |.....................| 2.672 | 2.552 | 3.064 |...........|
#> | U| 2195.3155 | 0.6113 | -2.238 | -0.1377 | 1.720 |
#> |.....................| 2.672 | 2.209 | 3.064 |...........|
#> | X| 2195.3155 | 1.843 | 0.1067 | 0.8714 | 1.720 |
#> |.....................| 2.672 | 2.209 | 3.064 |...........|
#> | 9| 1683.8275 | 0.2325 | 0.9417 | 0.9254 | 5.961 |
#> |.....................| 2.628 | 2.490 | 2.802 |...........|
#> | U| 1683.8275 | -0.02938 | -1.258 | -0.1222 | 1.988 |
#> |.....................| 2.628 | 2.157 | 2.802 |...........|
#> | X| 1683.8275 | 0.9710 | 0.2841 | 0.8850 | 1.988 |
#> |.....................| 2.628 | 2.157 | 2.802 |...........|
#> | F| Forward Diff. | -367.4 | -278.5 | -366.2 | -396.0 |
#> |.....................| -136.0 | -148.3 | -128.7 |...........|
#> | 10| 1365.3526 | 1.157 | 1.642 | 1.847 | 6.957 |
#> |.....................| 2.970 | 2.863 | 3.126 |...........|
#> | U| 1365.3526 | 0.8949 | -0.5576 | 0.7991 | 2.303 |
#> |.....................| 2.970 | 2.471 | 3.126 |...........|
#> | X| 1365.3526 | 2.447 | 0.5726 | 2.223 | 2.303 |
#> |.....................| 2.970 | 2.471 | 3.126 |...........|
#> | F| Forward Diff. | 14.96 | -11.95 | -65.60 | -184.8 |
#> |.....................| 0.09658 | -3.202 | -0.04207 |...........|
#> | 11| 1155.8710 | 0.7986 | 1.095 | 3.004 | 8.273 |
#> |.....................| 2.789 | 2.988 | 3.117 |...........|
#> | U| 1155.871 | 0.5367 | -1.105 | 1.956 | 2.719 |
#> |.....................| 2.789 | 2.577 | 3.117 |...........|
#> | X| 1155.871 | 1.710 | 0.3312 | 7.073 | 2.719 |
#> |.....................| 2.789 | 2.577 | 3.117 |...........|
#> | F| Forward Diff. | 9.408 | -18.52 | -39.80 | -98.59 |
#> |.....................| -0.01020 | 0.08670 | 0.1958 |...........|
#> | 12| 1013.0456 | 0.6350 | 1.417 | 3.696 | 9.987 |
#> |.....................| 2.790 | 2.987 | 3.114 |...........|
#> | U| 1013.0456 | 0.3731 | -0.7832 | 2.648 | 3.261 |
#> |.....................| 2.790 | 2.575 | 3.114 |...........|
#> | X| 1013.0456 | 1.452 | 0.4570 | 14.13 | 3.261 |
#> |.....................| 2.790 | 2.575 | 3.114 |...........|
#> | F| Forward Diff. | 4.063 | -6.729 | -19.62 | -45.95 |
#> |.....................| -0.02786 | -0.004702 | -0.02586 |...........|
#> | 13| 954.46654 | 0.3551 | 1.083 | 4.897 | 11.33 |
#> |.....................| 2.976 | 2.752 | 3.005 |...........|
#> | U| 954.46654 | 0.09319 | -1.117 | 3.850 | 3.687 |
#> |.....................| 2.976 | 2.378 | 3.005 |...........|
#> | X| 954.46654 | 1.098 | 0.3273 | 46.99 | 3.687 |
#> |.....................| 2.976 | 2.378 | 3.005 |...........|
#> | F| Forward Diff. | -1.787 | -0.5203 | -0.5185 | -25.46 |
#> |.....................| -0.02263 | -0.001252 | -0.1320 |...........|
#> | 14| 920.83833 | 0.4869 | 1.122 | 4.936 | 13.21 |
#> |.....................| 2.977 | 2.752 | 3.015 |...........|
#> | U| 920.83833 | 0.2250 | -1.078 | 3.888 | 4.281 |
#> |.....................| 2.977 | 2.378 | 3.015 |...........|
#> | X| 920.83833 | 1.252 | 0.3401 | 48.82 | 4.281 |
#> |.....................| 2.977 | 2.378 | 3.015 |...........|
#> | F| Forward Diff. | -1.091 | -0.3689 | -0.3078 | -11.55 |
#> |.....................| -0.01554 | -0.001042 | -0.09664 |...........|
#> | 15| 908.06825 | 0.6616 | 1.166 | 4.905 | 14.77 |
#> |.....................| 2.959 | 2.714 | 3.034 |...........|
#> | U| 908.06825 | 0.3997 | -1.034 | 3.858 | 4.775 |
#> |.....................| 2.959 | 2.346 | 3.034 |...........|
#> | X| 908.06825 | 1.491 | 0.3555 | 47.36 | 4.775 |
#> |.....................| 2.959 | 2.346 | 3.034 |...........|
#> | F| Forward Diff. | -0.4813 | -0.3327 | -0.8870 | -5.111 |
#> |.....................| -0.01133 | -0.001041 | -0.07454 |...........|
#> | 16| 903.90550 | 0.5986 | 1.171 | 5.157 | 16.06 |
#> |.....................| 3.003 | 2.739 | 2.984 |...........|
#> | U| 903.9055 | 0.3367 | -1.029 | 4.110 | 5.180 |
#> |.....................| 3.003 | 2.367 | 2.984 |...........|
#> | X| 903.9055 | 1.400 | 0.3575 | 60.92 | 5.180 |
#> |.....................| 3.003 | 2.367 | 2.984 |...........|
#> | F| Forward Diff. | -0.9727 | -0.1500 | 1.389 | -1.763 |
#> |.....................| -0.009274 |-0.0005595 | -0.06998 |...........|
#> | 17| 903.35260 | 1.073 | 1.285 | 4.679 | 16.99 |
#> |.....................| 2.872 | 2.583 | 3.097 |...........|
#> | U| 903.3526 | 0.8113 | -0.9154 | 3.631 | 5.477 |
#> |.....................| 2.872 | 2.236 | 3.097 |...........|
#> | X| 903.3526 | 2.251 | 0.4003 | 37.76 | 5.477 |
#> |.....................| 2.872 | 2.236 | 3.097 |...........|
#> | F| Forward Diff. | 0.3185 | -0.4553 | -2.706 | -0.02177 |
#> |.....................| -0.006657 | -0.002044 | -0.04719 |...........|
#> | 18| 902.88905 | 0.8702 | 1.256 | 4.951 | 16.99 |
#> |.....................| 2.930 | 2.640 | 3.032 |...........|
#> | U| 902.88905 | 0.6083 | -0.9445 | 3.903 | 5.477 |
#> |.....................| 2.930 | 2.284 | 3.032 |...........|
#> | X| 902.88905 | 1.837 | 0.3889 | 49.57 | 5.477 |
#> |.....................| 2.930 | 2.284 | 3.032 |...........|
#> | F| Forward Diff. | -0.1887 | -0.2474 | -0.6139 | 0.03049 |
#> |.....................| -0.007488 | -0.001042 | -0.05646 |...........|
#> | 19| 902.87438 | 0.8394 | 1.261 | 4.999 | 16.99 |
#> |.....................| 2.935 | 2.641 | 3.020 |...........|
#> | U| 902.87438 | 0.5775 | -0.9386 | 3.952 | 5.477 |
#> |.....................| 2.935 | 2.285 | 3.020 |...........|
#> | X| 902.87438 | 1.782 | 0.3912 | 52.03 | 5.477 |
#> |.....................| 2.935 | 2.285 | 3.020 |...........|
#> | F| Forward Diff. | -0.2905 | -0.2212 | -0.2257 | 0.03101 |
#> |.....................| -0.007644 |-0.0009604 | -0.05797 |...........|
#> | 20| 902.87438 | 0.8394 | 1.261 | 4.999 | 16.99 |
#> |.....................| 2.935 | 2.641 | 3.020 |...........|
#> | U| 902.87438 | 0.5775 | -0.9386 | 3.952 | 5.477 |
#> |.....................| 2.935 | 2.285 | 3.020 |...........|
#> | X| 902.87438 | 1.782 | 0.3912 | 52.03 | 5.477 |
#> |.....................| 2.935 | 2.285 | 3.020 |...........|
#> calculating covariance matrix
#> done
#> Calculating residuals/tables
#> done
#> Warning: gradient problems with initial estimate and covariance; see $scaleInfo
#> Warning: using S matrix to calculate covariance, can check sandwich or R matrix with $covRS and $covR
#> Warning: last objective function was not at minimum, possible problems in optimization
#> Warning: ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))
#> Warning: initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))
## You can also use the standard nlmixr functions to run FOCEi
library(data.table);
datr <- Infusion_1CPT;
datr$EVID<-ifelse(datr$EVID==1,10101,datr$EVID)
datr<-data.table(datr)
datr<-datr[EVID!=2]
datro<-copy(datr)
datIV<-datr[AMT>0][,TIME:=TIME+AMT/RATE][,AMT:=-1*AMT]
datr<-rbind(datr,datIV)
one.compartment.IV.model <- function(){
ini({ # Where initial conditions/variables are specified
# '<-' or '=' defines population parameters
# Simple numeric expressions are supported
lCl <- 1.6 #log Cl (L/hr)
lVc <- 4.5 #log V (L)
# Bounds may be specified by c(lower, est, upper), like NONMEM:
# Residuals errors are assumed to be population parameters
prop.sd <- 0.3
# Between subject variability estimates are specified by '~'
# Semicolons are optional
eta.Vc ~ 0.1 #IIV V
eta.Cl ~ 0.1; #IIV Cl
})
model({ # Where the model is specified
# The model uses the ini-defined variable names
Vc <- exp(lVc + eta.Vc)
Cl <- exp(lCl + eta.Cl)
# RxODE-style differential equations are supported
d / dt(centr) = -(Cl / Vc) * centr;
## Concentration is calculated
cp = centr / Vc;
# And is assumed to follow proportional error estimated by prop.err
cp ~ prop(prop.sd)
})}
fitIVp <- nlmixr(one.compartment.IV.model, datr, "focei");
#> ℹ parameter labels from comments will be replaced by 'label()'
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → calculate jacobian
#>
#> → calculate sensitivities
#>
#> → calculate ∂(f)/∂(η)
#>
#> → calculate ∂(R²)/∂(η)
#>
#> → finding duplicate expressions in inner model...
#>
#> → optimizing duplicate expressions in inner model...
#>
#> → finding duplicate expressions in EBE model...
#>
#> → optimizing duplicate expressions in EBE model...
#>
#> → compiling inner model...
#>
#> ✔ done
#> → finding duplicate expressions in FD model...
#>
#> → optimizing duplicate expressions in FD model...
#>
#> → compiling EBE model...
#>
#> ✔ done
#> → compiling events FD model...
#>
#> ✔ done
#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
#> F: Forward difference gradient approximation
#> C: Central difference gradient approximation
#> M: Mixed forward and central difference gradient approximation
#> Unscaled parameters for Omegas=chol(solve(omega));
#> Diagonals are transformed, as specified by foceiControl(diagXform=)
#> |-----+---------------+-----------+-----------+-----------+-----------|
#> | #| Objective Fun | lCl | lVc | prop.sd | o1 |
#> |.....................| o2 |...........|...........|...........|
#> | 1| 64568.752 | -0.3810 | 1.000 | -1.000 | -0.2961 |
#> |.....................| -0.2961 |...........|...........|...........|
#> | U| 64568.752 | 1.600 | 4.500 | 0.3000 | 1.778 |
#> |.....................| 1.778 |...........|...........|...........|
#> | X| 64568.752 | 4.953 | 90.02 | 0.3000 | 1.778 |
#> |.....................| 1.778 |...........|...........|...........|
#> | G| Gill Diff. | 393.9 | 429.3 | 3259. | 120.0 |
#> |.....................| 29.08 |...........|...........|...........|
#> | 2| 64109.890 | -0.4998 | 0.8704 | -1.984 | -0.3323 |
#> |.....................| -0.3048 |...........|...........|...........|
#> | U| 64109.89 | 1.481 | 4.370 | 0.1524 | 1.714 |
#> |.....................| 1.763 |...........|...........|...........|
#> | X| 64109.89 | 4.398 | 79.08 | 0.1524 | 1.714 |
#> |.....................| 1.763 |...........|...........|...........|
#> | F| Forward Diff. | 251.9 | 236.8 | -8957. | -33.21 |
#> |.....................| -56.48 |...........|...........|...........|
#> | 3| 64024.129 | -0.9601 | 0.3843 | -1.247 | -0.4272 |
#> |.....................| -0.3079 |...........|...........|...........|
#> | U| 64024.129 | 1.021 | 3.884 | 0.2630 | 1.545 |
#> |.....................| 1.757 |...........|...........|...........|
#> | X| 64024.129 | 2.776 | 48.64 | 0.2630 | 1.545 |
#> |.....................| 1.757 |...........|...........|...........|
#> | F| Forward Diff. | -882.9 | -551.1 | 3015. | 261.8 |
#> |.....................| 575.1 |...........|...........|...........|
#> | 4| 63443.873 | -0.6286 | 0.5642 | -1.412 | -0.5504 |
#> |.....................| -0.5633 |...........|...........|...........|
#> | U| 63443.873 | 1.352 | 4.064 | 0.2382 | 1.326 |
#> |.....................| 1.303 |...........|...........|...........|
#> | X| 63443.873 | 3.867 | 58.22 | 0.2382 | 1.326 |
#> |.....................| 1.303 |...........|...........|...........|
#> | F| Forward Diff. | -34.16 | -163.7 | 2292. | -353.2 |
#> |.....................| -497.6 |...........|...........|...........|
#> | 5| 63537.109 | -0.6214 | 0.5986 | -1.894 | -0.4762 |
#> |.....................| -0.4587 |...........|...........|...........|
#> | U| 63537.109 | 1.360 | 4.099 | 0.1659 | 1.458 |
#> |.....................| 1.489 |...........|...........|...........|
#> | X| 63537.109 | 3.895 | 60.26 | 0.1659 | 1.458 |
#> |.....................| 1.489 |...........|...........|...........|
#> | 6| 63077.077 | -0.6252 | 0.5802 | -1.636 | -0.5160 |
#> |.....................| -0.5148 |...........|...........|...........|
#> | U| 63077.077 | 1.356 | 4.080 | 0.2047 | 1.387 |
#> |.....................| 1.389 |...........|...........|...........|
#> | X| 63077.077 | 3.880 | 59.16 | 0.2047 | 1.387 |
#> |.....................| 1.389 |...........|...........|...........|
#> | F| Forward Diff. | -29.34 | -170.2 | 423.5 | -311.4 |
#> |.....................| -427.5 |...........|...........|...........|
#> | 7| 63054.788 | -0.5967 | 0.6538 | -1.760 | -0.4083 |
#> |.....................| -0.3719 |...........|...........|...........|
#> | U| 63054.788 | 1.384 | 4.154 | 0.1860 | 1.579 |
#> |.....................| 1.643 |...........|...........|...........|
#> | X| 63054.788 | 3.992 | 63.68 | 0.1860 | 1.579 |
#> |.....................| 1.643 |...........|...........|...........|
#> | F| Forward Diff. | 4.050 | -165.6 | -1561. | -178.1 |
#> |.....................| -216.7 |...........|...........|...........|
#> | 8| 62969.106 | -0.5155 | 0.7783 | -1.622 | -0.3297 |
#> |.....................| -0.2922 |...........|...........|...........|
#> | U| 62969.106 | 1.465 | 4.278 | 0.2067 | 1.718 |
#> |.....................| 1.785 |...........|...........|...........|
#> | X| 62969.106 | 4.330 | 72.12 | 0.2067 | 1.718 |
#> |.....................| 1.785 |...........|...........|...........|
#> | F| Forward Diff. | 182.4 | 9.478 | 568.8 | -86.96 |
#> |.....................| -65.44 |...........|...........|...........|
#> | 9| 62998.048 | -0.6441 | 0.9364 | -1.672 | -0.2506 |
#> |.....................| -0.3504 |...........|...........|...........|
#> | U| 62998.048 | 1.337 | 4.436 | 0.1992 | 1.859 |
#> |.....................| 1.682 |...........|...........|...........|
#> | X| 62998.048 | 3.807 | 84.47 | 0.1992 | 1.859 |
#> |.....................| 1.682 |...........|...........|...........|
#> | 10| 62952.677 | -0.5553 | 0.8115 | -1.671 | -0.3069 |
#> |.....................| -0.3002 |...........|...........|...........|
#> | U| 62952.677 | 1.426 | 4.311 | 0.1994 | 1.759 |
#> |.....................| 1.771 |...........|...........|...........|
#> | X| 62952.677 | 4.161 | 74.55 | 0.1994 | 1.759 |
#> |.....................| 1.771 |...........|...........|...........|
#> | F| Forward Diff. | 89.32 | 92.67 | -64.43 | -39.17 |
#> |.....................| -98.39 |...........|...........|...........|
#> | 11| 62948.640 | -0.5929 | 0.7724 | -1.644 | -0.2904 |
#> |.....................| -0.2588 |...........|...........|...........|
#> | U| 62948.64 | 1.388 | 4.272 | 0.2035 | 1.788 |
#> |.....................| 1.845 |...........|...........|...........|
#> | X| 62948.64 | 4.007 | 71.70 | 0.2035 | 1.788 |
#> |.....................| 1.845 |...........|...........|...........|
#> | F| Forward Diff. | -2.681 | 1.104 | 311.3 | -18.19 |
#> |.....................| -38.52 |...........|...........|...........|
#> | 12| 62953.843 | -0.5695 | 0.7334 | -1.694 | -0.2978 |
#> |.....................| -0.2279 |...........|...........|...........|
#> | U| 62953.843 | 1.411 | 4.233 | 0.1958 | 1.775 |
#> |.....................| 1.899 |...........|...........|...........|
#> | X| 62953.843 | 4.102 | 68.95 | 0.1958 | 1.775 |
#> |.....................| 1.899 |...........|...........|...........|
#> | 13| 62945.577 | -0.5927 | 0.7723 | -1.672 | -0.2888 |
#> |.....................| -0.2553 |...........|...........|...........|
#> | U| 62945.577 | 1.388 | 4.272 | 0.1992 | 1.791 |
#> |.....................| 1.851 |...........|...........|...........|
#> | X| 62945.577 | 4.008 | 71.69 | 0.1992 | 1.791 |
#> |.....................| 1.851 |...........|...........|...........|
#> | F| Forward Diff. | 2.884 | 5.280 | -75.09 | -14.48 |
#> |.....................| -32.10 |...........|...........|...........|
#> | 14| 62945.270 | -0.5774 | 0.7667 | -1.665 | -0.2864 |
#> |.....................| -0.2327 |...........|...........|...........|
#> | U| 62945.27 | 1.404 | 4.267 | 0.2003 | 1.795 |
#> |.....................| 1.891 |...........|...........|...........|
#> | X| 62945.27 | 4.070 | 71.29 | 0.2003 | 1.795 |
#> |.....................| 1.891 |...........|...........|...........|
#> | F| Forward Diff. | 47.89 | -10.31 | 26.42 | -11.01 |
#> |.....................| 6.198 |...........|...........|...........|
#> | 15| 62945.307 | -0.5956 | 0.7884 | -1.668 | -0.2822 |
#> |.....................| -0.2313 |...........|...........|...........|
#> | U| 62945.307 | 1.385 | 4.288 | 0.1998 | 1.803 |
#> |.....................| 1.893 |...........|...........|...........|
#> | X| 62945.307 | 3.996 | 72.85 | 0.1998 | 1.803 |
#> |.....................| 1.893 |...........|...........|...........|
#> | 16| 62945.133 | -0.5892 | 0.7692 | -1.671 | -0.2837 |
#> |.....................| -0.2342 |...........|...........|...........|
#> | U| 62945.133 | 1.392 | 4.269 | 0.1993 | 1.800 |
#> |.....................| 1.888 |...........|...........|...........|
#> | X| 62945.133 | 4.022 | 71.47 | 0.1993 | 1.800 |
#> |.....................| 1.888 |...........|...........|...........|
#> | F| Forward Diff. | 13.61 | -2.370 | -62.81 | -5.572 |
#> |.....................| 2.957 |...........|...........|...........|
#> | 17| 62945.092 | -0.5937 | 0.7743 | -1.660 | -0.2804 |
#> |.....................| -0.2358 |...........|...........|...........|
#> | U| 62945.092 | 1.387 | 4.274 | 0.2011 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | X| 62945.092 | 4.004 | 71.83 | 0.2011 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | F| Forward Diff. | -2.171 | 8.859 | 99.54 | 0.4147 |
#> |.....................| 0.1833 |...........|...........|...........|
#> | 18| 62944.869 | -0.5935 | 0.7737 | -1.667 | -0.2804 |
#> |.....................| -0.2358 |...........|...........|...........|
#> | U| 62944.869 | 1.387 | 4.274 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | X| 62944.869 | 4.004 | 71.79 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | F| Forward Diff. | -0.5306 | 8.265 | 3.463 | 0.4065 |
#> |.....................| 0.2434 |...........|...........|...........|
#> | 19| 62944.927 | -0.5932 | 0.7670 | -1.668 | -0.2800 |
#> |.....................| -0.2371 |...........|...........|...........|
#> | U| 62944.927 | 1.388 | 4.267 | 0.1998 | 1.807 |
#> |.....................| 1.883 |...........|...........|...........|
#> | X| 62944.927 | 4.006 | 71.31 | 0.1998 | 1.807 |
#> |.....................| 1.883 |...........|...........|...........|
#> | 20| 62944.877 | -0.5934 | 0.7720 | -1.667 | -0.2805 |
#> |.....................| -0.2358 |...........|...........|...........|
#> | U| 62944.877 | 1.388 | 4.272 | 0.1999 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | X| 62944.877 | 4.005 | 71.67 | 0.1999 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | 21| 62944.870 | -0.5935 | 0.7731 | -1.667 | -0.2804 |
#> |.....................| -0.2358 |...........|...........|...........|
#> | U| 62944.87 | 1.387 | 4.273 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | X| 62944.87 | 4.005 | 71.75 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | 22| 62944.870 | -0.5935 | 0.7735 | -1.667 | -0.2804 |
#> |.....................| -0.2358 |...........|...........|...........|
#> | U| 62944.87 | 1.387 | 4.273 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | X| 62944.87 | 4.005 | 71.77 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | 23| 62944.869 | -0.5935 | 0.7736 | -1.667 | -0.2804 |
#> |.....................| -0.2358 |...........|...........|...........|
#> | U| 62944.869 | 1.387 | 4.274 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | X| 62944.869 | 4.004 | 71.78 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | 24| 62944.869 | -0.5935 | 0.7737 | -1.667 | -0.2804 |
#> |.....................| -0.2358 |...........|...........|...........|
#> | U| 62944.869 | 1.387 | 4.274 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | X| 62944.869 | 4.004 | 71.78 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | 25| 62944.869 | -0.5935 | 0.7737 | -1.667 | -0.2804 |
#> |.....................| -0.2358 |...........|...........|...........|
#> | U| 62944.869 | 1.387 | 4.274 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | X| 62944.869 | 4.004 | 71.79 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | 26| 62944.869 | -0.5935 | 0.7737 | -1.667 | -0.2804 |
#> |.....................| -0.2358 |...........|...........|...........|
#> | U| 62944.869 | 1.387 | 4.274 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | X| 62944.869 | 4.004 | 71.79 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | 27| 62944.869 | -0.5935 | 0.7737 | -1.667 | -0.2804 |
#> |.....................| -0.2358 |...........|...........|...........|
#> | U| 62944.869 | 1.387 | 4.274 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | X| 62944.869 | 4.004 | 71.79 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | F| Forward Diff. | -0.1716 | 8.728 | 3.629 | 0.8155 |
#> |.....................| 0.4376 |...........|...........|...........|
#> | 28| 62944.869 | -0.5935 | 0.7737 | -1.667 | -0.2804 |
#> |.....................| -0.2358 |...........|...........|...........|
#> | U| 62944.869 | 1.387 | 4.274 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | X| 62944.869 | 4.004 | 71.79 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | 29| 62944.869 | -0.5935 | 0.7737 | -1.667 | -0.2804 |
#> |.....................| -0.2358 |...........|...........|...........|
#> | U| 62944.869 | 1.387 | 4.274 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | X| 62944.869 | 4.004 | 71.79 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | 30| 62944.869 | -0.5935 | 0.7737 | -1.667 | -0.2804 |
#> |.....................| -0.2358 |...........|...........|...........|
#> | U| 62944.869 | 1.387 | 4.274 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | X| 62944.869 | 4.004 | 71.79 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | 31| 62944.869 | -0.5935 | 0.7737 | -1.667 | -0.2804 |
#> |.....................| -0.2358 |...........|...........|...........|
#> | U| 62944.869 | 1.387 | 4.274 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | X| 62944.869 | 4.004 | 71.79 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | 32| 62944.869 | -0.5935 | 0.7737 | -1.667 | -0.2804 |
#> |.....................| -0.2358 |...........|...........|...........|
#> | U| 62944.869 | 1.387 | 4.274 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | X| 62944.869 | 4.004 | 71.79 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | 33| 62944.869 | -0.5935 | 0.7737 | -1.667 | -0.2804 |
#> |.....................| -0.2358 |...........|...........|...........|
#> | U| 62944.869 | 1.387 | 4.274 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | X| 62944.869 | 4.004 | 71.79 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | 34| 62944.869 | -0.5935 | 0.7737 | -1.667 | -0.2804 |
#> |.....................| -0.2358 |...........|...........|...........|
#> | U| 62944.869 | 1.387 | 4.274 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | X| 62944.869 | 4.004 | 71.79 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | 35| 62944.869 | -0.5935 | 0.7737 | -1.667 | -0.2804 |
#> |.....................| -0.2358 |...........|...........|...........|
#> | U| 62944.869 | 1.387 | 4.274 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | X| 62944.869 | 4.004 | 71.79 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | 36| 62944.869 | -0.5935 | 0.7737 | -1.667 | -0.2804 |
#> |.....................| -0.2358 |...........|...........|...........|
#> | U| 62944.869 | 1.387 | 4.274 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | X| 62944.869 | 4.004 | 71.79 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | 37| 62944.869 | -0.5935 | 0.7737 | -1.667 | -0.2804 |
#> |.....................| -0.2358 |...........|...........|...........|
#> | U| 62944.869 | 1.387 | 4.274 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> | X| 62944.869 | 4.004 | 71.79 | 0.2000 | 1.806 |
#> |.....................| 1.885 |...........|...........|...........|
#> calculating covariance matrix
#> done
#> Calculating residuals/tables
#> done
#> Warning: initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))
#> Warning: ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))
#> Warning: last objective function was not at minimum, possible problems in optimization
#> Warning: gradient problems with covariance; see $scaleInfo
#> Warning: 'ss' is ignored with classic RxODE 'EVID's
## You can also use the Box-Cox Transform of both sides with
## proportional error (Donse 2016)
one.compartment.IV.model <- function(){
ini({ # Where initial conditions/variables are specified
## '<-' or '=' defines population parameters
## Simple numeric expressions are supported
lCl <- 1.6 #log Cl (L/hr)
lVc <- 4.5 #log V (L)
## Bounds may be specified by c(lower, est, upper), like NONMEM:
## Residuals errors are assumed to be population parameters
prop.err <- 0.3
add.err <- 0.01
lambda <- c(-2, 1, 2)
zeta <- c(0.1, 1, 10)
## Between subject variability estimates are specified by '~'
## Semicolons are optional
eta.Vc ~ 0.1 #IIV V
eta.Cl ~ 0.1; #IIV Cl
})
model({ ## Where the model is specified
## The model uses the ini-defined variable names
Vc <- exp(lVc + eta.Vc)
Cl <- exp(lCl + eta.Cl)
## RxODE-style differential equations are supported
d / dt(centr) = -(Cl / Vc) * centr;
## Concentration is calculated
cp = centr / Vc;
## And is assumed to follow proportional error estimated by prop.err
cp ~ pow(prop.err, zeta) + add(add.err) + boxCox(lambda)
## This is proportional to the untransformed f; You can use the transformed f by using powT()
})}
fitIVtbs <- nlmixr(one.compartment.IV.model, datr, "focei")
#> ℹ parameter labels from comments will be replaced by 'label()'
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → calculate jacobian
#>
#> → calculate sensitivities
#>
#> → calculate ∂(f)/∂(η)
#>
#> → calculate ∂(R²)/∂(η)
#>
#> → finding duplicate expressions in inner model...
#>
#> → optimizing duplicate expressions in inner model...
#>
#> → finding duplicate expressions in EBE model...
#>
#> → optimizing duplicate expressions in EBE model...
#>
#> → compiling inner model...
#>
#> ✔ done
#> → finding duplicate expressions in FD model...
#>
#> → optimizing duplicate expressions in FD model...
#>
#> → compiling EBE model...
#>
#> ✔ done
#> → compiling events FD model...
