Stepwise Covariate Model-selection (SCM) method
an nlmixr 'fit' object
a list of candidate variables to which the covariates could be added
a list of candidate covariates that need to be tested
a named list with names 'fwd' and 'bck' for specifying the p-values for the forward and backward searches, respectively
a list containing additionl information on the variables-covariates pairs that should be passed on to addCovMultiple function
a list of covariates that should be treated as categorical
one of 'scm', 'forward' and 'backward' to specify the covariate search method; default is 'scm'
a boolean that controls if the search should be restarted; default is FALSE
A list summarizing the covariate selection steps and output; This list has the "summaryTable" for the overall summary of the covariate selection as well as "resFwd" for the forward selection method and "resBck" for the backward selection method.
# \donttest{
one.cmt <- function() {
ini({
## You may label each parameter with a comment
tka <- 0.45 # Log Ka
tcl <- log(c(0, 2.7, 100)) # Log Cl
## This works with interactive models
## You may also label the preceding line with label("label text")
tv <- 3.45; label("log V")
## the label("Label name") works with all models
eta.ka ~ 0.6
eta.cl ~ 0.3
eta.v ~ 0.1
add.sd <- 0.7
})
model({
ka <- exp(tka + eta.ka)
cl <- exp(tcl + eta.cl)
v <- exp(tv + eta.v)
linCmt() ~ add(add.sd)
})
}
fit <- nlmixr(one.cmt, theo_sd,"focei")
#> ℹ parameter labels from comments will be replaced by 'label()'
#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
#> F: Forward difference gradient approximation
#> C: Central difference gradient approximation
#> M: Mixed forward and central difference gradient approximation
#> Unscaled parameters for Omegas=chol(solve(omega));
#> Diagonals are transformed, as specified by foceiControl(diagXform=)
#> |-----+---------------+-----------+-----------+-----------+-----------|
#> | #| Objective Fun | tka | tcl | tv | add.sd |
#> |.....................| o1 | o2 | o3 |...........|
#> | 1| 133.57512 | -1.000 | -0.6378 | 1.000 | -0.8333 |
#> |.....................| -0.5425 | -0.3992 | -0.1145 |...........|
#> | U| 133.57512 | 0.4500 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 133.57512 | 1.568 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | G| Gill Diff. | -0.9310 | -1.614 | -3.052 | 1.541 |
#> |.....................| -11.80 | -35.24 | -34.65 |...........|
#> | 2| 122.59020 | -0.9817 | -0.6062 | 1.060 | -0.8636 |
#> |.....................| -0.3110 | 0.2924 | 0.5654 |...........|
#> | U| 122.5902 | 0.4683 | 1.025 | 3.510 | 0.6894 |
#> |.....................| 1.399 | 2.286 | 2.987 |...........|
#> | X| 122.5902 | 1.597 | 2.787 | 33.44 | 0.6894 |
#> |.....................| 1.399 | 2.286 | 2.987 |...........|
#> | F| Forward Diff. | -0.9193 | 14.79 | 70.12 | -4.948 |
#> |.....................| 14.22 | 16.76 | 13.93 |...........|
#> | 3| 691.01138 | -0.9592 | -0.7976 | 0.1049 | -0.8098 |
#> |.....................| -0.3897 | 0.4190 | 0.7258 |...........|
#> | U| 691.01138 | 0.4908 | 0.8335 | 2.555 | 0.7082 |
#> |.....................| 1.310 | 2.457 | 3.272 |...........|
#> | X| 691.01138 | 1.634 | 2.301 | 12.87 | 0.7082 |
#> |.....................| 1.310 | 2.457 | 3.272 |...........|
#> | 4| 121.02313 | -0.9805 | -0.6255 | 0.9681 | -0.8571 |
#> |.....................| -0.3296 | 0.2704 | 0.5472 |...........|
#> | U| 121.02313 | 0.4695 | 1.006 | 3.418 | 0.6917 |
#> |.....................| 1.378 | 2.256 | 2.955 |...........|
#> | X| 121.02313 | 1.599 | 2.733 | 30.51 | 0.6917 |
#> |.....................| 1.378 | 2.256 | 2.955 |...........|
#> | F| Forward Diff. | 2.644 | -6.902 | -53.13 | -3.008 |
#> |.....................| 13.05 | 15.51 | 9.450 |...........|
#> | 5| 118.40944 | -0.9856 | -0.6239 | 1.019 | -0.8463 |
#> |.....................| -0.3724 | 0.2115 | 0.5032 |...........|
#> | U| 118.40944 | 0.4644 | 1.007 | 3.469 | 0.6955 |
#> |.....................| 1.329 | 2.176 | 2.877 |...........|
#> | X| 118.40944 | 1.591 | 2.738 | 32.12 | 0.6955 |
#> |.....................| 1.329 | 2.176 | 2.877 |...........|
#> | F| Forward Diff. | 0.01257 | -0.06271 | 11.65 | -1.181 |
#> |.....................| 7.396 | 11.24 | 6.682 |...........|
#> | 6| 117.95102 | -0.9860 | -0.6177 | 0.9748 | -0.8413 |
#> |.....................| -0.4126 | 0.1437 | 0.4615 |...........|
#> | U| 117.95102 | 0.4640 | 1.013 | 3.425 | 0.6972 |
#> |.....................| 1.284 | 2.085 | 2.803 |...........|
#> | X| 117.95102 | 1.590 | 2.755 | 30.72 | 0.6972 |
#> |.....................| 1.284 | 2.085 | 2.803 |...........|
#> | F| Forward Diff. | 1.122 | -2.134 | -37.05 | 0.6672 |
#> |.....................| 3.102 | 7.185 | 4.243 |...........|
#> | 7| 117.01192 | -0.9844 | -0.6189 | 1.027 | -0.8580 |
#> |.....................| -0.4206 | 0.07306 | 0.4170 |...........|
#> | U| 117.01192 | 0.4656 | 1.012 | 3.477 | 0.6914 |
#> |.....................| 1.275 | 1.989 | 2.723 |...........|
#> | X| 117.01192 | 1.593 | 2.752 | 32.35 | 0.6914 |
#> |.....................| 1.275 | 1.989 | 2.723 |...........|
#> | F| Forward Diff. | -0.2405 | 1.324 | 17.06 | -1.389 |
#> |.....................| 1.899 | 2.064 | 1.794 |...........|
#> | 8| 117.12874 | -0.9866 | -0.6555 | 1.005 | -0.8409 |
#> |.....................| -0.4185 | 0.01390 | 0.3507 |...........|
#> | U| 117.12874 | 0.4634 | 0.9756 | 3.455 | 0.6973 |
#> |.....................| 1.277 | 1.909 | 2.606 |...........|
#> | X| 117.12874 | 1.590 | 2.653 | 31.66 | 0.6973 |
#> |.....................| 1.277 | 1.909 | 2.606 |...........|
#> | 9| 116.86111 | -0.9850 | -0.6329 | 1.006 | -0.8508 |
#> |.....................| -0.4213 | 0.05044 | 0.3921 |...........|
#> | U| 116.86111 | 0.4650 | 0.9982 | 3.456 | 0.6939 |
#> |.....................| 1.274 | 1.959 | 2.679 |...........|
#> | X| 116.86111 | 1.592 | 2.713 | 31.68 | 0.6939 |
#> |.....................| 1.274 | 1.959 | 2.679 |...........|
#> | F| Forward Diff. | 0.1372 | -4.279 | -4.745 | -0.1588 |
#> |.....................| 1.829 | 0.4197 | -0.2277 |...........|
#> | 10| 116.90243 | -0.9853 | -0.5936 | 1.006 | -0.8456 |
#> |.....................| -0.4367 | 0.04760 | 0.3910 |...........|
#> | U| 116.90243 | 0.4647 | 1.037 | 3.456 | 0.6957 |
#> |.....................| 1.256 | 1.955 | 2.677 |...........|
#> | X| 116.90243 | 1.592 | 2.822 | 31.68 | 0.6957 |
#> |.....................| 1.256 | 1.955 | 2.677 |...........|
#> | 11| 116.81300 | -0.9853 | -0.6177 | 1.012 | -0.8493 |
#> |.....................| -0.4275 | 0.04920 | 0.3921 |...........|
#> | U| 116.813 | 0.4647 | 1.013 | 3.462 | 0.6944 |
#> |.....................| 1.267 | 1.957 | 2.679 |...........|
#> | X| 116.813 | 1.592 | 2.755 | 31.88 | 0.6944 |
#> |.....................| 1.267 | 1.957 | 2.679 |...........|
#> | F| Forward Diff. | 0.04146 | 0.5982 | 2.027 | -0.1930 |
#> |.....................| 1.293 | 0.4341 | -0.1919 |...........|
#> | 12| 116.81643 | -0.9859 | -0.6188 | 1.005 | -0.8484 |
#> |.....................| -0.4420 | 0.04884 | 0.3991 |...........|
#> | U| 116.81643 | 0.4641 | 1.012 | 3.455 | 0.6947 |
#> |.....................| 1.250 | 1.957 | 2.692 |...........|
#> | X| 116.81643 | 1.591 | 2.752 | 31.66 | 0.6947 |
#> |.....................| 1.250 | 1.957 | 2.692 |...........|
#> | 13| 116.81366 | -0.9854 | -0.6194 | 1.006 | -0.8487 |
#> |.....................| -0.4322 | 0.04799 | 0.3932 |...........|
#> | U| 116.81366 | 0.4646 | 1.012 | 3.456 | 0.6946 |
#> |.....................| 1.262 | 1.955 | 2.681 |...........|
#> | X| 116.81366 | 1.591 | 2.750 | 31.69 | 0.6946 |
#> |.....................| 1.262 | 1.955 | 2.681 |...........|
#> | 14| 116.80890 | -0.9853 | -0.6186 | 1.009 | -0.8490 |
#> |.....................| -0.4295 | 0.04853 | 0.3924 |...........|
#> | U| 116.8089 | 0.4647 | 1.012 | 3.459 | 0.6945 |
#> |.....................| 1.265 | 1.956 | 2.680 |...........|
#> | X| 116.8089 | 1.592 | 2.752 | 31.78 | 0.6945 |
#> |.....................| 1.265 | 1.956 | 2.680 |...........|
#> | F| Forward Diff. | 0.09967 | 0.1293 | -0.9650 | 0.1356 |
#> |.....................| 1.065 | 0.2446 | -0.1725 |...........|
#> | 15| 116.80676 | -0.9856 | -0.6189 | 1.011 | -0.8494 |
#> |.....................| -0.4323 | 0.04789 | 0.3929 |...........|
#> | U| 116.80676 | 0.4644 | 1.012 | 3.461 | 0.6944 |
#> |.....................| 1.261 | 1.955 | 2.680 |...........|
#> | X| 116.80676 | 1.591 | 2.752 | 31.86 | 0.6944 |
#> |.....................| 1.261 | 1.955 | 2.680 |...........|
#> | F| Forward Diff. | 0.01623 | 0.1762 | 1.448 | 0.001944 |
#> |.....................| 0.8101 | 0.3560 | -0.1495 |...........|
#> | 16| 116.80511 | -0.9857 | -0.6196 | 1.009 | -0.8499 |
#> |.....................| -0.4347 | 0.04738 | 0.3939 |...........|
#> | U| 116.80511 | 0.4643 | 1.012 | 3.459 | 0.6942 |
#> |.....................| 1.259 | 1.955 | 2.682 |...........|
#> | X| 116.80511 | 1.591 | 2.750 | 31.77 | 0.6942 |
#> |.....................| 1.259 | 1.955 | 2.682 |...........|
#> | F| Forward Diff. | 0.06298 | -0.1883 | -1.085 | -0.05009 |
#> |.....................| 0.4485 | 0.2102 | -0.08332 |...........|
#> | 17| 116.80401 | -0.9859 | -0.6193 | 1.011 | -0.8500 |
#> |.....................| -0.4369 | 0.04655 | 0.3962 |...........|
#> | U| 116.80401 | 0.4641 | 1.012 | 3.461 | 0.6942 |
#> |.....................| 1.256 | 1.954 | 2.686 |...........|
#> | X| 116.80401 | 1.591 | 2.750 | 31.84 | 0.6942 |
#> |.....................| 1.256 | 1.954 | 2.686 |...........|
#> | F| Forward Diff. |-0.0009677 | 0.002269 | 0.9503 | -0.2533 |
#> |.....................| 0.1402 | 0.3095 | -0.009911 |...........|
#> | 18| 116.80364 | -0.9861 | -0.6189 | 1.010 | -0.8474 |
#> |.....................| -0.4369 | 0.04466 | 0.3982 |...........|
#> | U| 116.80364 | 0.4639 | 1.012 | 3.460 | 0.6951 |
#> |.....................| 1.256 | 1.951 | 2.690 |...........|
#> | X| 116.80364 | 1.590 | 2.752 | 31.81 | 0.6951 |
#> |.....................| 1.256 | 1.951 | 2.690 |...........|
#> | F| Forward Diff. | 0.01764 | 0.05231 | 0.02747 | 0.2443 |
#> |.....................| 0.1370 | 0.07969 | 0.09639 |...........|
#> | 19| 116.80372 | -0.9864 | -0.6195 | 1.009 | -0.8504 |
#> |.....................| -0.4386 | 0.04367 | 0.3970 |...........|
#> | U| 116.80372 | 0.4636 | 1.012 | 3.459 | 0.6940 |
#> |.....................| 1.254 | 1.950 | 2.688 |...........|
#> | X| 116.80372 | 1.590 | 2.750 | 31.80 | 0.6940 |
#> |.....................| 1.254 | 1.950 | 2.688 |...........|
#> | 20| 116.80348 | -0.9862 | -0.6192 | 1.010 | -0.8488 |
#> |.....................| -0.4377 | 0.04420 | 0.3976 |...........|
#> | U| 116.80348 | 0.4638 | 1.012 | 3.460 | 0.6946 |
#> |.....................| 1.255 | 1.950 | 2.689 |...........|
#> | X| 116.80348 | 1.590 | 2.751 | 31.80 | 0.6946 |
#> |.....................| 1.255 | 1.950 | 2.689 |...........|
#> | F| Forward Diff. | 0.01066 | -0.05164 | -0.1358 | 0.07351 |
#> |.....................| 0.1166 | 0.04721 | 0.07105 |...........|
#> | 21| 116.80394 | -0.9863 | -0.6188 | 1.011 | -0.8494 |
#> |.....................| -0.4387 | 0.04380 | 0.3970 |...........|
#> | U| 116.80394 | 0.4637 | 1.012 | 3.461 | 0.6944 |
#> |.....................| 1.254 | 1.950 | 2.688 |...........|
#> | X| 116.80394 | 1.590 | 2.752 | 31.84 | 0.6944 |
#> |.....................| 1.254 | 1.950 | 2.688 |...........|
#> | 22| 116.80348 | -0.9862 | -0.6192 | 1.010 | -0.8488 |
#> |.....................| -0.4377 | 0.04420 | 0.3976 |...........|
#> | U| 116.80348 | 0.4638 | 1.012 | 3.460 | 0.6946 |
#> |.....................| 1.255 | 1.950 | 2.689 |...........|
#> | X| 116.80348 | 1.590 | 2.751 | 31.80 | 0.6946 |
#> |.....................| 1.255 | 1.950 | 2.689 |...........|
#> calculating covariance matrix
#> done
#> Calculating residuals/tables
#> done
#> Warning: initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))
#> Warning: ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))
#> Warning: last objective function was not at minimum, possible problems in optimization
#> Warning: gradient problems with initial estimate and covariance; see $scaleInfo
RxODE::.rxWithWd(tempdir(), {# with temporary directory
covarSearchAuto(fit, varsVec = c("ka", "cl"),
covarsVec = c("WT", "SEX"), catCovariates = c("SEX"))
})
#> Warning: some covariates are not in the dataset: 'WT', ''
#>
#> ── starting forward search... ──────────────────────────────────────────────────
#> ✔ added centered_WT*cov_WT_ka to ka's equation in the model
#> ✔ updated value: ka<-exp(tka+centered_WT*cov_WT_ka+eta.ka)
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → calculate jacobian
#>
#> → calculate ∂(f)/∂(η)
#>
#> → calculate ∂(R²)/∂(η)
#>
#> → finding duplicate expressions in inner model...