#>
#> ✔ done
#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
#> F: Forward difference gradient approximation
#> C: Central difference gradient approximation
#> M: Mixed forward and central difference gradient approximation
#> Unscaled parameters for Omegas=chol(solve(omega));
#> Diagonals are transformed, as specified by foceiControl(diagXform=)
#> |-----+---------------+-----------+-----------+-----------+-----------|
#> | #| Objective Fun | lCl | lVc | prop.err | add.err |
#> |.....................| lambda | zeta | o1 | o2 |
#> | 1| 64568.832 | -0.2918 | 1.000 | -0.8708 | -1.000 |
#> |.....................| -0.5590 | -0.5590 | -0.2123 | -0.2123 |
#> | U| 64568.832 | 1.600 | 4.500 | 0.3000 | 0.01000 |
#> |.....................| 1.000 | 1.000 | 1.778 | 1.778 |
#> | X| 64568.832 | 4.953 | 90.02 | 0.3000 | 0.01000 |
#> |.....................| 1.000 | 1.000 | 1.778 | 1.778 |
#> | G| Gill Diff. | 393.9 | 429.4 | 6520. | 0.09480 |
#> |.....................|-3.575e+04 | 3.615e+04 | 120.1 | 29.08 |
#> | 2| 1.0276305e+12 | -0.2994 | 0.9916 | -0.9980 | -1.000 |
#> |.....................| 0.1384 | -1.264 | -0.2147 | -0.2129 |
#> | U| 1.0276305e+12 | 1.592 | 4.492 | 0.2618 | 0.01000 |
#> |.....................| 1.697 | 0.2948 | 1.774 | 1.777 |
#> | X| 1.0276305e+12 | 4.915 | 89.27 | 0.2618 | 0.01000 |
#> |.....................| 1.697 | 0.2948 | 1.774 | 1.777 |
#> | 3| 66771.949 | -0.2925 | 0.9992 | -0.8835 | -1.000 |
#> |.....................| -0.4893 | -0.6295 | -0.2126 | -0.2124 |
#> | U| 66771.949 | 1.599 | 4.499 | 0.2962 | 0.01000 |
#> |.....................| 1.070 | 0.9295 | 1.778 | 1.778 |
#> | X| 66771.949 | 4.949 | 89.94 | 0.2962 | 0.01000 |
#> |.....................| 1.070 | 0.9295 | 1.778 | 1.778 |
#> | 4| 63293.426 | -0.2920 | 0.9997 | -0.8753 | -1.000 |
#> |.....................| -0.5346 | -0.5837 | -0.2124 | -0.2124 |
#> | U| 63293.426 | 1.600 | 4.500 | 0.2987 | 0.01000 |
#> |.....................| 1.024 | 0.9753 | 1.778 | 1.778 |
#> | X| 63293.426 | 4.952 | 89.99 | 0.2987 | 0.01000 |
#> |.....................| 1.024 | 0.9753 | 1.778 | 1.778 |
#> | M| Mixed Diff. | 476.3 | 520.7 | 2601. | 0.1372 |
#> |.....................|-1.185e+04 | 1.258e+04 | 199.6 | 92.13 |
#> | 5| 63200.181 | -0.3051 | 0.9854 | -0.8920 | -1.000 |
#> |.....................| -0.5341 | -0.6065 | -0.2185 | -0.2155 |
#> | U| 63200.181 | 1.587 | 4.485 | 0.2937 | 0.01000 |
#> |.....................| 1.025 | 0.9525 | 1.767 | 1.773 |
#> | X| 63200.181 | 4.887 | 88.71 | 0.2937 | 0.01000 |
#> |.....................| 1.025 | 0.9525 | 1.767 | 1.773 |
#> | F| Forward Diff. | 470.8 | 507.5 | -866.7 | 0.1619 |
#> |.....................| 9381. | -8466. | 186.4 | 86.65 |
#> | 6| 63122.745 | -0.3196 | 0.9697 | -0.9094 | -1.000 |
#> |.....................| -0.5538 | -0.6125 | -0.2242 | -0.2181 |
#> | U| 63122.745 | 1.572 | 4.470 | 0.2884 | 0.01000 |
#> |.....................| 1.005 | 0.9466 | 1.757 | 1.768 |
#> | X| 63122.745 | 4.817 | 87.33 | 0.2884 | 0.01000 |
#> |.....................| 1.005 | 0.9466 | 1.757 | 1.768 |
#> | F| Forward Diff. | 421.1 | 448.6 | 750.0 | 0.1359 |
#> |.....................| -489.4 | 1348. | 131.8 | 46.42 |
#> | 7| 63088.098 | -0.3331 | 0.9554 | -0.9294 | -1.000 |
#> |.....................| -0.5690 | -0.6264 | -0.2280 | -0.2192 |
#> | U| 63088.098 | 1.559 | 4.455 | 0.2824 | 0.01000 |
#> |.....................| 0.9900 | 0.9327 | 1.750 | 1.766 |
#> | X| 63088.098 | 4.753 | 86.09 | 0.2824 | 0.01000 |
#> |.....................| 0.9900 | 0.9327 | 1.750 | 1.766 |
#> | 8| 62996.626 | -0.3735 | 0.9127 | -0.9890 | -1.000 |
#> |.....................| -0.6172 | -0.6655 | -0.2391 | -0.2224 |
#> | U| 62996.626 | 1.518 | 4.413 | 0.2646 | 0.01000 |
#> |.....................| 0.9419 | 0.8935 | 1.731 | 1.760 |
#> | X| 62996.626 | 4.564 | 82.49 | 0.2646 | 0.01000 |
#> |.....................| 0.9419 | 0.8935 | 1.731 | 1.760 |
#> | 9| 62874.199 | -0.4851 | 0.7948 | -1.153 | -1.000 |
#> |.....................| -0.7500 | -0.7735 | -0.2698 | -0.2312 |
#> | U| 62874.199 | 1.407 | 4.295 | 0.2153 | 0.01000 |
#> |.....................| 0.8091 | 0.7855 | 1.676 | 1.745 |
#> | X| 62874.199 | 4.082 | 73.31 | 0.2153 | 0.01000 |
#> |.....................| 0.8091 | 0.7855 | 1.676 | 1.745 |
#> | M| Mixed Diff. | 40.28 | 45.22 | -2158. | -0.1938 |
#> |.....................| 1.039e+04 | -9689. | -125.0 | -126.6 |
#> | 10| 62992.547 | -0.5795 | 0.6968 | -1.042 | -1.000 |
#> |.....................| -1.024 | -1.035 | -0.2069 | -0.1551 |
#> | U| 62992.547 | 1.312 | 4.197 | 0.2487 | 0.01000 |
#> |.....................| 0.5352 | 0.5239 | 1.788 | 1.880 |
#> | X| 62992.547 | 3.715 | 66.47 | 0.2487 | 0.01000 |
#> |.....................| 0.5352 | 0.5239 | 1.788 | 1.880 |
#> | 11| 62998.204 | -0.5239 | 0.7545 | -1.106 | -1.000 |
#> |.....................| -0.8724 | -0.8716 | -0.2439 | -0.1998 |
#> | U| 62998.204 | 1.368 | 4.254 | 0.2296 | 0.01000 |
#> |.....................| 0.6866 | 0.6875 | 1.722 | 1.801 |
#> | X| 62998.204 | 3.927 | 70.42 | 0.2296 | 0.01000 |
#> |.....................| 0.6866 | 0.6875 | 1.722 | 1.801 |
#> | 12| 63010.689 | -0.4993 | 0.7800 | -1.134 | -1.000 |
#> |.....................| -0.8055 | -0.7994 | -0.2602 | -0.2196 |
#> | U| 63010.689 | 1.392 | 4.280 | 0.2212 | 0.01000 |
#> |.....................| 0.7535 | 0.7597 | 1.693 | 1.765 |
#> | X| 63010.689 | 4.025 | 72.24 | 0.2212 | 0.01000 |
#> |.....................| 0.7535 | 0.7597 | 1.693 | 1.765 |
#> | 13| 63019.151 | -0.4871 | 0.7927 | -1.148 | -1.000 |
#> |.....................| -0.7722 | -0.7633 | -0.2683 | -0.2294 |
#> | U| 63019.151 | 1.405 | 4.293 | 0.2170 | 0.01000 |
#> |.....................| 0.7869 | 0.7957 | 1.679 | 1.748 |
#> | X| 63019.151 | 4.074 | 73.16 | 0.2170 | 0.01000 |
#> |.....................| 0.7869 | 0.7957 | 1.679 | 1.748 |
#> | 14| 62821.926 | -0.4851 | 0.7947 | -1.152 | -1.000 |
#> |.....................| -0.7564 | -0.7675 | -0.2697 | -0.2311 |
#> | U| 62821.926 | 1.407 | 4.295 | 0.2157 | 0.01000 |
#> |.....................| 0.8026 | 0.7915 | 1.676 | 1.745 |
#> | X| 62821.926 | 4.082 | 73.31 | 0.2157 | 0.01000 |
#> |.....................| 0.8026 | 0.7915 | 1.676 | 1.745 |
#> | F| Forward Diff. | 32.26 | 37.52 | 558.0 | -0.2255 |
#> |.....................| -1181. | 1893. | -126.5 | -127.6 |
#> | 15| 62816.370 | -0.4852 | 0.7946 | -1.152 | -1.000 |
#> |.....................| -0.7612 | -0.7741 | -0.2672 | -0.2287 |
#> | U| 62816.37 | 1.407 | 4.295 | 0.2156 | 0.01000 |
#> |.....................| 0.7978 | 0.7849 | 1.681 | 1.749 |
#> | X| 62816.37 | 4.082 | 73.31 | 0.2156 | 0.01000 |
#> |.....................| 0.7978 | 0.7849 | 1.681 | 1.749 |
#> | F| Forward Diff. | 33.65 | 38.88 | 204.1 | -0.2187 |
#> |.....................| 350.7 | 365.4 | -121.9 | -123.6 |
#> | 16| 62812.352 | -0.4857 | 0.7940 | -1.155 | -1.000 |
#> |.....................| -0.7666 | -0.7797 | -0.2653 | -0.2267 |
#> | U| 62812.352 | 1.406 | 4.294 | 0.2147 | 0.01000 |
#> |.....................| 0.7924 | 0.7793 | 1.684 | 1.753 |
#> | X| 62812.352 | 4.080 | 73.26 | 0.2147 | 0.01000 |
#> |.....................| 0.7924 | 0.7793 | 1.684 | 1.753 |
#> | 17| 62808.363 | -0.4864 | 0.7932 | -1.159 | -1.000 |
#> |.....................| -0.7738 | -0.7872 | -0.2628 | -0.2242 |
#> | U| 62808.363 | 1.405 | 4.293 | 0.2134 | 0.01000 |
#> |.....................| 0.7852 | 0.7718 | 1.689 | 1.757 |
#> | X| 62808.363 | 4.077 | 73.20 | 0.2134 | 0.01000 |
#> |.....................| 0.7852 | 0.7718 | 1.689 | 1.757 |
#> | F| Forward Diff. | 33.00 | 38.24 | -263.9 | -0.2280 |
#> |.....................| 2263. | -1543. | -114.3 | -116.5 |
#> | 18| 62797.224 | -0.4868 | 0.7928 | -1.158 | -1.000 |
#> |.....................| -0.7884 | -0.7997 | -0.2576 | -0.2192 |
#> | U| 62797.224 | 1.405 | 4.293 | 0.2138 | 0.01000 |
#> |.....................| 0.7706 | 0.7593 | 1.698 | 1.766 |
#> | X| 62797.224 | 4.075 | 73.17 | 0.2138 | 0.01000 |
#> |.....................| 0.7706 | 0.7593 | 1.698 | 1.766 |
#> | F| Forward Diff. | 30.03 | 35.66 | 225.9 | -0.2221 |
#> |.....................| 160.3 | 537.2 | -105.9 | -109.0 |
#> | 19| 62788.798 | -0.4873 | 0.7921 | -1.157 | -1.000 |
#> |.....................| -0.8017 | -0.8145 | -0.2538 | -0.2153 |
#> | U| 62788.798 | 1.404 | 4.292 | 0.2141 | 0.01000 |
#> |.....................| 0.7573 | 0.7445 | 1.705 | 1.773 |
#> | X| 62788.798 | 4.073 | 73.12 | 0.2141 | 0.01000 |
#> |.....................| 0.7573 | 0.7445 | 1.705 | 1.773 |
#> | 20| 62777.504 | -0.4879 | 0.7913 | -1.155 | -1.000 |
#> |.....................| -0.8202 | -0.8338 | -0.2486 | -0.2101 |
#> | U| 62777.504 | 1.404 | 4.291 | 0.2148 | 0.01000 |
#> |.....................| 0.7389 | 0.7252 | 1.714 | 1.782 |
#> | X| 62777.504 | 4.071 | 73.06 | 0.2148 | 0.01000 |
#> |.....................| 0.7389 | 0.7252 | 1.714 | 1.782 |
#> | 21| 62750.011 | -0.4895 | 0.7893 | -1.149 | -1.000 |
#> |.....................| -0.8683 | -0.8840 | -0.2352 | -0.1965 |
#> | U| 62750.011 | 1.402 | 4.289 | 0.2166 | 0.01000 |
#> |.....................| 0.6907 | 0.6750 | 1.738 | 1.807 |
#> | X| 62750.011 | 4.064 | 72.91 | 0.2166 | 0.01000 |
#> |.....................| 0.6907 | 0.6750 | 1.738 | 1.807 |
#> | 22| 62703.017 | -0.4926 | 0.7851 | -1.137 | -0.9999 |
#> |.....................| -0.9657 | -0.9856 | -0.2081 | -0.1690 |
#> | U| 62703.017 | 1.399 | 4.285 | 0.2203 | 0.01000 |
#> |.....................| 0.5933 | 0.5734 | 1.786 | 1.855 |
#> | X| 62703.017 | 4.052 | 72.61 | 0.2203 | 0.01000 |
#> |.....................| 0.5933 | 0.5734 | 1.786 | 1.855 |
#> | F| Forward Diff. | 13.57 | 20.34 | -351.5 | -0.08971 |
#> |.....................| 2884. | -2298. | -20.93 | -28.77 |
#> | 23| 62702.907 | -0.3746 | 0.9015 | -1.173 | -0.9999 |
#> |.....................| -1.105 | -1.107 | -0.2710 | -0.2371 |
#> | U| 62702.907 | 1.517 | 4.401 | 0.2095 | 0.01000 |
#> |.....................| 0.4539 | 0.4523 | 1.674 | 1.734 |
#> | X| 62702.907 | 4.559 | 81.57 | 0.2095 | 0.01000 |
#> |.....................| 0.4539 | 0.4523 | 1.674 | 1.734 |
#> | F| Forward Diff. | 253.6 | 220.9 | 1543. | -0.1092 |
#> |.....................| -5768. | 6235. | -77.05 | -78.54 |
#> | 24| 62715.639 | -0.3664 | 0.9328 | -1.151 | -1.000 |
#> |.....................| -1.163 | -1.185 | -0.3229 | -0.3021 |
#> | U| 62715.639 | 1.525 | 4.433 | 0.2159 | 0.01000 |
#> |.....................| 0.3962 | 0.3740 | 1.582 | 1.619 |
#> | X| 62715.639 | 4.597 | 84.17 | 0.2159 | 0.01000 |
#> |.....................| 0.3962 | 0.3740 | 1.582 | 1.619 |
#> | 25| 62703.309 | -0.3711 | 0.9151 | -1.164 | -1.000 |
#> |.....................| -1.127 | -1.145 | -0.2938 | -0.2657 |
#> | U| 62703.309 | 1.521 | 4.415 | 0.2120 | 0.01000 |
#> |.....................| 0.4319 | 0.4140 | 1.633 | 1.683 |
#> | X| 62703.309 | 4.575 | 82.69 | 0.2120 | 0.01000 |
#> |.....................| 0.4319 | 0.4140 | 1.633 | 1.683 |
#> | 26| 62700.138 | -0.3731 | 0.9079 | -1.169 | -0.9999 |
#> |.....................| -1.112 | -1.128 | -0.2819 | -0.2507 |
#> | U| 62700.138 | 1.519 | 4.408 | 0.2104 | 0.01000 |
#> |.....................| 0.4467 | 0.4305 | 1.655 | 1.710 |
#> | X| 62700.138 | 4.566 | 82.09 | 0.2104 | 0.01000 |
#> |.....................| 0.4467 | 0.4305 | 1.655 | 1.710 |
#> | F| Forward Diff. | 248.7 | 228.1 | -1322. | -0.1120 |
#> |.....................| 6344. | -5841. | -87.69 | -97.51 |
#> | 27| 62679.045 | -0.3782 | 0.9060 | -1.162 | -1.000 |
#> |.....................| -1.120 | -1.131 | -0.2877 | -0.2577 |
#> | U| 62679.045 | 1.514 | 4.406 | 0.2126 | 0.01000 |
#> |.....................| 0.4394 | 0.4285 | 1.644 | 1.698 |
#> | X| 62679.045 | 4.543 | 81.94 | 0.2126 | 0.01000 |
#> |.....................| 0.4394 | 0.4285 | 1.644 | 1.698 |
#> | F| Forward Diff. | 228.4 | 216.4 | 214.3 | -0.08924 |
#> |.....................| -61.83 | 539.3 | -102.1 | -116.4 |
#> | 28| 62678.033 | -0.3836 | 0.9035 | -1.156 | -1.000 |
#> |.....................| -1.124 | -1.137 | -0.2940 | -0.2646 |
#> | U| 62678.033 | 1.508 | 4.404 | 0.2145 | 0.01000 |
#> |.....................| 0.4354 | 0.4222 | 1.633 | 1.685 |
#> | X| 62678.033 | 4.519 | 81.74 | 0.2145 | 0.01000 |
#> |.....................| 0.4354 | 0.4222 | 1.633 | 1.685 |
#> | F| Forward Diff. | 211.9 | 206.7 | 52.43 | -0.07778 |
#> |.....................| 720.6 | -242.8 | -116.0 | -132.8 |
#> | 29| 62677.555 | -0.3879 | 0.9027 | -1.150 | -1.000 |
#> |.....................| -1.131 | -1.144 | -0.3010 | -0.2693 |
#> | U| 62677.555 | 1.504 | 4.403 | 0.2162 | 0.009999 |
#> |.....................| 0.4282 | 0.4155 | 1.621 | 1.677 |
#> | X| 62677.555 | 4.499 | 81.67 | 0.2162 | 0.009999 |
#> |.....................| 0.4282 | 0.4155 | 1.621 | 1.677 |
#> | F| Forward Diff. | 198.6 | 198.4 | 447.6 | -0.06424 |
#> |.....................| -921.0 | 1388. | -130.2 | -144.9 |
#> | 30| 62674.099 | -0.3845 | 0.9071 | -1.157 | -1.001 |
#> |.....................| -1.136 | -1.148 | -0.2966 | -0.2608 |
#> | U| 62674.099 | 1.507 | 4.407 | 0.2141 | 0.009997 |
#> |.....................| 0.4233 | 0.4108 | 1.628 | 1.692 |
#> | X| 62674.099 | 4.514 | 82.03 | 0.2141 | 0.009997 |
#> |.....................| 0.4233 | 0.4108 | 1.628 | 1.692 |
#> | F| Forward Diff. | 212.8 | 209.9 | 137.2 | -0.07613 |
#> |.....................| 326.9 | 140.8 | -117.9 | -127.5 |
#> | 31| 62671.953 | -0.3856 | 0.8997 | -1.161 | -1.001 |
#> |.....................| -1.141 | -1.150 | -0.2860 | -0.2614 |
#> | U| 62671.953 | 1.506 | 4.400 | 0.2129 | 0.009996 |
#> |.....................| 0.4177 | 0.4086 | 1.647 | 1.691 |
#> | X| 62671.953 | 4.509 | 81.43 | 0.2129 | 0.009996 |
#> |.....................| 0.4177 | 0.4086 | 1.647 | 1.691 |
#> | F| Forward Diff. | 208.9 | 205.7 | 632.7 | -0.07763 |
#> |.....................| -1850. | 2306. | -105.5 | -130.2 |
#> | 32| 64804.354 | -0.3813 | 0.8864 | -1.158 | -1.001 |
#> |.....................| -1.142 | -1.154 | -0.2844 | -0.2628 |
#> | U| 64804.354 | 1.510 | 4.386 | 0.2137 | 0.009995 |
#> |.....................| 0.4174 | 0.4051 | 1.650 | 1.689 |
#> | X| 64804.354 | 4.529 | 80.35 | 0.2137 | 0.009995 |
#> |.....................| 0.4174 | 0.4051 | 1.650 | 1.689 |
#> | 33| 62669.371 | -0.3857 | 0.8996 | -1.161 | -1.001 |
#> |.....................| -1.140 | -1.152 | -0.2860 | -0.2614 |
#> | U| 62669.371 | 1.506 | 4.400 | 0.2128 | 0.009996 |
#> |.....................| 0.4186 | 0.4075 | 1.647 | 1.691 |
#> | X| 62669.371 | 4.509 | 81.42 | 0.2128 | 0.009996 |
#> |.....................| 0.4186 | 0.4075 | 1.647 | 1.691 |
#> | F| Forward Diff. | 209.7 | 206.4 | 205.0 | -0.08148 |
#> |.....................| -24.92 | 488.6 | -105.0 | -129.8 |
#> | 34| 62669.050 | -0.3858 | 0.8987 | -1.162 | -1.001 |
#> |.....................| -1.141 | -1.152 | -0.2863 | -0.2608 |
#> | U| 62669.05 | 1.506 | 4.399 | 0.2128 | 0.009996 |
#> |.....................| 0.4185 | 0.4066 | 1.647 | 1.692 |
#> | X| 62669.05 | 4.509 | 81.34 | 0.2128 | 0.009996 |
#> |.....................| 0.4185 | 0.4066 | 1.647 | 1.692 |
#> | F| Forward Diff. | 210.4 | 204.7 | 36.12 | -0.08278 |
#> |.....................| 695.6 | -230.0 | -106.5 | -128.6 |
#> | 35| 62668.664 | -0.3857 | 0.8977 | -1.161 | -1.001 |
#> |.....................| -1.141 | -1.152 | -0.2869 | -0.2603 |
#> | U| 62668.664 | 1.506 | 4.398 | 0.2129 | 0.009996 |
#> |.....................| 0.4177 | 0.4065 | 1.646 | 1.693 |
#> | X| 62668.664 | 4.509 | 81.27 | 0.2129 | 0.009996 |
#> |.....................| 0.4177 | 0.4065 | 1.646 | 1.693 |
#> | F| Forward Diff. | 210.8 | 202.3 | 205.0 | -0.08097 |
#> |.....................| -23.06 | 485.5 | -108.4 | -127.8 |
#> | 36| 62668.266 | -0.3861 | 0.8969 | -1.161 | -1.001 |
#> |.....................| -1.142 | -1.154 | -0.2871 | -0.2599 |
#> | U| 62668.266 | 1.506 | 4.397 | 0.2129 | 0.009996 |
#> |.....................| 0.4175 | 0.4055 | 1.645 | 1.694 |
#> | X| 62668.266 | 4.507 | 81.20 | 0.2129 | 0.009996 |
#> |.....................| 0.4175 | 0.4055 | 1.645 | 1.694 |
#> | F| Forward Diff. | 210.7 | 200.9 | 37.76 | -0.08203 |
#> |.....................| 691.8 | -227.0 | -109.4 | -127.4 |
#> | 37| 62667.748 | -0.3869 | 0.8966 | -1.161 | -1.001 |
#> |.....................| -1.143 | -1.154 | -0.2869 | -0.2600 |
#> | U| 62667.748 | 1.505 | 4.397 | 0.2130 | 0.009996 |
#> |.....................| 0.4164 | 0.4052 | 1.646 | 1.694 |
#> | X| 62667.748 | 4.503 | 81.17 | 0.2130 | 0.009996 |
#> |.....................| 0.4164 | 0.4052 | 1.646 | 1.694 |
#> | F| Forward Diff. | 208.5 | 200.1 | 204.5 | -0.07998 |
#> |.....................| -17.85 | 479.7 | -109.5 | -128.5 |
#> | 38| 62667.337 | -0.3877 | 0.8963 | -1.161 | -1.001 |
#> |.....................| -1.143 | -1.155 | -0.2866 | -0.2601 |
#> | U| 62667.337 | 1.504 | 4.396 | 0.2129 | 0.009996 |
#> |.....................| 0.4161 | 0.4040 | 1.646 | 1.693 |
#> | X| 62667.337 | 4.500 | 81.15 | 0.2129 | 0.009996 |
#> |.....................| 0.4161 | 0.4040 | 1.646 | 1.693 |
#> | F| Forward Diff. | 207.2 | 200.2 | 37.30 | -0.08142 |
#> |.....................| 695.4 | -232.2 | -109.1 | -129.1 |
#> | 39| 64771.821 | -0.3882 | 0.8957 | -1.161 | -1.001 |
#> |.....................| -1.144 | -1.155 | -0.2867 | -0.2600 |
#> | U| 64771.821 | 1.504 | 4.396 | 0.2130 | 0.009996 |
#> |.....................| 0.4149 | 0.4036 | 1.646 | 1.694 |
#> | X| 64771.821 | 4.498 | 81.10 | 0.2130 | 0.009996 |
#> |.....................| 0.4149 | 0.4036 | 1.646 | 1.694 |
#> | 40| 62667.236 | -0.3878 | 0.8962 | -1.161 | -1.001 |
#> |.....................| -1.143 | -1.155 | -0.2866 | -0.2601 |
#> | U| 62667.236 | 1.504 | 4.396 | 0.2129 | 0.009996 |
#> |.....................| 0.4160 | 0.4041 | 1.646 | 1.693 |
#> | X| 62667.236 | 4.500 | 81.14 | 0.2129 | 0.009996 |
#> |.....................| 0.4160 | 0.4041 | 1.646 | 1.693 |
#> | F| Forward Diff. | 207.1 | 200.1 | 72.42 | -0.08091 |
#> |.....................| 545.2 | -81.95 | -109.2 | -129.2 |
#> | 41| 64780.015 | -0.3879 | 0.8961 | -1.161 | -1.001 |
#> |.....................| -1.143 | -1.155 | -0.2866 | -0.2600 |
#> | U| 64780.015 | 1.504 | 4.396 | 0.2129 | 0.009996 |
#> |.....................| 0.4157 | 0.4041 | 1.646 | 1.694 |
#> | X| 64780.015 | 4.499 | 81.14 | 0.2129 | 0.009996 |
#> |.....................| 0.4157 | 0.4041 | 1.646 | 1.694 |
#> | 42| 62667.218 | -0.3878 | 0.8962 | -1.161 | -1.001 |
#> |.....................| -1.143 | -1.155 | -0.2866 | -0.2600 |
#> | U| 62667.218 | 1.504 | 4.396 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | X| 62667.218 | 4.500 | 81.14 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | F| Forward Diff. | 207.0 | 200.0 | 78.21 | -0.08100 |
#> |.....................| 520.6 | -57.36 | -109.1 | -129.2 |
#> | 43| 64783.859 | -0.3878 | 0.8962 | -1.161 | -1.001 |
#> |.....................| -1.143 | -1.155 | -0.2866 | -0.2600 |
#> | U| 64783.859 | 1.504 | 4.396 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | X| 64783.859 | 4.499 | 81.14 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | 44| 62667.215 | -0.3878 | 0.8962 | -1.161 | -1.001 |
#> |.....................| -1.143 | -1.155 | -0.2866 | -0.2600 |
#> | U| 62667.215 | 1.504 | 4.396 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | X| 62667.215 | 4.500 | 81.14 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | F| Forward Diff. | 207.1 | 200.1 | 79.36 | -0.08072 |
#> |.....................| 516.1 | -52.53 | -109.1 | -129.1 |
#> | 45| 64784.589 | -0.3878 | 0.8962 | -1.161 | -1.001 |
#> |.....................| -1.143 | -1.155 | -0.2866 | -0.2600 |
#> | U| 64784.589 | 1.504 | 4.396 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | X| 64784.589 | 4.500 | 81.14 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | 46| 64784.775 | -0.3878 | 0.8962 | -1.161 | -1.001 |
#> |.....................| -1.143 | -1.155 | -0.2866 | -0.2600 |
#> | U| 64784.775 | 1.504 | 4.396 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | X| 64784.775 | 4.500 | 81.14 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | 47| 62667.215 | -0.3878 | 0.8962 | -1.161 | -1.001 |
#> |.....................| -1.143 | -1.155 | -0.2866 | -0.2600 |
#> | U| 62667.215 | 1.504 | 4.396 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | X| 62667.215 | 4.500 | 81.14 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | F| Forward Diff. | 207.2 | 200.2 | 79.48 | -0.08018 |
#> |.....................| 516.6 | -51.61 | -109.0 | -129.2 |
#> | 48| 62667.215 | -0.3878 | 0.8962 | -1.161 | -1.001 |
#> |.....................| -1.143 | -1.155 | -0.2866 | -0.2600 |
#> | U| 62667.215 | 1.504 | 4.396 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | X| 62667.215 | 4.500 | 81.14 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | 49| 62667.215 | -0.3878 | 0.8962 | -1.161 | -1.001 |
#> |.....................| -1.143 | -1.155 | -0.2866 | -0.2600 |
#> | U| 62667.215 | 1.504 | 4.396 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | X| 62667.215 | 4.500 | 81.14 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | 50| 62667.215 | -0.3878 | 0.8962 | -1.161 | -1.001 |
#> |.....................| -1.143 | -1.155 | -0.2866 | -0.2600 |
#> | U| 62667.215 | 1.504 | 4.396 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | X| 62667.215 | 4.500 | 81.14 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | 51| 62667.215 | -0.3878 | 0.8962 | -1.161 | -1.001 |
#> |.....................| -1.143 | -1.155 | -0.2866 | -0.2600 |
#> | U| 62667.215 | 1.504 | 4.396 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | X| 62667.215 | 4.500 | 81.14 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | 52| 62667.215 | -0.3878 | 0.8962 | -1.161 | -1.001 |
#> |.....................| -1.143 | -1.155 | -0.2866 | -0.2600 |
#> | U| 62667.215 | 1.504 | 4.396 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | X| 62667.215 | 4.500 | 81.14 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | 53| 62667.215 | -0.3878 | 0.8962 | -1.161 | -1.001 |
#> |.....................| -1.143 | -1.155 | -0.2866 | -0.2600 |
#> | U| 62667.215 | 1.504 | 4.396 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | X| 62667.215 | 4.500 | 81.14 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | 54| 62667.215 | -0.3878 | 0.8962 | -1.161 | -1.001 |
#> |.....................| -1.143 | -1.155 | -0.2866 | -0.2600 |
#> | U| 62667.215 | 1.504 | 4.396 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | X| 62667.215 | 4.500 | 81.14 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | 55| 62667.215 | -0.3878 | 0.8962 | -1.161 | -1.001 |
#> |.....................| -1.143 | -1.155 | -0.2866 | -0.2600 |
#> | U| 62667.215 | 1.504 | 4.396 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | X| 62667.215 | 4.500 | 81.14 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | 56| 62667.215 | -0.3878 | 0.8962 | -1.161 | -1.001 |
#> |.....................| -1.143 | -1.155 | -0.2866 | -0.2600 |
#> | U| 62667.215 | 1.504 | 4.396 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | X| 62667.215 | 4.500 | 81.14 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | 57| 62667.215 | -0.3878 | 0.8962 | -1.161 | -1.001 |
#> |.....................| -1.143 | -1.155 | -0.2866 | -0.2600 |
#> | U| 62667.215 | 1.504 | 4.396 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> | X| 62667.215 | 4.500 | 81.14 | 0.2129 | 0.009996 |
#> |.....................| 0.4159 | 0.4041 | 1.646 | 1.693 |
#> calculating covariance matrix
#> done
#> Calculating residuals/tables
#> done
#> Warning: Hessian reset during optimization; (can control by foceiControl(resetHessianAndEta=.))
#> Warning: initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))
#> Warning: ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))
#> Warning: last objective function was not at minimum, possible problems in optimization
#> Warning: numerical difficulties solving forward sensitivity inner problem, tried approximating with more inaccurate numeric differences
#> Warning: gradient problems with initial estimate and covariance; see $scaleInfo
#> Warning: 'ss' is ignored with classic RxODE 'EVID's
## If you want to use a variance normalizing distribution with
## negative/positive data you can use the Yeo-Johnson transformation
## as well. This is implemented by the yeoJohnson(lambda) function.
one.compartment.IV.model <- function(){
ini({ # Where initial conditions/variables are specified
## '<-' or '=' defines population parameters
## Simple numeric expressions are supported
lCl <- 1.6 #log Cl (L/hr)
lVc <- 4.5 #log V (L)
## Bounds may be specified by c(lower, est, upper), like NONMEM:
## Residuals errors are assumed to be population parameters
prop.err <- 0.3
delta <- c(0.1, 1, 10)
add.err <- 0.01
lambda <- c(-2, 1, 2)
## Between subject variability estimates are specified by '~'
## Semicolons are optional
eta.Vc ~ 0.1 #IIV V
eta.Cl ~ 0.1; #IIV Cl
})
model({ ## Where the model is specified
## The model uses the ini-defined variable names
Vc <- exp(lVc + eta.Vc)
Cl <- exp(lCl + eta.Cl)
## RxODE-style differential equations are supported
d / dt(centr) = -(Cl / Vc) * centr;
## Concentration is calculated
cp = centr / Vc;
## And is assumed to follow proportional error estimated by prop.err
cp ~ pow(prop.err, delta) + add(add.err) + yeoJohnson(lambda)
})}
fitIVyj <- nlmixr(one.compartment.IV.model, datr, "focei")
#> ℹ parameter labels from comments will be replaced by 'label()'
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → calculate jacobian
#>
#> → calculate sensitivities
#>
#> → calculate ∂(f)/∂(η)
#>
#> → calculate ∂(R²)/∂(η)
#>
#> → finding duplicate expressions in inner model...
#>
#> → optimizing duplicate expressions in inner model...
#>
#> → finding duplicate expressions in EBE model...
#>
#> → optimizing duplicate expressions in EBE model...
#>
#> → compiling inner model...
#>
#> ✔ done
#> → finding duplicate expressions in FD model...
#>
#> → optimizing duplicate expressions in FD model...
#>
#> → compiling EBE model...
#>
#> ✔ done
#> → compiling events FD model...
#>
#> ✔ done
#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
#> F: Forward difference gradient approximation
#> C: Central difference gradient approximation
#> M: Mixed forward and central difference gradient approximation
#> Unscaled parameters for Omegas=chol(solve(omega));
#> Diagonals are transformed, as specified by foceiControl(diagXform=)
#> |-----+---------------+-----------+-----------+-----------+-----------|
#> | #| Objective Fun | lCl | lVc | prop.err | delta |
#> |.....................| add.err | lambda | o1 | o2 |
#> | 1| 64568.832 | -0.2918 | 1.000 | -0.8708 | -0.5590 |
#> |.....................| -1.000 | -0.5590 | -0.2123 | -0.2123 |
#> | U| 64568.832 | 1.600 | 4.500 | 0.3000 | 1.000 |
#> |.....................| 0.01000 | 1.000 | 1.778 | 1.778 |
#> | X| 64568.832 | 4.953 | 90.02 | 0.3000 | 1.000 |
#> |.....................| 0.01000 | 1.000 | 1.778 | 1.778 |
#> | G| Gill Diff. | 393.9 | 429.4 | 6520. | 3.615e+04 |
#> |.....................| 0.09466 |-3.587e+04 | 120.1 | 29.07 |
#> | 2| 1.0288594e+12 | -0.2994 | 0.9916 | -0.9978 | -1.263 |
#> |.....................| -1.000 | 0.1396 | -0.2147 | -0.2129 |
#> | U| 1.0288594e+12 | 1.592 | 4.492 | 0.2619 | 0.2960 |
#> |.....................| 0.01000 | 1.699 | 1.774 | 1.777 |
#> | X| 1.0288594e+12 | 4.915 | 89.27 | 0.2619 | 0.2960 |
#> |.....................| 0.01000 | 1.699 | 1.774 | 1.777 |
#> | 3| 66770.764 | -0.2925 | 0.9992 | -0.8835 | -0.6294 |
#> |.....................| -1.000 | -0.4892 | -0.2126 | -0.2124 |
#> | U| 66770.764 | 1.599 | 4.499 | 0.2962 | 0.9296 |
#> |.....................| 0.01000 | 1.070 | 1.778 | 1.778 |
#> | X| 66770.764 | 4.949 | 89.94 | 0.2962 | 0.9296 |
#> |.....................| 0.01000 | 1.070 | 1.778 | 1.778 |
#> | 4| 63290.492 | -0.2920 | 0.9997 | -0.8753 | -0.5837 |
#> |.....................| -1.000 | -0.5346 | -0.2124 | -0.2124 |
#> | U| 63290.492 | 1.600 | 4.500 | 0.2987 | 0.9754 |
#> |.....................| 0.01000 | 1.024 | 1.778 | 1.778 |
#> | X| 63290.492 | 4.952 | 89.99 | 0.2987 | 0.9754 |
#> |.....................| 0.01000 | 1.024 | 1.778 | 1.778 |
#> | M| Mixed Diff. | 476.4 | 520.7 | 2590. | 1.254e+04 |
#> |.....................| 0.1054 |-1.192e+04 | 199.3 | 92.20 |
#> | 5| 63198.276 | -0.3056 | 0.9849 | -0.8921 | -0.6057 |
#> |.....................| -1.000 | -0.5333 | -0.2187 | -0.2156 |
#> | U| 63198.276 | 1.586 | 4.485 | 0.2936 | 0.9533 |
#> |.....................| 0.01000 | 1.026 | 1.767 | 1.772 |
#> | X| 63198.276 | 4.885 | 88.66 | 0.2936 | 0.9533 |
#> |.....................| 0.01000 | 1.026 | 1.767 | 1.772 |
#> | F| Forward Diff. | 469.6 | 505.8 | -881.0 | -8510. |
#> |.....................| 0.1282 | 9342. | 184.7 | 85.57 |
#> | 6| 63122.208 | -0.3206 | 0.9686 | -0.9098 | -0.6107 |
#> |.....................| -1.000 | -0.5521 | -0.2247 | -0.2183 |
#> | U| 63122.208 | 1.571 | 4.469 | 0.2883 | 0.9483 |
#> |.....................| 0.01000 | 1.007 | 1.756 | 1.768 |
#> | X| 63122.208 | 4.812 | 87.23 | 0.2883 | 0.9483 |
#> |.....................| 0.01000 | 1.007 | 1.756 | 1.768 |
#> | F| Forward Diff. | 418.5 | 445.5 | 740.6 | 1305. |
#> |.....................| 0.1268 | -534.4 | 129.0 | 44.35 |
#> | 7| 63088.887 | -0.3346 | 0.9538 | -0.9303 | -0.6236 |
#> |.....................| -1.000 | -0.5664 | -0.2285 | -0.2194 |
#> | U| 63088.887 | 1.557 | 4.454 | 0.2822 | 0.9354 |
#> |.....................| 0.01000 | 0.9926 | 1.750 | 1.766 |
#> | X| 63088.887 | 4.745 | 85.95 | 0.2822 | 0.9354 |
#> |.....................| 0.01000 | 0.9926 | 1.750 | 1.766 |
#> | 8| 63001.136 | -0.3765 | 0.9095 | -0.9916 | -0.6600 |
#> |.....................| -1.000 | -0.6121 | -0.2398 | -0.2225 |
#> | U| 63001.136 | 1.515 | 4.410 | 0.2638 | 0.8990 |
#> |.....................| 0.01000 | 0.9469 | 1.729 | 1.760 |
#> | X| 63001.136 | 4.550 | 82.23 | 0.2638 | 0.8990 |
#> |.....................| 0.01000 | 0.9469 | 1.729 | 1.760 |
#> | 9| 62886.372 | -0.4913 | 0.7883 | -1.159 | -0.7597 |
#> |.....................| -1.000 | -0.7371 | -0.2709 | -0.2311 |
#> | U| 62886.372 | 1.400 | 4.288 | 0.2135 | 0.7993 |
#> |.....................| 0.01000 | 0.8219 | 1.674 | 1.745 |
#> | X| 62886.372 | 4.057 | 72.84 | 0.2135 | 0.7993 |
#> |.....................| 0.01000 | 0.8219 | 1.674 | 1.745 |
#> | M| Mixed Diff. | 27.33 | 34.14 | -2160. |-1.002e+04 |
#> |.....................| 0.1288 | 1.064e+04 | -127.4 | -127.2 |
#> | 10| 63023.932 | -0.5841 | 0.6908 | -1.050 | -1.017 |
#> |.....................| -1.000 | -1.006 | -0.1944 | -0.1421 |
#> | U| 63023.932 | 1.308 | 4.191 | 0.2463 | 0.5419 |
#> |.....................| 0.009999 | 0.5527 | 1.810 | 1.903 |
#> | X| 63023.932 | 3.698 | 66.08 | 0.2463 | 0.5419 |
#> |.....................| 0.009999 | 0.5527 | 1.810 | 1.903 |
#> | 11| 63000.944 | -0.5280 | 0.7497 | -1.114 | -0.8521 |
#> |.....................| -1.000 | -0.8535 | -0.2406 | -0.1958 |
#> | U| 63000.944 | 1.364 | 4.250 | 0.2271 | 0.7069 |
#> |.....................| 0.009999 | 0.7055 | 1.728 | 1.808 |
#> | X| 63000.944 | 3.911 | 70.08 | 0.2271 | 0.7069 |
#> |.....................| 0.009999 | 0.7055 | 1.728 | 1.808 |