#>
#> → optimizing duplicate expressions in inner model...
#>
#> → finding duplicate expressions in EBE model...
#>
#> → optimizing duplicate expressions in EBE model...
#>
#> → compiling inner model...
#>
#> ✔ done
#> → finding duplicate expressions in FD model...
#>
#> → compiling EBE model...
#>
#> ✔ done
#> → compiling events FD model...
#>
#> ✔ done
#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
#> F: Forward difference gradient approximation
#> C: Central difference gradient approximation
#> M: Mixed forward and central difference gradient approximation
#> Unscaled parameters for Omegas=chol(solve(omega));
#> Diagonals are transformed, as specified by foceiControl(diagXform=)
#> |-----+---------------+-----------+-----------+-----------+-----------|
#> | #| Objective Fun | tka | tcl | tv | add.sd |
#> |.....................|centered_WT | cov_WT_ka | o1 | o2 |
#> |.....................| o3 |...........|...........|...........|
#> | 1| 133.57512 | -0.7391 | -0.4242 | 1.000 | -0.5942 |
#> |.....................| -0.4203 | -1.000 | -0.3413 | -0.2167 |
#> |.....................| 0.03089 |...........|...........|...........|
#> | U| 133.57512 | 0.4500 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.000 | 0.000 | 1.136 | 1.351 |
#> |.....................| 1.778 |...........|...........|...........|
#> | X| 133.57512 | 1.568 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 2.718 | 1.000 | 1.136 | 1.351 |
#> |.....................| 1.778 |...........|...........|...........|
#> | G| Gill Diff. | -0.9310 | -1.614 | -3.052 | 1.591 |
#> |.....................| -0.001938 | -0.9310 | -11.78 | -35.27 |
#> |.....................| -34.78 |...........|...........|...........|
#> | 2| 122.56663 | -0.7209 | -0.3926 | 1.060 | -0.6254 |
#> |.....................| -0.4201 | -0.9818 | -0.1106 | 0.4739 |
#> |.....................| 0.7118 |...........|...........|...........|
#> | U| 122.56663 | 0.4682 | 1.025 | 3.510 | 0.6891 |
#> |.....................| 1.000 | 0.01823 | 1.398 | 2.284 |
#> |.....................| 2.989 |...........|...........|...........|
#> | X| 122.56663 | 1.597 | 2.787 | 33.44 | 0.6891 |
#> |.....................| 2.719 | 1.018 | 1.398 | 2.284 |
#> |.....................| 2.989 |...........|...........|...........|
#> | F| Forward Diff. | 0.5883 | 14.89 | 69.34 | -5.082 |
#> |.....................| 0.01707 | 0.5885 | 14.10 | 16.71 |
#> |.....................| 13.90 |...........|...........|...........|
#> | 3| 690.01754 | -0.7198 | -0.5879 | 0.1045 | -0.5693 |
#> |.....................| -0.4204 | -0.9806 | -0.1910 | 0.5963 |
#> |.....................| 0.8691 |...........|...........|...........|
#> | U| 690.01754 | 0.4694 | 0.8295 | 2.554 | 0.7087 |
#> |.....................| 0.9999 | 0.01936 | 1.307 | 2.450 |
#> |.....................| 3.269 |...........|...........|...........|
#> | X| 690.01754 | 1.599 | 2.292 | 12.86 | 0.7087 |
#> |.....................| 2.718 | 1.020 | 1.307 | 2.450 |
#> |.....................| 3.269 |...........|...........|...........|
#> | 4| 121.05724 | -0.7217 | -0.4123 | 0.9681 | -0.6186 |
#> |.....................| -0.4202 | -0.9826 | -0.1293 | 0.4518 |
#> |.....................| 0.6935 |...........|...........|...........|
#> | U| 121.05724 | 0.4674 | 1.005 | 3.418 | 0.6914 |
#> |.....................| 1.000 | 0.01745 | 1.377 | 2.254 |
#> |.....................| 2.957 |...........|...........|...........|
#> | X| 121.05724 | 1.596 | 2.732 | 30.51 | 0.6914 |
#> |.....................| 2.719 | 1.018 | 1.377 | 2.254 |
#> |.....................| 2.957 |...........|...........|...........|
#> | F| Forward Diff. | 3.837 | -6.944 | -53.83 | -3.090 |
#> |.....................| 0.06934 | 3.838 | 13.37 | 15.43 |
#> |.....................| 9.539 |...........|...........|...........|
#> | 5| 118.41302 | -0.7303 | -0.4110 | 1.020 | -0.6076 |
#> |.....................| -0.4203 | -0.9912 | -0.1722 | 0.3939 |
#> |.....................| 0.6500 |...........|...........|...........|
#> | U| 118.41302 | 0.4588 | 1.007 | 3.470 | 0.6953 |
#> |.....................| 1.000 | 0.008841 | 1.328 | 2.176 |
#> |.....................| 2.879 |...........|...........|...........|
#> | X| 118.41302 | 1.582 | 2.736 | 32.12 | 0.6953 |
#> |.....................| 2.718 | 1.009 | 1.328 | 2.176 |
#> |.....................| 2.879 |...........|...........|...........|
#> | F| Forward Diff. | 0.2193 | -0.3076 | 11.77 | -1.219 |
#> |.....................|-0.0007891 | 0.2195 | 7.249 | 11.25 |
#> |.....................| 6.750 |...........|...........|...........|
#> | 6| 117.95957 | -0.7313 | -0.4033 | 0.9747 | -0.6024 |
#> |.....................| -0.4203 | -0.9922 | -0.2116 | 0.3262 |
#> |.....................| 0.6080 |...........|...........|...........|
#> | U| 117.95957 | 0.4578 | 1.014 | 3.425 | 0.6971 |
#> |.....................| 1.000 | 0.007833 | 1.284 | 2.085 |
#> |.....................| 2.805 |...........|...........|...........|
#> | X| 117.95957 | 1.581 | 2.757 | 30.71 | 0.6971 |
#> |.....................| 2.718 | 1.008 | 1.284 | 2.085 |
#> |.....................| 2.805 |...........|...........|...........|
#> | F| Forward Diff. | 1.235 | -1.853 | -37.21 | 0.1988 |
#> |.....................| 0.01043 | 1.235 | 3.123 | 7.245 |
#> |.....................| 4.285 |...........|...........|...........|
#> | 7| 117.01527 | -0.7254 | -0.4049 | 1.027 | -0.6142 |
#> |.....................| -0.4200 | -0.9862 | -0.2186 | 0.2552 |
#> |.....................| 0.5634 |...........|...........|...........|
#> | U| 117.01527 | 0.4638 | 1.013 | 3.477 | 0.6930 |
#> |.....................| 1.000 | 0.01375 | 1.276 | 1.989 |
#> |.....................| 2.725 |...........|...........|...........|
#> | X| 117.01527 | 1.590 | 2.753 | 32.36 | 0.6930 |
#> |.....................| 2.719 | 1.014 | 1.276 | 1.989 |
#> |.....................| 2.725 |...........|...........|...........|
#> | F| Forward Diff. | 0.4612 | 1.530 | 17.00 | -0.8240 |
#> |.....................| 0.009037 | 0.4613 | 2.046 | 2.040 |
#> |.....................| 1.907 |...........|...........|...........|
#> | 8| 117.25439 | -0.7495 | -0.4529 | 1.005 | -0.6159 |
#> |.....................| -0.4203 | -1.010 | -0.2219 | 0.2056 |
#> |.....................| 0.5036 |...........|...........|...........|
#> | U| 117.25439 | 0.4396 | 0.9646 | 3.455 | 0.6924 |
#> |.....................| 1.000 | -0.01039 | 1.272 | 1.922 |
#> |.....................| 2.619 |...........|...........|...........|
#> | X| 117.25439 | 1.552 | 2.624 | 31.67 | 0.6924 |
#> |.....................| 2.718 | 0.9897 | 1.272 | 1.922 |
#> |.....................| 2.619 |...........|...........|...........|
#> | 9| 116.86499 | -0.7327 | -0.4199 | 1.006 | -0.6140 |
#> |.....................| -0.4201 | -0.9935 | -0.2213 | 0.2393 |
#> |.....................| 0.5447 |...........|...........|...........|
#> | U| 116.86499 | 0.4565 | 0.9976 | 3.456 | 0.6931 |
#> |.....................| 1.000 | 0.006478 | 1.273 | 1.967 |
#> |.....................| 2.692 |...........|...........|...........|