#> | 12| 63005.195 | -0.5049 | 0.7740 | -1.140 | -0.7841 |
#> |.....................| -1.000 | -0.7906 | -0.2596 | -0.2179 |
#> | U| 63005.195 | 1.387 | 4.274 | 0.2191 | 0.7749 |
#> |.....................| 0.01000 | 0.7685 | 1.694 | 1.768 |
#> | X| 63005.195 | 4.002 | 71.81 | 0.2191 | 0.7749 |
#> |.....................| 0.01000 | 0.7685 | 1.694 | 1.768 |
#> | 13| 63010.268 | -0.4936 | 0.7859 | -1.153 | -0.7508 |
#> |.....................| -1.000 | -0.7597 | -0.2689 | -0.2287 |
#> | U| 63010.268 | 1.398 | 4.286 | 0.2152 | 0.8083 |
#> |.....................| 0.01000 | 0.7994 | 1.678 | 1.749 |
#> | X| 63010.268 | 4.048 | 72.67 | 0.2152 | 0.8083 |
#> |.....................| 0.01000 | 0.7994 | 1.678 | 1.749 |
#> | 14| 62832.106 | -0.4913 | 0.7882 | -1.158 | -0.7534 |
#> |.....................| -1.000 | -0.7438 | -0.2708 | -0.2310 |
#> | U| 62832.106 | 1.400 | 4.288 | 0.2139 | 0.8057 |
#> |.....................| 0.01000 | 0.8152 | 1.674 | 1.745 |
#> | X| 62832.106 | 4.057 | 72.84 | 0.2139 | 0.8057 |
#> |.....................| 0.01000 | 0.8152 | 1.674 | 1.745 |
#> | F| Forward Diff. | 18.91 | 26.01 | 704.6 | 2154. |
#> |.....................| 0.1358 | -1471. | -128.4 | -128.0 |
#> | 15| 62825.819 | -0.4908 | 0.7887 | -1.159 | -0.7600 |
#> |.....................| -1.000 | -0.7486 | -0.2678 | -0.2282 |
#> | U| 62825.819 | 1.401 | 4.289 | 0.2136 | 0.7990 |
#> |.....................| 0.01000 | 0.8104 | 1.680 | 1.750 |
#> | X| 62825.819 | 4.059 | 72.87 | 0.2136 | 0.7990 |
#> |.....................| 0.01000 | 0.8104 | 1.680 | 1.750 |
#> | F| Forward Diff. | 21.75 | 28.62 | 297.2 | 408.1 |
#> |.....................| 0.1421 | 279.0 | -122.9 | -123.4 |
#> | 16| 62823.067 | -0.4909 | 0.7886 | -1.162 | -0.7664 |
#> |.....................| -1.000 | -0.7536 | -0.2655 | -0.2259 |
#> | U| 62823.067 | 1.401 | 4.289 | 0.2125 | 0.7927 |
#> |.....................| 0.01000 | 0.8054 | 1.684 | 1.754 |
#> | X| 62823.067 | 4.059 | 72.86 | 0.2125 | 0.7927 |
#> |.....................| 0.01000 | 0.8054 | 1.684 | 1.754 |
#> | F| Forward Diff. | 23.39 | 30.01 | -154.3 | -1488. |
#> |.....................| 0.1460 | 2183. | -118.8 | -119.7 |
#> | 17| 62817.053 | -0.4904 | 0.7891 | -1.163 | -0.7711 |
#> |.....................| -1.000 | -0.7606 | -0.2626 | -0.2233 |
#> | U| 62817.053 | 1.401 | 4.289 | 0.2124 | 0.7880 |
#> |.....................| 0.01000 | 0.7985 | 1.689 | 1.759 |
#> | X| 62817.053 | 4.061 | 72.90 | 0.2124 | 0.7880 |
#> |.....................| 0.01000 | 0.7985 | 1.689 | 1.759 |
#> | F| Forward Diff. | 22.69 | 29.48 | 296.4 | 423.2 |
#> |.....................| 0.1510 | 254.3 | -114.1 | -115.7 |
#> | 18| 62813.882 | -0.4903 | 0.7891 | -1.165 | -0.7775 |
#> |.....................| -1.000 | -0.7658 | -0.2602 | -0.2210 |
#> | U| 62813.882 | 1.401 | 4.289 | 0.2116 | 0.7815 |
#> |.....................| 0.01000 | 0.7932 | 1.693 | 1.763 |
#> | X| 62813.882 | 4.061 | 72.90 | 0.2116 | 0.7815 |
#> |.....................| 0.01000 | 0.7932 | 1.693 | 1.763 |
#> | F| Forward Diff. | 24.47 | 31.03 | -82.41 | -1167. |
#> |.....................| 0.1555 | 1850. | -109.8 | -111.9 |
#> | 19| 62808.616 | -0.4898 | 0.7896 | -1.166 | -0.7826 |
#> |.....................| -1.000 | -0.7727 | -0.2576 | -0.2185 |
#> | U| 62808.616 | 1.402 | 4.290 | 0.2116 | 0.7764 |
#> |.....................| 0.01000 | 0.7863 | 1.698 | 1.767 |
#> | X| 62808.616 | 4.063 | 72.94 | 0.2116 | 0.7764 |
#> |.....................| 0.01000 | 0.7863 | 1.698 | 1.767 |
#> | F| Forward Diff. | 24.12 | 30.73 | 298.9 | 439.3 |
#> |.....................| 0.1608 | 229.0 | -105.4 | -108.2 |
#> | 20| 62805.255 | -0.4895 | 0.7898 | -1.167 | -0.7892 |
#> |.....................| -1.000 | -0.7782 | -0.2553 | -0.2163 |
#> | U| 62805.255 | 1.402 | 4.290 | 0.2110 | 0.7698 |
#> |.....................| 0.01000 | 0.7809 | 1.702 | 1.771 |
#> | X| 62805.255 | 4.064 | 72.95 | 0.2110 | 0.7698 |
#> |.....................| 0.01000 | 0.7809 | 1.702 | 1.771 |
#> | F| Forward Diff. | 25.94 | 32.38 | -24.81 | -921.6 |
#> |.....................| 0.1652 | 1592. | -101.4 | -104.6 |
#> | 21| 62800.532 | -0.4889 | 0.7904 | -1.167 | -0.7945 |
#> |.....................| -1.000 | -0.7851 | -0.2531 | -0.2142 |
#> | U| 62800.532 | 1.403 | 4.290 | 0.2110 | 0.7645 |
#> |.....................| 0.01000 | 0.7739 | 1.706 | 1.775 |
#> | X| 62800.532 | 4.067 | 72.99 | 0.2110 | 0.7645 |
#> |.....................| 0.01000 | 0.7739 | 1.706 | 1.775 |
#> | F| Forward Diff. | 25.92 | 32.40 | 306.4 | 465.8 |
#> |.....................| 0.1705 | 192.5 | -97.58 | -101.3 |
#> | 22| 62797.070 | -0.4885 | 0.7908 | -1.169 | -0.8013 |
#> |.....................| -1.000 | -0.7908 | -0.2510 | -0.2122 |
#> | U| 62797.07 | 1.403 | 4.291 | 0.2107 | 0.7578 |
#> |.....................| 0.01000 | 0.7683 | 1.709 | 1.778 |
#> | X| 62797.07 | 4.068 | 73.02 | 0.2107 | 0.7578 |
#> |.....................| 0.01000 | 0.7683 | 1.709 | 1.778 |
#> | F| Forward Diff. | 27.93 | 34.26 | 35.36 | -677.5 |
#> |.....................| 0.1751 | 1337. | -93.89 | -98.04 |
#> | 23| 62792.827 | -0.4879 | 0.7915 | -1.168 | -0.8069 |
#> |.....................| -1.000 | -0.7977 | -0.2492 | -0.2105 |
#> | U| 62792.827 | 1.404 | 4.291 | 0.2107 | 0.7522 |
#> |.....................| 0.01000 | 0.7613 | 1.713 | 1.782 |
#> | X| 62792.827 | 4.071 | 73.07 | 0.2107 | 0.7522 |
#> |.....................| 0.01000 | 0.7613 | 1.713 | 1.782 |
#> | F| Forward Diff. | 28.27 | 34.63 | 316.2 | 492.9 |
#> |.....................| 0.1800 | 154.8 | -90.82 | -95.28 |
#> | 24| 62789.403 | -0.4873 | 0.7920 | -1.169 | -0.8137 |
#> |.....................| -1.000 | -0.8035 | -0.2475 | -0.2089 |
#> | U| 62789.403 | 1.404 | 4.292 | 0.2105 | 0.7453 |
#> |.....................| 0.009999 | 0.7555 | 1.716 | 1.784 |
#> | X| 62789.403 | 4.073 | 73.12 | 0.2105 | 0.7453 |
#> |.....................| 0.009999 | 0.7555 | 1.716 | 1.784 |
#> | F| Forward Diff. | 30.52 | 36.76 | 75.25 | -527.4 |
#> |.....................| 0.1843 | 1175. | -87.68 | -92.58 |
#> | 25| 62785.488 | -0.4865 | 0.7929 | -1.169 | -0.8195 |
#> |.....................| -1.000 | -0.8104 | -0.2460 | -0.2075 |
#> | U| 62785.488 | 1.405 | 4.293 | 0.2105 | 0.7396 |
#> |.....................| 0.009999 | 0.7486 | 1.718 | 1.787 |
#> | X| 62785.488 | 4.076 | 73.18 | 0.2105 | 0.7396 |
#> |.....................| 0.009999 | 0.7486 | 1.718 | 1.787 |
#> | F| Forward Diff. | 31.28 | 37.58 | 327.1 | 518.5 |
#> |.....................| 0.1887 | 117.9 | -85.20 | -90.38 |
#> | 26| 62782.148 | -0.4858 | 0.7937 | -1.169 | -0.8263 |
#> |.....................| -1.000 | -0.8163 | -0.2447 | -0.2062 |
#> | U| 62782.148 | 1.406 | 4.294 | 0.2104 | 0.7327 |
#> |.....................| 0.009999 | 0.7427 | 1.721 | 1.789 |
#> | X| 62782.148 | 4.079 | 73.24 | 0.2104 | 0.7327 |
#> |.....................| 0.009999 | 0.7427 | 1.721 | 1.789 |
#> | F| Forward Diff. | 33.83 | 40.07 | 104.4 | -427.3 |
#> |.....................| 0.1926 | 1064. | -82.57 | -88.17 |
#> | 27| 62775.171 | -0.4840 | 0.7958 | -1.169 | -0.8387 |
#> |.....................| -1.000 | -0.8296 | -0.2422 | -0.2039 |
#> | U| 62775.171 | 1.408 | 4.296 | 0.2106 | 0.7204 |
#> |.....................| 0.009999 | 0.7295 | 1.725 | 1.793 |
#> | X| 62775.171 | 4.087 | 73.39 | 0.2106 | 0.7204 |
#> |.....................| 0.009999 | 0.7295 | 1.725 | 1.793 |
#> | 28| 62767.621 | -0.4818 | 0.7983 | -1.168 | -0.8538 |
#> |.....................| -1.000 | -0.8445 | -0.2392 | -0.2013 |
#> | U| 62767.621 | 1.410 | 4.298 | 0.2108 | 0.7053 |
#> |.....................| 0.009999 | 0.7145 | 1.730 | 1.798 |
#> | X| 62767.621 | 4.096 | 73.58 | 0.2108 | 0.7053 |
#> |.....................| 0.009999 | 0.7145 | 1.730 | 1.798 |
#> | 29| 62751.407 | -0.4768 | 0.8041 | -1.166 | -0.8883 |
#> |.....................| -1.000 | -0.8787 | -0.2326 | -0.1953 |
#> | U| 62751.407 | 1.415 | 4.304 | 0.2114 | 0.6707 |
#> |.....................| 0.009999 | 0.6804 | 1.742 | 1.809 |
#> | X| 62751.407 | 4.116 | 74.00 | 0.2114 | 0.6707 |
#> |.....................| 0.009999 | 0.6804 | 1.742 | 1.809 |
#> | 30| 62725.011 | -0.4674 | 0.8149 | -1.163 | -0.9528 |
#> |.....................| -1.000 | -0.9424 | -0.2202 | -0.1842 |
#> | U| 62725.011 | 1.424 | 4.315 | 0.2124 | 0.6063 |
#> |.....................| 0.009998 | 0.6166 | 1.764 | 1.828 |
#> | X| 62725.011 | 4.155 | 74.81 | 0.2124 | 0.6063 |
#> |.....................| 0.009998 | 0.6166 | 1.764 | 1.828 |
#> | F| Forward Diff. | 78.30 | 86.51 | 508.6 | 971.1 |
#> |.....................| 0.2291 | -451.3 | -35.26 | -49.56 |
#> | 31| 62755.647 | -0.5563 | 0.7451 | -1.155 | -0.9528 |
#> |.....................| -1.004 | -0.9345 | -0.09571 | -0.1106 |
#> | U| 62755.647 | 1.335 | 4.245 | 0.2146 | 0.6062 |
#> |.....................| 0.009979 | 0.6245 | 1.986 | 1.959 |
#> | X| 62755.647 | 3.802 | 69.76 | 0.2146 | 0.6062 |
#> |.....................| 0.009979 | 0.6245 | 1.986 | 1.959 |
#> | 32| 62733.330 | -0.4854 | 0.8007 | -1.163 | -0.9557 |
#> |.....................| -1.001 | -0.9395 | -0.1952 | -0.1693 |
#> | U| 62733.33 | 1.406 | 4.301 | 0.2124 | 0.6033 |
#> |.....................| 0.009994 | 0.6196 | 1.809 | 1.855 |
#> | X| 62733.33 | 4.081 | 73.75 | 0.2124 | 0.6033 |
#> |.....................| 0.009994 | 0.6196 | 1.809 | 1.855 |
#> | 33| 62734.499 | -0.4715 | 0.8116 | -1.164 | -0.9563 |
#> |.....................| -1.001 | -0.9404 | -0.2146 | -0.1808 |
#> | U| 62734.499 | 1.420 | 4.312 | 0.2119 | 0.6027 |
#> |.....................| 0.009997 | 0.6186 | 1.774 | 1.834 |
#> | X| 62734.499 | 4.138 | 74.56 | 0.2119 | 0.6027 |
#> |.....................| 0.009997 | 0.6186 | 1.774 | 1.834 |
#> | 34| 62725.362 | -0.4675 | 0.8148 | -1.164 | -0.9543 |
#> |.....................| -1.000 | -0.9417 | -0.2201 | -0.1841 |
#> | U| 62725.362 | 1.424 | 4.315 | 0.2122 | 0.6048 |
#> |.....................| 0.009998 | 0.6173 | 1.764 | 1.828 |
#> | X| 62725.362 | 4.155 | 74.80 | 0.2122 | 0.6048 |
#> |.....................| 0.009998 | 0.6173 | 1.764 | 1.828 |
#> | 35| 62724.552 | -0.4674 | 0.8148 | -1.163 | -0.9534 |
#> |.....................| -1.000 | -0.9421 | -0.2201 | -0.1842 |
#> | U| 62724.552 | 1.424 | 4.315 | 0.2123 | 0.6056 |
#> |.....................| 0.009998 | 0.6169 | 1.764 | 1.828 |
#> | X| 62724.552 | 4.155 | 74.80 | 0.2123 | 0.6056 |
#> |.....................| 0.009998 | 0.6169 | 1.764 | 1.828 |
#> | F| Forward Diff. | 78.94 | 87.09 | 298.6 | 80.70 |
#> |.....................| 0.2285 | 443.2 | -35.08 | -49.39 |
#> | 36| 62724.246 | -0.4675 | 0.8147 | -1.164 | -0.9535 |
#> |.....................| -1.000 | -0.9427 | -0.2201 | -0.1841 |
#> | U| 62724.246 | 1.424 | 4.315 | 0.2122 | 0.6055 |
#> |.....................| 0.009998 | 0.6163 | 1.765 | 1.829 |
#> | X| 62724.246 | 4.155 | 74.79 | 0.2122 | 0.6055 |
#> |.....................| 0.009998 | 0.6163 | 1.765 | 1.829 |
#> | F| Forward Diff. | 78.32 | 86.49 | 383.4 | 445.1 |
#> |.....................| 0.2286 | 76.43 | -35.13 | -49.35 |
#> | 37| 62723.979 | -0.4676 | 0.8146 | -1.164 | -0.9541 |
#> |.....................| -1.000 | -0.9428 | -0.2200 | -0.1840 |
#> | U| 62723.979 | 1.424 | 4.315 | 0.2120 | 0.6049 |
#> |.....................| 0.009998 | 0.6162 | 1.765 | 1.829 |
#> | X| 62723.979 | 4.154 | 74.78 | 0.2120 | 0.6049 |
#> |.....................| 0.009998 | 0.6162 | 1.765 | 1.829 |
#> | F| Forward Diff. | 78.50 | 86.64 | 259.3 | -77.64 |
#> |.....................| 0.2283 | 601.6 | -34.99 | -49.21 |
#> | 38| 62723.726 | -0.4677 | 0.8145 | -1.164 | -0.9540 |
#> |.....................| -1.000 | -0.9436 | -0.2200 | -0.1840 |
#> | U| 62723.726 | 1.424 | 4.314 | 0.2119 | 0.6050 |
#> |.....................| 0.009998 | 0.6155 | 1.765 | 1.829 |
#> | X| 62723.726 | 4.154 | 74.78 | 0.2119 | 0.6050 |
#> |.....................| 0.009998 | 0.6155 | 1.765 | 1.829 |
#> | F| Forward Diff. | 77.73 | 85.92 | 408.6 | 559.3 |
#> |.....................| 0.2288 | -38.26 | -35.09 | -49.25 |
#> | 39| 62723.481 | -0.4678 | 0.8144 | -1.165 | -0.9547 |
#> |.....................| -1.000 | -0.9435 | -0.2200 | -0.1839 |
#> | U| 62723.481 | 1.424 | 4.314 | 0.2118 | 0.6044 |
#> |.....................| 0.009998 | 0.6155 | 1.765 | 1.829 |
#> | X| 62723.481 | 4.154 | 74.77 | 0.2118 | 0.6044 |
#> |.....................| 0.009998 | 0.6155 | 1.765 | 1.829 |
#> | F| Forward Diff. | 78.07 | 86.21 | 247.5 | -120.3 |
#> |.....................| 0.2283 | 644.3 | -34.92 | -49.10 |
#> | 40| 62723.231 | -0.4679 | 0.8143 | -1.165 | -0.9545 |
#> |.....................| -1.000 | -0.9442 | -0.2199 | -0.1839 |
#> | U| 62723.231 | 1.424 | 4.314 | 0.2117 | 0.6045 |
#> |.....................| 0.009998 | 0.6148 | 1.765 | 1.829 |
#> | X| 62723.231 | 4.153 | 74.76 | 0.2117 | 0.6045 |
#> |.....................| 0.009998 | 0.6148 | 1.765 | 1.829 |
#> | F| Forward Diff. | 77.27 | 85.47 | 408.9 | 566.5 |
#> |.....................| 0.2288 | -45.63 | -35.01 | -49.11 |
#> | 41| 62722.987 | -0.4680 | 0.8142 | -1.166 | -0.9551 |
#> |.....................| -1.000 | -0.9442 | -0.2199 | -0.1838 |
#> | U| 62722.987 | 1.424 | 4.314 | 0.2116 | 0.6039 |
#> |.....................| 0.009998 | 0.6148 | 1.765 | 1.829 |
#> | X| 62722.987 | 4.153 | 74.75 | 0.2116 | 0.6039 |
#> |.....................| 0.009998 | 0.6148 | 1.765 | 1.829 |
#> | F| Forward Diff. | 77.62 | 85.77 | 245.6 | -121.5 |
#> |.....................| 0.2283 | 645.2 | -34.85 | -48.96 |
#> | 42| 62722.739 | -0.4681 | 0.8141 | -1.166 | -0.9550 |
#> |.....................| -1.000 | -0.9449 | -0.2198 | -0.1837 |
#> | U| 62722.739 | 1.424 | 4.314 | 0.2115 | 0.6040 |
#> |.....................| 0.009998 | 0.6141 | 1.765 | 1.829 |
#> | X| 62722.739 | 4.152 | 74.75 | 0.2115 | 0.6040 |
#> |.....................| 0.009998 | 0.6141 | 1.765 | 1.829 |
#> | F| Forward Diff. | 76.82 | 85.03 | 407.6 | 567.4 |
#> |.....................| 0.2288 | -46.78 | -34.94 | -49.03 |
#> | 43| 62722.497 | -0.4681 | 0.8140 | -1.166 | -0.9556 |
#> |.....................| -1.000 | -0.9449 | -0.2198 | -0.1837 |
#> | U| 62722.497 | 1.424 | 4.314 | 0.2114 | 0.6034 |
#> |.....................| 0.009998 | 0.6142 | 1.765 | 1.829 |
#> | X| 62722.497 | 4.152 | 74.74 | 0.2114 | 0.6034 |
#> |.....................| 0.009998 | 0.6142 | 1.765 | 1.829 |
#> | F| Forward Diff. | 77.18 | 85.33 | 243.7 | -122.4 |
#> |.....................| 0.2283 | 645.7 | -34.79 | -48.83 |
#> | 44| 62722.249 | -0.4682 | 0.8139 | -1.167 | -0.9555 |
#> |.....................| -1.000 | -0.9456 | -0.2198 | -0.1836 |
#> | U| 62722.249 | 1.424 | 4.314 | 0.2113 | 0.6035 |
#> |.....................| 0.009998 | 0.6134 | 1.765 | 1.829 |
#> | X| 62722.249 | 4.152 | 74.73 | 0.2113 | 0.6035 |
#> |.....................| 0.009998 | 0.6134 | 1.765 | 1.829 |
#> | F| Forward Diff. | 76.38 | 84.59 | 406.4 | 568.5 |
#> |.....................| 0.2288 | -48.39 | -34.88 | -48.86 |
#> | 45| 62722.009 | -0.4683 | 0.8138 | -1.167 | -0.9561 |
#> |.....................| -1.000 | -0.9455 | -0.2197 | -0.1836 |
#> | U| 62722.009 | 1.423 | 4.314 | 0.2111 | 0.6029 |
#> |.....................| 0.009998 | 0.6135 | 1.765 | 1.829 |
#> | X| 62722.009 | 4.151 | 74.73 | 0.2111 | 0.6029 |
#> |.....................| 0.009998 | 0.6135 | 1.765 | 1.829 |
#> | F| Forward Diff. | 76.74 | 84.90 | 241.8 | -123.7 |
#> |.....................| 0.2283 | 646.8 | -34.74 | -48.71 |
#> | 46| 62721.763 | -0.4684 | 0.8137 | -1.167 | -0.9560 |
#> |.....................| -1.000 | -0.9462 | -0.2197 | -0.1835 |
#> | U| 62721.763 | 1.423 | 4.314 | 0.2111 | 0.6030 |
#> |.....................| 0.009998 | 0.6128 | 1.765 | 1.830 |
#> | X| 62721.763 | 4.151 | 74.72 | 0.2111 | 0.6030 |
#> |.....................| 0.009998 | 0.6128 | 1.765 | 1.830 |
#> | F| Forward Diff. | 75.93 | 84.15 | 405.1 | 569.4 |
#> |.....................| 0.2288 | -49.59 | -34.81 | -48.80 |
#> | 47| 62721.524 | -0.4685 | 0.8136 | -1.168 | -0.9566 |
#> |.....................| -1.000 | -0.9462 | -0.2196 | -0.1835 |
#> | U| 62721.524 | 1.423 | 4.314 | 0.2109 | 0.6024 |
#> |.....................| 0.009998 | 0.6128 | 1.765 | 1.830 |
#> | X| 62721.524 | 4.151 | 74.71 | 0.2109 | 0.6024 |
#> |.....................| 0.009998 | 0.6128 | 1.765 | 1.830 |
#> | F| Forward Diff. | 76.29 | 84.46 | 239.9 | -124.5 |
#> |.....................| 0.2283 | 647.4 | -34.68 | -48.58 |
#> | 48| 62721.280 | -0.4686 | 0.8135 | -1.168 | -0.9565 |
#> |.....................| -1.000 | -0.9469 | -0.2196 | -0.1834 |
#> | U| 62721.28 | 1.423 | 4.314 | 0.2108 | 0.6025 |
#> |.....................| 0.009998 | 0.6121 | 1.765 | 1.830 |
#> | X| 62721.28 | 4.150 | 74.70 | 0.2108 | 0.6025 |
#> |.....................| 0.009998 | 0.6121 | 1.765 | 1.830 |
#> | F| Forward Diff. | 75.49 | 83.71 | 403.9 | 570.4 |
#> |.....................| 0.2288 | -50.64 | -34.74 | -48.63 |
#> | 49| 62721.043 | -0.4687 | 0.8135 | -1.168 | -0.9571 |
#> |.....................| -1.000 | -0.9468 | -0.2196 | -0.1834 |
#> | U| 62721.043 | 1.423 | 4.313 | 0.2107 | 0.6019 |
#> |.....................| 0.009998 | 0.6122 | 1.765 | 1.830 |
#> | X| 62721.043 | 4.150 | 74.70 | 0.2107 | 0.6019 |
#> |.....................| 0.009998 | 0.6122 | 1.765 | 1.830 |
#> | F| Forward Diff. | 75.85 | 84.02 | 238.0 | -125.3 |
#> |.....................| 0.2283 | 648.1 | -34.62 | -48.50 |
#> | 50| 62720.799 | -0.4687 | 0.8134 | -1.169 | -0.9570 |
#> |.....................| -1.000 | -0.9476 | -0.2195 | -0.1833 |
#> | U| 62720.799 | 1.423 | 4.313 | 0.2106 | 0.6020 |
#> |.....................| 0.009998 | 0.6115 | 1.766 | 1.830 |
#> | X| 62720.799 | 4.150 | 74.69 | 0.2106 | 0.6020 |
#> |.....................| 0.009998 | 0.6115 | 1.766 | 1.830 |
#> | F| Forward Diff. | 75.05 | 83.27 | 402.6 | 571.3 |
#> |.....................| 0.2288 | -51.83 | -34.67 | -48.49 |
#> | 51| 62720.564 | -0.4688 | 0.8133 | -1.169 | -0.9576 |
#> |.....................| -1.000 | -0.9475 | -0.2195 | -0.1833 |
#> | U| 62720.564 | 1.423 | 4.313 | 0.2105 | 0.6014 |
#> |.....................| 0.009998 | 0.6115 | 1.766 | 1.830 |
#> | X| 62720.564 | 4.149 | 74.68 | 0.2105 | 0.6014 |
#> |.....................| 0.009998 | 0.6115 | 1.766 | 1.830 |
#> | F| Forward Diff. | 75.42 | 83.58 | 236.2 | -126.3 |
#> |.....................| 0.2283 | 648.7 | -34.56 | -48.34 |
#> | 52| 62720.322 | -0.4689 | 0.8132 | -1.169 | -0.9575 |
#> |.....................| -1.000 | -0.9482 | -0.2194 | -0.1832 |
#> | U| 62720.322 | 1.423 | 4.313 | 0.2104 | 0.6015 |
#> |.....................| 0.009998 | 0.6108 | 1.766 | 1.830 |
#> | X| 62720.322 | 4.149 | 74.68 | 0.2104 | 0.6015 |
#> |.....................| 0.009998 | 0.6108 | 1.766 | 1.830 |
#> | F| Forward Diff. | 74.62 | 82.85 | 401.4 | 572.2 |
#> |.....................| 0.2289 | -52.91 | -34.61 | -48.41 |
#> | 53| 62720.087 | -0.4690 | 0.8131 | -1.170 | -0.9581 |
#> |.....................| -1.000 | -0.9482 | -0.2194 | -0.1831 |
#> | U| 62720.087 | 1.423 | 4.313 | 0.2103 | 0.6009 |
#> |.....................| 0.009998 | 0.6108 | 1.766 | 1.830 |
#> | X| 62720.087 | 4.149 | 74.67 | 0.2103 | 0.6009 |
#> |.....................| 0.009998 | 0.6108 | 1.766 | 1.830 |
#> | F| Forward Diff. | 74.98 | 83.16 | 234.3 | -127.1 |
#> |.....................| 0.2283 | 649.1 | -34.45 | -48.23 |
#> | 54| 62719.847 | -0.4691 | 0.8130 | -1.170 | -0.9580 |
#> |.....................| -1.000 | -0.9489 | -0.2194 | -0.1831 |
#> | U| 62719.847 | 1.423 | 4.313 | 0.2102 | 0.6010 |
#> |.....................| 0.009998 | 0.6101 | 1.766 | 1.830 |
#> | X| 62719.847 | 4.148 | 74.66 | 0.2102 | 0.6010 |
#> |.....................| 0.009998 | 0.6101 | 1.766 | 1.830 |
#> | F| Forward Diff. | 74.18 | 82.42 | 400.1 | 573.2 |
#> |.....................| 0.2289 | -54.22 | -34.56 | -48.28 |
#> | 55| 62719.614 | -0.4692 | 0.8129 | -1.171 | -0.9586 |
#> |.....................| -1.000 | -0.9488 | -0.2193 | -0.1830 |
#> | U| 62719.614 | 1.423 | 4.313 | 0.2101 | 0.6004 |
#> |.....................| 0.009998 | 0.6102 | 1.766 | 1.830 |
#> | X| 62719.614 | 4.148 | 74.66 | 0.2101 | 0.6004 |
#> |.....................| 0.009998 | 0.6102 | 1.766 | 1.830 |
#> | F| Forward Diff. | 74.55 | 82.73 | 232.5 | -128.0 |
#> |.....................| 0.2282 | 649.8 | -34.40 | -48.11 |
#> | 56| 62719.374 | -0.4692 | 0.8128 | -1.171 | -0.9585 |
#> |.....................| -1.000 | -0.9496 | -0.2193 | -0.1830 |
#> | U| 62719.374 | 1.423 | 4.313 | 0.2100 | 0.6005 |
#> |.....................| 0.009998 | 0.6095 | 1.766 | 1.830 |
#> | X| 62719.374 | 4.148 | 74.65 | 0.2100 | 0.6005 |
#> |.....................| 0.009998 | 0.6095 | 1.766 | 1.830 |
#> | F| Forward Diff. | 73.73 | 81.97 | 398.7 | 573.0 |
#> |.....................| 0.2288 | -54.52 | -34.47 | -48.17 |
#> | 57| 62719.143 | -0.4693 | 0.8127 | -1.171 | -0.9591 |
#> |.....................| -1.000 | -0.9495 | -0.2193 | -0.1829 |
#> | U| 62719.143 | 1.422 | 4.313 | 0.2099 | 0.5999 |
#> |.....................| 0.009998 | 0.6095 | 1.766 | 1.831 |
#> | X| 62719.143 | 4.147 | 74.64 | 0.2099 | 0.5999 |
#> |.....................| 0.009998 | 0.6095 | 1.766 | 1.831 |
#> | F| Forward Diff. | 74.10 | 82.29 | 230.6 | -128.9 |
#> |.....................| 0.2283 | 650.2 | -34.32 | -48.02 |
#> | 58| 62718.903 | -0.4694 | 0.8126 | -1.172 | -0.9590 |
#> |.....................| -1.000 | -0.9502 | -0.2192 | -0.1829 |
#> | U| 62718.903 | 1.422 | 4.313 | 0.2098 | 0.6000 |
#> |.....................| 0.009998 | 0.6088 | 1.766 | 1.831 |
#> | X| 62718.903 | 4.147 | 74.63 | 0.2098 | 0.6000 |
#> |.....................| 0.009998 | 0.6088 | 1.766 | 1.831 |
#> | F| Forward Diff. | 73.24 | 81.50 | 396.6 | 570.4 |
#> |.....................| 0.2289 | -52.03 | -34.42 | -48.05 |
#> | 59| 62718.672 | -0.4695 | 0.8125 | -1.172 | -0.9596 |
#> |.....................| -1.000 | -0.9502 | -0.2192 | -0.1828 |
#> | U| 62718.672 | 1.422 | 4.312 | 0.2097 | 0.5994 |
#> |.....................| 0.009998 | 0.6089 | 1.766 | 1.831 |
#> | X| 62718.672 | 4.146 | 74.63 | 0.2097 | 0.5994 |
#> |.....................| 0.009998 | 0.6089 | 1.766 | 1.831 |
#> | F| Forward Diff. | 73.60 | 81.81 | 228.9 | -129.5 |
#> |.....................| 0.2283 | 650.7 | -34.24 | -47.89 |
#> | 60| 62718.432 | -0.4696 | 0.8124 | -1.172 | -0.9595 |
#> |.....................| -1.000 | -0.9509 | -0.2191 | -0.1828 |
#> | U| 62718.432 | 1.422 | 4.312 | 0.2096 | 0.5995 |
#> |.....................| 0.009998 | 0.6081 | 1.766 | 1.831 |
#> | X| 62718.432 | 4.146 | 74.62 | 0.2096 | 0.5995 |
#> |.....................| 0.009998 | 0.6081 | 1.766 | 1.831 |
#> | F| Forward Diff. | 72.71 | 81.00 | 394.6 | 567.8 |
#> |.....................| 0.2289 | -49.96 | -34.31 | -47.92 |
#> | 61| 62718.204 | -0.4697 | 0.8123 | -1.173 | -0.9602 |
#> |.....................| -1.000 | -0.9508 | -0.2191 | -0.1827 |
#> | U| 62718.204 | 1.422 | 4.312 | 0.2095 | 0.5989 |
#> |.....................| 0.009998 | 0.6082 | 1.766 | 1.831 |
#> | X| 62718.204 | 4.146 | 74.61 | 0.2095 | 0.5989 |
#> |.....................| 0.009998 | 0.6082 | 1.766 | 1.831 |
#> | F| Forward Diff. | 73.07 | 81.31 | 227.1 | -130.5 |
#> |.....................| 0.2283 | 651.5 | -34.13 | -47.74 |
#> | 62| 62717.963 | -0.4699 | 0.8121 | -1.173 | -0.9600 |
#> |.....................| -1.000 | -0.9516 | -0.2190 | -0.1827 |
#> | U| 62717.963 | 1.422 | 4.312 | 0.2094 | 0.5990 |
#> |.....................| 0.009998 | 0.6075 | 1.766 | 1.831 |
#> | X| 62717.963 | 4.145 | 74.60 | 0.2094 | 0.5990 |
#> |.....................| 0.009998 | 0.6075 | 1.766 | 1.831 |
#> | F| Forward Diff. | 72.15 | 80.48 | 392.5 | 564.8 |
#> |.....................| 0.2288 | -46.84 | -34.19 | -47.81 |
#> | 63| 62717.736 | -0.4699 | 0.8121 | -1.173 | -0.9607 |
#> |.....................| -1.000 | -0.9515 | -0.2190 | -0.1826 |
#> | U| 62717.736 | 1.422 | 4.312 | 0.2093 | 0.5983 |
#> |.....................| 0.009998 | 0.6075 | 1.766 | 1.831 |
#> | X| 62717.736 | 4.145 | 74.59 | 0.2093 | 0.5983 |
#> |.....................| 0.009998 | 0.6075 | 1.766 | 1.831 |
#> | F| Forward Diff. | 72.51 | 80.78 | 225.3 | -131.6 |
#> |.....................| 0.2282 | 652.0 | -34.06 | -47.67 |
#> | 64| 62717.496 | -0.4701 | 0.8119 | -1.174 | -0.9606 |
#> |.....................| -1.000 | -0.9522 | -0.2189 | -0.1826 |
#> | U| 62717.496 | 1.422 | 4.312 | 0.2092 | 0.5985 |
#> |.....................| 0.009998 | 0.6068 | 1.767 | 1.831 |
#> | X| 62717.496 | 4.144 | 74.58 | 0.2092 | 0.5985 |
#> |.....................| 0.009998 | 0.6068 | 1.767 | 1.831 |
#> | F| Forward Diff. | 71.58 | 79.94 | 390.7 | 562.8 |
#> |.....................| 0.2288 | -45.43 | -34.13 | -47.70 |
#> | 65| 62717.271 | -0.4702 | 0.8118 | -1.174 | -0.9612 |
#> |.....................| -1.000 | -0.9522 | -0.2189 | -0.1825 |
#> | U| 62717.271 | 1.422 | 4.312 | 0.2091 | 0.5978 |
#> |.....................| 0.009998 | 0.6068 | 1.767 | 1.831 |
#> | X| 62717.271 | 4.144 | 74.58 | 0.2091 | 0.5978 |
#> |.....................| 0.009998 | 0.6068 | 1.767 | 1.831 |
#> | F| Forward Diff. | 71.92 | 80.24 | 223.7 | -132.0 |
#> |.....................| 0.2282 | 652.1 | -34.00 | -47.56 |
#> | 66| 62717.031 | -0.4703 | 0.8117 | -1.174 | -0.9611 |
#> |.....................| -1.000 | -0.9529 | -0.2188 | -0.1825 |
#> | U| 62717.031 | 1.421 | 4.312 | 0.2090 | 0.5979 |
#> |.....................| 0.009998 | 0.6061 | 1.767 | 1.831 |
#> | X| 62717.031 | 4.143 | 74.56 | 0.2090 | 0.5979 |
#> |.....................| 0.009998 | 0.6061 | 1.767 | 1.831 |
#> | F| Forward Diff. | 70.97 | 79.38 | 388.8 | 560.2 |
#> |.....................| 0.2288 | -43.07 | -34.06 | -47.62 |
#> | 67| 62716.807 | -0.4704 | 0.8116 | -1.175 | -0.9617 |
#> |.....................| -1.000 | -0.9529 | -0.2188 | -0.1824 |
#> | U| 62716.807 | 1.421 | 4.312 | 0.2089 | 0.5973 |
#> |.....................| 0.009998 | 0.6061 | 1.767 | 1.832 |
#> | X| 62716.807 | 4.143 | 74.56 | 0.2089 | 0.5973 |
#> |.....................| 0.009998 | 0.6061 | 1.767 | 1.832 |
#> | F| Forward Diff. | 71.32 | 79.67 | 222.1 | -132.9 |
#> |.....................| 0.2282 | 652.7 | -33.90 | -47.48 |
#> | 68| 62716.568 | -0.4705 | 0.8114 | -1.175 | -0.9616 |
#> |.....................| -1.000 | -0.9536 | -0.2187 | -0.1824 |
#> | U| 62716.568 | 1.421 | 4.311 | 0.2088 | 0.5974 |
#> |.....................| 0.009998 | 0.6054 | 1.767 | 1.832 |
#> | X| 62716.568 | 4.142 | 74.55 | 0.2088 | 0.5974 |
#> |.....................| 0.009998 | 0.6054 | 1.767 | 1.832 |
#> | F| Forward Diff. | 70.35 | 78.79 | 387.0 | 557.8 |
#> |.....................| 0.2288 | -41.26 | -33.96 | -47.54 |
#> | 69| 62716.345 | -0.4706 | 0.8113 | -1.175 | -0.9623 |
#> |.....................| -1.000 | -0.9536 | -0.2187 | -0.1823 |
#> | U| 62716.345 | 1.421 | 4.311 | 0.2087 | 0.5967 |
#> |.....................| 0.009998 | 0.6054 | 1.767 | 1.832 |
#> | X| 62716.345 | 4.142 | 74.54 | 0.2087 | 0.5967 |
#> |.....................| 0.009998 | 0.6054 | 1.767 | 1.832 |
#> | F| Forward Diff. | 70.69 | 79.09 | 220.5 | -133.6 |
#> |.....................| 0.2282 | 653.1 | -33.83 | -47.38 |
#> | 70| 62716.107 | -0.4708 | 0.8112 | -1.175 | -0.9622 |
#> |.....................| -1.000 | -0.9543 | -0.2187 | -0.1823 |
#> | U| 62716.107 | 1.421 | 4.311 | 0.2086 | 0.5968 |
#> |.....................| 0.009998 | 0.6047 | 1.767 | 1.832 |
#> | X| 62716.107 | 4.141 | 74.53 | 0.2086 | 0.5968 |
#> |.....................| 0.009998 | 0.6047 | 1.767 | 1.832 |
#> | F| Forward Diff. | 69.71 | 78.20 | 385.0 | 554.9 |
#> |.....................| 0.2288 | -38.67 | -33.95 | -47.47 |
#> | 71| 62715.886 | -0.4709 | 0.8111 | -1.176 | -0.9628 |
#> |.....................| -1.000 | -0.9543 | -0.2186 | -0.1822 |
#> | U| 62715.886 | 1.421 | 4.311 | 0.2085 | 0.5962 |
#> |.....................| 0.009998 | 0.6048 | 1.767 | 1.832 |
#> | X| 62715.886 | 4.141 | 74.52 | 0.2085 | 0.5962 |
#> |.....................| 0.009998 | 0.6048 | 1.767 | 1.832 |
#> | F| Forward Diff. | 70.07 | 78.49 | 218.7 | -134.9 |
#> |.....................| 0.2282 | 654.1 | -33.78 | -47.31 |
#> | 72| 62715.648 | -0.4710 | 0.8109 | -1.176 | -0.9628 |
#> |.....................| -1.000 | -0.9550 | -0.2186 | -0.1822 |
#> | U| 62715.648 | 1.421 | 4.311 | 0.2085 | 0.5963 |
#> |.....................| 0.009998 | 0.6040 | 1.767 | 1.832 |
#> | X| 62715.648 | 4.140 | 74.51 | 0.2085 | 0.5963 |
#> |.....................| 0.009998 | 0.6040 | 1.767 | 1.832 |
#> | F| Forward Diff. | 69.08 | 77.58 | 383.1 | 552.2 |
#> |.....................| 0.2288 | -36.26 | -33.86 | -47.40 |
#> | 73| 62715.429 | -0.4711 | 0.8108 | -1.176 | -0.9634 |
#> |.....................| -1.000 | -0.9550 | -0.2185 | -0.1821 |
#> | U| 62715.429 | 1.421 | 4.311 | 0.2083 | 0.5956 |
#> |.....................| 0.009998 | 0.6041 | 1.767 | 1.832 |
#> | X| 62715.429 | 4.140 | 74.50 | 0.2083 | 0.5956 |
#> |.....................| 0.009998 | 0.6041 | 1.767 | 1.832 |
#> | F| Forward Diff. | 69.43 | 77.90 | 217.1 | -136.0 |
#> |.....................| 0.2282 | 654.9 | -33.71 | -47.25 |
#> | 74| 62715.191 | -0.4713 | 0.8106 | -1.177 | -0.9633 |
#> |.....................| -1.000 | -0.9557 | -0.2185 | -0.1821 |
#> | U| 62715.191 | 1.421 | 4.311 | 0.2083 | 0.5957 |
#> |.....................| 0.009998 | 0.6033 | 1.767 | 1.832 |
#> | X| 62715.191 | 4.139 | 74.49 | 0.2083 | 0.5957 |
#> |.....................| 0.009998 | 0.6033 | 1.767 | 1.832 |
#> | F| Forward Diff. | 68.43 | 76.98 | 381.3 | 549.4 |
#> |.....................| 0.2288 | -33.76 | -33.85 | -47.33 |
#> | 75| 62714.974 | -0.4713 | 0.8105 | -1.177 | -0.9640 |
#> |.....................| -1.000 | -0.9557 | -0.2185 | -0.1821 |
#> | U| 62714.974 | 1.420 | 4.311 | 0.2081 | 0.5951 |
#> |.....................| 0.009998 | 0.6034 | 1.767 | 1.832 |
#> | X| 62714.974 | 4.139 | 74.48 | 0.2081 | 0.5951 |
#> |.....................| 0.009998 | 0.6034 | 1.767 | 1.832 |
#> | F| Forward Diff. | 68.79 | 77.28 | 215.6 | -136.8 |
#> |.....................| 0.2282 | 655.2 | -33.68 | -47.17 |
#> | 76| 62714.737 | -0.4715 | 0.8104 | -1.177 | -0.9639 |
#> |.....................| -1.000 | -0.9564 | -0.2184 | -0.1820 |
#> | U| 62714.737 | 1.420 | 4.310 | 0.2081 | 0.5951 |
#> |.....................| 0.009998 | 0.6026 | 1.767 | 1.832 |
#> | X| 62714.737 | 4.138 | 74.47 | 0.2081 | 0.5951 |
#> |.....................| 0.009998 | 0.6026 | 1.767 | 1.832 |
#> | F| Forward Diff. | 67.79 | 76.36 | 379.6 | 547.3 |
#> |.....................| 0.2288 | -32.02 | -33.80 | -47.26 |
#> | 77| 62714.521 | -0.4716 | 0.8103 | -1.178 | -0.9645 |
#> |.....................| -1.000 | -0.9564 | -0.2184 | -0.1820 |
#> | U| 62714.521 | 1.420 | 4.310 | 0.2080 | 0.5945 |
#> |.....................| 0.009998 | 0.6027 | 1.768 | 1.832 |
#> | X| 62714.521 | 4.138 | 74.46 | 0.2080 | 0.5945 |
#> |.....................| 0.009998 | 0.6027 | 1.768 | 1.832 |
#> | F| Forward Diff. | 68.14 | 76.67 | 214.0 | -137.5 |
#> |.....................| 0.2282 | 655.5 | -33.65 | -47.15 |
#> | 78| 62714.285 | -0.4717 | 0.8101 | -1.178 | -0.9645 |
#> |.....................| -1.000 | -0.9571 | -0.2184 | -0.1820 |
#> | U| 62714.285 | 1.420 | 4.310 | 0.2079 | 0.5946 |
#> |.....................| 0.009998 | 0.6019 | 1.768 | 1.832 |
#> | X| 62714.285 | 4.137 | 74.45 | 0.2079 | 0.5946 |
#> |.....................| 0.009998 | 0.6019 | 1.768 | 1.832 |
#> | F| Forward Diff. | 67.14 | 75.74 | 377.9 | 545.1 |
#> |.....................| 0.2288 | -30.41 | -33.81 | -47.24 |
#> | 79| 62714.070 | -0.4718 | 0.8100 | -1.178 | -0.9651 |
#> |.....................| -1.000 | -0.9571 | -0.2183 | -0.1819 |
#> | U| 62714.07 | 1.420 | 4.310 | 0.2078 | 0.5939 |
#> |.....................| 0.009998 | 0.6020 | 1.768 | 1.832 |
#> | X| 62714.07 | 4.137 | 74.44 | 0.2078 | 0.5939 |
#> |.....................| 0.009998 | 0.6020 | 1.768 | 1.832 |
#> | F| Forward Diff. | 67.49 | 76.04 | 212.5 | -138.5 |
#> |.....................| 0.2282 | 656.1 | -33.62 | -47.08 |
#> | 80| 62713.834 | -0.4720 | 0.8098 | -1.178 | -0.9650 |
#> |.....................| -1.000 | -0.9578 | -0.2183 | -0.1819 |
#> | U| 62713.834 | 1.420 | 4.310 | 0.2078 | 0.5940 |
#> |.....................| 0.009998 | 0.6012 | 1.768 | 1.832 |
#> | X| 62713.834 | 4.136 | 74.43 | 0.2078 | 0.5940 |
#> |.....................| 0.009998 | 0.6012 | 1.768 | 1.832 |
#> | F| Forward Diff. | 66.49 | 75.11 | 376.0 | 542.2 |
#> |.....................| 0.2288 | -27.91 | -33.81 | -47.22 |
#> | 81| 62713.621 | -0.4721 | 0.8097 | -1.179 | -0.9657 |
#> |.....................| -1.000 | -0.9578 | -0.2183 | -0.1819 |
#> | U| 62713.621 | 1.420 | 4.310 | 0.2076 | 0.5933 |
#> |.....................| 0.009998 | 0.6012 | 1.768 | 1.832 |
#> | X| 62713.621 | 4.136 | 74.42 | 0.2076 | 0.5933 |
#> |.....................| 0.009998 | 0.6012 | 1.768 | 1.832 |
#> | F| Forward Diff. | 66.85 | 75.41 | 211.0 | -139.1 |
#> |.....................| 0.2282 | 656.4 | -33.57 | -47.07 |
#> | 82| 62713.386 | -0.4722 | 0.8096 | -1.179 | -0.9656 |
#> |.....................| -1.000 | -0.9585 | -0.2183 | -0.1819 |
#> | U| 62713.386 | 1.420 | 4.310 | 0.2076 | 0.5934 |
#> |.....................| 0.009998 | 0.6005 | 1.768 | 1.832 |
#> | X| 62713.386 | 4.135 | 74.41 | 0.2076 | 0.5934 |
#> |.....................| 0.009998 | 0.6005 | 1.768 | 1.832 |
#> | F| Forward Diff. | 65.85 | 74.48 | 374.4 | 540.0 |
#> |.....................| 0.2288 | -26.17 | -33.79 | -47.19 |
#> | 83| 62713.175 | -0.4723 | 0.8095 | -1.179 | -0.9663 |
#> |.....................| -1.000 | -0.9585 | -0.2182 | -0.1818 |
#> | U| 62713.175 | 1.419 | 4.309 | 0.2075 | 0.5928 |
#> |.....................| 0.009998 | 0.6005 | 1.768 | 1.833 |
#> | X| 62713.175 | 4.135 | 74.40 | 0.2075 | 0.5928 |
#> |.....................| 0.009998 | 0.6005 | 1.768 | 1.833 |
#> | F| Forward Diff. | 66.20 | 74.78 | 209.6 | -139.8 |
#> |.....................| 0.2281 | 656.6 | -33.65 | -47.08 |
#> | 84| 62712.941 | -0.4725 | 0.8093 | -1.179 | -0.9662 |
#> |.....................| -1.000 | -0.9592 | -0.2183 | -0.1818 |
#> | U| 62712.941 | 1.419 | 4.309 | 0.2074 | 0.5928 |
#> |.....................| 0.009998 | 0.5998 | 1.768 | 1.833 |
#> | X| 62712.941 | 4.134 | 74.39 | 0.2074 | 0.5928 |
#> |.....................| 0.009998 | 0.5998 | 1.768 | 1.833 |
#> | F| Forward Diff. | 65.20 | 73.84 | 372.8 | 538.0 |
#> |.....................| 0.2288 | -24.41 | -33.81 | -47.17 |
#> | 85| 62712.730 | -0.4725 | 0.8092 | -1.180 | -0.9668 |
#> |.....................| -1.000 | -0.9592 | -0.2182 | -0.1818 |
#> | U| 62712.73 | 1.419 | 4.309 | 0.2073 | 0.5922 |
#> |.....................| 0.009998 | 0.5998 | 1.768 | 1.833 |
#> | X| 62712.73 | 4.134 | 74.38 | 0.2073 | 0.5922 |
#> |.....................| 0.009998 | 0.5998 | 1.768 | 1.833 |
#> | F| Forward Diff. | 65.55 | 74.13 | 208.2 | -140.4 |
#> |.....................| 0.2281 | 656.8 | -33.69 | -47.06 |
#> | 86| 62712.497 | -0.4727 | 0.8090 | -1.180 | -0.9668 |
#> |.....................| -1.000 | -0.9600 | -0.2182 | -0.1818 |
#> | U| 62712.497 | 1.419 | 4.309 | 0.2073 | 0.5922 |
#> |.....................| 0.009998 | 0.5991 | 1.768 | 1.833 |
#> | X| 62712.497 | 4.133 | 74.37 | 0.2073 | 0.5922 |
#> |.....................| 0.009998 | 0.5991 | 1.768 | 1.833 |
#> | F| Forward Diff. | 64.56 | 73.20 | 371.2 | 536.0 |
#> |.....................| 0.2288 | -22.86 | -33.84 | -47.19 |
#> | 87| 62712.287 | -0.4728 | 0.8089 | -1.180 | -0.9674 |
#> |.....................| -1.000 | -0.9599 | -0.2182 | -0.1817 |
#> | U| 62712.287 | 1.419 | 4.309 | 0.2071 | 0.5916 |
#> |.....................| 0.009998 | 0.5991 | 1.768 | 1.833 |
#> | X| 62712.287 | 4.133 | 74.36 | 0.2071 | 0.5916 |
#> |.....................| 0.009998 | 0.5991 | 1.768 | 1.833 |
#> | F| Forward Diff. | 64.91 | 73.50 | 206.7 | -141.1 |
#> |.....................| 0.2281 | 657.2 | -33.71 | -47.01 |
#> | 88| 62712.055 | -0.4729 | 0.8088 | -1.180 | -0.9674 |
#> |.....................| -1.000 | -0.9607 | -0.2182 | -0.1817 |
#> | U| 62712.055 | 1.419 | 4.309 | 0.2071 | 0.5916 |
#> |.....................| 0.009998 | 0.5983 | 1.768 | 1.833 |
#> | X| 62712.055 | 4.132 | 74.35 | 0.2071 | 0.5916 |
#> |.....................| 0.009998 | 0.5983 | 1.768 | 1.833 |
#> | F| Forward Diff. | 63.93 | 72.57 | 369.5 | 533.8 |
#> |.....................| 0.2287 | -20.96 | -33.85 | -47.20 |
#> | 89| 62711.847 | -0.4730 | 0.8087 | -1.181 | -0.9680 |
#> |.....................| -1.000 | -0.9607 | -0.2182 | -0.1817 |
#> | U| 62711.847 | 1.419 | 4.309 | 0.2070 | 0.5910 |
#> |.....................| 0.009998 | 0.5984 | 1.768 | 1.833 |
#> | X| 62711.847 | 4.132 | 74.34 | 0.2070 | 0.5910 |
#> |.....................| 0.009998 | 0.5984 | 1.768 | 1.833 |
#> | F| Forward Diff. | 64.28 | 72.86 | 205.3 | -141.7 |
#> |.....................| 0.2281 | 657.3 | -33.72 | -47.06 |
#> | 90| 62711.615 | -0.4731 | 0.8085 | -1.181 | -0.9680 |
#> |.....................| -1.000 | -0.9614 | -0.2182 | -0.1817 |
#> | U| 62711.615 | 1.419 | 4.308 | 0.2069 | 0.5910 |
#> |.....................| 0.009998 | 0.5976 | 1.768 | 1.833 |
#> | X| 62711.615 | 4.131 | 74.33 | 0.2069 | 0.5910 |
#> |.....................| 0.009998 | 0.5976 | 1.768 | 1.833 |
#> | F| Forward Diff. | 63.30 | 71.93 | 368.0 | 532.1 |
#> |.....................| 0.2288 | -19.53 | -33.95 | -47.21 |
#> | 91| 62711.408 | -0.4732 | 0.8084 | -1.181 | -0.9686 |
#> |.....................| -1.000 | -0.9614 | -0.2181 | -0.1817 |
#> | U| 62711.408 | 1.419 | 4.308 | 0.2068 | 0.5904 |
#> |.....................| 0.009998 | 0.5976 | 1.768 | 1.833 |
#> | X| 62711.408 | 4.131 | 74.32 | 0.2068 | 0.5904 |
#> |.....................| 0.009998 | 0.5976 | 1.768 | 1.833 |
#> | F| Forward Diff. | 63.65 | 72.23 | 203.9 | -142.3 |
#> |.....................| 0.2281 | 657.7 | -33.81 | -47.04 |
#> | 92| 62711.178 | -0.4734 | 0.8082 | -1.182 | -0.9686 |
#> |.....................| -1.000 | -0.9621 | -0.2182 | -0.1817 |
#> | U| 62711.178 | 1.418 | 4.308 | 0.2068 | 0.5904 |
#> |.....................| 0.009998 | 0.5969 | 1.768 | 1.833 |
#> | X| 62711.178 | 4.130 | 74.31 | 0.2068 | 0.5904 |
#> |.....................| 0.009998 | 0.5969 | 1.768 | 1.833 |
#> | F| Forward Diff. | 62.68 | 71.30 | 366.4 | 530.0 |
#> |.....................| 0.2287 | -18.05 | -34.05 | -47.20 |
#> | 93| 62710.972 | -0.4734 | 0.8081 | -1.182 | -0.9692 |
#> |.....................| -1.000 | -0.9621 | -0.2181 | -0.1816 |
#> | U| 62710.972 | 1.418 | 4.308 | 0.2066 | 0.5898 |
#> |.....................| 0.009998 | 0.5969 | 1.768 | 1.833 |
#> | X| 62710.972 | 4.130 | 74.30 | 0.2066 | 0.5898 |
#> |.....................| 0.009998 | 0.5969 | 1.768 | 1.833 |
#> | F| Forward Diff. | 63.03 | 71.59 | 202.5 | -143.1 |
#> |.....................| 0.2281 | 657.9 | -33.84 | -47.05 |
#> | 94| 62710.742 | -0.4736 | 0.8080 | -1.182 | -0.9692 |
#> |.....................| -1.000 | -0.9629 | -0.2182 | -0.1817 |
#> | U| 62710.742 | 1.418 | 4.308 | 0.2066 | 0.5898 |
#> |.....................| 0.009998 | 0.5961 | 1.768 | 1.833 |
#> | X| 62710.742 | 4.130 | 74.29 | 0.2066 | 0.5898 |
#> |.....................| 0.009998 | 0.5961 | 1.768 | 1.833 |
#> | F| Forward Diff. | 62.07 | 70.67 | 364.8 | 527.7 |
#> |.....................| 0.2287 | -16.06 | -34.09 | -47.25 |
#> | 95| 62710.538 | -0.4737 | 0.8079 | -1.183 | -0.9699 |
#> |.....................| -1.000 | -0.9629 | -0.2181 | -0.1816 |
#> | U| 62710.538 | 1.418 | 4.308 | 0.2065 | 0.5892 |
#> |.....................| 0.009998 | 0.5962 | 1.768 | 1.833 |
#> | X| 62710.538 | 4.129 | 74.28 | 0.2065 | 0.5892 |
#> |.....................| 0.009998 | 0.5962 | 1.768 | 1.833 |
#> | F| Forward Diff. | 62.41 | 70.97 | 201.2 | -143.5 |
#> |.....................| 0.2281 | 658.2 | -33.95 | -47.13 |
#> | 96| 62710.309 | -0.4738 | 0.8077 | -1.183 | -0.9698 |
#> |.....................| -1.000 | -0.9636 | -0.2182 | -0.1817 |
#> | U| 62710.309 | 1.418 | 4.308 | 0.2065 | 0.5892 |
#> |.....................| 0.009998 | 0.5954 | 1.768 | 1.833 |
#> | X| 62710.309 | 4.129 | 74.27 | 0.2065 | 0.5892 |
#> |.....................| 0.009998 | 0.5954 | 1.768 | 1.833 |
#> | F| Forward Diff. | 61.46 | 70.04 | 363.3 | 525.9 |
#> |.....................| 0.2287 | -14.73 | -34.20 | -47.31 |
#> | 97| 62710.106 | -0.4739 | 0.8076 | -1.183 | -0.9705 |
#> |.....................| -1.000 | -0.9636 | -0.2181 | -0.1816 |
#> | U| 62710.106 | 1.418 | 4.308 | 0.2063 | 0.5886 |
#> |.....................| 0.009998 | 0.5954 | 1.768 | 1.833 |
#> | X| 62710.106 | 4.128 | 74.26 | 0.2063 | 0.5886 |
#> |.....................| 0.009998 | 0.5954 | 1.768 | 1.833 |
#> | F| Forward Diff. | 61.81 | 70.34 | 199.8 | -144.3 |
#> |.....................| 0.2281 | 658.3 | -34.00 | -47.15 |
#> | 98| 62709.877 | -0.4740 | 0.8075 | -1.183 | -0.9704 |
#> |.....................| -1.000 | -0.9643 | -0.2182 | -0.1817 |
#> | U| 62709.877 | 1.418 | 4.307 | 0.2063 | 0.5886 |
#> |.....................| 0.009998 | 0.5947 | 1.768 | 1.833 |
#> | X| 62709.877 | 4.128 | 74.25 | 0.2063 | 0.5886 |
#> |.....................| 0.009998 | 0.5947 | 1.768 | 1.833 |
#> | F| Forward Diff. | 60.86 | 69.42 | 361.7 | 523.9 |
#> |.....................| 0.2287 | -13.07 | -34.26 | -47.37 |
#> | 99| 62709.675 | -0.4741 | 0.8074 | -1.184 | -0.9711 |
#> |.....................| -1.000 | -0.9643 | -0.2182 | -0.1816 |
#> | U| 62709.675 | 1.418 | 4.307 | 0.2062 | 0.5879 |
#> |.....................| 0.009998 | 0.5947 | 1.768 | 1.833 |
#> | X| 62709.675 | 4.127 | 74.25 | 0.2062 | 0.5879 |
#> |.....................| 0.009998 | 0.5947 | 1.768 | 1.833 |
#> | F| Forward Diff. | 61.21 | 69.71 | 198.5 | -144.8 |
#> |.....................| 0.2280 | 658.5 | -34.15 | -47.20 |
#> | 100| 62709.448 | -0.4742 | 0.8072 | -1.184 | -0.9711 |
#> |.....................| -1.000 | -0.9651 | -0.2182 | -0.1817 |
#> | U| 62709.448 | 1.418 | 4.307 | 0.2062 | 0.5880 |
#> |.....................| 0.009998 | 0.5939 | 1.768 | 1.833 |
#> | X| 62709.448 | 4.127 | 74.23 | 0.2062 | 0.5880 |
#> |.....................| 0.009998 | 0.5939 | 1.768 | 1.833 |
#> | F| Forward Diff. | 60.27 | 68.81 | 360.2 | 522.1 |
#> |.....................| 0.2287 | -11.87 | -34.36 | -47.39 |
#> | 101| 62709.247 | -0.4743 | 0.8071 | -1.184 | -0.9717 |
#> |.....................| -1.000 | -0.9651 | -0.2182 | -0.1816 |
#> | U| 62709.247 | 1.417 | 4.307 | 0.2060 | 0.5873 |
#> |.....................| 0.009998 | 0.5939 | 1.768 | 1.833 |
#> | X| 62709.247 | 4.127 | 74.23 | 0.2060 | 0.5873 |
#> |.....................| 0.009998 | 0.5939 | 1.768 | 1.833 |
#> | F| Forward Diff. | 60.62 | 69.10 | 197.1 | -145.6 |
#> |.....................| 0.2280 | 658.8 | -34.23 | -47.25 |
#> | 102| 62709.020 | -0.4744 | 0.8070 | -1.184 | -0.9717 |
#> |.....................| -1.000 | -0.9658 | -0.2182 | -0.1817 |
#> | U| 62709.02 | 1.417 | 4.307 | 0.2060 | 0.5873 |
#> |.....................| 0.009998 | 0.5932 | 1.768 | 1.833 |
#> | X| 62709.02 | 4.126 | 74.21 | 0.2060 | 0.5873 |
#> |.....................| 0.009998 | 0.5932 | 1.768 | 1.833 |
#> | F| Forward Diff. | 59.69 | 68.20 | 358.6 | 519.8 |
#> |.....................| 0.2287 | -9.876 | -34.52 | -47.46 |
#> | 103| 62708.820 | -0.4745 | 0.8069 | -1.185 | -0.9723 |
#> |.....................| -1.000 | -0.9658 | -0.2182 | -0.1816 |
#> | U| 62708.82 | 1.417 | 4.307 | 0.2059 | 0.5867 |
#> |.....................| 0.009998 | 0.5932 | 1.768 | 1.833 |
#> | X| 62708.82 | 4.126 | 74.21 | 0.2059 | 0.5867 |
#> |.....................| 0.009998 | 0.5932 | 1.768 | 1.833 |
#> | F| Forward Diff. | 60.03 | 68.49 | 195.9 | -146.0 |
#> |.....................| 0.2280 | 658.7 | -34.32 | -47.29 |
#> | 104| 62708.594 | -0.4746 | 0.8067 | -1.185 | -0.9723 |
#> |.....................| -1.000 | -0.9666 | -0.2183 | -0.1817 |
#> | U| 62708.594 | 1.417 | 4.307 | 0.2058 | 0.5867 |
#> |.....................| 0.009998 | 0.5924 | 1.768 | 1.833 |
#> | X| 62708.594 | 4.125 | 74.20 | 0.2058 | 0.5867 |
#> |.....................| 0.009998 | 0.5924 | 1.768 | 1.833 |
#> | F| Forward Diff. | 59.12 | 67.60 | 357.2 | 518.3 |
#> |.....................| 0.2287 | -8.700 | -34.67 | -47.53 |
#> | 105| 62708.396 | -0.4747 | 0.8066 | -1.185 | -0.9729 |
#> |.....................| -1.000 | -0.9666 | -0.2182 | -0.1816 |
#> | U| 62708.396 | 1.417 | 4.307 | 0.2057 | 0.5861 |
#> |.....................| 0.009998 | 0.5925 | 1.768 | 1.833 |
#> | X| 62708.396 | 4.125 | 74.19 | 0.2057 | 0.5861 |
#> |.....................| 0.009998 | 0.5925 | 1.768 | 1.833 |
#> | F| Forward Diff. | 59.46 | 67.89 | 194.5 | -146.5 |
#> |.....................| 0.2280 | 658.7 | -34.46 | -47.39 |
#> | 106| 62708.171 | -0.4749 | 0.8065 | -1.185 | -0.9729 |
#> |.....................| -1.000 | -0.9673 | -0.2183 | -0.1817 |
#> | U| 62708.171 | 1.417 | 4.306 | 0.2057 | 0.5861 |
#> |.....................| 0.009998 | 0.5917 | 1.768 | 1.833 |
#> | X| 62708.171 | 4.124 | 74.18 | 0.2057 | 0.5861 |
#> |.....................| 0.009998 | 0.5917 | 1.768 | 1.833 |
#> | F| Forward Diff. | 58.55 | 66.99 | 355.8 | 516.7 |
#> |.....................| 0.2286 | -7.747 | -34.74 | -47.61 |
#> | 107| 62707.973 | -0.4749 | 0.8064 | -1.186 | -0.9736 |
#> |.....................| -1.000 | -0.9673 | -0.2183 | -0.1816 |
#> | U| 62707.973 | 1.417 | 4.306 | 0.2056 | 0.5854 |
#> |.....................| 0.009998 | 0.5917 | 1.768 | 1.833 |
#> | X| 62707.973 | 4.124 | 74.17 | 0.2056 | 0.5854 |
#> |.....................| 0.009998 | 0.5917 | 1.768 | 1.833 |
#> | F| Forward Diff. | 58.89 | 67.28 | 193.2 | -147.4 |
#> |.....................| 0.2280 | 659.0 | -34.59 | -47.46 |
#> | 108| 62707.749 | -0.4750 | 0.8062 | -1.186 | -0.9736 |
#> |.....................| -1.000 | -0.9681 | -0.2184 | -0.1817 |
#> | U| 62707.749 | 1.417 | 4.306 | 0.2055 | 0.5855 |
#> |.....................| 0.009998 | 0.5909 | 1.768 | 1.833 |
#> | X| 62707.749 | 4.124 | 74.16 | 0.2055 | 0.5855 |
#> |.....................| 0.009998 | 0.5909 | 1.768 | 1.833 |
#> | F| Forward Diff. | 58.00 | 66.39 | 354.2 | 514.5 |
#> |.....................| 0.2286 | -5.668 | -34.88 | -47.69 |
#> | 109| 62707.552 | -0.4751 | 0.8062 | -1.186 | -0.9742 |
#> |.....................| -1.000 | -0.9681 | -0.2183 | -0.1816 |
#> | U| 62707.552 | 1.417 | 4.306 | 0.2054 | 0.5848 |
#> |.....................| 0.009998 | 0.5910 | 1.768 | 1.833 |
#> | X| 62707.552 | 4.123 | 74.15 | 0.2054 | 0.5848 |
#> |.....................| 0.009998 | 0.5910 | 1.768 | 1.833 |
#> | F| Forward Diff. | 58.34 | 66.68 | 192.0 | -147.5 |
#> |.....................| 0.2280 | 658.8 | -34.77 | -47.55 |
#> | 110| 62707.329 | -0.4752 | 0.8060 | -1.186 | -0.9742 |
#> |.....................| -1.001 | -0.9688 | -0.2184 | -0.1817 |
#> | U| 62707.329 | 1.417 | 4.306 | 0.2054 | 0.5848 |
#> |.....................| 0.009997 | 0.5902 | 1.768 | 1.833 |
#> | X| 62707.329 | 4.123 | 74.14 | 0.2054 | 0.5848 |
#> |.....................| 0.009997 | 0.5902 | 1.768 | 1.833 |
#> | F| Forward Diff. | 57.44 | 65.81 | 352.9 | 513.5 |
#> |.....................| 0.2286 | -5.170 | -35.07 | -47.79 |
#> | 111| 62707.133 | -0.4753 | 0.8059 | -1.187 | -0.9748 |
#> |.....................| -1.001 | -0.9688 | -0.2184 | -0.1817 |
#> | U| 62707.133 | 1.416 | 4.306 | 0.2053 | 0.5842 |
#> |.....................| 0.009997 | 0.5902 | 1.768 | 1.833 |
#> | X| 62707.133 | 4.122 | 74.14 | 0.2053 | 0.5842 |
#> |.....................| 0.009997 | 0.5902 | 1.768 | 1.833 |
#> | F| Forward Diff. | 57.79 | 66.10 | 190.6 | -148.3 |
#> |.....................| 0.2280 | 659.1 | -34.95 | -47.62 |
#> | 112| 62706.910 | -0.4754 | 0.8058 | -1.187 | -0.9748 |
#> |.....................| -1.001 | -0.9696 | -0.2184 | -0.1817 |
#> | U| 62706.91 | 1.416 | 4.306 | 0.2052 | 0.5842 |
#> |.....................| 0.009997 | 0.5894 | 1.767 | 1.833 |
#> | X| 62706.91 | 4.122 | 74.13 | 0.2052 | 0.5842 |
#> |.....................| 0.009997 | 0.5894 | 1.767 | 1.833 |
#> | F| Forward Diff. | 56.91 | 65.23 | 351.4 | 511.4 |
#> |.....................| 0.2286 | -3.598 | -35.20 | -47.86 |
#> | 113| 62706.716 | -0.4755 | 0.8057 | -1.187 | -0.9755 |
#> |.....................| -1.001 | -0.9696 | -0.2184 | -0.1817 |
#> | U| 62706.716 | 1.416 | 4.306 | 0.2051 | 0.5835 |
#> |.....................| 0.009997 | 0.5895 | 1.768 | 1.833 |
#> | X| 62706.716 | 4.122 | 74.12 | 0.2051 | 0.5835 |
#> |.....................| 0.009997 | 0.5895 | 1.768 | 1.833 |
#> | F| Forward Diff. | 57.25 | 65.52 | 189.3 | -148.8 |
#> |.....................| 0.2279 | 659.2 | -35.10 | -47.69 |
#> | 114| 62706.494 | -0.4756 | 0.8055 | -1.187 | -0.9755 |
#> |.....................| -1.001 | -0.9703 | -0.2185 | -0.1818 |
#> | U| 62706.494 | 1.416 | 4.306 | 0.2051 | 0.5836 |
#> |.....................| 0.009997 | 0.5887 | 1.767 | 1.833 |
#> | X| 62706.494 | 4.121 | 74.11 | 0.2051 | 0.5836 |
#> |.....................| 0.009997 | 0.5887 | 1.767 | 1.833 |
#> | F| Forward Diff. | 56.37 | 64.65 | 349.9 | 509.5 |
#> |.....................| 0.2286 | -2.168 | -35.40 | -47.96 |
#> | 115| 62706.301 | -0.4757 | 0.8055 | -1.188 | -0.9761 |
#> |.....................| -1.001 | -0.9703 | -0.2185 | -0.1817 |
#> | U| 62706.301 | 1.416 | 4.305 | 0.2050 | 0.5829 |
#> |.....................| 0.009997 | 0.5887 | 1.767 | 1.833 |
#> | X| 62706.301 | 4.121 | 74.10 | 0.2050 | 0.5829 |
#> |.....................| 0.009997 | 0.5887 | 1.767 | 1.833 |
#> | F| Forward Diff. | 56.71 | 64.93 | 188.1 | -149.3 |
#> |.....................| 0.2279 | 659.2 | -35.25 | -47.81 |
#> | 116| 62706.079 | -0.4758 | 0.8053 | -1.188 | -0.9761 |
#> |.....................| -1.001 | -0.9711 | -0.2186 | -0.1818 |
#> | U| 62706.079 | 1.416 | 4.305 | 0.2049 | 0.5829 |
#> |.....................| 0.009997 | 0.5879 | 1.767 | 1.833 |
#> | X| 62706.079 | 4.120 | 74.09 | 0.2049 | 0.5829 |
#> |.....................| 0.009997 | 0.5879 | 1.767 | 1.833 |
#> | F| Forward Diff. | 55.84 | 64.09 | 348.5 | 507.9 |
#> |.....................| 0.2286 | -1.142 | -35.56 | -48.04 |
#> | 117| 62705.887 | -0.4759 | 0.8052 | -1.188 | -0.9768 |
#> |.....................| -1.001 | -0.9711 | -0.2185 | -0.1817 |
#> | U| 62705.887 | 1.416 | 4.305 | 0.2048 | 0.5823 |
#> |.....................| 0.009997 | 0.5879 | 1.767 | 1.833 |
#> | X| 62705.887 | 4.120 | 74.09 | 0.2048 | 0.5823 |
#> |.....................| 0.009997 | 0.5879 | 1.767 | 1.833 |
#> | F| Forward Diff. | 56.18 | 64.37 | 186.8 | -150.1 |
#> |.....................| 0.2279 | 659.9 | -35.37 | -47.89 |
#> | 118| 62705.666 | -0.4760 | 0.8051 | -1.188 | -0.9767 |
#> |.....................| -1.001 | -0.9718 | -0.2186 | -0.1818 |
#> | U| 62705.666 | 1.416 | 4.305 | 0.2048 | 0.5823 |
#> |.....................| 0.009997 | 0.5872 | 1.767 | 1.833 |
#> | X| 62705.666 | 4.120 | 74.08 | 0.2048 | 0.5823 |
#> |.....................| 0.009997 | 0.5872 | 1.767 | 1.833 |
#> | F| Forward Diff. | 55.32 | 63.52 | 346.9 | 505.3 |
#> |.....................| 0.2285 | 1.009 | -35.74 | -48.15 |
#> | 119| 62705.475 | -0.4761 | 0.8050 | -1.189 | -0.9774 |
#> |.....................| -1.001 | -0.9718 | -0.2186 | -0.1818 |
#> | U| 62705.475 | 1.416 | 4.305 | 0.2047 | 0.5816 |
#> |.....................| 0.009997 | 0.5872 | 1.767 | 1.833 |
#> | X| 62705.475 | 4.119 | 74.07 | 0.2047 | 0.5816 |
#> |.....................| 0.009997 | 0.5872 | 1.767 | 1.833 |
#> | F| Forward Diff. | 55.66 | 63.80 | 185.6 | -150.2 |
#> |.....................| 0.2279 | 659.5 | -35.56 | -48.00 |
#> | 120| 62705.255 | -0.4762 | 0.8049 | -1.189 | -0.9774 |
#> |.....................| -1.001 | -0.9726 | -0.2187 | -0.1819 |
#> | U| 62705.255 | 1.416 | 4.305 | 0.2047 | 0.5816 |
#> |.....................| 0.009997 | 0.5864 | 1.767 | 1.832 |
#> | X| 62705.255 | 4.119 | 74.06 | 0.2047 | 0.5816 |
#> |.....................| 0.009997 | 0.5864 | 1.767 | 1.832 |
#> | F| Forward Diff. | 54.81 | 62.96 | 345.6 | 504.0 |
#> |.....................| 0.2285 | 1.763 | -35.92 | -48.28 |
#> | 121| 62705.065 | -0.4762 | 0.8048 | -1.189 | -0.9780 |
#> |.....................| -1.001 | -0.9726 | -0.2187 | -0.1818 |
#> | U| 62705.065 | 1.416 | 4.305 | 0.2045 | 0.5810 |
#> |.....................| 0.009997 | 0.5864 | 1.767 | 1.833 |
#> | X| 62705.065 | 4.119 | 74.05 | 0.2045 | 0.5810 |
#> |.....................| 0.009997 | 0.5864 | 1.767 | 1.833 |
#> | F| Forward Diff. | 55.14 | 63.25 | 184.2 | -151.0 |
#> |.....................| 0.2278 | 659.7 | -35.81 | -48.13 |
#> | 122| 62704.846 | -0.4763 | 0.8046 | -1.189 | -0.9780 |
#> |.....................| -1.001 | -0.9734 | -0.2188 | -0.1819 |
#> | U| 62704.846 | 1.415 | 4.305 | 0.2045 | 0.5810 |
#> |.....................| 0.009997 | 0.5857 | 1.767 | 1.832 |
#> | X| 62704.846 | 4.118 | 74.04 | 0.2045 | 0.5810 |
#> |.....................| 0.009997 | 0.5857 | 1.767 | 1.832 |
#> | F| Forward Diff. | 54.30 | 62.40 | 344.1 | 502.1 |
#> |.....................| 0.2285 | 3.385 | -36.11 | -48.38 |
#> | 123| 62704.656 | -0.4764 | 0.8046 | -1.190 | -0.9787 |
#> |.....................| -1.001 | -0.9734 | -0.2187 | -0.1819 |
#> | U| 62704.656 | 1.415 | 4.305 | 0.2044 | 0.5803 |
#> |.....................| 0.009997 | 0.5857 | 1.767 | 1.832 |
#> | X| 62704.656 | 4.118 | 74.04 | 0.2044 | 0.5803 |
#> |.....................| 0.009997 | 0.5857 | 1.767 | 1.832 |
#> | F| Forward Diff. | 54.63 | 62.69 | 183.1 | -151.3 |
#> |.....................| 0.2278 | 659.5 | -35.94 | -48.23 |
#> | 124| 62704.438 | -0.4765 | 0.8044 | -1.190 | -0.9787 |
#> |.....................| -1.001 | -0.9741 | -0.2188 | -0.1820 |
#> | U| 62704.438 | 1.415 | 4.304 | 0.2044 | 0.5803 |
#> |.....................| 0.009997 | 0.5849 | 1.767 | 1.832 |
#> | X| 62704.438 | 4.117 | 74.03 | 0.2044 | 0.5803 |
#> |.....................| 0.009997 | 0.5849 | 1.767 | 1.832 |
#> | F| Forward Diff. | 53.80 | 61.86 | 342.8 | 500.9 |
#> |.....................| 0.2285 | 4.238 | -36.33 | -48.50 |
#> | 125| 62704.249 | -0.4766 | 0.8043 | -1.190 | -0.9793 |
#> |.....................| -1.001 | -0.9741 | -0.2188 | -0.1819 |
#> | U| 62704.249 | 1.415 | 4.304 | 0.2042 | 0.5797 |
#> |.....................| 0.009997 | 0.5849 | 1.767 | 1.832 |
#> | X| 62704.249 | 4.117 | 74.02 | 0.2042 | 0.5797 |
#> |.....................| 0.009997 | 0.5849 | 1.767 | 1.832 |
#> | F| Forward Diff. | 54.13 | 62.15 | 181.8 | -151.8 |
#> |.....................| 0.2278 | 659.5 | -36.14 | -48.33 |
#> | 126| 62704.032 | -0.4767 | 0.8042 | -1.190 | -0.9793 |
#> |.....................| -1.001 | -0.9749 | -0.2189 | -0.1820 |
#> | U| 62704.032 | 1.415 | 4.304 | 0.2042 | 0.5797 |
#> |.....................| 0.009997 | 0.5841 | 1.767 | 1.832 |
#> | X| 62704.032 | 4.117 | 74.01 | 0.2042 | 0.5797 |
#> |.....................| 0.009997 | 0.5841 | 1.767 | 1.832 |
#> | F| Forward Diff. | 53.30 | 61.32 | 341.4 | 499.4 |
#> |.....................| 0.2284 | 5.072 | -36.52 | -48.61 |
#> | 127| 62703.845 | -0.4768 | 0.8041 | -1.191 | -0.9800 |
#> |.....................| -1.001 | -0.9749 | -0.2189 | -0.1820 |
#> | U| 62703.845 | 1.415 | 4.304 | 0.2041 | 0.5790 |
#> |.....................| 0.009997 | 0.5841 | 1.767 | 1.832 |
#> | X| 62703.845 | 4.116 | 74.01 | 0.2041 | 0.5790 |
#> |.....................| 0.009997 | 0.5841 | 1.767 | 1.832 |
#> | F| Forward Diff. | 53.63 | 61.60 | 180.5 | -152.5 |
#> |.....................| 0.2278 | 659.7 | -36.42 | -48.45 |
#> | 128| 62703.627 | -0.4769 | 0.8040 | -1.191 | -0.9800 |
#> |.....................| -1.001 | -0.9756 | -0.2190 | -0.1821 |
#> | U| 62703.627 | 1.415 | 4.304 | 0.2041 | 0.5790 |
#> |.....................| 0.009997 | 0.5834 | 1.766 | 1.832 |
#> | X| 62703.627 | 4.116 | 74.00 | 0.2041 | 0.5790 |
#> |.....................| 0.009997 | 0.5834 | 1.766 | 1.832 |
#> | F| Forward Diff. | 52.80 | 60.78 | 339.9 | 497.3 |
#> |.....................| 0.2284 | 6.677 | -36.71 | -48.73 |
#> | 129| 62703.441 | -0.4769 | 0.8039 | -1.191 | -0.9806 |
#> |.....................| -1.001 | -0.9757 | -0.2190 | -0.1820 |
#> | U| 62703.441 | 1.415 | 4.304 | 0.2039 | 0.5784 |
#> |.....................| 0.009997 | 0.5834 | 1.767 | 1.832 |
#> | X| 62703.441 | 4.116 | 73.99 | 0.2039 | 0.5784 |
#> |.....................| 0.009997 | 0.5834 | 1.767 | 1.832 |
#> | F| Forward Diff. | 53.14 | 61.07 | 179.3 | -152.8 |
#> |.....................| 0.2278 | 659.6 | -36.56 | -48.60 |
#> | 130| 62703.224 | -0.4770 | 0.8038 | -1.191 | -0.9806 |
#> |.....................| -1.001 | -0.9764 | -0.2191 | -0.1821 |
#> | U| 62703.224 | 1.415 | 4.304 | 0.2039 | 0.5784 |
#> |.....................| 0.009997 | 0.5826 | 1.766 | 1.832 |
#> | X| 62703.224 | 4.115 | 73.98 | 0.2039 | 0.5784 |
#> |.....................| 0.009997 | 0.5826 | 1.766 | 1.832 |
#> | F| Forward Diff. | 52.32 | 60.26 | 338.6 | 495.8 |
#> |.....................| 0.2284 | 7.799 | -36.91 | -48.85 |
#> | 131| 62703.039 | -0.4771 | 0.8037 | -1.191 | -0.9813 |
#> |.....................| -1.001 | -0.9764 | -0.2190 | -0.1821 |
#> | U| 62703.039 | 1.415 | 4.304 | 0.2038 | 0.5777 |
#> |.....................| 0.009997 | 0.5826 | 1.766 | 1.832 |
#> | X| 62703.039 | 4.115 | 73.97 | 0.2038 | 0.5777 |
#> |.....................| 0.009997 | 0.5826 | 1.766 | 1.832 |
#> | F| Forward Diff. | 52.65 | 60.54 | 178.1 | -153.2 |
#> |.....................| 0.2277 | 659.6 | -36.80 | -48.69 |
#> | 132| 62702.823 | -0.4772 | 0.8036 | -1.192 | -0.9813 |
#> |.....................| -1.001 | -0.9772 | -0.2192 | -0.1822 |
#> | U| 62702.823 | 1.415 | 4.304 | 0.2038 | 0.5777 |
#> |.....................| 0.009997 | 0.5818 | 1.766 | 1.832 |
#> | X| 62702.823 | 4.115 | 73.96 | 0.2038 | 0.5777 |
#> |.....................| 0.009997 | 0.5818 | 1.766 | 1.832 |
#> | F| Forward Diff. | 51.84 | 59.73 | 337.2 | 494.4 |
#> |.....................| 0.2284 | 8.798 | -37.13 | -48.97 |
#> | 133| 62702.639 | -0.4773 | 0.8035 | -1.192 | -0.9819 |
#> |.....................| -1.001 | -0.9772 | -0.2191 | -0.1821 |
#> | U| 62702.639 | 1.414 | 4.304 | 0.2037 | 0.5771 |
#> |.....................| 0.009997 | 0.5818 | 1.766 | 1.832 |
#> | X| 62702.639 | 4.114 | 73.96 | 0.2037 | 0.5771 |
#> |.....................| 0.009997 | 0.5818 | 1.766 | 1.832 |
#> | F| Forward Diff. | 52.17 | 60.01 | 176.9 | -153.7 |
#> |.....................| 0.2277 | 659.6 | -36.98 | -48.83 |
#> | 134| 62702.424 | -0.4774 | 0.8034 | -1.192 | -0.9819 |
#> |.....................| -1.001 | -0.9779 | -0.2193 | -0.1822 |
#> | U| 62702.424 | 1.414 | 4.303 | 0.2036 | 0.5771 |
#> |.....................| 0.009997 | 0.5811 | 1.766 | 1.832 |
#> | X| 62702.424 | 4.114 | 73.95 | 0.2036 | 0.5771 |
#> |.....................| 0.009997 | 0.5811 | 1.766 | 1.832 |
#> | F| Forward Diff. | 51.36 | 59.21 | 335.9 | 492.8 |
#> |.....................| 0.2284 | 9.903 | -37.32 | -49.11 |
#> | 135| 62702.240 | -0.4774 | 0.8033 | -1.192 | -0.9826 |
#> |.....................| -1.001 | -0.9780 | -0.2192 | -0.1822 |
#> | U| 62702.24 | 1.414 | 4.303 | 0.2035 | 0.5764 |
#> |.....................| 0.009997 | 0.5811 | 1.766 | 1.832 |
#> | X| 62702.24 | 4.114 | 73.94 | 0.2035 | 0.5764 |
#> |.....................| 0.009997 | 0.5811 | 1.766 | 1.832 |
#> | F| Forward Diff. | 51.69 | 59.48 | 175.7 | -154.1 |
#> |.....................| 0.2277 | 659.6 | -37.17 | -48.97 |
#> | 136| 62702.026 | -0.4775 | 0.8032 | -1.192 | -0.9826 |
#> |.....................| -1.001 | -0.9787 | -0.2194 | -0.1823 |
#> | U| 62702.026 | 1.414 | 4.303 | 0.2035 | 0.5764 |
#> |.....................| 0.009997 | 0.5803 | 1.766 | 1.832 |
#> | X| 62702.026 | 4.113 | 73.93 | 0.2035 | 0.5764 |
#> |.....................| 0.009997 | 0.5803 | 1.766 | 1.832 |
#> | F| Forward Diff. | 50.89 | 58.69 | 334.5 | 491.3 |
#> |.....................| 0.2283 | 10.90 | -37.52 | -49.27 |
#> | 137| 62701.843 | -0.4776 | 0.8031 | -1.193 | -0.9832 |
#> |.....................| -1.001 | -0.9787 | -0.2193 | -0.1822 |
#> | U| 62701.843 | 1.414 | 4.303 | 0.2034 | 0.5758 |
#> |.....................| 0.009997 | 0.5803 | 1.766 | 1.832 |
#> | X| 62701.843 | 4.113 | 73.93 | 0.2034 | 0.5758 |
#> |.....................| 0.009997 | 0.5803 | 1.766 | 1.832 |
#> | F| Forward Diff. | 51.22 | 58.97 | 174.4 | -154.7 |
#> |.....................| 0.2276 | 659.6 | -37.41 | -49.10 |
#> | 138| 62701.629 | -0.4777 | 0.8030 | -1.193 | -0.9833 |
#> |.....................| -1.001 | -0.9795 | -0.2194 | -0.1824 |
#> | U| 62701.629 | 1.414 | 4.303 | 0.2034 | 0.5758 |
#> |.....................| 0.009997 | 0.5795 | 1.766 | 1.832 |
#> | X| 62701.629 | 4.113 | 73.92 | 0.2034 | 0.5758 |
#> |.....................| 0.009997 | 0.5795 | 1.766 | 1.832 |
#> | F| Forward Diff. | 50.42 | 58.19 | 333.1 | 489.5 |
#> |.....................| 0.2283 | 12.39 | -37.73 | -49.38 |
#> | 139| 62701.448 | -0.4777 | 0.8029 | -1.193 | -0.9839 |
#> |.....................| -1.001 | -0.9795 | -0.2194 | -0.1823 |
#> | U| 62701.448 | 1.414 | 4.303 | 0.2032 | 0.5751 |
#> |.....................| 0.009997 | 0.5795 | 1.766 | 1.832 |
#> | X| 62701.448 | 4.112 | 73.91 | 0.2032 | 0.5751 |
#> |.....................| 0.009997 | 0.5795 | 1.766 | 1.832 |
#> | F| Forward Diff. | 50.75 | 58.46 | 173.3 | -154.8 |
#> |.....................| 0.2276 | 659.4 | -37.60 | -49.25 |
#> | 140| 62701.234 | -0.4778 | 0.8028 | -1.193 | -0.9839 |
#> |.....................| -1.001 | -0.9803 | -0.2195 | -0.1824 |
#> | U| 62701.234 | 1.414 | 4.303 | 0.2032 | 0.5751 |
#> |.....................| 0.009997 | 0.5788 | 1.765 | 1.832 |
#> | X| 62701.234 | 4.112 | 73.91 | 0.2032 | 0.5751 |
#> |.....................| 0.009997 | 0.5788 | 1.765 | 1.832 |
#> | F| Forward Diff. | 49.95 | 57.66 | 331.9 | 488.5 |
#> |.....................| 0.2283 | 12.72 | -37.98 | -49.56 |
#> | 141| 62701.054 | -0.4779 | 0.8027 | -1.194 | -0.9846 |
#> |.....................| -1.001 | -0.9803 | -0.2195 | -0.1824 |
#> | U| 62701.054 | 1.414 | 4.303 | 0.2031 | 0.5745 |
#> |.....................| 0.009997 | 0.5787 | 1.766 | 1.832 |
#> | X| 62701.054 | 4.112 | 73.90 | 0.2031 | 0.5745 |
#> |.....................| 0.009997 | 0.5787 | 1.766 | 1.832 |
#> | F| Forward Diff. | 50.29 | 57.95 | 172.0 | -155.7 |
#> |.....................| 0.2276 | 659.6 | -37.80 | -49.39 |
#> | 142| 62700.841 | -0.4780 | 0.8026 | -1.194 | -0.9846 |
#> |.....................| -1.001 | -0.9810 | -0.2196 | -0.1825 |
#> | U| 62700.841 | 1.414 | 4.303 | 0.2031 | 0.5744 |
#> |.....................| 0.009997 | 0.5780 | 1.765 | 1.831 |
#> | X| 62700.841 | 4.111 | 73.89 | 0.2031 | 0.5744 |
#> |.....................| 0.009997 | 0.5780 | 1.765 | 1.831 |
#> | F| Forward Diff. | 49.70 | 57.42 | 330.3 | 486.3 |
#> |.....................| 0.2282 | 14.60 | -38.20 | -49.67 |