#> | X| 116.86499 | 1.579 | 2.712 | 31.69 | 0.6931 |
#> |.....................| 2.719 | 1.006 | 1.273 | 1.967 |
#> |.....................| 2.692 |...........|...........|...........|
#> | F| Forward Diff. | 0.01173 | -4.519 | -4.436 | -0.4241 |
#> |.....................| 0.002109 | 0.01176 | 1.833 | 0.9175 |
#> |.....................| 0.1786 |...........|...........|...........|
#> | 10| 116.86782 | -0.7345 | -0.3853 | 1.007 | -0.6104 |
#> |.....................| -0.4202 | -0.9954 | -0.2332 | 0.2360 |
#> |.....................| 0.5422 |...........|...........|...........|
#> | U| 116.86782 | 0.4546 | 1.032 | 3.457 | 0.6943 |
#> |.....................| 1.000 | 0.004634 | 1.259 | 1.963 |
#> |.....................| 2.688 |...........|...........|...........|
#> | X| 116.86782 | 1.576 | 2.807 | 31.71 | 0.6943 |
#> |.....................| 2.719 | 1.005 | 1.259 | 1.963 |
#> |.....................| 2.688 |...........|...........|...........|
#> | 11| 116.81520 | -0.7332 | -0.4038 | 1.012 | -0.6124 |
#> |.....................| -0.4201 | -0.9941 | -0.2272 | 0.2372 |
#> |.....................| 0.5438 |...........|...........|...........|
#> | U| 116.8152 | 0.4559 | 1.014 | 3.462 | 0.6936 |
#> |.....................| 1.000 | 0.005913 | 1.266 | 1.964 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.8152 | 1.578 | 2.756 | 31.88 | 0.6936 |
#> |.....................| 2.719 | 1.006 | 1.266 | 1.964 |
#> |.....................| 2.690 |...........|...........|...........|
#> | F| Forward Diff. | -0.1208 | 0.6475 | 2.176 | -0.4241 |
#> |.....................| -0.002311 | -0.1208 | 1.132 | 0.7265 |
#> |.....................| 0.2261 |...........|...........|...........|
#> | 12| 116.82949 | -0.7297 | -0.4041 | 1.003 | -0.6069 |
#> |.....................| -0.4201 | -0.9905 | -0.2406 | 0.2349 |
#> |.....................| 0.5478 |...........|...........|...........|
#> | U| 116.82949 | 0.4595 | 1.013 | 3.453 | 0.6956 |
#> |.....................| 1.000 | 0.009473 | 1.251 | 1.961 |
#> |.....................| 2.697 |...........|...........|...........|
#> | X| 116.82949 | 1.583 | 2.755 | 31.60 | 0.6956 |
#> |.....................| 2.719 | 1.010 | 1.251 | 1.961 |
#> |.....................| 2.697 |...........|...........|...........|
#> | 13| 116.81371 | -0.7329 | -0.4054 | 1.006 | -0.6114 |
#> |.....................| -0.4201 | -0.9938 | -0.2300 | 0.2354 |
#> |.....................| 0.5432 |...........|...........|...........|
#> | U| 116.81371 | 0.4562 | 1.012 | 3.456 | 0.6940 |
#> |.....................| 1.000 | 0.006211 | 1.263 | 1.962 |
#> |.....................| 2.689 |...........|...........|...........|
#> | X| 116.81371 | 1.578 | 2.751 | 31.70 | 0.6940 |
#> |.....................| 2.719 | 1.006 | 1.263 | 1.962 |
#> |.....................| 2.689 |...........|...........|...........|
#> | F| Forward Diff. | 0.02145 | -0.1768 | -3.058 | -0.3040 |
#> |.....................| -0.001671 | 0.02153 | 0.8004 | 0.6029 |
#> |.....................| 0.05288 |...........|...........|...........|
#> | 14| 116.80660 | -0.7322 | -0.4068 | 1.011 | -0.6095 |
#> |.....................| -0.4201 | -0.9930 | -0.2339 | 0.2343 |
#> |.....................| 0.5446 |...........|...........|...........|
#> | U| 116.8066 | 0.4570 | 1.011 | 3.461 | 0.6947 |
#> |.....................| 1.000 | 0.006954 | 1.258 | 1.961 |
#> |.....................| 2.692 |...........|...........|...........|
#> | X| 116.8066 | 1.579 | 2.747 | 31.84 | 0.6947 |
#> |.....................| 2.719 | 1.007 | 1.258 | 1.961 |
#> |.....................| 2.692 |...........|...........|...........|
#> | F| Forward Diff. | -0.01093 | -0.3104 | 1.002 | -0.06813 |
#> |.....................| -0.001589 | -0.01078 | -0.05248 | 0.5435 |
#> |.....................| 0.2242 |...........|...........|...........|
#> | 15| 116.80565 | -0.7313 | -0.4052 | 1.010 | -0.6079 |
#> |.....................| -0.4200 | -0.9922 | -0.2311 | 0.2290 |
#> |.....................| 0.5449 |...........|...........|...........|
#> | U| 116.80565 | 0.4579 | 1.012 | 3.460 | 0.6952 |
#> |.....................| 1.000 | 0.007846 | 1.261 | 1.953 |
#> |.....................| 2.692 |...........|...........|...........|
#> | X| 116.80565 | 1.581 | 2.752 | 31.80 | 0.6952 |
#> |.....................| 2.719 | 1.008 | 1.261 | 1.953 |
#> |.....................| 2.692 |...........|...........|...........|
#> | F| Forward Diff. | 0.1391 | 0.07373 | -0.1581 | 0.1321 |
#> |.....................| 0.002361 | 0.1391 | 0.6135 | 0.2208 |
#> |.....................| 0.1250 |...........|...........|...........|
#> | 16| 116.80376 | -0.7328 | -0.4058 | 1.010 | -0.6099 |
#> |.....................| -0.4201 | -0.9936 | -0.2364 | 0.2264 |
#> |.....................| 0.5442 |...........|...........|...........|
#> | U| 116.80376 | 0.4564 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.000 | 0.006367 | 1.255 | 1.950 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 116.80376 | 1.578 | 2.750 | 31.83 | 0.6945 |
#> |.....................| 2.719 | 1.006 | 1.255 | 1.950 |
#> |.....................| 2.691 |...........|...........|...........|
#> | F| Forward Diff. | -0.06478 | -0.07166 | 0.6997 | -0.09342 |
#> |.....................| -0.001903 | -0.06475 | -0.03712 | 0.005775 |
#> |.....................| 0.09210 |...........|...........|...........|
#> | 17| 116.81449 | -0.7316 | -0.4055 | 1.005 | -0.6086 |
#> |.....................| -0.4200 | -0.9925 | -0.2394 | 0.2273 |
#> |.....................| 0.5426 |...........|...........|...........|
#> | U| 116.81449 | 0.4575 | 1.012 | 3.455 | 0.6950 |
#> |.....................| 1.000 | 0.007498 | 1.252 | 1.951 |
#> |.....................| 2.688 |...........|...........|...........|
#> | X| 116.81449 | 1.580 | 2.751 | 31.66 | 0.6950 |
#> |.....................| 2.719 | 1.008 | 1.252 | 1.951 |
#> |.....................| 2.688 |...........|...........|...........|
#> | 18| 116.80356 | -0.7327 | -0.4057 | 1.009 | -0.6098 |
#> |.....................| -0.4201 | -0.9936 | -0.2364 | 0.2264 |
#> |.....................| 0.5441 |...........|...........|...........|
#> | U| 116.80356 | 0.4565 | 1.012 | 3.459 | 0.6946 |
#> |.....................| 1.000 | 0.006447 | 1.255 | 1.950 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 116.80356 | 1.578 | 2.750 | 31.80 | 0.6946 |
#> |.....................| 2.719 | 1.006 | 1.255 | 1.950 |
#> |.....................| 2.691 |...........|...........|...........|
#> | F| Forward Diff. | -0.03566 | -0.09869 | -0.1316 | -0.02313 |
#> |.....................| -0.001623 | -0.03572 | -0.02324 | 0.01337 |
#> |.....................| 0.06508 |...........|...........|...........|
#> | 19| 116.80346 | -0.7324 | -0.4054 | 1.010 | -0.6097 |
#> |.....................| -0.4200 | -0.9933 | -0.2364 | 0.2266 |
#> |.....................| 0.5435 |...........|...........|...........|
#> | U| 116.80346 | 0.4567 | 1.012 | 3.460 | 0.6946 |
#> |.....................| 1.000 | 0.006727 | 1.255 | 1.950 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80346 | 1.579 | 2.751 | 31.81 | 0.6946 |