#> | 143| 62700.661 | -0.4781 | 0.8025 | -1.194 | -0.9852 |
#> |.....................| -1.001 | -0.9810 | -0.2196 | -0.1824 |
#> | U| 62700.661 | 1.414 | 4.303 | 0.2030 | 0.5738 |
#> |.....................| 0.009997 | 0.5780 | 1.765 | 1.832 |
#> | X| 62700.661 | 4.111 | 73.89 | 0.2030 | 0.5738 |
#> |.....................| 0.009997 | 0.5780 | 1.765 | 1.832 |
#> | F| Forward Diff. | 49.83 | 57.45 | 171.0 | -155.5 |
#> |.....................| 0.2276 | 659.2 | -38.11 | -49.51 |
#> | 144| 62700.449 | -0.4782 | 0.8024 | -1.194 | -0.9852 |
#> |.....................| -1.001 | -0.9818 | -0.2197 | -0.1825 |
#> | U| 62700.449 | 1.414 | 4.302 | 0.2030 | 0.5738 |
#> |.....................| 0.009997 | 0.5772 | 1.765 | 1.831 |
#> | X| 62700.449 | 4.111 | 73.88 | 0.2030 | 0.5738 |
#> |.....................| 0.009997 | 0.5772 | 1.765 | 1.831 |
#> | F| Forward Diff. | 49.23 | 56.91 | 329.2 | 485.6 |
#> |.....................| 0.2282 | 14.98 | -38.45 | -49.81 |
#> | 145| 62700.270 | -0.4782 | 0.8023 | -1.195 | -0.9859 |
#> |.....................| -1.001 | -0.9818 | -0.2197 | -0.1825 |
#> | U| 62700.27 | 1.414 | 4.302 | 0.2028 | 0.5731 |
#> |.....................| 0.009997 | 0.5772 | 1.765 | 1.831 |
#> | X| 62700.27 | 4.110 | 73.87 | 0.2028 | 0.5731 |
#> |.....................| 0.009997 | 0.5772 | 1.765 | 1.831 |
#> | F| Forward Diff. | 49.36 | 56.94 | 169.7 | -156.0 |
#> |.....................| 0.2275 | 659.2 | -38.30 | -49.64 |
#> | 146| 62700.059 | -0.4783 | 0.8022 | -1.195 | -0.9859 |
#> |.....................| -1.001 | -0.9826 | -0.2198 | -0.1826 |
#> | U| 62700.059 | 1.413 | 4.302 | 0.2028 | 0.5731 |
#> |.....................| 0.009997 | 0.5764 | 1.765 | 1.831 |
#> | X| 62700.059 | 4.110 | 73.86 | 0.2028 | 0.5731 |
#> |.....................| 0.009997 | 0.5764 | 1.765 | 1.831 |
#> | F| Forward Diff. | 48.77 | 56.40 | 328.0 | 484.4 |
#> |.....................| 0.2282 | 15.57 | -38.66 | -49.94 |
#> | 147| 62699.881 | -0.4784 | 0.8021 | -1.195 | -0.9866 |
#> |.....................| -1.001 | -0.9826 | -0.2198 | -0.1825 |
#> | U| 62699.881 | 1.413 | 4.302 | 0.2027 | 0.5725 |
#> |.....................| 0.009997 | 0.5764 | 1.765 | 1.831 |
#> | X| 62699.881 | 4.110 | 73.86 | 0.2027 | 0.5725 |
#> |.....................| 0.009997 | 0.5764 | 1.765 | 1.831 |
#> | F| Forward Diff. | 48.90 | 56.43 | 168.5 | -156.9 |
#> |.....................| 0.2274 | 659.3 | -38.48 | -49.79 |
#> | 148| 62699.670 | -0.4785 | 0.8020 | -1.195 | -0.9866 |
#> |.....................| -1.001 | -0.9833 | -0.2199 | -0.1827 |
#> | U| 62699.67 | 1.413 | 4.302 | 0.2027 | 0.5724 |
#> |.....................| 0.009997 | 0.5757 | 1.765 | 1.831 |
#> | X| 62699.67 | 4.109 | 73.85 | 0.2027 | 0.5724 |
#> |.....................| 0.009997 | 0.5757 | 1.765 | 1.831 |
#> | F| Forward Diff. | 48.31 | 55.91 | 326.6 | 482.6 |
#> |.....................| 0.2282 | 17.00 | -38.88 | -50.08 |
#> | 149| 62699.493 | -0.4785 | 0.8019 | -1.196 | -0.9872 |
#> |.....................| -1.001 | -0.9834 | -0.2199 | -0.1826 |
#> | U| 62699.493 | 1.413 | 4.302 | 0.2025 | 0.5718 |
#> |.....................| 0.009997 | 0.5756 | 1.765 | 1.831 |
#> | X| 62699.493 | 4.109 | 73.84 | 0.2025 | 0.5718 |
#> |.....................| 0.009997 | 0.5756 | 1.765 | 1.831 |
#> | F| Forward Diff. | 48.44 | 55.93 | 167.4 | -157.2 |
#> |.....................| 0.2275 | 659.3 | -38.74 | -49.92 |
#> | 150| 62699.283 | -0.4786 | 0.8018 | -1.196 | -0.9872 |
#> |.....................| -1.001 | -0.9841 | -0.2200 | -0.1827 |
#> | U| 62699.283 | 1.413 | 4.302 | 0.2025 | 0.5718 |
#> |.....................| 0.009997 | 0.5749 | 1.765 | 1.831 |
#> | X| 62699.283 | 4.109 | 73.83 | 0.2025 | 0.5718 |
#> |.....................| 0.009997 | 0.5749 | 1.765 | 1.831 |
#> | F| Forward Diff. | 47.86 | 55.41 | 325.3 | 481.1 |
#> |.....................| 0.2281 | 17.79 | -39.11 | -50.23 |
#> | 151| 62699.107 | -0.4787 | 0.8017 | -1.196 | -0.9879 |
#> |.....................| -1.001 | -0.9841 | -0.2200 | -0.1827 |
#> | U| 62699.107 | 1.413 | 4.302 | 0.2024 | 0.5711 |
#> |.....................| 0.009997 | 0.5749 | 1.765 | 1.831 |
#> | X| 62699.107 | 4.109 | 73.83 | 0.2024 | 0.5711 |
#> |.....................| 0.009997 | 0.5749 | 1.765 | 1.831 |
#> | F| Forward Diff. | 47.98 | 55.44 | 166.2 | -157.8 |
#> |.....................| 0.2274 | 659.3 | -38.98 | -50.10 |
#> | 152| 62698.897 | -0.4788 | 0.8016 | -1.196 | -0.9879 |
#> |.....................| -1.001 | -0.9849 | -0.2201 | -0.1828 |
#> | U| 62698.897 | 1.413 | 4.302 | 0.2024 | 0.5711 |
#> |.....................| 0.009997 | 0.5741 | 1.764 | 1.831 |
#> | X| 62698.897 | 4.108 | 73.82 | 0.2024 | 0.5711 |
#> |.....................| 0.009997 | 0.5741 | 1.764 | 1.831 |
#> | F| Forward Diff. | 47.40 | 54.91 | 323.9 | 479.2 |
#> |.....................| 0.2281 | 19.15 | -39.37 | -50.38 |
#> | 153| 62698.722 | -0.4788 | 0.8015 | -1.197 | -0.9886 |
#> |.....................| -1.001 | -0.9849 | -0.2201 | -0.1827 |
#> | U| 62698.722 | 1.413 | 4.302 | 0.2023 | 0.5705 |
#> |.....................| 0.009997 | 0.5741 | 1.765 | 1.831 |
#> | X| 62698.722 | 4.108 | 73.81 | 0.2023 | 0.5705 |
#> |.....................| 0.009997 | 0.5741 | 1.765 | 1.831 |
#> | F| Forward Diff. | 47.54 | 54.95 | 164.9 | -159.6 |
#> |.....................| 0.2264 | 656.9 | -39.40 | -50.22 |
#> | 154| 62698.513 | -0.4789 | 0.8014 | -1.197 | -0.9886 |
#> |.....................| -1.001 | -0.9857 | -0.2202 | -0.1829 |
#> | U| 62698.513 | 1.413 | 4.301 | 0.2023 | 0.5704 |
#> |.....................| 0.009997 | 0.5733 | 1.764 | 1.831 |
#> | X| 62698.513 | 4.108 | 73.81 | 0.2023 | 0.5704 |
#> |.....................| 0.009997 | 0.5733 | 1.764 | 1.831 |
#> | F| Forward Diff. | 46.96 | 54.42 | 323.3 | 480.6 |
#> |.....................| 0.2281 | 17.22 | -39.59 | -50.53 |
#> | 155| 62698.336 | -0.4790 | 0.8013 | -1.197 | -0.9893 |
#> |.....................| -1.001 | -0.9857 | -0.2202 | -0.1829 |
#> | U| 62698.336 | 1.413 | 4.301 | 0.2022 | 0.5698 |
#> |.....................| 0.009997 | 0.5733 | 1.764 | 1.831 |
#> | X| 62698.336 | 4.107 | 73.80 | 0.2022 | 0.5698 |
#> |.....................| 0.009997 | 0.5733 | 1.764 | 1.831 |
#> | F| Forward Diff. | 47.06 | 54.42 | 166.1 | -150.0 |
#> |.....................| 0.2273 | 650.5 | -39.47 | -50.45 |
#> | 156| 62698.130 | -0.4791 | 0.8012 | -1.197 | -0.9893 |
#> |.....................| -1.001 | -0.9865 | -0.2204 | -0.1830 |
#> | U| 62698.13 | 1.413 | 4.301 | 0.2022 | 0.5697 |
#> |.....................| 0.009997 | 0.5725 | 1.764 | 1.830 |
#> | X| 62698.13 | 4.107 | 73.79 | 0.2022 | 0.5697 |
#> |.....................| 0.009997 | 0.5725 | 1.764 | 1.830 |
#> | F| Forward Diff. | 46.48 | 53.90 | 322.9 | 482.3 |
#> |.....................| 0.2281 | 14.95 | -39.84 | -50.73 |
#> | 157| 62697.955 | -0.4792 | 0.8012 | -1.197 | -0.9900 |
#> |.....................| -1.001 | -0.9865 | -0.2204 | -0.1830 |
#> | U| 62697.955 | 1.413 | 4.301 | 0.2020 | 0.5691 |
#> |.....................| 0.009997 | 0.5725 | 1.764 | 1.831 |
#> | X| 62697.955 | 4.107 | 73.78 | 0.2020 | 0.5691 |
#> |.....................| 0.009997 | 0.5725 | 1.764 | 1.831 |
#> | F| Forward Diff. | 46.60 | 53.91 | 164.7 | -151.8 |
#> |.....................| 0.2274 | 651.7 | -39.82 | -50.65 |
#> | 158| 62697.749 | -0.4792 | 0.8010 | -1.197 | -0.9900 |
#> |.....................| -1.001 | -0.9873 | -0.2205 | -0.1831 |
#> | U| 62697.749 | 1.413 | 4.301 | 0.2020 | 0.5690 |
#> |.....................| 0.009997 | 0.5717 | 1.764 | 1.830 |
#> | X| 62697.749 | 4.106 | 73.78 | 0.2020 | 0.5690 |
#> |.....................| 0.009997 | 0.5717 | 1.764 | 1.830 |
#> | F| Forward Diff. | 46.02 | 53.39 | 321.5 | 480.0 |
#> |.....................| 0.2280 | 16.95 | -40.20 | -50.94 |
#> | 159| 62697.575 | -0.4793 | 0.8010 | -1.198 | -0.9907 |
#> |.....................| -1.001 | -0.9873 | -0.2205 | -0.1831 |
#> | U| 62697.575 | 1.412 | 4.301 | 0.2019 | 0.5684 |
#> |.....................| 0.009997 | 0.5717 | 1.764 | 1.830 |
#> | X| 62697.575 | 4.106 | 73.77 | 0.2019 | 0.5684 |
#> |.....................| 0.009997 | 0.5717 | 1.764 | 1.830 |
#> | F| Forward Diff. | 46.15 | 53.41 | 163.2 | -155.1 |
#> |.....................| 0.2263 | 651.1 | -40.26 | -51.01 |
#> | 160| 62697.369 | -0.4794 | 0.8009 | -1.198 | -0.9907 |
#> |.....................| -1.001 | -0.9881 | -0.2207 | -0.1832 |
#> | U| 62697.369 | 1.412 | 4.301 | 0.2019 | 0.5683 |
#> |.....................| 0.009996 | 0.5709 | 1.763 | 1.830 |
#> | X| 62697.369 | 4.106 | 73.76 | 0.2019 | 0.5683 |
#> |.....................| 0.009996 | 0.5709 | 1.763 | 1.830 |
#> | F| Forward Diff. | 45.57 | 52.90 | 320.7 | 480.4 |
#> |.....................| 0.2280 | 15.74 | -40.42 | -51.16 |
#> | 161| 62697.194 | -0.4795 | 0.8008 | -1.198 | -0.9914 |
#> |.....................| -1.001 | -0.9881 | -0.2207 | -0.1832 |
#> | U| 62697.194 | 1.412 | 4.301 | 0.2018 | 0.5677 |
#> |.....................| 0.009996 | 0.5709 | 1.763 | 1.830 |
#> | X| 62697.194 | 4.105 | 73.76 | 0.2018 | 0.5677 |
#> |.....................| 0.009996 | 0.5709 | 1.763 | 1.830 |
#> | F| Forward Diff. | 45.68 | 52.89 | 164.3 | -146.2 |
#> |.....................| 0.2273 | 645.0 | -40.42 | -51.09 |
#> | 162| 62696.990 | -0.4795 | 0.8007 | -1.198 | -0.9914 |
#> |.....................| -1.001 | -0.9889 | -0.2208 | -0.1833 |
#> | U| 62696.99 | 1.412 | 4.301 | 0.2018 | 0.5676 |
#> |.....................| 0.009996 | 0.5701 | 1.763 | 1.830 |
#> | X| 62696.99 | 4.105 | 73.75 | 0.2018 | 0.5676 |
#> |.....................| 0.009996 | 0.5701 | 1.763 | 1.830 |
#> | F| Forward Diff. | 45.11 | 52.37 | 320.2 | 481.7 |
#> |.....................| 0.2279 | 14.14 | -40.83 | -51.37 |
#> | 163| 62696.817 | -0.4796 | 0.8006 | -1.199 | -0.9921 |
#> |.....................| -1.001 | -0.9889 | -0.2208 | -0.1833 |
#> | U| 62696.817 | 1.412 | 4.301 | 0.2017 | 0.5669 |
#> |.....................| 0.009996 | 0.5701 | 1.763 | 1.830 |
#> | X| 62696.817 | 4.105 | 73.74 | 0.2017 | 0.5669 |
#> |.....................| 0.009996 | 0.5701 | 1.763 | 1.830 |
#> | F| Forward Diff. | 45.23 | 52.40 | 162.8 | -149.5 |
#> |.....................| 0.2263 | 644.6 | -40.92 | -51.49 |
#> | 164| 62696.613 | -0.4797 | 0.8005 | -1.199 | -0.9921 |
#> |.....................| -1.001 | -0.9897 | -0.2210 | -0.1835 |
#> | U| 62696.613 | 1.412 | 4.300 | 0.2017 | 0.5669 |
#> |.....................| 0.009996 | 0.5693 | 1.763 | 1.830 |
#> | X| 62696.613 | 4.104 | 73.74 | 0.2017 | 0.5669 |
#> |.....................| 0.009996 | 0.5693 | 1.763 | 1.830 |
#> | F| Forward Diff. | 44.66 | 51.88 | 319.5 | 482.2 |
#> |.....................| 0.2279 | 12.91 | -41.11 | -51.62 |
#> | 165| 62696.439 | -0.4798 | 0.8004 | -1.199 | -0.9928 |
#> |.....................| -1.001 | -0.9898 | -0.2210 | -0.1835 |
#> | U| 62696.439 | 1.412 | 4.300 | 0.2016 | 0.5662 |
#> |.....................| 0.009996 | 0.5692 | 1.763 | 1.830 |
#> | X| 62696.439 | 4.104 | 73.73 | 0.2016 | 0.5662 |
#> |.....................| 0.009996 | 0.5692 | 1.763 | 1.830 |
#> | F| Forward Diff. | 44.77 | 51.89 | 163.7 | -142.3 |
#> |.....................| 0.2264 | 637.1 | -41.26 | -51.74 |
#> | 166| 62696.237 | -0.4798 | 0.8003 | -1.199 | -0.9928 |
#> |.....................| -1.001 | -0.9905 | -0.2212 | -0.1836 |
#> | U| 62696.237 | 1.412 | 4.300 | 0.2015 | 0.5662 |
#> |.....................| 0.009996 | 0.5685 | 1.763 | 1.829 |
#> | X| 62696.237 | 4.104 | 73.72 | 0.2015 | 0.5662 |
#> |.....................| 0.009996 | 0.5685 | 1.763 | 1.829 |
#> | F| Forward Diff. | 44.20 | 51.37 | 319.6 | 485.6 |
#> |.....................| 0.2279 | 8.895 | -41.48 | -51.88 |
#> | 167| 62696.063 | -0.4799 | 0.8002 | -1.199 | -0.9935 |
#> |.....................| -1.001 | -0.9906 | -0.2212 | -0.1836 |
#> | U| 62696.063 | 1.412 | 4.300 | 0.2014 | 0.5655 |
#> |.....................| 0.009996 | 0.5684 | 1.763 | 1.829 |
#> | X| 62696.063 | 4.104 | 73.71 | 0.2014 | 0.5655 |
#> |.....................| 0.009996 | 0.5684 | 1.763 | 1.829 |
#> | F| Forward Diff. | 44.32 | 51.38 | 164.3 | -136.6 |
#> |.....................| 0.2264 | 630.7 | -41.68 | -52.03 |
#> | 168| 62695.863 | -0.4800 | 0.8001 | -1.199 | -0.9936 |
#> |.....................| -1.001 | -0.9914 | -0.2214 | -0.1837 |
#> | U| 62695.863 | 1.412 | 4.300 | 0.2014 | 0.5655 |
#> |.....................| 0.009996 | 0.5677 | 1.762 | 1.829 |
#> | X| 62695.863 | 4.103 | 73.71 | 0.2014 | 0.5655 |
#> |.....................| 0.009996 | 0.5677 | 1.762 | 1.829 |
#> | F| Forward Diff. | 43.75 | 50.86 | 319.7 | 488.9 |
#> |.....................| 0.2279 | 5.045 | -41.93 | -52.18 |
#> | 169| 62695.688 | -0.4801 | 0.8000 | -1.200 | -0.9943 |
#> |.....................| -1.001 | -0.9914 | -0.2214 | -0.1838 |
#> | U| 62695.688 | 1.412 | 4.300 | 0.2013 | 0.5647 |
#> |.....................| 0.009996 | 0.5676 | 1.762 | 1.829 |
#> | X| 62695.688 | 4.103 | 73.70 | 0.2013 | 0.5647 |
#> |.....................| 0.009996 | 0.5676 | 1.762 | 1.829 |
#> | F| Forward Diff. | 43.86 | 50.87 | 164.9 | -131.0 |
#> |.....................| 0.2263 | 624.4 | -42.04 | -52.34 |
#> | 170| 62695.491 | -0.4801 | 0.7999 | -1.200 | -0.9943 |
#> |.....................| -1.001 | -0.9922 | -0.2215 | -0.1839 |
#> | U| 62695.491 | 1.412 | 4.300 | 0.2013 | 0.5647 |
#> |.....................| 0.009996 | 0.5668 | 1.762 | 1.829 |
#> | X| 62695.491 | 4.103 | 73.69 | 0.2013 | 0.5647 |
#> |.....................| 0.009996 | 0.5668 | 1.762 | 1.829 |
#> | F| Forward Diff. | 43.31 | 50.37 | 319.9 | 492.5 |
#> |.....................| 0.2278 | 0.9138 | -42.27 | -52.46 |
#> | 171| 62695.315 | -0.4802 | 0.7998 | -1.200 | -0.9950 |
#> |.....................| -1.001 | -0.9923 | -0.2216 | -0.1840 |
#> | U| 62695.315 | 1.412 | 4.300 | 0.2012 | 0.5640 |
#> |.....................| 0.009996 | 0.5667 | 1.762 | 1.829 |
#> | X| 62695.315 | 4.102 | 73.69 | 0.2012 | 0.5640 |
#> |.....................| 0.009996 | 0.5667 | 1.762 | 1.829 |
#> | F| Forward Diff. | 43.42 | 50.37 | 165.7 | -124.9 |
#> |.....................| 0.2263 | 617.9 | -42.44 | -52.61 |
#> | 172| 62695.119 | -0.4803 | 0.7997 | -1.200 | -0.9951 |
#> |.....................| -1.001 | -0.9930 | -0.2217 | -0.1841 |
#> | U| 62695.119 | 1.411 | 4.300 | 0.2012 | 0.5640 |
#> |.....................| 0.009996 | 0.5660 | 1.762 | 1.829 |
#> | X| 62695.119 | 4.102 | 73.68 | 0.2012 | 0.5640 |
#> |.....................| 0.009996 | 0.5660 | 1.762 | 1.829 |
#> | F| Forward Diff. | 42.72 | 49.69 | 320.0 | 494.9 |
#> |.....................| 0.2270 | -4.817 | -42.80 | -52.90 |
#> | 173| 62694.943 | -0.4803 | 0.7997 | -1.200 | -0.9958 |
#> |.....................| -1.001 | -0.9931 | -0.2218 | -0.1841 |
#> | U| 62694.943 | 1.411 | 4.300 | 0.2011 | 0.5632 |
#> |.....................| 0.009996 | 0.5659 | 1.761 | 1.828 |
#> | X| 62694.943 | 4.102 | 73.68 | 0.2011 | 0.5632 |
#> |.....................| 0.009996 | 0.5659 | 1.761 | 1.828 |
#> | F| Forward Diff. | 43.01 | 49.91 | 165.8 | -121.3 |
#> |.....................| 0.2264 | 613.9 | -42.84 | -52.92 |
#> | 174| 62694.746 | -0.4804 | 0.7996 | -1.200 | -0.9958 |
#> |.....................| -1.001 | -0.9939 | -0.2220 | -0.1843 |
#> | U| 62694.746 | 1.411 | 4.300 | 0.2011 | 0.5632 |
#> |.....................| 0.009996 | 0.5651 | 1.761 | 1.828 |
#> | X| 62694.746 | 4.102 | 73.67 | 0.2011 | 0.5632 |
#> |.....................| 0.009996 | 0.5651 | 1.761 | 1.828 |
#> | F| Forward Diff. | 42.18 | 49.07 | 318.6 | 492.2 |
#> |.....................| 0.2271 | -2.693 | -43.25 | -53.25 |
#> | 175| 62694.570 | -0.4805 | 0.7995 | -1.201 | -0.9965 |
#> |.....................| -1.001 | -0.9940 | -0.2220 | -0.1843 |
#> | U| 62694.57 | 1.411 | 4.300 | 0.2010 | 0.5625 |
#> |.....................| 0.009996 | 0.5651 | 1.761 | 1.828 |
#> | X| 62694.57 | 4.101 | 73.66 | 0.2010 | 0.5625 |
#> |.....................| 0.009996 | 0.5651 | 1.761 | 1.828 |
#> | F| Forward Diff. | 42.63 | 49.48 | 164.4 | -123.6 |
#> |.....................| 0.2263 | 615.7 | -43.25 | -53.25 |
#> | 176| 62694.372 | -0.4805 | 0.7994 | -1.201 | -0.9966 |
#> |.....................| -1.001 | -0.9947 | -0.2222 | -0.1844 |
#> | U| 62694.372 | 1.411 | 4.299 | 0.2010 | 0.5624 |
#> |.....................| 0.009996 | 0.5643 | 1.761 | 1.828 |
#> | X| 62694.372 | 4.101 | 73.66 | 0.2010 | 0.5624 |
#> |.....................| 0.009996 | 0.5643 | 1.761 | 1.828 |
#> | F| Forward Diff. | 41.82 | 48.66 | 317.1 | 489.0 |
#> |.....................| 0.2270 | -0.1372 | -43.61 | -53.50 |
#> | 177| 62694.197 | -0.4806 | 0.7994 | -1.201 | -0.9973 |
#> |.....................| -1.001 | -0.9948 | -0.2222 | -0.1845 |
#> | U| 62694.197 | 1.411 | 4.299 | 0.2009 | 0.5617 |
#> |.....................| 0.009996 | 0.5642 | 1.761 | 1.828 |
#> | X| 62694.197 | 4.101 | 73.65 | 0.2009 | 0.5617 |
#> |.....................| 0.009996 | 0.5642 | 1.761 | 1.828 |
#> | F| Forward Diff. | 42.11 | 48.89 | 162.9 | -126.0 |
#> |.....................| 0.2263 | 617.9 | -43.66 | -53.56 |
#> | 178| 62693.996 | -0.4806 | 0.7993 | -1.201 | -0.9973 |
#> |.....................| -1.001 | -0.9956 | -0.2224 | -0.1846 |
#> | U| 62693.996 | 1.411 | 4.299 | 0.2009 | 0.5617 |
#> |.....................| 0.009996 | 0.5635 | 1.760 | 1.828 |
#> | X| 62693.996 | 4.101 | 73.65 | 0.2009 | 0.5617 |
#> |.....................| 0.009996 | 0.5635 | 1.760 | 1.828 |
#> | F| Forward Diff. | 41.58 | 48.42 | 315.6 | 487.0 |
#> |.....................| 0.2277 | 4.056 | -43.85 | -53.69 |
#> | 179| 62693.823 | -0.4807 | 0.7992 | -1.202 | -0.9980 |
#> |.....................| -1.001 | -0.9957 | -0.2224 | -0.1846 |
#> | U| 62693.823 | 1.411 | 4.299 | 0.2008 | 0.5610 |
#> |.....................| 0.009996 | 0.5634 | 1.760 | 1.828 |
#> | X| 62693.823 | 4.100 | 73.64 | 0.2008 | 0.5610 |
#> |.....................| 0.009996 | 0.5634 | 1.760 | 1.828 |
#> | F| Forward Diff. | 41.74 | 48.49 | 161.7 | -127.4 |
#> |.....................| 0.2263 | 618.5 | -44.01 | -53.82 |
#> | 180| 62693.624 | -0.4808 | 0.7991 | -1.202 | -0.9981 |
#> |.....................| -1.001 | -0.9964 | -0.2225 | -0.1848 |
#> | U| 62693.624 | 1.411 | 4.299 | 0.2008 | 0.5609 |
#> |.....................| 0.009996 | 0.5626 | 1.760 | 1.827 |
#> | X| 62693.624 | 4.100 | 73.64 | 0.2008 | 0.5609 |
#> |.....................| 0.009996 | 0.5626 | 1.760 | 1.827 |
#> | F| Forward Diff. | 41.19 | 47.99 | 315.5 | 489.3 |
#> |.....................| 0.2276 | 1.123 | -44.25 | -53.98 |
#> | 181| 62693.449 | -0.4808 | 0.7991 | -1.202 | -0.9988 |
#> |.....................| -1.001 | -0.9965 | -0.2226 | -0.1848 |
#> | U| 62693.449 | 1.411 | 4.299 | 0.2007 | 0.5602 |
#> |.....................| 0.009996 | 0.5625 | 1.760 | 1.827 |
#> | X| 62693.449 | 4.100 | 73.63 | 0.2007 | 0.5602 |
#> |.....................| 0.009996 | 0.5625 | 1.760 | 1.827 |
#> | F| Forward Diff. | 41.47 | 48.22 | 162.2 | -121.4 |
#> |.....................| 0.2270 | 614.7 | -44.25 | -53.97 |
#> | 182| 62693.253 | -0.4809 | 0.7990 | -1.202 | -0.9988 |
#> |.....................| -1.001 | -0.9973 | -0.2227 | -0.1849 |
#> | U| 62693.253 | 1.411 | 4.299 | 0.2006 | 0.5602 |
#> |.....................| 0.009995 | 0.5618 | 1.760 | 1.827 |
#> | X| 62693.253 | 4.100 | 73.62 | 0.2006 | 0.5602 |
#> |.....................| 0.009995 | 0.5618 | 1.760 | 1.827 |
#> | F| Forward Diff. | 40.78 | 47.55 | 314.8 | 489.6 |
#> |.....................| 0.2277 | 0.3288 | -44.60 | -54.24 |
#> | 183| 62693.080 | -0.4810 | 0.7989 | -1.202 | -0.9996 |
#> |.....................| -1.001 | -0.9974 | -0.2228 | -0.1850 |
#> | U| 62693.08 | 1.411 | 4.299 | 0.2005 | 0.5595 |
#> |.....................| 0.009995 | 0.5617 | 1.760 | 1.827 |
#> | X| 62693.08 | 4.099 | 73.62 | 0.2005 | 0.5595 |
#> |.....................| 0.009995 | 0.5617 | 1.760 | 1.827 |
#> | F| Forward Diff. | 41.06 | 47.78 | 160.6 | -124.6 |
#> |.....................| 0.2269 | 617.4 | -44.63 | -54.26 |
#> | 184| 62692.883 | -0.4810 | 0.7988 | -1.202 | -0.9996 |
#> |.....................| -1.001 | -0.9981 | -0.2229 | -0.1851 |
#> | U| 62692.883 | 1.411 | 4.299 | 0.2005 | 0.5594 |
#> |.....................| 0.009995 | 0.5609 | 1.759 | 1.827 |
#> | X| 62692.883 | 4.099 | 73.61 | 0.2005 | 0.5594 |
#> |.....................| 0.009995 | 0.5609 | 1.759 | 1.827 |
#> | F| Forward Diff. | 40.36 | 47.09 | 313.2 | 485.8 |
#> |.....................| 0.2276 | 3.391 | -44.97 | -54.53 |
#> | 185| 62692.711 | -0.4811 | 0.7987 | -1.203 | -1.000 |
#> |.....................| -1.001 | -0.9982 | -0.2230 | -0.1851 |
#> | U| 62692.711 | 1.411 | 4.299 | 0.2004 | 0.5587 |
#> |.....................| 0.009995 | 0.5608 | 1.759 | 1.827 |
#> | X| 62692.711 | 4.099 | 73.61 | 0.2004 | 0.5587 |
#> |.....................| 0.009995 | 0.5608 | 1.759 | 1.827 |
#> | F| Forward Diff. | 40.65 | 47.34 | 158.9 | -128.4 |
#> |.....................| 0.2269 | 620.2 | -44.96 | -54.54 |
#> | 186| 62692.511 | -0.4812 | 0.7986 | -1.203 | -1.000 |
#> |.....................| -1.001 | -0.9990 | -0.2231 | -0.1852 |
#> | U| 62692.511 | 1.411 | 4.299 | 0.2004 | 0.5587 |
#> |.....................| 0.009995 | 0.5601 | 1.759 | 1.827 |
#> | X| 62692.511 | 4.098 | 73.60 | 0.2004 | 0.5587 |
#> |.....................| 0.009995 | 0.5601 | 1.759 | 1.827 |
#> | F| Forward Diff. | 39.97 | 46.67 | 311.5 | 482.1 |
#> |.....................| 0.2275 | 6.685 | -45.29 | -54.79 |
#> | 187| 62692.339 | -0.4812 | 0.7986 | -1.203 | -1.001 |
#> |.....................| -1.001 | -0.9991 | -0.2231 | -0.1852 |
#> | U| 62692.339 | 1.411 | 4.299 | 0.2003 | 0.5579 |
#> |.....................| 0.009995 | 0.5600 | 1.759 | 1.826 |
#> | X| 62692.339 | 4.098 | 73.59 | 0.2003 | 0.5579 |
#> |.....................| 0.009995 | 0.5600 | 1.759 | 1.826 |
#> | F| Forward Diff. | 40.26 | 46.91 | 157.4 | -130.9 |
#> |.....................| 0.2269 | 622.1 | -45.33 | -54.78 |
#> | 188| 62692.138 | -0.4813 | 0.7985 | -1.203 | -1.001 |
#> |.....................| -1.001 | -0.9998 | -0.2233 | -0.1854 |
#> | U| 62692.138 | 1.410 | 4.298 | 0.2003 | 0.5579 |
#> |.....................| 0.009995 | 0.5592 | 1.759 | 1.826 |
#> | X| 62692.138 | 4.098 | 73.59 | 0.2003 | 0.5579 |
#> |.....................| 0.009995 | 0.5592 | 1.759 | 1.826 |
#> | F| Forward Diff. | 39.58 | 46.25 | 310.1 | 479.2 |
#> |.....................| 0.2275 | 8.935 | -45.66 | -55.07 |
#> | 189| 62691.967 | -0.4813 | 0.7984 | -1.203 | -1.002 |
#> |.....................| -1.001 | -0.9999 | -0.2233 | -0.1854 |
#> | U| 62691.967 | 1.410 | 4.298 | 0.2002 | 0.5572 |
#> |.....................| 0.009995 | 0.5591 | 1.759 | 1.826 |
#> | X| 62691.967 | 4.098 | 73.58 | 0.2002 | 0.5572 |
#> |.....................| 0.009995 | 0.5591 | 1.759 | 1.826 |
#> | F| Forward Diff. | 39.87 | 46.49 | 155.9 | -133.3 |
#> |.....................| 0.2268 | 624.0 | -45.65 | -55.04 |
#> | 190| 62691.764 | -0.4814 | 0.7983 | -1.204 | -1.002 |
#> |.....................| -1.001 | -1.001 | -0.2234 | -0.1855 |
#> | U| 62691.764 | 1.410 | 4.298 | 0.2002 | 0.5571 |
#> |.....................| 0.009995 | 0.5584 | 1.759 | 1.826 |
#> | X| 62691.764 | 4.097 | 73.58 | 0.2002 | 0.5571 |
#> |.....................| 0.009995 | 0.5584 | 1.759 | 1.826 |
#> | F| Forward Diff. | 39.20 | 45.84 | 308.6 | 476.2 |
#> |.....................| 0.2275 | 11.24 | -45.97 | -55.29 |
#> | 191| 62691.594 | -0.4815 | 0.7983 | -1.204 | -1.003 |
#> |.....................| -1.001 | -1.001 | -0.2235 | -0.1855 |
#> | U| 62691.594 | 1.410 | 4.298 | 0.2001 | 0.5564 |
#> |.....................| 0.009995 | 0.5583 | 1.759 | 1.826 |
#> | X| 62691.594 | 4.097 | 73.57 | 0.2001 | 0.5564 |
#> |.....................| 0.009995 | 0.5583 | 1.759 | 1.826 |
#> | F| Forward Diff. | 39.50 | 46.08 | 154.4 | -136.0 |
#> |.....................| 0.2268 | 626.2 | -45.92 | -55.25 |
#> | 192| 62691.389 | -0.4815 | 0.7982 | -1.204 | -1.003 |
#> |.....................| -1.001 | -1.002 | -0.2236 | -0.1856 |
#> | U| 62691.389 | 1.410 | 4.298 | 0.2001 | 0.5564 |
#> |.....................| 0.009995 | 0.5575 | 1.758 | 1.826 |
#> | X| 62691.389 | 4.097 | 73.57 | 0.2001 | 0.5564 |
#> |.....................| 0.009995 | 0.5575 | 1.758 | 1.826 |
#> | F| Forward Diff. | 38.83 | 45.45 | 307.0 | 472.8 |
#> |.....................| 0.2274 | 14.13 | -46.24 | -55.52 |
#> | 193| 62691.220 | -0.4816 | 0.7981 | -1.204 | -1.003 |
#> |.....................| -1.001 | -1.002 | -0.2236 | -0.1856 |
#> | U| 62691.22 | 1.410 | 4.298 | 0.2000 | 0.5557 |
#> |.....................| 0.009995 | 0.5574 | 1.758 | 1.826 |
#> | X| 62691.22 | 4.097 | 73.56 | 0.2000 | 0.5557 |
#> |.....................| 0.009995 | 0.5574 | 1.758 | 1.826 |
#> | F| Forward Diff. | 39.13 | 45.69 | 152.7 | -139.1 |
#> |.....................| 0.2267 | 628.9 | -46.25 | -55.48 |
#> | 194| 62691.014 | -0.4817 | 0.7980 | -1.204 | -1.003 |
#> |.....................| -1.001 | -1.002 | -0.2237 | -0.1857 |
#> | U| 62691.014 | 1.410 | 4.298 | 0.2000 | 0.5556 |
#> |.....................| 0.009995 | 0.5567 | 1.758 | 1.826 |
#> | X| 62691.014 | 4.096 | 73.55 | 0.2000 | 0.5556 |
#> |.....................| 0.009995 | 0.5567 | 1.758 | 1.826 |
#> | F| Forward Diff. | 38.45 | 45.03 | 305.3 | 469.5 |
#> |.....................| 0.2274 | 16.86 | -46.54 | -55.73 |
#> | 195| 62690.846 | -0.4817 | 0.7980 | -1.205 | -1.004 |
#> |.....................| -1.001 | -1.002 | -0.2237 | -0.1857 |
#> | U| 62690.846 | 1.410 | 4.298 | 0.1998 | 0.5549 |
#> |.....................| 0.009995 | 0.5566 | 1.758 | 1.826 |
#> | X| 62690.846 | 4.096 | 73.55 | 0.1998 | 0.5549 |
#> |.....................| 0.009995 | 0.5566 | 1.758 | 1.826 |
#> | F| Forward Diff. | 38.75 | 45.28 | 151.0 | -142.5 |
#> |.....................| 0.2267 | 631.5 | -46.50 | -55.69 |
#> | 196| 62690.638 | -0.4818 | 0.7979 | -1.205 | -1.004 |
#> |.....................| -1.001 | -1.003 | -0.2239 | -0.1858 |
#> | U| 62690.638 | 1.410 | 4.298 | 0.1998 | 0.5549 |
#> |.....................| 0.009995 | 0.5558 | 1.758 | 1.825 |
#> | X| 62690.638 | 4.096 | 73.54 | 0.1998 | 0.5549 |
#> |.....................| 0.009995 | 0.5558 | 1.758 | 1.825 |
#> | F| Forward Diff. | 38.08 | 44.63 | 303.7 | 466.0 |
#> |.....................| 0.2274 | 19.86 | -46.85 | -55.94 |
#> | 197| 62690.471 | -0.4818 | 0.7978 | -1.205 | -1.005 |
#> |.....................| -1.001 | -1.003 | -0.2239 | -0.1858 |
#> | U| 62690.471 | 1.410 | 4.298 | 0.1997 | 0.5542 |
#> |.....................| 0.009995 | 0.5557 | 1.758 | 1.825 |
#> | X| 62690.471 | 4.096 | 73.54 | 0.1997 | 0.5542 |
#> |.....................| 0.009995 | 0.5557 | 1.758 | 1.825 |
#> | F| Forward Diff. | 38.38 | 44.89 | 149.2 | -145.2 |
#> |.....................| 0.2266 | 634.3 | -46.78 | -55.82 |
#> | 198| 62690.262 | -0.4819 | 0.7977 | -1.205 | -1.005 |
#> |.....................| -1.001 | -1.004 | -0.2240 | -0.1859 |
#> | U| 62690.262 | 1.410 | 4.298 | 0.1997 | 0.5541 |
#> |.....................| 0.009994 | 0.5550 | 1.758 | 1.825 |
#> | X| 62690.262 | 4.095 | 73.53 | 0.1997 | 0.5541 |
#> |.....................| 0.009994 | 0.5550 | 1.758 | 1.825 |
#> | F| Forward Diff. | 37.70 | 44.23 | 302.0 | 462.7 |
#> |.....................| 0.2273 | 22.63 | -47.07 | -56.09 |
#> | 199| 62690.097 | -0.4820 | 0.7976 | -1.205 | -1.006 |
#> |.....................| -1.001 | -1.004 | -0.2240 | -0.1859 |
#> | U| 62690.097 | 1.410 | 4.298 | 0.1996 | 0.5534 |
#> |.....................| 0.009994 | 0.5549 | 1.758 | 1.825 |
#> | X| 62690.097 | 4.095 | 73.53 | 0.1996 | 0.5534 |
#> |.....................| 0.009994 | 0.5549 | 1.758 | 1.825 |
#> | F| Forward Diff. | 38.00 | 44.47 | 147.2 | -149.6 |
#> |.....................| 0.2266 | 637.7 | -46.95 | -56.02 |
#> | 200| 62689.886 | -0.4820 | 0.7976 | -1.206 | -1.006 |
#> |.....................| -1.001 | -1.005 | -0.2241 | -0.1860 |
#> | U| 62689.886 | 1.410 | 4.298 | 0.1996 | 0.5534 |
#> |.....................| 0.009994 | 0.5541 | 1.757 | 1.825 |
#> | X| 62689.886 | 4.095 | 73.52 | 0.1996 | 0.5534 |
#> |.....................| 0.009994 | 0.5541 | 1.757 | 1.825 |
#> | F| Forward Diff. | 37.33 | 43.83 | 300.2 | 459.0 |
#> |.....................| 0.2273 | 25.69 | -47.30 | -56.23 |
#> | 201| 62689.723 | -0.4821 | 0.7975 | -1.206 | -1.006 |
#> |.....................| -1.001 | -1.005 | -0.2241 | -0.1860 |
#> | U| 62689.723 | 1.410 | 4.297 | 0.1995 | 0.5527 |
#> |.....................| 0.009994 | 0.5540 | 1.757 | 1.825 |
#> | X| 62689.723 | 4.095 | 73.52 | 0.1995 | 0.5527 |
#> |.....................| 0.009994 | 0.5540 | 1.757 | 1.825 |
#> | F| Forward Diff. | 37.63 | 44.08 | 145.5 | -152.7 |
#> |.....................| 0.2265 | 640.5 | -47.22 | -56.12 |
#> | 202| 62689.510 | -0.4822 | 0.7974 | -1.206 | -1.006 |
#> |.....................| -1.001 | -1.006 | -0.2242 | -0.1861 |
#> | U| 62689.51 | 1.410 | 4.297 | 0.1995 | 0.5526 |
#> |.....................| 0.009994 | 0.5533 | 1.757 | 1.825 |
#> | X| 62689.51 | 4.094 | 73.51 | 0.1995 | 0.5526 |
#> |.....................| 0.009994 | 0.5533 | 1.757 | 1.825 |
#> | F| Forward Diff. | 36.96 | 43.43 | 298.5 | 455.5 |
#> |.....................| 0.2272 | 28.76 | -47.51 | -56.35 |
#> | 203| 62689.349 | -0.4822 | 0.7973 | -1.206 | -1.007 |
#> |.....................| -1.001 | -1.006 | -0.2242 | -0.1860 |
#> | U| 62689.349 | 1.410 | 4.297 | 0.1994 | 0.5519 |
#> |.....................| 0.009994 | 0.5532 | 1.757 | 1.825 |
#> | X| 62689.349 | 4.094 | 73.50 | 0.1994 | 0.5519 |
#> |.....................| 0.009994 | 0.5532 | 1.757 | 1.825 |
#> | F| Forward Diff. | 37.27 | 43.69 | 143.5 | -156.5 |
#> |.....................| 0.2265 | 643.6 | -47.37 | -56.22 |
#> | 204| 62689.136 | -0.4823 | 0.7973 | -1.206 | -1.007 |
#> |.....................| -1.001 | -1.007 | -0.2243 | -0.1861 |
#> | U| 62689.136 | 1.409 | 4.297 | 0.1993 | 0.5519 |
#> |.....................| 0.009994 | 0.5524 | 1.757 | 1.825 |
#> | X| 62689.136 | 4.094 | 73.50 | 0.1993 | 0.5519 |
#> |.....................| 0.009994 | 0.5524 | 1.757 | 1.825 |
#> | F| Forward Diff. | 36.58 | 43.04 | 296.7 | 452.4 |
#> |.....................| 0.2271 | 31.70 | -47.66 | -56.49 |
#> | 205| 62688.977 | -0.4823 | 0.7972 | -1.207 | -1.008 |
#> |.....................| -1.001 | -1.007 | -0.2242 | -0.1861 |
#> | U| 62688.977 | 1.409 | 4.297 | 0.1992 | 0.5512 |
#> |.....................| 0.009994 | 0.5524 | 1.757 | 1.825 |
#> | X| 62688.977 | 4.094 | 73.49 | 0.1992 | 0.5512 |
#> |.....................| 0.009994 | 0.5524 | 1.757 | 1.825 |
#> | F| Forward Diff. | 36.90 | 43.29 | 141.7 | -159.6 |
#> |.....................| 0.2264 | 646.2 | -47.56 | -56.37 |
#> | 206| 62688.763 | -0.4824 | 0.7971 | -1.207 | -1.008 |
#> |.....................| -1.001 | -1.007 | -0.2244 | -0.1862 |
#> | U| 62688.763 | 1.409 | 4.297 | 0.1992 | 0.5511 |
#> |.....................| 0.009994 | 0.5516 | 1.757 | 1.825 |
#> | X| 62688.763 | 4.093 | 73.49 | 0.1992 | 0.5511 |
#> |.....................| 0.009994 | 0.5516 | 1.757 | 1.825 |
#> | F| Forward Diff. | 36.21 | 42.63 | 295.2 | 449.9 |
#> |.....................| 0.2271 | 33.71 | -47.91 | -56.60 |
#> | 207| 62688.606 | -0.4825 | 0.7970 | -1.207 | -1.009 |
#> |.....................| -1.001 | -1.007 | -0.2243 | -0.1861 |
#> | U| 62688.606 | 1.409 | 4.297 | 0.1991 | 0.5505 |
#> |.....................| 0.009994 | 0.5515 | 1.757 | 1.825 |
#> | X| 62688.606 | 4.093 | 73.48 | 0.1991 | 0.5505 |
#> |.....................| 0.009994 | 0.5515 | 1.757 | 1.825 |
#> | F| Forward Diff. | 36.52 | 42.90 | 140.2 | -161.5 |
#> |.....................| 0.2263 | 647.7 | -47.76 | -56.46 |
#> | 208| 62688.393 | -0.4825 | 0.7969 | -1.207 | -1.009 |
#> |.....................| -1.001 | -1.008 | -0.2245 | -0.1862 |
#> | U| 62688.393 | 1.409 | 4.297 | 0.1991 | 0.5504 |
#> |.....................| 0.009994 | 0.5508 | 1.757 | 1.825 |
#> | X| 62688.393 | 4.093 | 73.47 | 0.1991 | 0.5504 |
#> |.....................| 0.009994 | 0.5508 | 1.757 | 1.825 |
#> | F| Forward Diff. | 35.83 | 42.23 | 293.7 | 447.2 |
#> |.....................| 0.2271 | 35.37 | -48.08 | -56.74 |
#> | 209| 62688.237 | -0.4826 | 0.7969 | -1.208 | -1.009 |
#> |.....................| -1.001 | -1.008 | -0.2244 | -0.1862 |
#> | U| 62688.237 | 1.409 | 4.297 | 0.1990 | 0.5497 |
#> |.....................| 0.009994 | 0.5507 | 1.757 | 1.825 |
#> | X| 62688.237 | 4.093 | 73.47 | 0.1990 | 0.5497 |
#> |.....................| 0.009994 | 0.5507 | 1.757 | 1.825 |
#> | F| Forward Diff. | 36.14 | 42.50 | 138.4 | -164.6 |
#> |.....................| 0.2263 | 650.4 | -47.94 | -56.56 |
#> | 210| 62688.022 | -0.4827 | 0.7968 | -1.208 | -1.009 |
#> |.....................| -1.001 | -1.009 | -0.2245 | -0.1863 |
#> | U| 62688.022 | 1.409 | 4.297 | 0.1990 | 0.5497 |
#> |.....................| 0.009994 | 0.5499 | 1.757 | 1.825 |
#> | X| 62688.022 | 4.092 | 73.46 | 0.1990 | 0.5497 |
#> |.....................| 0.009994 | 0.5499 | 1.757 | 1.825 |
#> | F| Forward Diff. | 35.46 | 41.83 | 291.9 | 443.8 |
#> |.....................| 0.2270 | 38.66 | -48.24 | -56.81 |
#> | 211| 62687.869 | -0.4827 | 0.7967 | -1.208 | -1.010 |
#> |.....................| -1.001 | -1.009 | -0.2245 | -0.1862 |
#> | U| 62687.869 | 1.409 | 4.297 | 0.1988 | 0.5490 |
#> |.....................| 0.009994 | 0.5499 | 1.757 | 1.825 |
#> | X| 62687.869 | 4.092 | 73.46 | 0.1988 | 0.5490 |
#> |.....................| 0.009994 | 0.5499 | 1.757 | 1.825 |
#> | F| Forward Diff. | 35.78 | 42.11 | 136.3 | -168.7 |
#> |.....................| 0.2262 | 653.9 | -48.06 | -56.65 |
#> | 212| 62687.655 | -0.4828 | 0.7966 | -1.208 | -1.010 |
#> |.....................| -1.001 | -1.010 | -0.2246 | -0.1863 |
#> | U| 62687.655 | 1.409 | 4.297 | 0.1988 | 0.5490 |
#> |.....................| 0.009993 | 0.5491 | 1.756 | 1.825 |
#> | X| 62687.655 | 4.092 | 73.45 | 0.1988 | 0.5490 |
#> |.....................| 0.009993 | 0.5491 | 1.756 | 1.825 |
#> | F| Forward Diff. | 35.09 | 41.44 | 290.3 | 440.7 |
#> |.....................| 0.2270 | 41.01 | -48.37 | -56.89 |
#> | 213| 62687.502 | -0.4828 | 0.7966 | -1.208 | -1.011 |
#> |.....................| -1.001 | -1.010 | -0.2245 | -0.1862 |
#> | U| 62687.502 | 1.409 | 4.297 | 0.1987 | 0.5483 |
#> |.....................| 0.009993 | 0.5491 | 1.757 | 1.825 |
#> | X| 62687.502 | 4.092 | 73.45 | 0.1987 | 0.5483 |
#> |.....................| 0.009993 | 0.5491 | 1.757 | 1.825 |
#> | F| Forward Diff. | 35.42 | 41.72 | 135.3 | -168.7 |
#> |.....................| 0.2261 | 653.3 | -48.22 | -56.70 |
#> | 214| 62687.288 | -0.4829 | 0.7965 | -1.208 | -1.011 |
#> |.....................| -1.001 | -1.011 | -0.2247 | -0.1863 |
#> | U| 62687.288 | 1.409 | 4.296 | 0.1987 | 0.5482 |
#> |.....................| 0.009993 | 0.5483 | 1.756 | 1.825 |
#> | X| 62687.288 | 4.091 | 73.44 | 0.1987 | 0.5482 |
#> |.....................| 0.009993 | 0.5483 | 1.756 | 1.825 |
#> | F| Forward Diff. | 34.73 | 41.05 | 289.0 | 439.4 |
#> |.....................| 0.2268 | 41.89 | -48.54 | -56.95 |
#> | 215| 62687.136 | -0.4830 | 0.7964 | -1.209 | -1.011 |
#> |.....................| -1.001 | -1.011 | -0.2246 | -0.1863 |
#> | U| 62687.136 | 1.409 | 4.296 | 0.1986 | 0.5476 |
#> |.....................| 0.009993 | 0.5482 | 1.757 | 1.825 |
#> | X| 62687.136 | 4.091 | 73.44 | 0.1986 | 0.5476 |
#> |.....................| 0.009993 | 0.5482 | 1.757 | 1.825 |
#> | F| Forward Diff. | 35.05 | 41.32 | 134.3 | -168.9 |
#> |.....................| 0.2261 | 653.0 | -48.36 | -56.75 |
#> | 216| 62686.924 | -0.4830 | 0.7963 | -1.209 | -1.011 |
#> |.....................| -1.001 | -1.012 | -0.2247 | -0.1864 |
#> | U| 62686.924 | 1.409 | 4.296 | 0.1986 | 0.5475 |
#> |.....................| 0.009993 | 0.5475 | 1.756 | 1.824 |
#> | X| 62686.924 | 4.091 | 73.43 | 0.1986 | 0.5475 |
#> |.....................| 0.009993 | 0.5475 | 1.756 | 1.824 |
#> | F| Forward Diff. | 34.35 | 40.65 | 287.9 | 438.4 |
#> |.....................| 0.2268 | 42.35 | -48.65 | -57.02 |
#> | 217| 62686.773 | -0.4831 | 0.7963 | -1.209 | -1.012 |
#> |.....................| -1.001 | -1.012 | -0.2247 | -0.1863 |
#> | U| 62686.773 | 1.409 | 4.296 | 0.1985 | 0.5469 |
#> |.....................| 0.009993 | 0.5474 | 1.756 | 1.825 |
#> | X| 62686.773 | 4.090 | 73.42 | 0.1985 | 0.5469 |
#> |.....................| 0.009993 | 0.5474 | 1.756 | 1.825 |
#> | F| Forward Diff. | 34.68 | 40.93 | 133.1 | -169.4 |
#> |.....................| 0.2260 | 652.9 | -48.50 | -56.85 |
#> | 218| 62686.562 | -0.4832 | 0.7962 | -1.209 | -1.012 |
#> |.....................| -1.001 | -1.012 | -0.2248 | -0.1864 |
#> | U| 62686.562 | 1.409 | 4.296 | 0.1985 | 0.5468 |
#> |.....................| 0.009993 | 0.5467 | 1.756 | 1.824 |
#> | X| 62686.562 | 4.090 | 73.42 | 0.1985 | 0.5468 |
#> |.....................| 0.009993 | 0.5467 | 1.756 | 1.824 |
#> | F| Forward Diff. | 33.99 | 40.26 | 286.6 | 437.2 |
#> |.....................| 0.2267 | 43.00 | -48.82 | -57.12 |
#> | 219| 62686.411 | -0.4832 | 0.7961 | -1.210 | -1.013 |
#> |.....................| -1.001 | -1.012 | -0.2247 | -0.1863 |
#> | U| 62686.411 | 1.409 | 4.296 | 0.1983 | 0.5461 |
#> |.....................| 0.009993 | 0.5466 | 1.756 | 1.825 |
#> | X| 62686.411 | 4.090 | 73.41 | 0.1983 | 0.5461 |
#> |.....................| 0.009993 | 0.5466 | 1.756 | 1.825 |
#> | F| Forward Diff. | 34.31 | 40.53 | 132.0 | -169.6 |
#> |.....................| 0.2260 | 652.6 | -48.63 | -56.89 |
#> | 220| 62686.201 | -0.4833 | 0.7960 | -1.210 | -1.013 |
#> |.....................| -1.001 | -1.013 | -0.2249 | -0.1864 |
#> | U| 62686.201 | 1.408 | 4.296 | 0.1983 | 0.5461 |
#> |.....................| 0.009993 | 0.5458 | 1.756 | 1.824 |
#> | X| 62686.201 | 4.090 | 73.41 | 0.1983 | 0.5461 |
#> |.....................| 0.009993 | 0.5458 | 1.756 | 1.824 |
#> | F| Forward Diff. | 33.62 | 39.87 | 285.4 | 435.9 |
#> |.....................| 0.2267 | 43.54 | -49.02 | -57.18 |
#> | 221| 62686.052 | -0.4834 | 0.7960 | -1.210 | -1.014 |
#> |.....................| -1.001 | -1.013 | -0.2248 | -0.1864 |
#> | U| 62686.052 | 1.408 | 4.296 | 0.1982 | 0.5454 |
#> |.....................| 0.009993 | 0.5458 | 1.756 | 1.824 |
#> | X| 62686.052 | 4.089 | 73.40 | 0.1982 | 0.5454 |
#> |.....................| 0.009993 | 0.5458 | 1.756 | 1.824 |
#> | F| Forward Diff. | 33.94 | 40.13 | 130.9 | -170.1 |
#> |.....................| 0.2259 | 652.6 | -48.82 | -57.00 |
#> | 222| 62685.841 | -0.4834 | 0.7959 | -1.210 | -1.014 |
#> |.....................| -1.001 | -1.014 | -0.2249 | -0.1865 |
#> | U| 62685.841 | 1.408 | 4.296 | 0.1982 | 0.5454 |
#> |.....................| 0.009993 | 0.5450 | 1.756 | 1.824 |
#> | X| 62685.841 | 4.089 | 73.39 | 0.1982 | 0.5454 |
#> |.....................| 0.009993 | 0.5450 | 1.756 | 1.824 |
#> | F| Forward Diff. | 33.24 | 39.47 | 284.1 | 434.2 |
#> |.....................| 0.2266 | 45.09 | -49.20 | -57.27 |
#> | 223| 62685.692 | -0.4835 | 0.7958 | -1.210 | -1.014 |
#> |.....................| -1.001 | -1.014 | -0.2249 | -0.1864 |
#> | U| 62685.692 | 1.408 | 4.296 | 0.1981 | 0.5447 |
#> |.....................| 0.009993 | 0.5449 | 1.756 | 1.824 |
#> | X| 62685.692 | 4.089 | 73.39 | 0.1981 | 0.5447 |
#> |.....................| 0.009993 | 0.5449 | 1.756 | 1.824 |
#> | F| Forward Diff. | 33.56 | 39.74 | 130.1 | -169.6 |
#> |.....................| 0.2258 | 651.6 | -48.97 | -57.10 |
#> | 224| 62685.484 | -0.4836 | 0.7957 | -1.210 | -1.014 |
#> |.....................| -1.001 | -1.015 | -0.2250 | -0.1865 |
#> | U| 62685.484 | 1.408 | 4.296 | 0.1981 | 0.5446 |
#> |.....................| 0.009993 | 0.5442 | 1.756 | 1.824 |
#> | X| 62685.484 | 4.089 | 73.38 | 0.1981 | 0.5446 |
#> |.....................| 0.009993 | 0.5442 | 1.756 | 1.824 |
#> | F| Forward Diff. | 32.87 | 39.07 | 283.2 | 434.0 |
#> |.....................| 0.2265 | 44.80 | -49.31 | -57.37 |
#> | 225| 62685.335 | -0.4836 | 0.7956 | -1.211 | -1.015 |
#> |.....................| -1.001 | -1.015 | -0.2249 | -0.1864 |
#> | U| 62685.335 | 1.408 | 4.296 | 0.1980 | 0.5440 |
#> |.....................| 0.009993 | 0.5441 | 1.756 | 1.824 |
#> | X| 62685.335 | 4.088 | 73.38 | 0.1980 | 0.5440 |
#> |.....................| 0.009993 | 0.5441 | 1.756 | 1.824 |
#> | F| Forward Diff. | 33.19 | 39.34 | 128.9 | -170.5 |
#> |.....................| 0.2258 | 652.0 | -49.15 | -57.18 |
#> | 226| 62685.127 | -0.4837 | 0.7955 | -1.211 | -1.015 |
#> |.....................| -1.001 | -1.016 | -0.2251 | -0.1866 |
#> | U| 62685.127 | 1.408 | 4.296 | 0.1980 | 0.5439 |
#> |.....................| 0.009993 | 0.5434 | 1.756 | 1.824 |
#> | X| 62685.127 | 4.088 | 73.37 | 0.1980 | 0.5439 |
#> |.....................| 0.009993 | 0.5434 | 1.756 | 1.824 |
#> | F| Forward Diff. | 32.50 | 38.66 | 282.0 | 432.4 |
#> |.....................| 0.2265 | 45.45 | -49.49 | -57.47 |
#> | 227| 62684.980 | -0.4837 | 0.7955 | -1.211 | -1.016 |
#> |.....................| -1.001 | -1.016 | -0.2250 | -0.1865 |
#> | U| 62684.98 | 1.408 | 4.295 | 0.1979 | 0.5432 |
#> |.....................| 0.009993 | 0.5433 | 1.756 | 1.824 |
#> | X| 62684.98 | 4.088 | 73.37 | 0.1979 | 0.5432 |
#> |.....................| 0.009993 | 0.5433 | 1.756 | 1.824 |
#> | F| Forward Diff. | 32.82 | 38.94 | 127.8 | -170.8 |
#> |.....................| 0.2257 | 651.6 | -49.31 | -57.27 |
#> | 228| 62684.772 | -0.4838 | 0.7954 | -1.211 | -1.016 |
#> |.....................| -1.001 | -1.016 | -0.2252 | -0.1866 |
#> | U| 62684.772 | 1.408 | 4.295 | 0.1979 | 0.5432 |
#> |.....................| 0.009993 | 0.5425 | 1.755 | 1.824 |
#> | X| 62684.772 | 4.088 | 73.36 | 0.1979 | 0.5432 |
#> |.....................| 0.009993 | 0.5425 | 1.755 | 1.824 |
#> | F| Forward Diff. | 32.14 | 38.28 | 280.7 | 431.1 |
#> |.....................| 0.2265 | 46.78 | -49.62 | -57.51 |
#> | 229| 62684.625 | -0.4839 | 0.7953 | -1.212 | -1.016 |
#> |.....................| -1.001 | -1.017 | -0.2251 | -0.1865 |
#> | U| 62684.625 | 1.408 | 4.295 | 0.1977 | 0.5425 |
#> |.....................| 0.009993 | 0.5425 | 1.756 | 1.824 |
#> | X| 62684.625 | 4.087 | 73.36 | 0.1977 | 0.5425 |
#> |.....................| 0.009993 | 0.5425 | 1.756 | 1.824 |
#> | F| Forward Diff. | 32.46 | 38.55 | 126.9 | -170.6 |
#> |.....................| 0.2256 | 650.9 | -49.43 | -57.34 |
#> | 230| 62684.419 | -0.4839 | 0.7952 | -1.212 | -1.017 |
#> |.....................| -1.002 | -1.017 | -0.2253 | -0.1866 |
#> | U| 62684.419 | 1.408 | 4.295 | 0.1978 | 0.5424 |
#> |.....................| 0.009992 | 0.5417 | 1.755 | 1.824 |
#> | X| 62684.419 | 4.087 | 73.35 | 0.1978 | 0.5424 |
#> |.....................| 0.009992 | 0.5417 | 1.755 | 1.824 |
#> | F| Forward Diff. | 31.77 | 37.89 | 279.8 | 430.9 |
#> |.....................| 0.2264 | 46.27 | -49.82 | -57.62 |
#> | 231| 62684.273 | -0.4840 | 0.7952 | -1.212 | -1.017 |
#> |.....................| -1.002 | -1.017 | -0.2252 | -0.1866 |
#> | U| 62684.273 | 1.408 | 4.295 | 0.1976 | 0.5418 |
#> |.....................| 0.009992 | 0.5416 | 1.755 | 1.824 |
#> | X| 62684.273 | 4.087 | 73.35 | 0.1976 | 0.5418 |
#> |.....................| 0.009992 | 0.5416 | 1.755 | 1.824 |
#> | F| Forward Diff. | 32.09 | 38.17 | 125.7 | -171.7 |
#> |.....................| 0.2256 | 651.5 | -49.65 | -57.43 |
#> | 232| 62684.066 | -0.4841 | 0.7951 | -1.212 | -1.017 |
#> |.....................| -1.002 | -1.018 | -0.2253 | -0.1867 |
#> | U| 62684.066 | 1.408 | 4.295 | 0.1976 | 0.5417 |
#> |.....................| 0.009992 | 0.5409 | 1.755 | 1.824 |
#> | X| 62684.066 | 4.087 | 73.34 | 0.1976 | 0.5417 |
#> |.....................| 0.009992 | 0.5409 | 1.755 | 1.824 |
#> | F| Forward Diff. | 31.41 | 37.50 | 278.4 | 428.9 |
#> |.....................| 0.2264 | 47.75 | -49.98 | -57.70 |
#> | 233| 62683.921 | -0.4841 | 0.7950 | -1.212 | -1.018 |
#> |.....................| -1.002 | -1.018 | -0.2253 | -0.1866 |
#> | U| 62683.921 | 1.408 | 4.295 | 0.1975 | 0.5411 |
#> |.....................| 0.009992 | 0.5408 | 1.755 | 1.824 |
#> | X| 62683.921 | 4.086 | 73.33 | 0.1975 | 0.5411 |
#> |.....................| 0.009992 | 0.5408 | 1.755 | 1.824 |
#> | F| Forward Diff. | 31.73 | 37.77 | 124.9 | -171.2 |
#> |.....................| 0.2255 | 650.6 | -49.77 | -57.53 |
#> | 234| 62683.715 | -0.4842 | 0.7949 | -1.212 | -1.018 |
#> |.....................| -1.002 | -1.019 | -0.2254 | -0.1867 |
#> | U| 62683.715 | 1.408 | 4.295 | 0.1975 | 0.5410 |
#> |.....................| 0.009992 | 0.5401 | 1.755 | 1.824 |
#> | X| 62683.715 | 4.086 | 73.33 | 0.1975 | 0.5410 |
#> |.....................| 0.009992 | 0.5401 | 1.755 | 1.824 |
#> | F| Forward Diff. | 31.05 | 37.11 | 277.4 | 428.0 |
#> |.....................| 0.2264 | 47.94 | -50.08 | -57.80 |
#> | 235| 62683.571 | -0.4842 | 0.7949 | -1.213 | -1.019 |
#> |.....................| -1.002 | -1.019 | -0.2253 | -0.1867 |
#> | U| 62683.571 | 1.408 | 4.295 | 0.1974 | 0.5403 |
#> |.....................| 0.009992 | 0.5400 | 1.755 | 1.824 |
#> | X| 62683.571 | 4.086 | 73.32 | 0.1974 | 0.5403 |
#> |.....................| 0.009992 | 0.5400 | 1.755 | 1.824 |
#> | F| Forward Diff. | 31.37 | 37.38 | 123.8 | -171.9 |
#> |.....................| 0.2255 | 650.7 | -49.92 | -57.61 |
#> | 236| 62683.366 | -0.4843 | 0.7948 | -1.213 | -1.019 |
#> |.....................| -1.002 | -1.020 | -0.2255 | -0.1868 |
#> | U| 62683.366 | 1.407 | 4.295 | 0.1974 | 0.5403 |
#> |.....................| 0.009992 | 0.5392 | 1.755 | 1.824 |
#> | X| 62683.366 | 4.086 | 73.32 | 0.1974 | 0.5403 |
#> |.....................| 0.009992 | 0.5392 | 1.755 | 1.824 |
#> | F| Forward Diff. | 30.70 | 36.72 | 276.2 | 426.5 |
#> |.....................| 0.2263 | 49.18 | -50.35 | -57.88 |
#> | 237| 62683.221 | -0.4844 | 0.7947 | -1.213 | -1.019 |
#> |.....................| -1.002 | -1.020 | -0.2254 | -0.1867 |
#> | U| 62683.221 | 1.407 | 4.295 | 0.1973 | 0.5396 |
#> |.....................| 0.009992 | 0.5392 | 1.755 | 1.824 |
#> | X| 62683.221 | 4.085 | 73.31 | 0.1973 | 0.5396 |
#> |.....................| 0.009992 | 0.5392 | 1.755 | 1.824 |
#> | F| Forward Diff. | 31.02 | 37.01 | 122.9 | -171.5 |
#> |.....................| 0.2254 | 649.8 | -50.08 | -57.70 |
#> | 238| 62683.017 | -0.4844 | 0.7946 | -1.213 | -1.019 |
#> |.....................| -1.002 | -1.021 | -0.2256 | -0.1868 |
#> | U| 62683.017 | 1.407 | 4.295 | 0.1973 | 0.5395 |
#> |.....................| 0.009992 | 0.5384 | 1.755 | 1.824 |
#> | X| 62683.017 | 4.085 | 73.30 | 0.1973 | 0.5395 |
#> |.....................| 0.009992 | 0.5384 | 1.755 | 1.824 |
#> | F| Forward Diff. | 30.33 | 36.35 | 275.3 | 426.3 |
#> |.....................| 0.2262 | 48.69 | -50.46 | -57.98 |
#> | 239| 62682.874 | -0.4845 | 0.7946 | -1.214 | -1.020 |
#> |.....................| -1.002 | -1.021 | -0.2255 | -0.1867 |
#> | U| 62682.874 | 1.407 | 4.295 | 0.1972 | 0.5389 |
#> |.....................| 0.009992 | 0.5383 | 1.755 | 1.824 |
#> | X| 62682.874 | 4.085 | 73.30 | 0.1972 | 0.5389 |
#> |.....................| 0.009992 | 0.5383 | 1.755 | 1.824 |
#> | F| Forward Diff. | 30.65 | 36.62 | 121.7 | -172.7 |
#> |.....................| 0.2254 | 650.3 | -50.29 | -57.81 |
#> | 240| 62682.670 | -0.4845 | 0.7945 | -1.214 | -1.020 |
#> |.....................| -1.002 | -1.021 | -0.2256 | -0.1869 |
#> | U| 62682.67 | 1.407 | 4.294 | 0.1972 | 0.5388 |
#> |.....................| 0.009992 | 0.5376 | 1.755 | 1.824 |
#> | X| 62682.67 | 4.085 | 73.29 | 0.1972 | 0.5388 |
#> |.....................| 0.009992 | 0.5376 | 1.755 | 1.824 |
#> | F| Forward Diff. | 29.98 | 35.97 | 274.0 | 424.6 |
#> |.....................| 0.2262 | 50.32 | -50.65 | -58.08 |
#> | 241| 62682.527 | -0.4846 | 0.7944 | -1.214 | -1.021 |
#> |.....................| -1.002 | -1.022 | -0.2256 | -0.1868 |
#> | U| 62682.527 | 1.407 | 4.294 | 0.1970 | 0.5381 |
#> |.....................| 0.009992 | 0.5375 | 1.755 | 1.824 |
#> | X| 62682.527 | 4.084 | 73.29 | 0.1970 | 0.5381 |
#> |.....................| 0.009992 | 0.5375 | 1.755 | 1.824 |
#> | F| Forward Diff. | 30.30 | 36.23 | 121.0 | -171.9 |
#> |.....................| 0.2253 | 649.3 | -50.49 | -57.93 |
#> | 242| 62682.324 | -0.4847 | 0.7943 | -1.214 | -1.021 |
#> |.....................| -1.002 | -1.022 | -0.2257 | -0.1869 |
#> | U| 62682.324 | 1.407 | 4.294 | 0.1971 | 0.5381 |
#> |.....................| 0.009992 | 0.5368 | 1.754 | 1.823 |
#> | X| 62682.324 | 4.084 | 73.28 | 0.1971 | 0.5381 |
#> |.....................| 0.009992 | 0.5368 | 1.754 | 1.823 |
#> | F| Forward Diff. | 29.62 | 35.58 | 273.1 | 424.3 |
#> |.....................| 0.2261 | 49.72 | -50.82 | -58.16 |
#> | 243| 62682.182 | -0.4847 | 0.7943 | -1.214 | -1.022 |
#> |.....................| -1.002 | -1.022 | -0.2256 | -0.1868 |
#> | U| 62682.182 | 1.407 | 4.294 | 0.1969 | 0.5374 |
#> |.....................| 0.009992 | 0.5367 | 1.755 | 1.824 |
#> | X| 62682.182 | 4.084 | 73.28 | 0.1969 | 0.5374 |
#> |.....................| 0.009992 | 0.5367 | 1.755 | 1.824 |
#> | F| Forward Diff. | 29.94 | 35.85 | 119.7 | -173.1 |
#> |.....................| 0.2253 | 649.8 | -50.61 | -57.99 |
#> | 244| 62681.979 | -0.4848 | 0.7942 | -1.214 | -1.022 |
#> |.....................| -1.002 | -1.023 | -0.2258 | -0.1870 |
#> | U| 62681.979 | 1.407 | 4.294 | 0.1969 | 0.5373 |
#> |.....................| 0.009992 | 0.5359 | 1.754 | 1.823 |
#> | X| 62681.979 | 4.084 | 73.27 | 0.1969 | 0.5373 |
#> |.....................| 0.009992 | 0.5359 | 1.754 | 1.823 |
#> | F| Forward Diff. | 29.27 | 35.20 | 271.8 | 422.4 |
#> |.....................| 0.2260 | 51.22 | -51.01 | -58.25 |
#> | 245| 62681.838 | -0.4848 | 0.7941 | -1.215 | -1.022 |
#> |.....................| -1.002 | -1.023 | -0.2257 | -0.1869 |
#> | U| 62681.838 | 1.407 | 4.294 | 0.1968 | 0.5367 |
#> |.....................| 0.009992 | 0.5358 | 1.754 | 1.824 |
#> | X| 62681.838 | 4.083 | 73.27 | 0.1968 | 0.5367 |
#> |.....................| 0.009992 | 0.5358 | 1.754 | 1.824 |
#> | F| Forward Diff. | 29.59 | 35.48 | 119.0 | -172.8 |
#> |.....................| 0.2252 | 648.9 | -50.78 | -58.07 |
#> | 246| 62681.635 | -0.4849 | 0.7940 | -1.215 | -1.022 |
#> |.....................| -1.002 | -1.024 | -0.2259 | -0.1870 |
#> | U| 62681.635 | 1.407 | 4.294 | 0.1968 | 0.5366 |
#> |.....................| 0.009991 | 0.5351 | 1.754 | 1.823 |
#> | X| 62681.635 | 4.083 | 73.26 | 0.1968 | 0.5366 |
#> |.....................| 0.009991 | 0.5351 | 1.754 | 1.823 |
#> | F| Forward Diff. | 28.92 | 34.82 | 270.9 | 421.7 |
#> |.....................| 0.2260 | 51.15 | -51.16 | -58.36 |
#> | 247| 62681.494 | -0.4850 | 0.7940 | -1.215 | -1.023 |
#> |.....................| -1.002 | -1.024 | -0.2258 | -0.1869 |
#> | U| 62681.494 | 1.407 | 4.294 | 0.1967 | 0.5359 |
#> |.....................| 0.009991 | 0.5350 | 1.754 | 1.823 |
#> | X| 62681.494 | 4.083 | 73.26 | 0.1967 | 0.5359 |
#> |.....................| 0.009991 | 0.5350 | 1.754 | 1.823 |
#> | F| Forward Diff. | 29.24 | 35.09 | 117.9 | -173.5 |
#> |.....................| 0.2251 | 648.9 | -50.96 | -58.18 |
#> | 248| 62681.292 | -0.4850 | 0.7939 | -1.215 | -1.023 |
#> |.....................| -1.002 | -1.025 | -0.2260 | -0.1871 |
#> | U| 62681.292 | 1.407 | 4.294 | 0.1967 | 0.5358 |
#> |.....................| 0.009991 | 0.5343 | 1.754 | 1.823 |
#> | X| 62681.292 | 4.083 | 73.25 | 0.1967 | 0.5358 |
#> |.....................| 0.009991 | 0.5343 | 1.754 | 1.823 |
#> | F| Forward Diff. | 28.57 | 34.45 | 269.7 | 420.3 |
#> |.....................| 0.2258 | 52.09 | -51.35 | -58.47 |
#> | 249| 62681.151 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.151 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5342 | 1.754 | 1.823 |
#> | X| 62681.151 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5342 | 1.754 | 1.823 |
#> | F| Forward Diff. | 28.89 | 34.72 | 117.0 | -173.4 |
#> |.....................| 0.2250 | 648.2 | -51.13 | -58.28 |
#> | 250| 64993.353 | -0.4851 | 0.7937 | -1.215 | -1.024 |
#> |.....................| -1.002 | -1.026 | -0.2260 | -0.1871 |
#> | U| 64993.353 | 1.407 | 4.294 | 0.1966 | 0.5351 |
#> |.....................| 0.009991 | 0.5334 | 1.754 | 1.823 |
#> | X| 64993.353 | 4.082 | 73.24 | 0.1966 | 0.5351 |
#> |.....................| 0.009991 | 0.5334 | 1.754 | 1.823 |
#> | 251| 62681.104 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.104 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.104 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | F| Forward Diff. | 28.84 | 34.67 | 137.5 | -92.88 |
#> |.....................| 0.2252 | 567.7 | -51.12 | -58.25 |
#> | 252| 65003.445 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1869 |
#> | U| 65003.445 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5340 | 1.754 | 1.823 |
#> | X| 65003.445 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5340 | 1.754 | 1.823 |
#> | 253| 62681.096 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.096 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.096 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | F| Forward Diff. | 28.83 | 34.66 | 141.2 | -78.30 |
#> |.....................| 0.2252 | 553.1 | -51.09 | -58.26 |
#> | 254| 65006.020 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 65006.02 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 65006.02 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | 255| 62681.094 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.094 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.094 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | F| Forward Diff. | 28.99 | 34.88 | 142.1 | -73.70 |
#> |.....................| 0.2262 | 552.0 | -50.85 | -58.13 |
#> | 256| 65006.524 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 65006.524 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 65006.524 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | 257| 62681.094 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.094 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.094 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | F| Forward Diff. | 28.85 | 34.70 | 142.1 | -74.52 |
#> |.....................| 0.2254 | 549.9 | -51.02 | -58.23 |
#> | 258| 62681.093 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.093 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.093 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | 259| 65006.582 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 65006.582 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 65006.582 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | F| Forward Diff. | 28.80 | 34.64 | 142.3 | -73.99 |
#> |.....................| 0.2252 | 548.3 | -51.08 | -58.26 |
#> | 260| 65006.554 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 65006.554 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 65006.554 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | 261| 62681.093 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.093 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.093 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | F| Forward Diff. | 28.82 | 34.66 | 142.4 | -73.45 |
#> |.....................| 0.2253 | 548.2 | -51.09 | -58.26 |
#> | 262| 62681.093 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.093 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.093 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | 263| 65006.579 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 65006.579 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 65006.579 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | F| Forward Diff. | 28.80 | 34.63 | 142.5 | -73.13 |
#> |.....................| 0.2251 | 547.4 | -51.13 | -58.28 |
#> | 264| 65006.565 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 65006.565 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 65006.565 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | 265| 62681.093 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.093 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.093 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | F| Forward Diff. | 28.81 | 34.64 | 142.6 | -72.88 |
#> |.....................| 0.2252 | 547.5 | -51.08 | -58.28 |
#> | 266| 62681.092 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.092 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.092 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | 267| 65006.573 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 65006.573 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 65006.573 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | F| Forward Diff. | 28.80 | 34.64 | 142.7 | -72.63 |
#> |.....................| 0.2251 | 546.9 | -51.12 | -58.28 |
#> | 268| 65006.565 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 65006.565 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 65006.565 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | 269| 62681.092 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.092 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.092 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | F| Forward Diff. | 28.81 | 34.64 | 142.7 | -72.56 |
#> |.....................| 0.2252 | 547.0 | -51.11 | -58.27 |
#> | 270| 62681.092 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.092 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.092 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | 271| 65006.573 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 65006.573 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 65006.573 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | F| Forward Diff. | 28.80 | 34.64 | 142.7 | -72.26 |
#> |.....................| 0.2251 | 546.6 | -51.12 | -58.25 |
#> | 272| 65006.567 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 65006.567 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 65006.567 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | 273| 65006.582 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 65006.582 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 65006.582 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | 274| 62681.092 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.092 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.092 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | F| Forward Diff. | 28.81 | 34.64 | 142.7 | -72.25 |
#> |.....................| 0.2251 | 546.8 | -51.09 | -58.27 |
#> | 275| 62681.092 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.092 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.092 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | C| Central Diff. | 26.89 | 33.37 | 103.0 | -136.1 |
#> |.....................| 0.2119 | 484.5 | -52.31 | -59.39 |
#> | 276| 65006.582 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 65006.582 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 65006.582 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | 277| 62681.092 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.092 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.092 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | F| Forward Diff. | 28.82 | 34.67 | 142.8 | -72.00 |
#> |.....................| 0.2253 | 546.9 | -51.11 | -58.26 |
#> | 278| 62681.092 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.092 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.092 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | 279| 62681.092 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.092 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.092 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | 280| 62681.092 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.092 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.092 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | 281| 62681.092 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.092 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.092 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | 282| 62681.092 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.092 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.092 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | 283| 62681.092 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.092 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.092 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | 284| 62681.092 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.092 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.092 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | 285| 62681.092 | -0.4851 | 0.7938 | -1.216 | -1.024 |
#> |.....................| -1.002 | -1.025 | -0.2259 | -0.1870 |
#> | U| 62681.092 | 1.407 | 4.294 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> | X| 62681.092 | 4.082 | 73.25 | 0.1966 | 0.5352 |
#> |.....................| 0.009991 | 0.5341 | 1.754 | 1.823 |
#> calculating covariance matrix
#> done
#> Calculating residuals/tables
#> done
#> Warning: Hessian reset during optimization; (can control by foceiControl(resetHessianAndEta=.))
#> Warning: initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))
#> Warning: ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))
#> Warning: last objective function was not at minimum, possible problems in optimization
#> Warning: numerical difficulties solving forward sensitivity inner problem, tried approximating with more inaccurate numeric differences
#> Warning: gradient problems with initial estimate and covariance; see $scaleInfo
#> Warning: 'ss' is ignored with classic RxODE 'EVID's
## In addition to using L-BFGS-B for FOCEi (outer problem) you may
## use other optimizers. An example is below
one.cmt <- function() {
ini({
tka <- .44 # log Ka
tcl <- log(c(0, 2.7, 100)) # log Cl
tv <- 3.45 # log V
eta.ka ~ 0.6
eta.cl ~ 0.3
eta.v ~ 0.1
add.err <- 0.7
})
model({
ka <- exp(tka + eta.ka)
cl <- exp(tcl + eta.cl)
v <- exp(tv + eta.v)
linCmt() ~ add(add.err)
})
}
fit <- nlmixr(one.cmt, theo_sd, "focei", foceiControl(outerOpt="bobyqa"))
#> ℹ parameter labels from comments will be replaced by 'label()'
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → calculate jacobian
#>
#> → calculate ∂(f)/∂(η)
#>
#> → calculate ∂(R²)/∂(η)
#>
#> → finding duplicate expressions in inner model...
#>
#> → optimizing duplicate expressions in inner model...
#>
#> → finding duplicate expressions in EBE model...
#>
#> → optimizing duplicate expressions in EBE model...
#>
#> → compiling inner model...
#>
#> ✔ done
#> → finding duplicate expressions in FD model...
#>
#> → compiling EBE model...
#>
#> ✔ done
#> → compiling events FD model...