#> |.....................| 2.719 | 1.007 | 1.255 | 1.950 |
#> |.....................| 2.690 |...........|...........|...........|
#> | C| Central Diff. | -0.02335 | -0.01419 | 0.08010 | 0.1344 |
#> |.....................| 0.03695 | -0.02340 | -0.1781 | 0.03927 |
#> |.....................| 0.05723 |...........|...........|...........|
#> | 20| 116.80346 | -0.7324 | -0.4054 | 1.010 | -0.6097 |
#> |.....................| -0.4200 | -0.9933 | -0.2364 | 0.2266 |
#> |.....................| 0.5435 |...........|...........|...........|
#> | U| 116.80346 | 0.4567 | 1.012 | 3.460 | 0.6946 |
#> |.....................| 1.000 | 0.006727 | 1.255 | 1.950 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80346 | 1.579 | 2.751 | 31.81 | 0.6946 |
#> |.....................| 2.719 | 1.007 | 1.255 | 1.950 |
#> |.....................| 2.690 |...........|...........|...........|
#> calculating covariance matrix
#> done
#> Calculating residuals/tables
#> done
#> ✔ added centered_WT*cov_WT_cl to cl's equation in the model
#> ✔ updated value: cl<-exp(tcl+centered_WT*cov_WT_cl+eta.cl)
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → calculate jacobian
#>
#> → calculate ∂(f)/∂(η)
#>
#> → calculate ∂(R²)/∂(η)
#>
#> → finding duplicate expressions in inner model...
#>
#> → optimizing duplicate expressions in inner model...
#>
#> → finding duplicate expressions in EBE model...
#>
#> → optimizing duplicate expressions in EBE model...
#>
#> → compiling inner model...
#>
#> ✔ done
#> → finding duplicate expressions in FD model...
#>
#> → compiling EBE model...
#>
#> ✔ done
#> → compiling events FD model...
#>
#> ✔ done
#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
#> F: Forward difference gradient approximation
#> C: Central difference gradient approximation
#> M: Mixed forward and central difference gradient approximation
#> Unscaled parameters for Omegas=chol(solve(omega));
#> Diagonals are transformed, as specified by foceiControl(diagXform=)
#> |-----+---------------+-----------+-----------+-----------+-----------|
#> | #| Objective Fun | tka | tcl | tv | add.sd |
#> |.....................|centered_WT | cov_WT_cl | o1 | o2 |
#> |.....................| o3 |...........|...........|...........|
#> | 1| 133.57512 | -0.7391 | -0.4242 | 1.000 | -0.5942 |
#> |.....................| -0.4203 | -1.000 | -0.3413 | -0.2167 |
#> |.....................| 0.03089 |...........|...........|...........|
#> | U| 133.57512 | 0.4500 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.000 | 0.000 | 1.136 | 1.351 |
#> |.....................| 1.778 |...........|...........|...........|
#> | X| 133.57512 | 1.568 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 2.718 | 1.000 | 1.136 | 1.351 |
#> |.....................| 1.778 |...........|...........|...........|
#> | G| Gill Diff. | -0.9310 | -1.614 | -3.052 | 1.589 |
#> |.....................| -0.001457 | -1.614 | -11.78 | -35.27 |
#> |.....................| -34.78 |...........|...........|...........|
#> | 2| 123.26516 | -0.7209 | -0.3926 | 1.060 | -0.6253 |
#> |.....................| -0.4201 | -0.9684 | -0.1107 | 0.4736 |
#> |.....................| 0.7116 |...........|...........|...........|
#> | U| 123.26516 | 0.4682 | 1.025 | 3.510 | 0.6891 |
#> |.....................| 1.000 | 0.03159 | 1.398 | 2.284 |
#> |.....................| 2.989 |...........|...........|...........|
#> | X| 123.26516 | 1.597 | 2.787 | 33.44 | 0.6891 |
#> |.....................| 2.719 | 1.032 | 1.398 | 2.284 |
#> |.....................| 2.989 |...........|...........|...........|
#> | F| Forward Diff. | -0.5868 | 30.11 | 74.23 | -5.071 |
#> |.....................| 0.5706 | 29.86 | 14.13 | 18.23 |
#> |.....................| 14.14 |...........|...........|...........|
#> | 3| 859.85007 | -0.7037 | -0.7267 | 0.2257 | -0.5836 |
#> |.....................| -0.4268 | -1.300 | -0.1453 | 0.6512 |
#> |.....................| 0.9315 |...........|...........|...........|
#> | U| 859.85007 | 0.4854 | 0.6908 | 2.676 | 0.7037 |
#> |.....................| 0.9935 | -0.2996 | 1.359 | 2.524 |
#> |.....................| 3.380 |...........|...........|...........|
#> | X| 859.85007 | 1.625 | 1.995 | 14.52 | 0.7037 |
#> |.....................| 2.701 | 0.7411 | 1.359 | 2.524 |
#> |.....................| 3.380 |...........|...........|...........|
#> | 4| 120.81610 | -0.7203 | -0.4261 | 0.9771 | -0.6196 |
#> |.....................| -0.4208 | -1.002 | -0.1264 | 0.4533 |
#> |.....................| 0.6959 |...........|...........|...........|
#> | U| 120.8161 | 0.4689 | 0.9913 | 3.427 | 0.6911 |
#> |.....................| 0.9995 | -0.001655 | 1.380 | 2.257 |
#> |.....................| 2.961 |...........|...........|...........|
#> | X| 120.8161 | 1.598 | 2.695 | 30.79 | 0.6911 |
#> |.....................| 2.717 | 0.9983 | 1.380 | 2.257 |
#> |.....................| 2.961 |...........|...........|...........|
#> | F| Forward Diff. | 2.099 | -13.28 | -43.93 | -3.395 |
#> |.....................| -0.1107 | -13.26 | 13.28 | 15.66 |
#> |.....................| 9.277 |...........|...........|...........|
#> | 5| 118.45977 | -0.7247 | -0.4172 | 1.022 | -0.6089 |
#> |.....................| -0.4209 | -0.9926 | -0.1681 | 0.3917 |
#> |.....................| 0.6499 |...........|...........|...........|
#> | U| 118.45977 | 0.4644 | 1.000 | 3.472 | 0.6948 |
#> |.....................| 0.9994 | 0.007380 | 1.333 | 2.173 |
#> |.....................| 2.879 |...........|...........|...........|
#> | X| 118.45977 | 1.591 | 2.719 | 32.22 | 0.6948 |
#> |.....................| 2.717 | 1.007 | 1.333 | 2.173 |
#> |.....................| 2.879 |...........|...........|...........|
#> | F| Forward Diff. | -0.07409 | 0.4343 | 15.45 | -1.363 |
#> |.....................| -1.321 | 0.4540 | 7.766 | 11.18 |
#> |.....................| 6.887 |...........|...........|...........|
#> | 6| 118.07299 | -0.7248 | -0.4061 | 0.9729 | -0.6038 |
#> |.....................| -0.4136 | -0.9817 | -0.2060 | 0.3287 |
#> |.....................| 0.6073 |...........|...........|...........|
#> | U| 118.07299 | 0.4643 | 1.011 | 3.423 | 0.6966 |
#> |.....................| 1.007 | 0.01828 | 1.290 | 2.088 |
#> |.....................| 2.803 |...........|...........|...........|
#> | X| 118.07299 | 1.591 | 2.749 | 30.66 | 0.6966 |
#> |.....................| 2.737 | 1.018 | 1.290 | 2.088 |
#> |.....................| 2.803 |...........|...........|...........|
#> | F| Forward Diff. | 1.344 | 3.736 | -37.78 | -0.04684 |
#> |.....................| 0.06989 | 3.762 | 3.849 | 7.447 |
#> |.....................| 4.174 |...........|...........|...........|
#> | 7| 117.26519 | -0.7264 | -0.4374 | 1.022 | -0.6094 |
#> |.....................| -0.4061 | -1.014 | -0.2254 | 0.2693 |
#> |.....................| 0.5676 |...........|...........|...........|
#> | U| 117.26519 | 0.4628 | 0.9800 | 3.472 | 0.6947 |
#> |.....................| 1.014 | -0.01353 | 1.268 | 2.008 |
#> |.....................| 2.733 |...........|...........|...........|
#> | X| 117.26519 | 1.588 | 2.664 | 32.21 | 0.6947 |