#>
#> ✔ done
#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
#> F: Forward difference gradient approximation
#> C: Central difference gradient approximation
#> M: Mixed forward and central difference gradient approximation
#> Unscaled parameters for Omegas=chol(solve(omega));
#> Diagonals are transformed, as specified by foceiControl(diagXform=)
#> |-----+---------------+-----------+-----------+-----------+-----------|
#> | #| Objective Fun | tka | tcl | tv | add.err |
#> |.....................| o1 | o2 | o3 |...........|
#> | 1| 133.58639 | -1.000 | -0.6324 | 1.000 | -0.8272 |
#> |.....................| -0.5374 | -0.3946 | -0.1108 |...........|
#> | U| 133.58639 | 0.4400 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 133.58639 | 1.553 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | 2| 133.58639 | -1.000 | -0.6324 | 1.000 | -0.8272 |
#> |.....................| -0.5374 | -0.3946 | -0.1108 |...........|
#> | U| 133.58639 | 0.4400 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 133.58639 | 1.553 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | 3| 134.07361 | -0.8000 | -0.6324 | 1.000 | -0.8272 |
#> |.....................| -0.5374 | -0.3946 | -0.1108 |...........|
#> | U| 134.07361 | 0.6400 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 134.07361 | 1.896 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | 4| 134.78512 | -1.000 | -0.4324 | 1.000 | -0.8272 |
#> |.....................| -0.5374 | -0.3946 | -0.1108 |...........|
#> | U| 134.78512 | 0.4400 | 1.193 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 134.78512 | 1.553 | 3.298 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | 5| 137.47499 | -1.000 | -0.6324 | 1.200 | -0.8272 |
#> |.....................| -0.5374 | -0.3946 | -0.1108 |...........|
#> | U| 137.47499 | 0.4400 | 0.9933 | 3.650 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 137.47499 | 1.553 | 2.700 | 38.47 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | 6| 135.53466 | -1.000 | -0.6324 | 1.000 | -0.6272 |
#> |.....................| -0.5374 | -0.3946 | -0.1108 |...........|
#> | U| 135.53466 | 0.4400 | 0.9933 | 3.450 | 0.7700 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 135.53466 | 1.553 | 2.700 | 31.50 | 0.7700 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | 7| 133.69855 | -1.000 | -0.6324 | 1.000 | -0.8272 |
#> |.....................| -0.3374 | -0.3946 | -0.1108 |...........|
#> | U| 133.69855 | 0.4400 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.363 | 1.351 | 1.778 |...........|
#> | X| 133.69855 | 1.553 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.363 | 1.351 | 1.778 |...........|
#> | 8| 128.07696 | -1.000 | -0.6324 | 1.000 | -0.8272 |
#> |.....................| -0.5374 | -0.1946 | -0.1108 |...........|
#> | U| 128.07696 | 0.4400 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.621 | 1.778 |...........|
#> | X| 128.07696 | 1.553 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.621 | 1.778 |...........|
#> | 9| 128.14520 | -1.000 | -0.6324 | 1.000 | -0.8272 |
#> |.....................| -0.5374 | -0.3946 | 0.08922 |...........|
#> | U| 128.1452 | 0.4400 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 2.134 |...........|
#> | X| 128.1452 | 1.553 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 2.134 |...........|
#> | 10| 134.59979 | -1.200 | -0.6324 | 1.000 | -0.8272 |
#> |.....................| -0.5374 | -0.3946 | -0.1108 |...........|
#> | U| 134.59979 | 0.2400 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 134.59979 | 1.271 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | 11| 135.43950 | -1.000 | -0.8324 | 1.000 | -0.8272 |
#> |.....................| -0.5374 | -0.3946 | -0.1108 |...........|
#> | U| 135.4395 | 0.4400 | 0.7933 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 135.4395 | 1.553 | 2.211 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | 12| 138.67902 | -1.000 | -0.6324 | 0.8000 | -0.8272 |
#> |.....................| -0.5374 | -0.3946 | -0.1108 |...........|
#> | U| 138.67902 | 0.4400 | 0.9933 | 3.250 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 138.67902 | 1.553 | 2.700 | 25.79 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | 13| 135.58963 | -1.000 | -0.6324 | 1.000 | -1.027 |
#> |.....................| -0.5374 | -0.3946 | -0.1108 |...........|
#> | U| 135.58963 | 0.4400 | 0.9933 | 3.450 | 0.6300 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 135.58963 | 1.553 | 2.700 | 31.50 | 0.6300 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | 14| 138.56769 | -1.000 | -0.6324 | 1.000 | -0.8272 |
#> |.....................| -0.7374 | -0.3946 | -0.1108 |...........|
#> | U| 138.56769 | 0.4400 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 0.9090 | 1.351 | 1.778 |...........|
#> | X| 138.56769 | 1.553 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 0.9090 | 1.351 | 1.778 |...........|
#> | 15| 142.37620 | -1.000 | -0.6324 | 1.000 | -0.8272 |
#> |.....................| -0.5374 | -0.5946 | -0.1108 |...........|
#> | U| 142.3762 | 0.4400 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.081 | 1.778 |...........|
#> | X| 142.3762 | 1.553 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.081 | 1.778 |...........|
#> | 16| 142.26587 | -1.000 | -0.6324 | 1.000 | -0.8272 |
#> |.....................| -0.5374 | -0.3946 | -0.3108 |...........|
#> | U| 142.26587 | 0.4400 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.423 |...........|
#> | X| 142.26587 | 1.553 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.423 |...........|
#> | 17| 121.38523 | -0.9927 | -0.6244 | 1.007 | -0.8266 |
#> |.....................| -0.4882 | -0.1019 | 0.05898 |...........|
#> | U| 121.38523 | 0.4473 | 1.001 | 3.457 | 0.7002 |
#> |.....................| 1.192 | 1.747 | 2.080 |...........|
#> | X| 121.38523 | 1.564 | 2.722 | 31.73 | 0.7002 |
#> |.....................| 1.192 | 1.747 | 2.080 |...........|
#> | 18| 117.00311 | -0.9739 | -0.6115 | 1.014 | -0.8259 |
#> |.....................| -0.4441 | 0.03626 | 0.3195 |...........|
#> | U| 117.00311 | 0.4661 | 1.014 | 3.464 | 0.7005 |
#> |.....................| 1.242 | 1.933 | 2.544 |...........|
#> | X| 117.00311 | 1.594 | 2.757 | 31.93 | 0.7005 |
#> |.....................| 1.242 | 1.933 | 2.544 |...........|
#> | 19| 116.92018 | -0.9612 | -0.6096 | 1.014 | -0.8258 |
#> |.....................| -0.4387 | 0.05447 | 0.3388 |...........|
#> | U| 116.92018 | 0.4788 | 1.016 | 3.464 | 0.7005 |
#> |.....................| 1.248 | 1.958 | 2.578 |...........|
#> | X| 116.92018 | 1.614 | 2.762 | 31.93 | 0.7005 |
#> |.....................| 1.248 | 1.958 | 2.578 |...........|
#> | 20| 117.04237 | -0.9022 | -0.6060 | 1.014 | -0.8258 |
#> |.....................| -0.4368 | 0.05053 | 0.3472 |...........|
#> | U| 117.04237 | 0.5378 | 1.020 | 3.464 | 0.7005 |
#> |.....................| 1.251 | 1.953 | 2.593 |...........|
#> | X| 117.04237 | 1.712 | 2.772 | 31.94 | 0.7005 |
#> |.....................| 1.251 | 1.953 | 2.593 |...........|
#> | 21| 116.92294 | -0.9600 | -0.6089 | 1.020 | -0.8257 |
#> |.....................| -0.4358 | 0.06769 | 0.3520 |...........|
#> | U| 116.92294 | 0.4800 | 1.017 | 3.470 | 0.7005 |
#> |.....................| 1.252 | 1.976 | 2.601 |...........|
#> | X| 116.92294 | 1.616 | 2.764 | 32.14 | 0.7005 |
#> |.....................| 1.252 | 1.976 | 2.601 |...........|
#> | 22| 116.94533 | -0.9661 | -0.6076 | 1.000 | -0.8258 |
#> |.....................| -0.4353 | 0.06673 | 0.3448 |...........|
#> | U| 116.94533 | 0.4739 | 1.018 | 3.450 | 0.7005 |
#> |.....................| 1.252 | 1.974 | 2.588 |...........|
#> | X| 116.94533 | 1.606 | 2.768 | 31.52 | 0.7005 |
#> |.....................| 1.252 | 1.974 | 2.588 |...........|
#> | 23| 116.88502 | -0.9600 | -0.6149 | 1.014 | -0.8257 |
#> |.....................| -0.4358 | 0.06791 | 0.3522 |...........|
#> | U| 116.88502 | 0.4800 | 1.011 | 3.464 | 0.7005 |
#> |.....................| 1.252 | 1.976 | 2.602 |...........|
#> | X| 116.88502 | 1.616 | 2.748 | 31.95 | 0.7005 |
#> |.....................| 1.252 | 1.976 | 2.602 |...........|
#> | 24| 116.86729 | -0.9609 | -0.6207 | 1.012 | -0.8249 |
#> |.....................| -0.4257 | 0.05604 | 0.3630 |...........|
#> | U| 116.86729 | 0.4791 | 1.005 | 3.462 | 0.7008 |
#> |.....................| 1.263 | 1.960 | 2.621 |...........|
#> | X| 116.86729 | 1.615 | 2.732 | 31.87 | 0.7008 |
#> |.....................| 1.263 | 1.960 | 2.621 |...........|
#> | 25| 116.85110 | -0.9598 | -0.6204 | 1.012 | -0.8306 |
#> |.....................| -0.4224 | 0.06903 | 0.3766 |...........|
#> | U| 116.8511 | 0.4802 | 1.005 | 3.462 | 0.6988 |
#> |.....................| 1.267 | 1.978 | 2.645 |...........|
#> | X| 116.8511 | 1.616 | 2.733 | 31.88 | 0.6988 |
#> |.....................| 1.267 | 1.978 | 2.645 |...........|
#> | 26| 116.86546 | -0.9573 | -0.6301 | 1.010 | -0.8443 |
#> |.....................| -0.4321 | 0.06513 | 0.3780 |...........|
#> | U| 116.86546 | 0.4827 | 0.9956 | 3.460 | 0.6940 |
#> |.....................| 1.256 | 1.972 | 2.647 |...........|
#> | X| 116.86546 | 1.620 | 2.706 | 31.83 | 0.6940 |
#> |.....................| 1.256 | 1.972 | 2.647 |...........|
#> | 27| 116.86249 | -0.9586 | -0.6201 | 1.012 | -0.8307 |
#> |.....................| -0.4249 | 0.08268 | 0.3910 |...........|
#> | U| 116.86249 | 0.4814 | 1.006 | 3.462 | 0.6988 |
#> |.....................| 1.264 | 1.996 | 2.671 |...........|
#> | X| 116.86249 | 1.618 | 2.734 | 31.90 | 0.6988 |
#> |.....................| 1.264 | 1.996 | 2.671 |...........|
#> | 28| 116.89929 | -0.9740 | -0.6320 | 1.014 | -0.8309 |
#> |.....................| -0.4220 | 0.07545 | 0.3724 |...........|
#> | U| 116.89929 | 0.4660 | 0.9936 | 3.464 | 0.6987 |
#> |.....................| 1.267 | 1.986 | 2.637 |...........|
#> | X| 116.89929 | 1.594 | 2.701 | 31.94 | 0.6987 |
#> |.....................| 1.267 | 1.986 | 2.637 |...........|
#> | 29| 116.94096 | -0.9490 | -0.6348 | 1.013 | -0.8253 |
#> |.....................| -0.4169 | 0.07225 | 0.3741 |...........|
#> | U| 116.94096 | 0.4910 | 0.9908 | 3.463 | 0.7007 |
#> |.....................| 1.273 | 1.982 | 2.640 |...........|
#> | X| 116.94096 | 1.634 | 2.693 | 31.90 | 0.7007 |
#> |.....................| 1.273 | 1.982 | 2.640 |...........|
#> | 30| 116.83181 | -0.9615 | -0.6098 | 1.007 | -0.8420 |
#> |.....................| -0.4314 | 0.06644 | 0.3826 |...........|
#> | U| 116.83181 | 0.4785 | 1.016 | 3.457 | 0.6948 |
#> |.....................| 1.257 | 1.974 | 2.656 |...........|
#> | X| 116.83181 | 1.614 | 2.762 | 31.71 | 0.6948 |
#> |.....................| 1.257 | 1.974 | 2.656 |...........|
#> | 31| 116.84097 | -0.9556 | -0.6156 | 1.008 | -0.8386 |
#> |.....................| -0.4336 | 0.06962 | 0.3771 |...........|
#> | U| 116.84097 | 0.4844 | 1.010 | 3.458 | 0.6960 |
#> |.....................| 1.254 | 1.978 | 2.646 |...........|
#> | X| 116.84097 | 1.623 | 2.746 | 31.74 | 0.6960 |
#> |.....................| 1.254 | 1.978 | 2.646 |...........|
#> | 32| 117.04648 | -0.9636 | -0.6140 | 0.9888 | -0.8390 |
#> |.....................| -0.4262 | 0.07155 | 0.3834 |...........|
#> | U| 117.04648 | 0.4764 | 1.012 | 3.439 | 0.6959 |
#> |.....................| 1.263 | 1.981 | 2.657 |...........|
#> | X| 117.04648 | 1.610 | 2.750 | 31.15 | 0.6959 |
#> |.....................| 1.263 | 1.981 | 2.657 |...........|
#> | 33| 116.88710 | -0.9653 | -0.6067 | 1.022 | -0.8467 |
#> |.....................| -0.4304 | 0.06017 | 0.3917 |...........|
#> | U| 116.8871 | 0.4747 | 1.019 | 3.472 | 0.6932 |
#> |.....................| 1.258 | 1.966 | 2.672 |...........|
#> | X| 116.8871 | 1.608 | 2.770 | 32.19 | 0.6932 |
#> |.....................| 1.258 | 1.966 | 2.672 |...........|
#> | 34| 116.84327 | -0.9666 | -0.6117 | 1.004 | -0.8294 |
#> |.....................| -0.4415 | 0.05682 | 0.3859 |...........|
#> | U| 116.84327 | 0.4734 | 1.014 | 3.454 | 0.6993 |
#> |.....................| 1.245 | 1.961 | 2.662 |...........|
#> | X| 116.84327 | 1.606 | 2.756 | 31.64 | 0.6993 |
#> |.....................| 1.245 | 1.961 | 2.662 |...........|
#> | 35| 116.83129 | -0.9748 | -0.6069 | 1.009 | -0.8392 |
#> |.....................| -0.4370 | 0.05832 | 0.3723 |...........|
#> | U| 116.83129 | 0.4652 | 1.019 | 3.459 | 0.6958 |
#> |.....................| 1.250 | 1.963 | 2.637 |...........|
#> | X| 116.83129 | 1.592 | 2.770 | 31.78 | 0.6958 |
#> |.....................| 1.250 | 1.963 | 2.637 |...........|
#> | 36| 116.85341 | -0.9757 | -0.6078 | 1.009 | -0.8388 |
#> |.....................| -0.4407 | 0.04169 | 0.3619 |...........|
#> | U| 116.85341 | 0.4643 | 1.018 | 3.459 | 0.6960 |
#> |.....................| 1.246 | 1.941 | 2.619 |...........|
#> | X| 116.85341 | 1.591 | 2.767 | 31.77 | 0.6960 |
#> |.....................| 1.246 | 1.941 | 2.619 |...........|
#> | 37| 116.83797 | -0.9562 | -0.6060 | 1.010 | -0.8381 |
#> |.....................| -0.4323 | 0.05852 | 0.3776 |...........|
#> | U| 116.83797 | 0.4838 | 1.020 | 3.460 | 0.6962 |
#> |.....................| 1.256 | 1.963 | 2.647 |...........|
#> | X| 116.83797 | 1.622 | 2.772 | 31.80 | 0.6962 |
#> |.....................| 1.256 | 1.963 | 2.647 |...........|
#> | 38| 116.82858 | -0.9733 | -0.6129 | 1.010 | -0.8373 |
#> |.....................| -0.4429 | 0.06218 | 0.3751 |...........|
#> | U| 116.82858 | 0.4667 | 1.013 | 3.460 | 0.6965 |
#> |.....................| 1.244 | 1.968 | 2.642 |...........|
#> | X| 116.82858 | 1.595 | 2.753 | 31.81 | 0.6965 |
#> |.....................| 1.244 | 1.968 | 2.642 |...........|
#> | 39| 116.82247 | -0.9728 | -0.6123 | 1.011 | -0.8350 |
#> |.....................| -0.4375 | 0.06548 | 0.3823 |...........|
#> | U| 116.82247 | 0.4672 | 1.013 | 3.461 | 0.6973 |
#> |.....................| 1.250 | 1.973 | 2.655 |...........|
#> | X| 116.82247 | 1.595 | 2.755 | 31.85 | 0.6973 |
#> |.....................| 1.250 | 1.973 | 2.655 |...........|
#> | 40| 116.82365 | -0.9769 | -0.6112 | 1.012 | -0.8348 |
#> |.....................| -0.4363 | 0.06712 | 0.3845 |...........|
#> | U| 116.82365 | 0.4631 | 1.014 | 3.462 | 0.6973 |
#> |.....................| 1.251 | 1.975 | 2.659 |...........|
#> | X| 116.82365 | 1.589 | 2.758 | 31.87 | 0.6973 |
#> |.....................| 1.251 | 1.975 | 2.659 |...........|
#> | 41| 116.82600 | -0.9725 | -0.6093 | 1.011 | -0.8332 |
#> |.....................| -0.4339 | 0.06459 | 0.3814 |...........|
#> | U| 116.826 | 0.4675 | 1.016 | 3.461 | 0.6979 |
#> |.....................| 1.254 | 1.972 | 2.653 |...........|
#> | X| 116.826 | 1.596 | 2.763 | 31.85 | 0.6979 |
#> |.....................| 1.254 | 1.972 | 2.653 |...........|
#> | 42| 116.82414 | -0.9727 | -0.6135 | 1.012 | -0.8361 |
#> |.....................| -0.4388 | 0.06765 | 0.3836 |...........|
#> | U| 116.82414 | 0.4673 | 1.012 | 3.462 | 0.6969 |
#> |.....................| 1.248 | 1.976 | 2.657 |...........|
#> | X| 116.82414 | 1.596 | 2.752 | 31.88 | 0.6969 |
#> |.....................| 1.248 | 1.976 | 2.657 |...........|
#> | 43| 116.82450 | -0.9724 | -0.6120 | 1.010 | -0.8345 |
#> |.....................| -0.4374 | 0.06556 | 0.3799 |...........|
#> | U| 116.8245 | 0.4676 | 1.014 | 3.460 | 0.6975 |
#> |.....................| 1.250 | 1.973 | 2.651 |...........|
#> | X| 116.8245 | 1.596 | 2.756 | 31.83 | 0.6975 |
#> |.....................| 1.250 | 1.973 | 2.651 |...........|
#> | 44| 116.82015 | -0.9735 | -0.6138 | 1.012 | -0.8351 |
#> |.....................| -0.4369 | 0.06380 | 0.3830 |...........|
#> | U| 116.82015 | 0.4665 | 1.012 | 3.462 | 0.6973 |
#> |.....................| 1.250 | 1.971 | 2.656 |...........|
#> | X| 116.82015 | 1.594 | 2.751 | 31.87 | 0.6973 |
#> |.....................| 1.250 | 1.971 | 2.656 |...........|
#> | 45| 116.81854 | -0.9777 | -0.6155 | 1.011 | -0.8348 |
#> |.....................| -0.4372 | 0.06149 | 0.3842 |...........|
#> | U| 116.81854 | 0.4623 | 1.010 | 3.461 | 0.6974 |
#> |.....................| 1.250 | 1.967 | 2.659 |...........|
#> | X| 116.81854 | 1.588 | 2.746 | 31.86 | 0.6974 |
#> |.....................| 1.250 | 1.967 | 2.659 |...........|
#> | 46| 116.82033 | -0.9822 | -0.6156 | 1.011 | -0.8344 |
#> |.....................| -0.4386 | 0.06050 | 0.3843 |...........|
#> | U| 116.82033 | 0.4578 | 1.010 | 3.461 | 0.6975 |
#> |.....................| 1.248 | 1.966 | 2.659 |...........|
#> | X| 116.82033 | 1.581 | 2.746 | 31.85 | 0.6975 |
#> |.....................| 1.248 | 1.966 | 2.659 |...........|
#> | 47| 116.81596 | -0.9794 | -0.6162 | 1.010 | -0.8357 |
#> |.....................| -0.4373 | 0.06087 | 0.3875 |...........|
#> | U| 116.81596 | 0.4606 | 1.009 | 3.460 | 0.6970 |
#> |.....................| 1.250 | 1.967 | 2.664 |...........|
#> | X| 116.81596 | 1.585 | 2.744 | 31.83 | 0.6970 |
#> |.....................| 1.250 | 1.967 | 2.664 |...........|
#> | 48| 116.81226 | -0.9796 | -0.6158 | 1.010 | -0.8383 |
#> |.....................| -0.4356 | 0.06162 | 0.3911 |...........|
#> | U| 116.81226 | 0.4604 | 1.010 | 3.460 | 0.6961 |
#> |.....................| 1.252 | 1.968 | 2.671 |...........|
#> | X| 116.81226 | 1.585 | 2.745 | 31.83 | 0.6961 |
#> |.....................| 1.252 | 1.968 | 2.671 |...........|
#> | 49| 116.81391 | -0.9830 | -0.6164 | 1.011 | -0.8407 |
#> |.....................| -0.4344 | 0.06379 | 0.3994 |...........|
#> | U| 116.81391 | 0.4570 | 1.009 | 3.461 | 0.6953 |
#> |.....................| 1.253 | 1.971 | 2.686 |...........|
#> | X| 116.81391 | 1.579 | 2.744 | 31.85 | 0.6953 |
#> |.....................| 1.253 | 1.971 | 2.686 |...........|
#> | 50| 116.81051 | -0.9803 | -0.6139 | 1.010 | -0.8392 |
#> |.....................| -0.4372 | 0.06001 | 0.3932 |...........|
#> | U| 116.81051 | 0.4597 | 1.012 | 3.460 | 0.6958 |
#> |.....................| 1.250 | 1.965 | 2.675 |...........|
#> | X| 116.81051 | 1.584 | 2.750 | 31.82 | 0.6958 |
#> |.....................| 1.250 | 1.965 | 2.675 |...........|
#> | 51| 116.81047 | -0.9824 | -0.6127 | 1.008 | -0.8426 |
#> |.....................| -0.4371 | 0.05853 | 0.3926 |...........|
#> | U| 116.81047 | 0.4576 | 1.013 | 3.458 | 0.6946 |
#> |.....................| 1.250 | 1.963 | 2.674 |...........|
#> | X| 116.81047 | 1.580 | 2.754 | 31.76 | 0.6946 |
#> |.....................| 1.250 | 1.963 | 2.674 |...........|
#> | 52| 116.80854 | -0.9815 | -0.6124 | 1.009 | -0.8428 |
#> |.....................| -0.4369 | 0.05688 | 0.3941 |...........|
#> | U| 116.80854 | 0.4585 | 1.013 | 3.459 | 0.6945 |
#> |.....................| 1.250 | 1.961 | 2.676 |...........|
#> | X| 116.80854 | 1.582 | 2.755 | 31.77 | 0.6945 |
#> |.....................| 1.250 | 1.961 | 2.676 |...........|
#> | 53| 116.80717 | -0.9819 | -0.6127 | 1.009 | -0.8421 |
#> |.....................| -0.4358 | 0.05526 | 0.3952 |...........|
#> | U| 116.80717 | 0.4581 | 1.013 | 3.459 | 0.6948 |
#> |.....................| 1.252 | 1.959 | 2.678 |...........|
#> | X| 116.80717 | 1.581 | 2.754 | 31.78 | 0.6948 |
#> |.....................| 1.252 | 1.959 | 2.678 |...........|
#> | 54| 116.80704 | -0.9841 | -0.6129 | 1.008 | -0.8422 |
#> |.....................| -0.4356 | 0.05297 | 0.3987 |...........|
#> | U| 116.80704 | 0.4559 | 1.013 | 3.458 | 0.6948 |
#> |.....................| 1.252 | 1.956 | 2.684 |...........|
#> | X| 116.80704 | 1.578 | 2.753 | 31.77 | 0.6948 |
#> |.....................| 1.252 | 1.956 | 2.684 |...........|
#> | 55| 116.80595 | -0.9815 | -0.6135 | 1.009 | -0.8423 |
#> |.....................| -0.4337 | 0.05380 | 0.3953 |...........|
#> | U| 116.80595 | 0.4585 | 1.012 | 3.459 | 0.6947 |
#> |.....................| 1.254 | 1.957 | 2.678 |...........|
#> | X| 116.80595 | 1.582 | 2.752 | 31.78 | 0.6947 |
#> |.....................| 1.254 | 1.957 | 2.678 |...........|
#> | 56| 116.80604 | -0.9803 | -0.6136 | 1.009 | -0.8416 |
#> |.....................| -0.4324 | 0.05402 | 0.3933 |...........|
#> | U| 116.80604 | 0.4597 | 1.012 | 3.459 | 0.6950 |
#> |.....................| 1.256 | 1.957 | 2.675 |...........|
#> | X| 116.80604 | 1.584 | 2.751 | 31.79 | 0.6950 |
#> |.....................| 1.256 | 1.957 | 2.675 |...........|
#> | 57| 116.80631 | -0.9831 | -0.6130 | 1.009 | -0.8431 |
#> |.....................| -0.4343 | 0.05181 | 0.3956 |...........|
#> | U| 116.80631 | 0.4569 | 1.013 | 3.459 | 0.6945 |
#> |.....................| 1.253 | 1.954 | 2.679 |...........|
#> | X| 116.80631 | 1.579 | 2.753 | 31.77 | 0.6945 |
#> |.....................| 1.253 | 1.954 | 2.679 |...........|
#> | 58| 116.80571 | -0.9807 | -0.6144 | 1.009 | -0.8431 |
#> |.....................| -0.4335 | 0.05354 | 0.3953 |...........|
#> | U| 116.80571 | 0.4593 | 1.011 | 3.459 | 0.6945 |
#> |.....................| 1.254 | 1.957 | 2.678 |...........|
#> | X| 116.80571 | 1.583 | 2.749 | 31.78 | 0.6945 |
#> |.....................| 1.254 | 1.957 | 2.678 |...........|
#> | 59| 116.80647 | -0.9816 | -0.6151 | 1.009 | -0.8431 |
#> |.....................| -0.4328 | 0.05391 | 0.3953 |...........|
#> | U| 116.80647 | 0.4584 | 1.011 | 3.459 | 0.6945 |
#> |.....................| 1.255 | 1.957 | 2.678 |...........|
#> | X| 116.80647 | 1.582 | 2.747 | 31.77 | 0.6945 |
#> |.....................| 1.255 | 1.957 | 2.678 |...........|
#> | 60| 116.80537 | -0.9797 | -0.6136 | 1.009 | -0.8433 |
#> |.....................| -0.4340 | 0.05318 | 0.3952 |...........|
#> | U| 116.80537 | 0.4603 | 1.012 | 3.459 | 0.6944 |
#> |.....................| 1.254 | 1.956 | 2.678 |...........|
#> | X| 116.80537 | 1.585 | 2.751 | 31.78 | 0.6944 |
#> |.....................| 1.254 | 1.956 | 2.678 |...........|
#> | 61| 116.80559 | -0.9789 | -0.6133 | 1.009 | -0.8433 |
#> |.....................| -0.4339 | 0.05291 | 0.3939 |...........|
#> | U| 116.80559 | 0.4611 | 1.012 | 3.459 | 0.6944 |
#> |.....................| 1.254 | 1.956 | 2.676 |...........|
#> | X| 116.80559 | 1.586 | 2.752 | 31.78 | 0.6944 |
#> |.....................| 1.254 | 1.956 | 2.676 |...........|
#> | 62| 116.80552 | -0.9788 | -0.6143 | 1.009 | -0.8434 |
#> |.....................| -0.4339 | 0.05366 | 0.3945 |...........|
#> | U| 116.80552 | 0.4612 | 1.011 | 3.459 | 0.6944 |
#> |.....................| 1.254 | 1.957 | 2.677 |...........|
#> | X| 116.80552 | 1.586 | 2.749 | 31.78 | 0.6944 |
#> |.....................| 1.254 | 1.957 | 2.677 |...........|
#> | 63| 116.80495 | -0.9797 | -0.6134 | 1.009 | -0.8440 |
#> |.....................| -0.4336 | 0.05378 | 0.3962 |...........|
#> | U| 116.80495 | 0.4603 | 1.012 | 3.459 | 0.6941 |
#> |.....................| 1.254 | 1.957 | 2.680 |...........|
#> | X| 116.80495 | 1.585 | 2.752 | 31.79 | 0.6941 |
#> |.....................| 1.254 | 1.957 | 2.680 |...........|
#> | 64| 116.80502 | -0.9804 | -0.6133 | 1.009 | -0.8451 |
#> |.....................| -0.4338 | 0.05389 | 0.3987 |...........|
#> | U| 116.80502 | 0.4596 | 1.012 | 3.459 | 0.6938 |
#> |.....................| 1.254 | 1.957 | 2.684 |...........|
#> | X| 116.80502 | 1.583 | 2.752 | 31.80 | 0.6938 |
#> |.....................| 1.254 | 1.957 | 2.684 |...........|
#> | 65| 116.80577 | -0.9791 | -0.6135 | 1.008 | -0.8438 |
#> |.....................| -0.4333 | 0.05449 | 0.3956 |...........|
#> | U| 116.80577 | 0.4609 | 1.012 | 3.458 | 0.6942 |
#> |.....................| 1.254 | 1.958 | 2.679 |...........|
#> | X| 116.80577 | 1.586 | 2.752 | 31.77 | 0.6942 |
#> |.....................| 1.254 | 1.958 | 2.679 |...........|
#> | 66| 116.80499 | -0.9802 | -0.6138 | 1.010 | -0.8441 |
#> |.....................| -0.4333 | 0.05386 | 0.3962 |...........|
#> | U| 116.80499 | 0.4598 | 1.012 | 3.460 | 0.6941 |
#> |.....................| 1.254 | 1.957 | 2.680 |...........|
#> | X| 116.80499 | 1.584 | 2.751 | 31.82 | 0.6941 |
#> |.....................| 1.254 | 1.957 | 2.680 |...........|
#> | 67| 116.80456 | -0.9794 | -0.6133 | 1.009 | -0.8430 |
#> |.....................| -0.4331 | 0.05317 | 0.3967 |...........|
#> | U| 116.80456 | 0.4606 | 1.012 | 3.459 | 0.6945 |
#> |.....................| 1.255 | 1.956 | 2.681 |...........|
#> | X| 116.80456 | 1.585 | 2.752 | 31.80 | 0.6945 |
#> |.....................| 1.255 | 1.956 | 2.681 |...........|
#> | 68| 116.80413 | -0.9790 | -0.6136 | 1.010 | -0.8429 |
#> |.....................| -0.4329 | 0.05223 | 0.3976 |...........|
#> | U| 116.80413 | 0.4610 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.255 | 1.955 | 2.682 |...........|
#> | X| 116.80413 | 1.586 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.255 | 1.955 | 2.682 |...........|
#> | 69| 116.80381 | -0.9788 | -0.6142 | 1.010 | -0.8432 |
#> |.....................| -0.4330 | 0.05048 | 0.3997 |...........|
#> | U| 116.80381 | 0.4612 | 1.011 | 3.460 | 0.6944 |
#> |.....................| 1.255 | 1.953 | 2.686 |...........|
#> | X| 116.80381 | 1.586 | 2.750 | 31.81 | 0.6944 |
#> |.....................| 1.255 | 1.953 | 2.686 |...........|
#> | 70| 116.80383 | -0.9792 | -0.6139 | 1.009 | -0.8441 |
#> |.....................| -0.4327 | 0.04927 | 0.4011 |...........|
#> | U| 116.80383 | 0.4608 | 1.012 | 3.459 | 0.6941 |
#> |.....................| 1.255 | 1.951 | 2.689 |...........|
#> | X| 116.80383 | 1.585 | 2.750 | 31.80 | 0.6941 |
#> |.....................| 1.255 | 1.951 | 2.689 |...........|
#> | 71| 116.80387 | -0.9780 | -0.6137 | 1.010 | -0.8434 |
#> |.....................| -0.4329 | 0.05106 | 0.3992 |...........|
#> | U| 116.80387 | 0.4620 | 1.012 | 3.460 | 0.6943 |
#> |.....................| 1.255 | 1.953 | 2.685 |...........|
#> | X| 116.80387 | 1.587 | 2.751 | 31.83 | 0.6943 |
#> |.....................| 1.255 | 1.953 | 2.685 |...........|
#> | 72| 116.80361 | -0.9776 | -0.6141 | 1.010 | -0.8435 |
#> |.....................| -0.4326 | 0.05049 | 0.4002 |...........|
#> | U| 116.80361 | 0.4624 | 1.012 | 3.460 | 0.6943 |
#> |.....................| 1.255 | 1.953 | 2.687 |...........|
#> | X| 116.80361 | 1.588 | 2.750 | 31.81 | 0.6943 |
#> |.....................| 1.255 | 1.953 | 2.687 |...........|
#> | 73| 116.80362 | -0.9763 | -0.6143 | 1.010 | -0.8430 |
#> |.....................| -0.4320 | 0.05061 | 0.4006 |...........|
#> | U| 116.80362 | 0.4637 | 1.011 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.953 | 2.688 |...........|
#> | X| 116.80362 | 1.590 | 2.749 | 31.82 | 0.6945 |
#> |.....................| 1.256 | 1.953 | 2.688 |...........|
#> | 74| 116.80348 | -0.9771 | -0.6138 | 1.010 | -0.8437 |
#> |.....................| -0.4324 | 0.04924 | 0.4003 |...........|
#> | U| 116.80348 | 0.4629 | 1.012 | 3.460 | 0.6942 |
#> |.....................| 1.255 | 1.951 | 2.687 |...........|
#> | X| 116.80348 | 1.589 | 2.751 | 31.81 | 0.6942 |
#> |.....................| 1.255 | 1.951 | 2.687 |...........|
#> | 75| 116.80350 | -0.9763 | -0.6136 | 1.009 | -0.8441 |
#> |.....................| -0.4323 | 0.04892 | 0.4002 |...........|
#> | U| 116.8035 | 0.4637 | 1.012 | 3.459 | 0.6941 |
#> |.....................| 1.256 | 1.950 | 2.687 |...........|
#> | X| 116.8035 | 1.590 | 2.751 | 31.80 | 0.6941 |
#> |.....................| 1.256 | 1.950 | 2.687 |...........|
#> | 76| 116.80344 | -0.9767 | -0.6135 | 1.010 | -0.8434 |
#> |.....................| -0.4322 | 0.04911 | 0.4003 |...........|
#> | U| 116.80344 | 0.4633 | 1.012 | 3.460 | 0.6943 |
#> |.....................| 1.256 | 1.951 | 2.687 |...........|
#> | X| 116.80344 | 1.589 | 2.751 | 31.80 | 0.6943 |
#> |.....................| 1.256 | 1.951 | 2.687 |...........|
#> | 77| 116.80344 | -0.9764 | -0.6136 | 1.010 | -0.8433 |
#> |.....................| -0.4320 | 0.04910 | 0.4001 |...........|
#> | U| 116.80344 | 0.4636 | 1.012 | 3.460 | 0.6944 |
#> |.....................| 1.256 | 1.951 | 2.687 |...........|
#> | X| 116.80344 | 1.590 | 2.751 | 31.81 | 0.6944 |
#> |.....................| 1.256 | 1.951 | 2.687 |...........|
#> | 78| 116.80343 | -0.9764 | -0.6136 | 1.010 | -0.8433 |
#> |.....................| -0.4320 | 0.04909 | 0.4002 |...........|
#> | U| 116.80343 | 0.4636 | 1.012 | 3.460 | 0.6944 |
#> |.....................| 1.256 | 1.951 | 2.687 |...........|
#> | X| 116.80343 | 1.590 | 2.751 | 31.81 | 0.6944 |
#> |.....................| 1.256 | 1.951 | 2.687 |...........|
#> | 79| 116.80326 | -0.9763 | -0.6136 | 1.010 | -0.8431 |
#> |.....................| -0.4323 | 0.04897 | 0.4002 |...........|
#> | U| 116.80326 | 0.4637 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.950 | 2.687 |...........|
#> | X| 116.80326 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.256 | 1.950 | 2.687 |...........|
#> | 80| 116.80346 | -0.9758 | -0.6138 | 1.010 | -0.8427 |
#> |.....................| -0.4327 | 0.04871 | 0.4004 |...........|
#> | U| 116.80346 | 0.4642 | 1.012 | 3.460 | 0.6946 |
#> |.....................| 1.255 | 1.950 | 2.687 |...........|
#> | X| 116.80346 | 1.591 | 2.751 | 31.81 | 0.6946 |
#> |.....................| 1.255 | 1.950 | 2.687 |...........|
#> | 81| 116.80342 | -0.9761 | -0.6136 | 1.010 | -0.8431 |
#> |.....................| -0.4323 | 0.04875 | 0.4005 |...........|
#> | U| 116.80342 | 0.4639 | 1.012 | 3.460 | 0.6944 |
#> |.....................| 1.256 | 1.950 | 2.688 |...........|
#> | X| 116.80342 | 1.590 | 2.751 | 31.81 | 0.6944 |
#> |.....................| 1.256 | 1.950 | 2.688 |...........|
#> | 82| 116.80346 | -0.9762 | -0.6136 | 1.010 | -0.8430 |
#> |.....................| -0.4324 | 0.04894 | 0.3999 |...........|
#> | U| 116.80346 | 0.4638 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.950 | 2.686 |...........|
#> | X| 116.80346 | 1.590 | 2.751 | 31.80 | 0.6945 |
#> |.....................| 1.256 | 1.950 | 2.686 |...........|
#> | 83| 116.80343 | -0.9763 | -0.6137 | 1.010 | -0.8430 |
#> |.....................| -0.4322 | 0.04891 | 0.4003 |...........|
#> | U| 116.80343 | 0.4637 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.950 | 2.687 |...........|
#> | X| 116.80343 | 1.590 | 2.751 | 31.80 | 0.6945 |
#> |.....................| 1.256 | 1.950 | 2.687 |...........|
#> | 84| 116.80343 | -0.9762 | -0.6137 | 1.010 | -0.8430 |
#> |.....................| -0.4323 | 0.04912 | 0.4002 |...........|
#> | U| 116.80343 | 0.4638 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.951 | 2.687 |...........|
#> | X| 116.80343 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.256 | 1.951 | 2.687 |...........|
#> | 85| 116.80343 | -0.9762 | -0.6136 | 1.010 | -0.8431 |
#> |.....................| -0.4323 | 0.04900 | 0.4002 |...........|
#> | U| 116.80343 | 0.4638 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.951 | 2.687 |...........|
#> | X| 116.80343 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.256 | 1.951 | 2.687 |...........|
#> | 86| 116.80343 | -0.9763 | -0.6136 | 1.010 | -0.8431 |
#> |.....................| -0.4323 | 0.04889 | 0.4002 |...........|
#> | U| 116.80343 | 0.4637 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.950 | 2.687 |...........|
#> | X| 116.80343 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.256 | 1.950 | 2.687 |...........|
#> | 87| 116.80343 | -0.9762 | -0.6137 | 1.010 | -0.8430 |
#> |.....................| -0.4323 | 0.04890 | 0.4002 |...........|
#> | U| 116.80343 | 0.4638 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.950 | 2.687 |...........|
#> | X| 116.80343 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.256 | 1.950 | 2.687 |...........|
#> | 88| 116.80349 | -0.9763 | -0.6137 | 1.010 | -0.8431 |
#> |.....................| -0.4323 | 0.04898 | 0.4002 |...........|
#> | U| 116.80349 | 0.4637 | 1.012 | 3.460 | 0.6944 |
#> |.....................| 1.256 | 1.951 | 2.687 |...........|
#> | X| 116.80349 | 1.590 | 2.751 | 31.81 | 0.6944 |
#> |.....................| 1.256 | 1.951 | 2.687 |...........|
#> | 89| 116.80343 | -0.9764 | -0.6137 | 1.010 | -0.8431 |
#> |.....................| -0.4323 | 0.04901 | 0.4002 |...........|
#> | U| 116.80343 | 0.4636 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.951 | 2.687 |...........|
#> | X| 116.80343 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.256 | 1.951 | 2.687 |...........|
#> | 90| 116.80342 | -0.9763 | -0.6136 | 1.010 | -0.8431 |
#> |.....................| -0.4323 | 0.04897 | 0.4003 |...........|
#> | U| 116.80342 | 0.4637 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.950 | 2.687 |...........|
#> | X| 116.80342 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.256 | 1.950 | 2.687 |...........|
#> | 91| 116.80343 | -0.9763 | -0.6136 | 1.010 | -0.8431 |
#> |.....................| -0.4323 | 0.04888 | 0.4002 |...........|
#> | U| 116.80343 | 0.4637 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.950 | 2.687 |...........|
#> | X| 116.80343 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.256 | 1.950 | 2.687 |...........|
#> | 92| 116.80344 | -0.9763 | -0.6137 | 1.010 | -0.8430 |
#> |.....................| -0.4323 | 0.04900 | 0.4002 |...........|
#> | U| 116.80344 | 0.4637 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.951 | 2.687 |...........|
#> | X| 116.80344 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.256 | 1.951 | 2.687 |...........|
#> | 93| 116.80342 | -0.9763 | -0.6136 | 1.010 | -0.8432 |
#> |.....................| -0.4323 | 0.04896 | 0.4002 |...........|
#> | U| 116.80342 | 0.4637 | 1.012 | 3.460 | 0.6944 |
#> |.....................| 1.256 | 1.950 | 2.687 |...........|
#> | X| 116.80342 | 1.590 | 2.751 | 31.81 | 0.6944 |
#> |.....................| 1.256 | 1.950 | 2.687 |...........|
#> | 94| 116.80391 | -0.9763 | -0.6136 | 1.010 | -0.8431 |
#> |.....................| -0.4323 | 0.04899 | 0.4002 |...........|
#> | U| 116.80391 | 0.4637 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.951 | 2.687 |...........|
#> | X| 116.80391 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.256 | 1.951 | 2.687 |...........|
#> | 95| 116.80314 | -0.9763 | -0.6136 | 1.010 | -0.8431 |
#> |.....................| -0.4323 | 0.04897 | 0.4002 |...........|
#> | U| 116.80314 | 0.4637 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.950 | 2.687 |...........|
#> | X| 116.80314 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.256 | 1.950 | 2.687 |...........|
#> calculating covariance matrix
#> done
#> Calculating residuals/tables
#> done
#> Warning: initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))
#> Warning: ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))
#> Warning: gradient problems with covariance; see $scaleInfo
## You may also make an arbitrary optimizer work by adding a wrapper function:
newuoa0 <- function(par, fn, gr, lower = -Inf, upper = Inf, control = list(), ...){