#> |.....................| 2.757 | 0.9866 | 1.268 | 2.008 |
#> |.....................| 2.733 |...........|...........|...........|
#> | F| Forward Diff. | -0.5664 | -13.66 | 9.555 | -0.2750 |
#> |.....................| -0.9035 | -13.85 | 1.175 | 3.410 |
#> |.....................| 2.098 |...........|...........|...........|
#> | 8| 118.05686 | -0.7225 | -0.3748 | 1.025 | -0.6188 |
#> |.....................| -0.3985 | -0.9492 | -0.2153 | 0.2362 |
#> |.....................| 0.5439 |...........|...........|...........|
#> | U| 118.05686 | 0.4666 | 1.043 | 3.475 | 0.6914 |
#> |.....................| 1.022 | 0.05084 | 1.279 | 1.963 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 118.05686 | 1.595 | 2.837 | 32.31 | 0.6914 |
#> |.....................| 2.778 | 1.052 | 1.279 | 1.963 |
#> |.....................| 2.691 |...........|...........|...........|
#> | 9| 116.87529 | -0.7255 | -0.4157 | 1.007 | -0.6090 |
#> |.....................| -0.4046 | -0.9915 | -0.2273 | 0.2638 |
#> |.....................| 0.5643 |...........|...........|...........|
#> | U| 116.87529 | 0.4637 | 1.002 | 3.457 | 0.6948 |
#> |.....................| 1.016 | 0.008506 | 1.266 | 2.000 |
#> |.....................| 2.727 |...........|...........|...........|
#> | X| 116.87529 | 1.590 | 2.723 | 31.72 | 0.6948 |
#> |.....................| 2.761 | 1.009 | 1.266 | 2.000 |
#> |.....................| 2.727 |...........|...........|...........|
#> | F| Forward Diff. | 0.09718 | -0.5758 | -2.570 | -0.1384 |
#> |.....................| -1.067 | -0.5840 | 1.029 | 2.643 |
#> |.....................| 1.329 |...........|...........|...........|
#> | 10| 117.00331 | -0.7263 | -0.4110 | 1.028 | -0.6079 |
#> |.....................| -0.3959 | -0.9867 | -0.2358 | 0.2421 |
#> |.....................| 0.5533 |...........|...........|...........|
#> | U| 117.00331 | 0.4629 | 1.006 | 3.478 | 0.6952 |
#> |.....................| 1.024 | 0.01331 | 1.256 | 1.971 |
#> |.....................| 2.707 |...........|...........|...........|
#> | X| 117.00331 | 1.589 | 2.736 | 32.40 | 0.6952 |
#> |.....................| 2.785 | 1.013 | 1.256 | 1.971 |
#> |.....................| 2.707 |...........|...........|...........|
#> | 11| 116.85677 | -0.7257 | -0.4144 | 1.013 | -0.6087 |
#> |.....................| -0.4023 | -0.9902 | -0.2296 | 0.2580 |
#> |.....................| 0.5613 |...........|...........|...........|
#> | U| 116.85677 | 0.4634 | 1.003 | 3.463 | 0.6949 |
#> |.....................| 1.018 | 0.009803 | 1.263 | 1.993 |
#> |.....................| 2.722 |...........|...........|...........|
#> | X| 116.85677 | 1.590 | 2.726 | 31.90 | 0.6949 |
#> |.....................| 2.768 | 1.010 | 1.263 | 1.993 |
#> |.....................| 2.722 |...........|...........|...........|
#> | F| Forward Diff. | -0.04765 | 0.6256 | 3.274 | -0.04788 |
#> |.....................| -1.060 | 0.6378 | 0.7205 | 2.183 |
#> |.....................| 1.251 |...........|...........|...........|
#> | 12| 116.84445 | -0.7256 | -0.4158 | 1.006 | -0.6086 |
#> |.....................| -0.3997 | -0.9916 | -0.2310 | 0.2530 |
#> |.....................| 0.5585 |...........|...........|...........|
#> | U| 116.84445 | 0.4635 | 1.002 | 3.456 | 0.6949 |
#> |.....................| 1.021 | 0.008432 | 1.262 | 1.986 |
#> |.....................| 2.716 |...........|...........|...........|
#> | X| 116.84445 | 1.590 | 2.723 | 31.69 | 0.6949 |
#> |.....................| 2.775 | 1.008 | 1.262 | 1.986 |
#> |.....................| 2.716 |...........|...........|...........|
#> | F| Forward Diff. | 0.09730 | -0.6994 | -3.538 | -0.03650 |
#> |.....................| -1.064 | -0.7129 | 0.6224 | 1.894 |
#> |.....................| 0.9409 |...........|...........|...........|
#> | 13| 116.82752 | -0.7257 | -0.4150 | 1.012 | -0.6089 |
#> |.....................| -0.3958 | -0.9907 | -0.2318 | 0.2475 |
#> |.....................| 0.5555 |...........|...........|...........|
#> | U| 116.82752 | 0.4634 | 1.002 | 3.462 | 0.6948 |
#> |.....................| 1.024 | 0.009266 | 1.261 | 1.978 |
#> |.....................| 2.711 |...........|...........|...........|
#> | X| 116.82752 | 1.589 | 2.725 | 31.88 | 0.6948 |
#> |.....................| 2.786 | 1.009 | 1.261 | 1.978 |
#> |.....................| 2.711 |...........|...........|...........|
#> | F| Forward Diff. | -0.04193 | 0.2040 | 2.262 | -0.1521 |
#> |.....................| -1.050 | 0.2102 | 0.4967 | 1.488 |
#> |.....................| 0.8587 |...........|...........|...........|
#> | 14| 116.81980 | -0.7256 | -0.4157 | 1.007 | -0.6086 |
#> |.....................| -0.3905 | -0.9915 | -0.2326 | 0.2422 |
#> |.....................| 0.5525 |...........|...........|...........|
#> | U| 116.8198 | 0.4635 | 1.002 | 3.457 | 0.6950 |
#> |.....................| 1.030 | 0.008500 | 1.260 | 1.971 |
#> |.....................| 2.706 |...........|...........|...........|
#> | X| 116.8198 | 1.590 | 2.723 | 31.72 | 0.6950 |
#> |.....................| 2.800 | 1.009 | 1.260 | 1.971 |
#> |.....................| 2.706 |...........|...........|...........|
#> | F| Forward Diff. | 0.06676 | -0.5802 | -2.545 | 0.01398 |
#> |.....................| -1.040 | -0.5962 | 0.01321 | 1.186 |
#> |.....................| 0.5819 |...........|...........|...........|
#> | 15| 116.81249 | -0.7257 | -0.4151 | 1.011 | -0.6086 |
#> |.....................| -0.3839 | -0.9908 | -0.2308 | 0.2379 |
#> |.....................| 0.5500 |...........|...........|...........|
#> | U| 116.81249 | 0.4634 | 1.002 | 3.461 | 0.6950 |
#> |.....................| 1.036 | 0.009190 | 1.262 | 1.965 |
#> |.....................| 2.701 |...........|...........|...........|
#> | X| 116.81249 | 1.590 | 2.725 | 31.86 | 0.6950 |
#> |.....................| 2.819 | 1.009 | 1.262 | 1.965 |
#> |.....................| 2.701 |...........|...........|...........|
#> | F| Forward Diff. | -0.02431 | 0.1156 | 1.592 | 0.04944 |
#> |.....................| -1.010 | 0.1201 | 0.6380 | 0.8200 |
#> |.....................| 0.4831 |...........|...........|...........|
#> | 16| 116.80960 | -0.7257 | -0.4154 | 1.008 | -0.6098 |
#> |.....................| -0.3758 | -0.9912 | -0.2330 | 0.2357 |
#> |.....................| 0.5487 |...........|...........|...........|
#> | U| 116.8096 | 0.4634 | 1.002 | 3.458 | 0.6946 |
#> |.....................| 1.045 | 0.008808 | 1.259 | 1.962 |
#> |.....................| 2.699 |...........|...........|...........|
#> | X| 116.8096 | 1.590 | 2.724 | 31.75 | 0.6946 |
#> |.....................| 2.842 | 1.009 | 1.259 | 1.962 |
#> |.....................| 2.699 |...........|...........|...........|
#> | F| Forward Diff. | 0.03766 | -0.3156 | -1.557 | 0.01295 |
#> |.....................| -0.9931 | -0.3284 | 0.4427 | 0.6703 |
#> |.....................| 0.3523 |...........|...........|...........|
#> | 17| 116.80820 | -0.7258 | -0.4149 | 1.011 | -0.6104 |
#> |.....................| -0.3679 | -0.9906 | -0.2371 | 0.2351 |
#> |.....................| 0.5484 |...........|...........|...........|
#> | U| 116.8082 | 0.4634 | 1.003 | 3.461 | 0.6943 |