## The function requires par, fn, gr, lower, upper and control
##
## The par, fn, gr, lower and upper and sent to the function from nlmixr's focei.
## The control is the foceiControl list
##
## The following code modifies the list control list for no warnings.
.ctl <- control;
if (is.null(.ctl$npt)) .ctl$npt <- length(par) * 2 + 1
## nlmixr will print information this is to suppress the printing from the
## optimizer
.ctl$iprint <- 0L;
.ctl <- .ctl[names(.ctl) %in% c("npt", "rhobeg", "rhoend", "iprint", "maxfun")];
## This does not require gradient and is an unbounded optimization:
.ret <- minqa::newuoa(par, fn, control=.ctl);
## The return statement must be a list with:
## - x for the final parameter message
## - message for a minimization message
## - convergence for a convergence code
.ret$x <- .ret$par;
.ret$message <- .ret$msg;
.ret$convergence <- .ret$ierr
## you can access the final list from the optimization by fit$optReturn
return(.ret);
}
fit <- nlmixr(one.cmt, theo_sd, "focei", foceiControl(outerOpt=newuoa0))
#> ℹ parameter labels from comments will be replaced by 'label()'
#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
#> F: Forward difference gradient approximation
#> C: Central difference gradient approximation
#> M: Mixed forward and central difference gradient approximation
#> Unscaled parameters for Omegas=chol(solve(omega));
#> Diagonals are transformed, as specified by foceiControl(diagXform=)
#> |-----+---------------+-----------+-----------+-----------+-----------|
#> | #| Objective Fun | tka | tcl | tv | add.err |
#> |.....................| o1 | o2 | o3 |...........|
#> | 1| 133.58639 | -1.000 | -0.6324 | 1.000 | -0.8272 |
#> |.....................| -0.5374 | -0.3946 | -0.1108 |...........|
#> | U| 133.58639 | 0.4400 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 133.58639 | 1.553 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | 2| 133.58639 | -1.000 | -0.6324 | 1.000 | -0.8272 |
#> |.....................| -0.5374 | -0.3946 | -0.1108 |...........|
#> | U| 133.58639 | 0.4400 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 133.58639 | 1.553 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | 3| 134.07361 | -0.8000 | -0.6324 | 1.000 | -0.8272 |
#> |.....................| -0.5374 | -0.3946 | -0.1108 |...........|
#> | U| 134.07361 | 0.6400 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 134.07361 | 1.896 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | 4| 134.78512 | -1.000 | -0.4324 | 1.000 | -0.8272 |
#> |.....................| -0.5374 | -0.3946 | -0.1108 |...........|
#> | U| 134.78512 | 0.4400 | 1.193 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 134.78512 | 1.553 | 3.298 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | 5| 137.47499 | -1.000 | -0.6324 | 1.200 | -0.8272 |
#> |.....................| -0.5374 | -0.3946 | -0.1108 |...........|
#> | U| 137.47499 | 0.4400 | 0.9933 | 3.650 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 137.47499 | 1.553 | 2.700 | 38.47 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | 6| 135.53466 | -1.000 | -0.6324 | 1.000 | -0.6272 |
#> |.....................| -0.5374 | -0.3946 | -0.1108 |...........|
#> | U| 135.53466 | 0.4400 | 0.9933 | 3.450 | 0.7700 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 135.53466 | 1.553 | 2.700 | 31.50 | 0.7700 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | 7| 133.69855 | -1.000 | -0.6324 | 1.000 | -0.8272 |
#> |.....................| -0.3374 | -0.3946 | -0.1108 |...........|
#> | U| 133.69855 | 0.4400 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.363 | 1.351 | 1.778 |...........|
#> | X| 133.69855 | 1.553 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.363 | 1.351 | 1.778 |...........|
#> | 8| 128.07696 | -1.000 | -0.6324 | 1.000 | -0.8272 |
#> |.....................| -0.5374 | -0.1946 | -0.1108 |...........|
#> | U| 128.07696 | 0.4400 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.621 | 1.778 |...........|
#> | X| 128.07696 | 1.553 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.621 | 1.778 |...........|
#> | 9| 128.14520 | -1.000 | -0.6324 | 1.000 | -0.8272 |
#> |.....................| -0.5374 | -0.3946 | 0.08922 |...........|
#> | U| 128.1452 | 0.4400 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 2.134 |...........|
#> | X| 128.1452 | 1.553 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 2.134 |...........|
#> | 10| 134.59979 | -1.200 | -0.6324 | 1.000 | -0.8272 |
#> |.....................| -0.5374 | -0.3946 | -0.1108 |...........|
#> | U| 134.59979 | 0.2400 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 134.59979 | 1.271 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | 11| 135.43950 | -1.000 | -0.8324 | 1.000 | -0.8272 |
#> |.....................| -0.5374 | -0.3946 | -0.1108 |...........|
#> | U| 135.4395 | 0.4400 | 0.7933 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 135.4395 | 1.553 | 2.211 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | 12| 138.67902 | -1.000 | -0.6324 | 0.8000 | -0.8272 |
#> |.....................| -0.5374 | -0.3946 | -0.1108 |...........|
#> | U| 138.67902 | 0.4400 | 0.9933 | 3.250 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 138.67902 | 1.553 | 2.700 | 25.79 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | 13| 135.58963 | -1.000 | -0.6324 | 1.000 | -1.027 |
#> |.....................| -0.5374 | -0.3946 | -0.1108 |...........|
#> | U| 135.58963 | 0.4400 | 0.9933 | 3.450 | 0.6300 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 135.58963 | 1.553 | 2.700 | 31.50 | 0.6300 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | 14| 138.56769 | -1.000 | -0.6324 | 1.000 | -0.8272 |
#> |.....................| -0.7374 | -0.3946 | -0.1108 |...........|
#> | U| 138.56769 | 0.4400 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 0.9090 | 1.351 | 1.778 |...........|
#> | X| 138.56769 | 1.553 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 0.9090 | 1.351 | 1.778 |...........|
#> | 15| 142.37620 | -1.000 | -0.6324 | 1.000 | -0.8272 |
#> |.....................| -0.5374 | -0.5946 | -0.1108 |...........|
#> | U| 142.3762 | 0.4400 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.081 | 1.778 |...........|
#> | X| 142.3762 | 1.553 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.081 | 1.778 |...........|
#> | 16| 142.26587 | -1.000 | -0.6324 | 1.000 | -0.8272 |
#> |.....................| -0.5374 | -0.3946 | -0.3108 |...........|
#> | U| 142.26587 | 0.4400 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.423 |...........|
#> | X| 142.26587 | 1.553 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.423 |...........|
#> | 17| 121.40007 | -0.9938 | -0.6246 | 1.014 | -0.8266 |
#> |.....................| -0.4797 | -0.1029 | 0.05647 |...........|
#> | U| 121.40007 | 0.4462 | 1.001 | 3.464 | 0.7002 |
#> |.....................| 1.202 | 1.745 | 2.076 |...........|
#> | X| 121.40007 | 1.562 | 2.721 | 31.95 | 0.7002 |
#> |.....................| 1.202 | 1.745 | 2.076 |...........|
#> | 18| 117.00301 | -0.9762 | -0.6116 | 1.014 | -0.8258 |
#> |.....................| -0.4438 | 0.03709 | 0.3197 |...........|
#> | U| 117.00301 | 0.4638 | 1.014 | 3.464 | 0.7005 |
#> |.....................| 1.243 | 1.934 | 2.544 |...........|
#> | X| 117.00301 | 1.590 | 2.757 | 31.96 | 0.7005 |
#> |.....................| 1.243 | 1.934 | 2.544 |...........|
#> | 19| 117.97899 | -0.9819 | -0.6163 | 1.013 | -0.8261 |
#> |.....................| -0.4614 | 0.2268 | 0.2593 |...........|
#> | U| 117.97899 | 0.4581 | 1.009 | 3.463 | 0.7004 |
#> |.....................| 1.223 | 2.191 | 2.436 |...........|
#> | X| 117.97899 | 1.581 | 2.744 | 31.90 | 0.7004 |
#> |.....................| 1.223 | 2.191 | 2.436 |...........|
#> | 20| 119.20639 | -0.9803 | -0.6106 | 1.033 | -0.8255 |
#> |.....................| -0.2474 | 0.06878 | 0.3121 |...........|
#> | U| 119.20639 | 0.4597 | 1.015 | 3.483 | 0.7006 |
#> |.....................| 1.466 | 1.977 | 2.530 |...........|
#> | X| 119.20639 | 1.584 | 2.760 | 32.55 | 0.7006 |
#> |.....................| 1.466 | 1.977 | 2.530 |...........|
#> | 21| 118.15782 | -1.176 | -0.6114 | 1.022 | -0.8257 |
#> |.....................| -0.4424 | 0.04761 | 0.3201 |...........|
#> | U| 118.15782 | 0.2643 | 1.014 | 3.472 | 0.7005 |
#> |.....................| 1.244 | 1.949 | 2.545 |...........|
#> | X| 118.15782 | 1.302 | 2.757 | 32.21 | 0.7005 |
#> |.....................| 1.244 | 1.949 | 2.545 |...........|
#> | 22| 122.51031 | -0.9776 | -0.8110 | 1.024 | -0.8257 |
#> |.....................| -0.4397 | 0.04890 | 0.3170 |...........|
#> | U| 122.51031 | 0.4624 | 0.8147 | 3.474 | 0.7005 |
#> |.....................| 1.247 | 1.950 | 2.539 |...........|
#> | X| 122.51031 | 1.588 | 2.258 | 32.26 | 0.7005 |
#> |.....................| 1.247 | 1.950 | 2.539 |...........|
#> | 23| 122.50248 | -0.9470 | -0.4308 | 1.005 | -0.8261 |
#> |.....................| -0.4292 | 0.1018 | 0.3639 |...........|
#> | U| 122.50248 | 0.4930 | 1.195 | 3.455 | 0.7004 |
#> |.....................| 1.259 | 2.022 | 2.622 |...........|
#> | X| 122.50248 | 1.637 | 3.303 | 31.67 | 0.7004 |
#> |.....................| 1.259 | 2.022 | 2.622 |...........|
#> | 24| 132.61810 | -0.9821 | -0.6217 | 0.8159 | -0.8259 |
#> |.....................| -0.4393 | 0.04882 | 0.3361 |...........|
#> | U| 132.6181 | 0.4579 | 1.004 | 3.266 | 0.7005 |
#> |.....................| 1.248 | 1.950 | 2.573 |...........|
#> | X| 132.6181 | 1.581 | 2.729 | 26.20 | 0.7005 |
#> |.....................| 1.248 | 1.950 | 2.573 |...........|
#> | 25| 131.84882 | -0.9594 | -0.6096 | 1.190 | -0.8230 |
#> |.....................| -0.4573 | 0.1057 | 0.3837 |...........|
#> | U| 131.84882 | 0.4806 | 1.016 | 3.640 | 0.7015 |
#> |.....................| 1.227 | 2.027 | 2.658 |...........|
#> | X| 131.84882 | 1.617 | 2.762 | 38.08 | 0.7015 |
#> |.....................| 1.227 | 2.027 | 2.658 |...........|
#> | 26| 118.90855 | -0.9762 | -0.6119 | 1.016 | -1.026 |
#> |.....................| -0.4437 | 0.03728 | 0.3206 |...........|
#> | U| 118.90855 | 0.4638 | 1.014 | 3.466 | 0.6305 |
#> |.....................| 1.243 | 1.935 | 2.545 |...........|
#> | X| 118.90855 | 1.590 | 2.756 | 32.00 | 0.6305 |
#> |.....................| 1.243 | 1.935 | 2.545 |...........|
#> | 27| 119.49288 | -0.9125 | -0.5652 | 1.041 | -0.7942 |
#> |.....................| -0.3778 | -0.1089 | 0.2398 |...........|
#> | U| 119.49288 | 0.5275 | 1.060 | 3.491 | 0.7116 |
#> |.....................| 1.318 | 1.737 | 2.402 |...........|
#> | X| 119.49288 | 1.695 | 2.888 | 32.83 | 0.7116 |
#> |.....................| 1.318 | 1.737 | 2.402 |...........|
#> | 28| 119.58825 | -0.9609 | -0.7320 | 1.008 | -0.8260 |
#> |.....................| -0.4101 | 0.1353 | 0.4400 |...........|
#> | U| 119.58825 | 0.4791 | 0.8936 | 3.458 | 0.7004 |
#> |.....................| 1.281 | 2.067 | 2.758 |...........|
#> | X| 119.58825 | 1.615 | 2.444 | 31.75 | 0.7004 |
#> |.....................| 1.281 | 2.067 | 2.758 |...........|
#> | 29| 118.85593 | -0.8264 | -0.6531 | 0.9943 | -0.8370 |
#> |.....................| -0.5008 | -0.02990 | 0.2326 |...........|
#> | U| 118.85593 | 0.6136 | 0.9725 | 3.444 | 0.6966 |
#> |.....................| 1.178 | 1.844 | 2.389 |...........|
#> | X| 118.85593 | 1.847 | 2.645 | 31.32 | 0.6966 |
#> |.....................| 1.178 | 1.844 | 2.389 |...........|
#> | 30| 122.37222 | -0.9681 | -0.5015 | 1.088 | -0.7881 |
#> |.....................| -0.5412 | -0.03281 | 0.2382 |...........|
#> | U| 122.37222 | 0.4719 | 1.124 | 3.538 | 0.7137 |
#> |.....................| 1.132 | 1.840 | 2.399 |...........|
#> | X| 122.37222 | 1.603 | 3.077 | 34.39 | 0.7137 |
#> |.....................| 1.132 | 1.840 | 2.399 |...........|
#> | 31| 118.95207 | -1.002 | -0.6469 | 0.9969 | -0.8366 |
#> |.....................| -0.5211 | -0.1406 | 0.3316 |...........|
#> | U| 118.95207 | 0.4385 | 0.9788 | 3.447 | 0.6967 |
#> |.....................| 1.155 | 1.694 | 2.565 |...........|
#> | X| 118.95207 | 1.550 | 2.661 | 31.40 | 0.6967 |
#> |.....................| 1.155 | 1.694 | 2.565 |...........|
#> | 32| 117.03066 | -1.026 | -0.6111 | 1.008 | -0.8311 |
#> |.....................| -0.4250 | 0.1083 | 0.3490 |...........|
#> | U| 117.03066 | 0.4137 | 1.015 | 3.458 | 0.6987 |
#> |.....................| 1.264 | 2.031 | 2.596 |...........|
#> | X| 117.03066 | 1.512 | 2.758 | 31.74 | 0.6987 |
#> |.....................| 1.264 | 2.031 | 2.596 |...........|
#> | 33| 117.00311 | -0.9687 | -0.5963 | 1.011 | -0.8262 |
#> |.....................| -0.4423 | 0.03819 | 0.3296 |...........|
#> | U| 117.00311 | 0.4713 | 1.029 | 3.461 | 0.7004 |
#> |.....................| 1.244 | 1.936 | 2.561 |...........|
#> | X| 117.00311 | 1.602 | 2.799 | 31.86 | 0.7004 |
#> |.....................| 1.244 | 1.936 | 2.561 |...........|
#> | 34| 116.89584 | -0.9773 | -0.6079 | 1.007 | -0.8367 |
#> |.....................| -0.4402 | 0.07412 | 0.3451 |...........|
#> | U| 116.89584 | 0.4627 | 1.018 | 3.457 | 0.6967 |
#> |.....................| 1.247 | 1.984 | 2.589 |...........|
#> | X| 116.89584 | 1.588 | 2.767 | 31.72 | 0.6967 |
#> |.....................| 1.247 | 1.984 | 2.589 |...........|
#> | 35| 116.94851 | -0.9604 | -0.6080 | 1.004 | -0.8377 |
#> |.....................| -0.4485 | 0.09295 | 0.3471 |...........|
#> | U| 116.94851 | 0.4796 | 1.018 | 3.454 | 0.6964 |
#> |.....................| 1.237 | 2.010 | 2.593 |...........|
#> | X| 116.94851 | 1.615 | 2.767 | 31.63 | 0.6964 |
#> |.....................| 1.237 | 2.010 | 2.593 |...........|
#> | 36| 116.88213 | -0.9804 | -0.6105 | 1.006 | -0.8385 |
#> |.....................| -0.4527 | 0.06685 | 0.3582 |...........|
#> | U| 116.88213 | 0.4596 | 1.015 | 3.456 | 0.6961 |
#> |.....................| 1.232 | 1.975 | 2.612 |...........|
#> | X| 116.88213 | 1.583 | 2.760 | 31.68 | 0.6961 |
#> |.....................| 1.232 | 1.975 | 2.612 |...........|
#> | 37| 116.86150 | -0.9920 | -0.6068 | 1.009 | -0.8460 |
#> |.....................| -0.4442 | 0.05638 | 0.3600 |...........|
#> | U| 116.8615 | 0.4480 | 1.019 | 3.459 | 0.6934 |
#> |.....................| 1.242 | 1.960 | 2.615 |...........|
#> | X| 116.8615 | 1.565 | 2.770 | 31.78 | 0.6934 |
#> |.....................| 1.242 | 1.960 | 2.615 |...........|
#> | 38| 116.88138 | -1.007 | -0.6055 | 1.010 | -0.8395 |
#> |.....................| -0.4416 | 0.04492 | 0.3619 |...........|
#> | U| 116.88138 | 0.4335 | 1.020 | 3.460 | 0.6957 |
#> |.....................| 1.245 | 1.945 | 2.619 |...........|
#> | X| 116.88138 | 1.543 | 2.774 | 31.83 | 0.6957 |
#> |.....................| 1.245 | 1.945 | 2.619 |...........|
#> | 39| 116.87044 | -0.9870 | -0.6252 | 1.011 | -0.8440 |
#> |.....................| -0.4417 | 0.05188 | 0.3584 |...........|
#> | U| 116.87044 | 0.4530 | 1.000 | 3.461 | 0.6941 |
#> |.....................| 1.245 | 1.954 | 2.613 |...........|
#> | X| 116.87044 | 1.573 | 2.719 | 31.84 | 0.6941 |
#> |.....................| 1.245 | 1.954 | 2.613 |...........|
#> | 40| 116.84641 | -0.9809 | -0.6139 | 1.009 | -0.8525 |
#> |.....................| -0.4368 | 0.04499 | 0.3611 |...........|
#> | U| 116.84641 | 0.4591 | 1.012 | 3.459 | 0.6912 |
#> |.....................| 1.251 | 1.945 | 2.617 |...........|
#> | X| 116.84641 | 1.583 | 2.751 | 31.79 | 0.6912 |
#> |.....................| 1.251 | 1.945 | 2.617 |...........|
#> | 41| 116.86758 | -0.9818 | -0.6136 | 1.012 | -0.8503 |
#> |.....................| -0.4180 | 0.04838 | 0.3567 |...........|
#> | U| 116.86758 | 0.4582 | 1.012 | 3.462 | 0.6919 |
#> |.....................| 1.272 | 1.950 | 2.610 |...........|
#> | X| 116.86758 | 1.581 | 2.751 | 31.89 | 0.6919 |
#> |.....................| 1.272 | 1.950 | 2.610 |...........|
#> | 42| 117.03264 | -0.9843 | -0.6160 | 0.9903 | -0.8543 |
#> |.....................| -0.4353 | 0.04478 | 0.3568 |...........|
#> | U| 117.03264 | 0.4557 | 1.010 | 3.440 | 0.6905 |
#> |.....................| 1.252 | 1.945 | 2.610 |...........|
#> | X| 117.03264 | 1.577 | 2.744 | 31.20 | 0.6905 |
#> |.....................| 1.252 | 1.945 | 2.610 |...........|
#> | 43| 116.97821 | -0.9779 | -0.6125 | 1.028 | -0.8494 |
#> |.....................| -0.4387 | 0.04871 | 0.3643 |...........|
#> | U| 116.97821 | 0.4621 | 1.013 | 3.478 | 0.6923 |
#> |.....................| 1.248 | 1.950 | 2.623 |...........|
#> | X| 116.97821 | 1.587 | 2.754 | 32.40 | 0.6923 |
#> |.....................| 1.248 | 1.950 | 2.623 |...........|
#> | 44| 116.89508 | -0.9822 | -0.6144 | 1.012 | -0.8707 |
#> |.....................| -0.4385 | 0.04515 | 0.3536 |...........|
#> | U| 116.89508 | 0.4578 | 1.011 | 3.462 | 0.6848 |
#> |.....................| 1.249 | 1.945 | 2.604 |...........|
#> | X| 116.89508 | 1.581 | 2.749 | 31.87 | 0.6848 |
#> |.....................| 1.249 | 1.945 | 2.604 |...........|
#> | 45| 116.83559 | -0.9760 | -0.6223 | 1.008 | -0.8515 |
#> |.....................| -0.4320 | 0.05378 | 0.3753 |...........|
#> | U| 116.83559 | 0.4640 | 1.003 | 3.458 | 0.6915 |
#> |.....................| 1.256 | 1.957 | 2.643 |...........|
#> | X| 116.83559 | 1.590 | 2.727 | 31.74 | 0.6915 |
#> |.....................| 1.256 | 1.957 | 2.643 |...........|
#> | 46| 116.84603 | -0.9925 | -0.6213 | 1.008 | -0.8500 |
#> |.....................| -0.4312 | 0.06459 | 0.3726 |...........|
#> | U| 116.84603 | 0.4475 | 1.004 | 3.458 | 0.6921 |
#> |.....................| 1.257 | 1.972 | 2.638 |...........|
#> | X| 116.84603 | 1.564 | 2.730 | 31.75 | 0.6921 |
#> |.....................| 1.257 | 1.972 | 2.638 |...........|
#> | 47| 116.81726 | -0.9801 | -0.6157 | 1.008 | -0.8500 |
#> |.....................| -0.4354 | 0.05206 | 0.3803 |...........|
#> | U| 116.81726 | 0.4599 | 1.010 | 3.458 | 0.6920 |
#> |.....................| 1.252 | 1.955 | 2.652 |...........|
#> | X| 116.81726 | 1.584 | 2.745 | 31.76 | 0.6920 |
#> |.....................| 1.252 | 1.955 | 2.652 |...........|
#> | 48| 116.81240 | -0.9859 | -0.6145 | 1.008 | -0.8502 |
#> |.....................| -0.4381 | 0.04621 | 0.3983 |...........|
#> | U| 116.8124 | 0.4541 | 1.011 | 3.458 | 0.6920 |
#> |.....................| 1.249 | 1.947 | 2.683 |...........|
#> | X| 116.8124 | 1.575 | 2.749 | 31.75 | 0.6920 |
#> |.....................| 1.249 | 1.947 | 2.683 |...........|
#> | 49| 116.82613 | -0.9831 | -0.6167 | 1.006 | -0.8539 |
#> |.....................| -0.4325 | 0.05876 | 0.4117 |...........|
#> | U| 116.82613 | 0.4569 | 1.009 | 3.456 | 0.6907 |
#> |.....................| 1.255 | 1.964 | 2.707 |...........|
#> | X| 116.82613 | 1.579 | 2.743 | 31.69 | 0.6907 |
#> |.....................| 1.255 | 1.964 | 2.707 |...........|
#> | 50| 116.83090 | -0.9931 | -0.6075 | 1.009 | -0.8546 |
#> |.....................| -0.4356 | 0.03221 | 0.4071 |...........|
#> | U| 116.8309 | 0.4469 | 1.018 | 3.459 | 0.6904 |
#> |.....................| 1.252 | 1.928 | 2.699 |...........|
#> | X| 116.8309 | 1.564 | 2.768 | 31.79 | 0.6904 |
#> |.....................| 1.252 | 1.928 | 2.699 |...........|
#> | 51| 116.84654 | -0.9837 | -0.6138 | 1.011 | -0.8677 |
#> |.....................| -0.4460 | 0.04931 | 0.3962 |...........|
#> | U| 116.84654 | 0.4563 | 1.012 | 3.461 | 0.6858 |
#> |.....................| 1.240 | 1.951 | 2.680 |...........|
#> | X| 116.84654 | 1.578 | 2.751 | 31.85 | 0.6858 |
#> |.....................| 1.240 | 1.951 | 2.680 |...........|
#> | 52| 116.84884 | -0.9870 | -0.6155 | 1.004 | -0.8399 |
#> |.....................| -0.4526 | 0.05292 | 0.4029 |...........|
#> | U| 116.84884 | 0.4530 | 1.010 | 3.454 | 0.6956 |
#> |.....................| 1.233 | 1.956 | 2.692 |...........|
#> | X| 116.84884 | 1.573 | 2.746 | 31.63 | 0.6956 |
#> |.....................| 1.233 | 1.956 | 2.692 |...........|
#> | 53| 116.81983 | -0.9806 | -0.6085 | 1.012 | -0.8462 |
#> |.....................| -0.4214 | 0.04483 | 0.3933 |...........|
#> | U| 116.81983 | 0.4594 | 1.017 | 3.462 | 0.6934 |
#> |.....................| 1.268 | 1.945 | 2.675 |...........|
#> | X| 116.81983 | 1.583 | 2.765 | 31.87 | 0.6934 |
#> |.....................| 1.268 | 1.945 | 2.675 |...........|
#> | 54| 116.80742 | -0.9818 | -0.6121 | 1.008 | -0.8461 |
#> |.....................| -0.4307 | 0.04842 | 0.3961 |...........|
#> | U| 116.80742 | 0.4582 | 1.014 | 3.458 | 0.6934 |
#> |.....................| 1.257 | 1.950 | 2.680 |...........|
#> | X| 116.80742 | 1.581 | 2.755 | 31.74 | 0.6934 |
#> |.....................| 1.257 | 1.950 | 2.680 |...........|
#> | 55| 116.83473 | -0.9946 | -0.6112 | 1.004 | -0.8424 |
#> |.....................| -0.4316 | 0.04859 | 0.3816 |...........|
#> | U| 116.83473 | 0.4454 | 1.014 | 3.454 | 0.6947 |
#> |.....................| 1.256 | 1.950 | 2.654 |...........|
#> | X| 116.83473 | 1.561 | 2.758 | 31.64 | 0.6947 |
#> |.....................| 1.256 | 1.950 | 2.654 |...........|
#> | 56| 116.98088 | -0.9794 | -0.6091 | 0.9906 | -0.8511 |
#> |.....................| -0.4301 | 0.04157 | 0.3914 |...........|
#> | U| 116.98088 | 0.4606 | 1.017 | 3.441 | 0.6917 |
#> |.....................| 1.258 | 1.940 | 2.671 |...........|
#> | X| 116.98088 | 1.585 | 2.764 | 31.21 | 0.6917 |
#> |.....................| 1.258 | 1.940 | 2.671 |...........|
#> | 57| 116.83011 | -0.9822 | -0.6215 | 1.008 | -0.8360 |
#> |.....................| -0.4374 | 0.04153 | 0.3854 |...........|
#> | U| 116.83011 | 0.4578 | 1.004 | 3.458 | 0.6969 |
#> |.....................| 1.250 | 1.940 | 2.661 |...........|
#> | X| 116.83011 | 1.581 | 2.730 | 31.74 | 0.6969 |
#> |.....................| 1.250 | 1.940 | 2.661 |...........|
#> | 58| 116.81303 | -0.9734 | -0.6141 | 1.007 | -0.8446 |
#> |.....................| -0.4267 | 0.04121 | 0.4120 |...........|
#> | U| 116.81303 | 0.4666 | 1.012 | 3.457 | 0.6939 |
#> |.....................| 1.262 | 1.940 | 2.708 |...........|
#> | X| 116.81303 | 1.595 | 2.750 | 31.72 | 0.6939 |
#> |.....................| 1.262 | 1.940 | 2.708 |...........|
#> | 59| 116.80397 | -0.9798 | -0.6133 | 1.009 | -0.8443 |
#> |.....................| -0.4320 | 0.04797 | 0.4014 |...........|
#> | U| 116.80397 | 0.4602 | 1.012 | 3.459 | 0.6940 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | X| 116.80397 | 1.584 | 2.752 | 31.79 | 0.6940 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | 60| 116.80382 | -0.9790 | -0.6134 | 1.009 | -0.8433 |
#> |.....................| -0.4326 | 0.04771 | 0.4034 |...........|
#> | U| 116.80382 | 0.4610 | 1.012 | 3.459 | 0.6944 |
#> |.....................| 1.255 | 1.949 | 2.693 |...........|
#> | X| 116.80382 | 1.586 | 2.752 | 31.80 | 0.6944 |
#> |.....................| 1.255 | 1.949 | 2.693 |...........|
#> | 61| 116.80407 | -0.9790 | -0.6121 | 1.010 | -0.8434 |
#> |.....................| -0.4331 | 0.04764 | 0.4032 |...........|
#> | U| 116.80407 | 0.4610 | 1.014 | 3.460 | 0.6943 |
#> |.....................| 1.255 | 1.949 | 2.692 |...........|
#> | X| 116.80407 | 1.586 | 2.755 | 31.81 | 0.6943 |
#> |.....................| 1.255 | 1.949 | 2.692 |...........|
#> | 62| 116.80365 | -0.9779 | -0.6134 | 1.009 | -0.8430 |
#> |.....................| -0.4325 | 0.04836 | 0.4030 |...........|
#> | U| 116.80365 | 0.4621 | 1.012 | 3.459 | 0.6945 |
#> |.....................| 1.255 | 1.950 | 2.692 |...........|
#> | X| 116.80365 | 1.587 | 2.752 | 31.80 | 0.6945 |
#> |.....................| 1.255 | 1.950 | 2.692 |...........|
#> | 63| 116.80362 | -0.9769 | -0.6134 | 1.009 | -0.8436 |
#> |.....................| -0.4329 | 0.04870 | 0.4024 |...........|
#> | U| 116.80362 | 0.4631 | 1.012 | 3.459 | 0.6943 |
#> |.....................| 1.255 | 1.950 | 2.691 |...........|
#> | X| 116.80362 | 1.589 | 2.752 | 31.79 | 0.6943 |
#> |.....................| 1.255 | 1.950 | 2.691 |...........|
#> | 64| 116.80381 | -0.9769 | -0.6133 | 1.009 | -0.8429 |
#> |.....................| -0.4325 | 0.04959 | 0.4018 |...........|
#> | U| 116.80381 | 0.4631 | 1.012 | 3.459 | 0.6945 |
#> |.....................| 1.255 | 1.951 | 2.690 |...........|
#> | X| 116.80381 | 1.589 | 2.752 | 31.79 | 0.6945 |
#> |.....................| 1.255 | 1.951 | 2.690 |...........|
#> | 65| 116.80488 | -0.9767 | -0.6132 | 1.008 | -0.8436 |
#> |.....................| -0.4327 | 0.04826 | 0.4021 |...........|
#> | U| 116.80488 | 0.4633 | 1.012 | 3.458 | 0.6943 |
#> |.....................| 1.255 | 1.950 | 2.690 |...........|
#> | X| 116.80488 | 1.589 | 2.752 | 31.75 | 0.6943 |
#> |.....................| 1.255 | 1.950 | 2.690 |...........|
#> | 66| 116.80361 | -0.9766 | -0.6138 | 1.010 | -0.8438 |
#> |.....................| -0.4325 | 0.04780 | 0.4031 |...........|
#> | U| 116.80361 | 0.4634 | 1.012 | 3.460 | 0.6942 |
#> |.....................| 1.255 | 1.949 | 2.692 |...........|
#> | X| 116.80361 | 1.590 | 2.751 | 31.81 | 0.6942 |
#> |.....................| 1.255 | 1.949 | 2.692 |...........|
#> | 67| 116.80373 | -0.9765 | -0.6131 | 1.009 | -0.8442 |
#> |.....................| -0.4321 | 0.04840 | 0.4039 |...........|
#> | U| 116.80373 | 0.4635 | 1.013 | 3.459 | 0.6941 |
#> |.....................| 1.256 | 1.950 | 2.694 |...........|
#> | X| 116.80373 | 1.590 | 2.753 | 31.80 | 0.6941 |
#> |.....................| 1.256 | 1.950 | 2.694 |...........|
#> | 68| 116.80366 | -0.9773 | -0.6137 | 1.010 | -0.8438 |
#> |.....................| -0.4334 | 0.04866 | 0.4029 |...........|
#> | U| 116.80366 | 0.4627 | 1.012 | 3.460 | 0.6942 |
#> |.....................| 1.254 | 1.950 | 2.692 |...........|
#> | X| 116.80366 | 1.588 | 2.751 | 31.81 | 0.6942 |
#> |.....................| 1.254 | 1.950 | 2.692 |...........|
#> | 69| 116.80362 | -0.9761 | -0.6137 | 1.010 | -0.8431 |
#> |.....................| -0.4325 | 0.04700 | 0.4024 |...........|
#> | U| 116.80362 | 0.4639 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.255 | 1.948 | 2.691 |...........|
#> | X| 116.80362 | 1.590 | 2.751 | 31.82 | 0.6945 |
#> |.....................| 1.255 | 1.948 | 2.691 |...........|
#> | 70| 116.80349 | -0.9766 | -0.6134 | 1.010 | -0.8433 |
#> |.....................| -0.4329 | 0.04803 | 0.4019 |...........|
#> | U| 116.80349 | 0.4634 | 1.012 | 3.460 | 0.6944 |
#> |.....................| 1.255 | 1.949 | 2.690 |...........|
#> | X| 116.80349 | 1.589 | 2.752 | 31.81 | 0.6944 |
#> |.....................| 1.255 | 1.949 | 2.690 |...........|
#> | 71| 116.80366 | -0.9775 | -0.6134 | 1.010 | -0.8442 |
#> |.....................| -0.4335 | 0.04822 | 0.3995 |...........|
#> | U| 116.80366 | 0.4625 | 1.012 | 3.460 | 0.6941 |
#> |.....................| 1.254 | 1.949 | 2.686 |...........|
#> | X| 116.80366 | 1.588 | 2.752 | 31.81 | 0.6941 |
#> |.....................| 1.254 | 1.949 | 2.686 |...........|
#> | 72| 116.80353 | -0.9757 | -0.6135 | 1.010 | -0.8424 |
#> |.....................| -0.4327 | 0.04826 | 0.4025 |...........|
#> | U| 116.80353 | 0.4643 | 1.012 | 3.460 | 0.6947 |
#> |.....................| 1.255 | 1.950 | 2.691 |...........|
#> | X| 116.80353 | 1.591 | 2.752 | 31.81 | 0.6947 |
#> |.....................| 1.255 | 1.950 | 2.691 |...........|
#> | 73| 116.80355 | -0.9761 | -0.6133 | 1.010 | -0.8429 |
#> |.....................| -0.4331 | 0.04803 | 0.4026 |...........|
#> | U| 116.80355 | 0.4639 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.255 | 1.949 | 2.691 |...........|
#> | X| 116.80355 | 1.590 | 2.752 | 31.81 | 0.6945 |
#> |.....................| 1.255 | 1.949 | 2.691 |...........|
#> | 74| 116.80357 | -0.9778 | -0.6131 | 1.010 | -0.8438 |
#> |.....................| -0.4324 | 0.04798 | 0.4018 |...........|
#> | U| 116.80357 | 0.4622 | 1.013 | 3.460 | 0.6942 |
#> |.....................| 1.256 | 1.949 | 2.690 |...........|
#> | X| 116.80357 | 1.588 | 2.752 | 31.81 | 0.6942 |
#> |.....................| 1.256 | 1.949 | 2.690 |...........|
#> | 75| 116.80378 | -0.9773 | -0.6123 | 1.010 | -0.8433 |
#> |.....................| -0.4333 | 0.04790 | 0.4022 |...........|
#> | U| 116.80378 | 0.4627 | 1.013 | 3.460 | 0.6944 |
#> |.....................| 1.254 | 1.949 | 2.690 |...........|
#> | X| 116.80378 | 1.588 | 2.755 | 31.81 | 0.6944 |
#> |.....................| 1.254 | 1.949 | 2.690 |...........|
#> | 76| 116.80346 | -0.9764 | -0.6136 | 1.010 | -0.8430 |
#> |.....................| -0.4325 | 0.04799 | 0.4017 |...........|
#> | U| 116.80346 | 0.4636 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.255 | 1.949 | 2.690 |...........|
#> | X| 116.80346 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.255 | 1.949 | 2.690 |...........|
#> | 77| 116.80342 | -0.9764 | -0.6136 | 1.010 | -0.8430 |
#> |.....................| -0.4324 | 0.04798 | 0.4016 |...........|
#> | U| 116.80342 | 0.4636 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.255 | 1.949 | 2.689 |...........|
#> | X| 116.80342 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.255 | 1.949 | 2.689 |...........|
#> | 78| 116.80345 | -0.9759 | -0.6134 | 1.010 | -0.8433 |
#> |.....................| -0.4323 | 0.04795 | 0.4014 |...........|
#> | U| 116.80345 | 0.4641 | 1.012 | 3.460 | 0.6944 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | X| 116.80345 | 1.591 | 2.752 | 31.81 | 0.6944 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | 79| 116.80346 | -0.9765 | -0.6137 | 1.010 | -0.8431 |
#> |.....................| -0.4325 | 0.04802 | 0.4015 |...........|
#> | U| 116.80346 | 0.4635 | 1.012 | 3.460 | 0.6944 |
#> |.....................| 1.255 | 1.949 | 2.689 |...........|
#> | X| 116.80346 | 1.590 | 2.751 | 31.81 | 0.6944 |
#> |.....................| 1.255 | 1.949 | 2.689 |...........|
#> | 80| 116.80358 | -0.9764 | -0.6137 | 1.010 | -0.8429 |
#> |.....................| -0.4323 | 0.04785 | 0.4014 |...........|
#> | U| 116.80358 | 0.4636 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | X| 116.80358 | 1.590 | 2.751 | 31.80 | 0.6945 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | 81| 116.80347 | -0.9764 | -0.6137 | 1.010 | -0.8430 |
#> |.....................| -0.4324 | 0.04797 | 0.4016 |...........|
#> | U| 116.80347 | 0.4636 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.255 | 1.949 | 2.689 |...........|
#> | X| 116.80347 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.255 | 1.949 | 2.689 |...........|
#> | 82| 116.80348 | -0.9764 | -0.6136 | 1.010 | -0.8431 |
#> |.....................| -0.4323 | 0.04802 | 0.4016 |...........|
#> | U| 116.80348 | 0.4636 | 1.012 | 3.460 | 0.6944 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | X| 116.80348 | 1.590 | 2.751 | 31.81 | 0.6944 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | 83| 116.80346 | -0.9764 | -0.6137 | 1.010 | -0.8431 |
#> |.....................| -0.4324 | 0.04799 | 0.4016 |...........|
#> | U| 116.80346 | 0.4636 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.255 | 1.949 | 2.689 |...........|
#> | X| 116.80346 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.255 | 1.949 | 2.689 |...........|
#> | 84| 116.80362 | -0.9763 | -0.6136 | 1.010 | -0.8430 |
#> |.....................| -0.4324 | 0.04803 | 0.4016 |...........|
#> | U| 116.80362 | 0.4637 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.255 | 1.949 | 2.689 |...........|
#> | X| 116.80362 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.255 | 1.949 | 2.689 |...........|
#> | 85| 116.80346 | -0.9764 | -0.6136 | 1.010 | -0.8430 |
#> |.....................| -0.4324 | 0.04806 | 0.4016 |...........|
#> | U| 116.80346 | 0.4636 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | X| 116.80346 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | 86| 116.80347 | -0.9765 | -0.6136 | 1.010 | -0.8431 |
#> |.....................| -0.4324 | 0.04791 | 0.4016 |...........|
#> | U| 116.80347 | 0.4635 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | X| 116.80347 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | 87| 116.80345 | -0.9765 | -0.6136 | 1.010 | -0.8431 |
#> |.....................| -0.4324 | 0.04798 | 0.4016 |...........|
#> | U| 116.80345 | 0.4635 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.255 | 1.949 | 2.689 |...........|
#> | X| 116.80345 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.255 | 1.949 | 2.689 |...........|
#> | 88| 116.80341 | -0.9763 | -0.6136 | 1.010 | -0.8430 |
#> |.....................| -0.4324 | 0.04792 | 0.4016 |...........|
#> | U| 116.80341 | 0.4637 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | X| 116.80341 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | 89| 116.80347 | -0.9763 | -0.6136 | 1.010 | -0.8431 |
#> |.....................| -0.4324 | 0.04786 | 0.4017 |...........|
#> | U| 116.80347 | 0.4637 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.255 | 1.949 | 2.690 |...........|
#> | X| 116.80347 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.255 | 1.949 | 2.690 |...........|
#> | 90| 116.80347 | -0.9763 | -0.6136 | 1.010 | -0.8431 |
#> |.....................| -0.4324 | 0.04793 | 0.4015 |...........|
#> | U| 116.80347 | 0.4637 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | X| 116.80347 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | 91| 116.80346 | -0.9763 | -0.6136 | 1.010 | -0.8431 |
#> |.....................| -0.4324 | 0.04792 | 0.4016 |...........|
#> | U| 116.80346 | 0.4637 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | X| 116.80346 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | 92| 116.80347 | -0.9763 | -0.6137 | 1.010 | -0.8430 |
#> |.....................| -0.4324 | 0.04792 | 0.4017 |...........|
#> | U| 116.80347 | 0.4637 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.949 | 2.690 |...........|
#> | X| 116.80347 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.256 | 1.949 | 2.690 |...........|
#> | 93| 116.80347 | -0.9763 | -0.6137 | 1.010 | -0.8430 |
#> |.....................| -0.4324 | 0.04789 | 0.4016 |...........|
#> | U| 116.80347 | 0.4637 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | X| 116.80347 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | 94| 116.80382 | -0.9763 | -0.6137 | 1.010 | -0.8430 |
#> |.....................| -0.4323 | 0.04791 | 0.4016 |...........|
#> | U| 116.80382 | 0.4637 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.949 | 2.690 |...........|
#> | X| 116.80382 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.256 | 1.949 | 2.690 |...........|
#> | 95| 116.80345 | -0.9763 | -0.6136 | 1.010 | -0.8430 |
#> |.....................| -0.4324 | 0.04792 | 0.4016 |...........|
#> | U| 116.80345 | 0.4637 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> | X| 116.80345 | 1.590 | 2.751 | 31.81 | 0.6945 |
#> |.....................| 1.256 | 1.949 | 2.689 |...........|
#> calculating covariance matrix
#> done
#> Calculating residuals/tables
#> done
#> Warning: initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))
#> Warning: ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))
#> Warning: last objective function was not at minimum, possible problems in optimization
#> Warning: gradient problems with covariance; see $scaleInfo
# }