#> |.....................| 1.052 | 0.009444 | 1.255 | 1.962 |
#> |.....................| 2.698 |...........|...........|...........|
#> | X| 116.8082 | 1.589 | 2.725 | 31.85 | 0.6943 |
#> |.....................| 2.865 | 1.009 | 1.255 | 1.962 |
#> |.....................| 2.698 |...........|...........|...........|
#> | F| Forward Diff. | -0.04468 | 0.2690 | 1.586 | -0.07671 |
#> |.....................| -0.9719 | 0.2856 | -0.09668 | 0.6631 |
#> |.....................| 0.4284 |...........|...........|...........|
#> | 18| 116.80691 | -0.7255 | -0.4153 | 1.008 | -0.6096 |
#> |.....................| -0.3590 | -0.9911 | -0.2364 | 0.2342 |
#> |.....................| 0.5472 |...........|...........|...........|
#> | U| 116.80691 | 0.4636 | 1.002 | 3.458 | 0.6946 |
#> |.....................| 1.061 | 0.008942 | 1.255 | 1.960 |
#> |.....................| 2.696 |...........|...........|...........|
#> | X| 116.80691 | 1.590 | 2.724 | 31.77 | 0.6946 |
#> |.....................| 2.890 | 1.009 | 1.255 | 1.960 |
#> |.....................| 2.696 |...........|...........|...........|
#> | F| Forward Diff. | 0.02779 | -0.1677 | -1.124 | -0.002516 |
#> |.....................| -0.9417 | -0.1689 |-0.0008595 | 0.5422 |
#> |.....................| 0.2791 |...........|...........|...........|
#> | 19| 116.80628 | -0.7255 | -0.4148 | 1.011 | -0.6090 |
#> |.....................| -0.3504 | -0.9906 | -0.2343 | 0.2327 |
#> |.....................| 0.5460 |...........|...........|...........|
#> | U| 116.80628 | 0.4636 | 1.003 | 3.461 | 0.6948 |
#> |.....................| 1.070 | 0.009366 | 1.258 | 1.958 |
#> |.....................| 2.694 |...........|...........|...........|
#> | X| 116.80628 | 1.590 | 2.726 | 31.85 | 0.6948 |
#> |.....................| 2.915 | 1.009 | 1.258 | 1.958 |
#> |.....................| 2.694 |...........|...........|...........|
#> | F| Forward Diff. | -0.02227 | 0.3104 | 1.408 | -0.07037 |
#> |.....................| -0.9140 | 0.3418 | 0.2318 | 0.4631 |
#> |.....................| 0.2483 |...........|...........|...........|
#> | 20| 116.80562 | -0.7255 | -0.4152 | 1.009 | -0.6085 |
#> |.....................| -0.3464 | -0.9912 | -0.2348 | 0.2322 |
#> |.....................| 0.5459 |...........|...........|...........|
#> | U| 116.80562 | 0.4636 | 1.002 | 3.459 | 0.6950 |
#> |.....................| 1.074 | 0.008778 | 1.257 | 1.958 |
#> |.....................| 2.694 |...........|...........|...........|
#> | X| 116.80562 | 1.590 | 2.724 | 31.77 | 0.6950 |
#> |.....................| 2.927 | 1.009 | 1.257 | 1.958 |
#> |.....................| 2.694 |...........|...........|...........|
#> | F| Forward Diff. | 0.02645 | -0.1435 | -0.9284 | 0.06898 |
#> |.....................| -0.9008 | -0.1445 | 0.2245 | 0.4178 |
#> |.....................| 0.2078 |...........|...........|...........|
#> | 21| 116.80523 | -0.7256 | -0.4148 | 1.011 | -0.6086 |
#> |.....................| -0.3424 | -0.9909 | -0.2356 | 0.2314 |
#> |.....................| 0.5457 |...........|...........|...........|
#> | U| 116.80523 | 0.4635 | 1.003 | 3.461 | 0.6950 |
#> |.....................| 1.078 | 0.009104 | 1.256 | 1.957 |
#> |.....................| 2.694 |...........|...........|...........|
#> | X| 116.80523 | 1.590 | 2.726 | 31.84 | 0.6950 |
#> |.....................| 2.939 | 1.009 | 1.256 | 1.957 |
#> |.....................| 2.694 |...........|...........|...........|
#> | F| Forward Diff. | -0.02893 | 0.2145 | 1.146 | 0.01324 |
#> |.....................| -0.9001 | 0.2420 | 0.06451 | 0.3671 |
#> |.....................| 0.2252 |...........|...........|...........|
#> | 22| 116.80465 | -0.7256 | -0.4151 | 1.009 | -0.6086 |
#> |.....................| -0.3410 | -0.9913 | -0.2357 | 0.2309 |
#> |.....................| 0.5453 |...........|...........|...........|
#> | U| 116.80465 | 0.4635 | 1.002 | 3.459 | 0.6950 |
#> |.....................| 1.079 | 0.008735 | 1.256 | 1.956 |
#> |.....................| 2.693 |...........|...........|...........|
#> | X| 116.80465 | 1.590 | 2.725 | 31.79 | 0.6950 |
#> |.....................| 2.943 | 1.009 | 1.256 | 1.956 |
#> |.....................| 2.693 |...........|...........|...........|
#> | F| Forward Diff. | 0.01212 | -0.1039 | -0.5735 | 0.06024 |
#> |.....................| -0.8870 | -0.1020 | 0.05391 | 0.3428 |
#> |.....................| 0.1724 |...........|...........|...........|
#> | 23| 116.80425 | -0.7256 | -0.4149 | 1.010 | -0.6088 |
#> |.....................| -0.3391 | -0.9911 | -0.2359 | 0.2302 |
#> |.....................| 0.5450 |...........|...........|...........|
#> | U| 116.80425 | 0.4635 | 1.003 | 3.460 | 0.6949 |
#> |.....................| 1.081 | 0.008948 | 1.256 | 1.955 |
#> |.....................| 2.692 |...........|...........|...........|
#> | X| 116.80425 | 1.590 | 2.725 | 31.82 | 0.6949 |
#> |.....................| 2.948 | 1.009 | 1.256 | 1.955 |
#> |.....................| 2.692 |...........|...........|...........|
#> | F| Forward Diff. | -0.01639 | 0.1037 | 0.5987 | 0.02830 |
#> |.....................| -0.8864 | 0.1225 | 0.04883 | 0.2777 |
#> |.....................| 0.1680 |...........|...........|...........|
#> | 24| 116.80424 | -0.7256 | -0.4151 | 1.009 | -0.6088 |
#> |.....................| -0.3373 | -0.9913 | -0.2360 | 0.2296 |
#> |.....................| 0.5446 |...........|...........|...........|
#> | U| 116.80424 | 0.4635 | 1.002 | 3.459 | 0.6949 |
#> |.....................| 1.083 | 0.008691 | 1.256 | 1.954 |
#> |.....................| 2.692 |...........|...........|...........|
#> | X| 116.80424 | 1.590 | 2.725 | 31.78 | 0.6949 |
#> |.....................| 2.954 | 1.009 | 1.256 | 1.954 |
#> |.....................| 2.692 |...........|...........|...........|
#> | C| Central Diff. |-0.0001167 | -0.1557 | -0.7359 | 0.05313 |
#> |.....................| 0.4682 | -0.1686 | -0.1753 | 0.2650 |
#> |.....................| 0.1198 |...........|...........|...........|
#> | 25| 116.80386 | -0.7256 | -0.4149 | 1.010 | -0.6089 |
#> |.....................| -0.3379 | -0.9911 | -0.2357 | 0.2293 |
#> |.....................| 0.5445 |...........|...........|...........|
#> | U| 116.80386 | 0.4635 | 1.003 | 3.460 | 0.6949 |
#> |.....................| 1.082 | 0.008898 | 1.256 | 1.954 |
#> |.....................| 2.692 |...........|...........|...........|
#> | X| 116.80386 | 1.590 | 2.725 | 31.81 | 0.6949 |
#> |.....................| 2.952 | 1.009 | 1.256 | 1.954 |
#> |.....................| 2.692 |...........|...........|...........|
#> | F| Forward Diff. | -0.005283 | 0.06096 | 0.2574 | 0.03751 |
#> |.....................| -0.8770 | 0.07625 | 0.05273 | 0.2261 |
#> |.....................| 0.1359 |...........|...........|...........|
#> | 26| 116.80382 | -0.7255 | -0.4149 | 1.010 | -0.6093 |
#> |.....................| -0.3369 | -0.9911 | -0.2353 | 0.2290 |
#> |.....................| 0.5444 |...........|...........|...........|
#> | U| 116.80382 | 0.4636 | 1.003 | 3.460 | 0.6947 |
#> |.....................| 1.083 | 0.008879 | 1.257 | 1.953 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 116.80382 | 1.590 | 2.725 | 31.82 | 0.6947 |
#> |.....................| 2.955 | 1.009 | 1.257 | 1.953 |
#> |.....................| 2.691 |...........|...........|...........|
#> | C| Central Diff. | -0.01642 | 0.03867 | 0.2678 | 0.03984 |
#> |.....................| 0.4930 | 0.04192 | -0.02741 | 0.2097 |
#> |.....................| 0.1227 |...........|...........|...........|
#> | 27| 116.80374 | -0.7255 | -0.4149 | 1.010 | -0.6093 |
#> |.....................| -0.3374 | -0.9912 | -0.2353 | 0.2288 |
#> |.....................| 0.5442 |...........|...........|...........|
#> | U| 116.80374 | 0.4636 | 1.003 | 3.460 | 0.6947 |
#> |.....................| 1.083 | 0.008839 | 1.257 | 1.953 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 116.80374 | 1.590 | 2.725 | 31.81 | 0.6947 |
#> |.....................| 2.953 | 1.009 | 1.257 | 1.953 |
#> |.....................| 2.691 |...........|...........|...........|
#> | C| Central Diff. | -0.01008 | -0.002947 | 0.01119 | -0.003481 |
#> |.....................| 0.4506 | -0.003364 | -0.06411 | 0.2096 |
#> |.....................| 0.1102 |...........|...........|...........|
#> | 28| 116.80370 | -0.7255 | -0.4149 | 1.010 | -0.6093 |
#> |.....................| -0.3379 | -0.9912 | -0.2352 | 0.2286 |
#> |.....................| 0.5441 |...........|...........|...........|
#> | U| 116.8037 | 0.4636 | 1.003 | 3.460 | 0.6947 |
#> |.....................| 1.082 | 0.008843 | 1.257 | 1.953 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 116.8037 | 1.590 | 2.725 | 31.81 | 0.6947 |
#> |.....................| 2.952 | 1.009 | 1.257 | 1.953 |
#> |.....................| 2.691 |...........|...........|...........|
#> | C| Central Diff. | -0.008927 | -0.003530 | -0.002543 | 0.03935 |
#> |.....................| 0.4491 | -0.003826 | -0.05456 | 0.1732 |
#> |.....................| 0.09266 |...........|...........|...........|
#> | 29| 116.80365 | -0.7255 | -0.4149 | 1.010 | -0.6094 |
#> |.....................| -0.3390 | -0.9911 | -0.2351 | 0.2282 |
#> |.....................| 0.5439 |...........|...........|...........|
#> | U| 116.80365 | 0.4637 | 1.003 | 3.460 | 0.6947 |
#> |.....................| 1.081 | 0.008852 | 1.257 | 1.952 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 116.80365 | 1.590 | 2.725 | 31.81 | 0.6947 |
#> |.....................| 2.949 | 1.009 | 1.257 | 1.952 |
#> |.....................| 2.691 |...........|...........|...........|
#> | C| Central Diff. | -0.007599 | -0.001520 | 0.0005778 | 0.02794 |
#> |.....................| 0.4720 | -0.001619 | -0.02704 | 0.1464 |
#> |.....................| 0.07022 |...........|...........|...........|
#> | 30| 116.80358 | -0.7254 | -0.4149 | 1.010 | -0.6096 |
#> |.....................| -0.3412 | -0.9911 | -0.2350 | 0.2275 |
#> |.....................| 0.5436 |...........|...........|...........|
#> | U| 116.80358 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.079 | 0.008860 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80358 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.942 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | C| Central Diff. | -0.005416 | -0.004754 | 0.003477 | 0.06070 |
#> |.....................| 0.4775 | -0.005155 | -0.009362 | 0.09563 |
#> |.....................| 0.04744 |...........|...........|...........|
#> | 31| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3423 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | C| Central Diff. | -0.004504 | -0.001809 | -0.007112 | -0.08529 |
#> |.....................| 0.4776 | -0.001961 | -0.04002 | 0.07330 |
#> |.....................| 0.05623 |...........|...........|...........|
#> | 32| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6096 |
#> |.....................| -0.3429 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.077 | 0.008874 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.937 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 33| 116.80362 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3426 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80362 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008873 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80362 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.938 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 34| 116.80362 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80362 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008873 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80362 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.938 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 35| 116.80355 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80355 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80355 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | C| Central Diff. | -0.004420 | -0.001815 | -0.01189 | -0.1646 |
#> |.....................| 0.5141 | -0.001996 | 0.02918 | 0.09605 |
#> |.....................| 0.03007 |...........|...........|...........|
#> | 36| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.938 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 37| 116.80358 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80358 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80358 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 38| 116.80358 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80358 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80358 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 39| 116.80357 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80357 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80357 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 40| 116.80357 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80357 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80357 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 41| 116.80357 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80357 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80357 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 42| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 43| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 44| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 45| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 46| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 47| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> calculating covariance matrix
#> done
#> Calculating residuals/tables
#> done
#>
#> ── objf value did not improve, exiting the search ... ──────────────────────────
#>
#> ── forward search complete ──
#>
#> ── starting backward search... ─────────────────────────────────────────────────
#> ! no covariates added in the forward search, skipping backward search
#> $summaryTable
#> step covar var objf deltObjf AIC BIC numParams qchisqr
#> 1 1 WT ka 116.8035 2.22349e-05 377.4032 403.3484 9 5.991465
#> 2 1 WT cl 116.8036 -7.923847e-05 377.4033 403.3485 9 5.991465
#> pchisqr included searchType covNames covarEffect
#> 1 1 forward cov_WT_ka 0.006727113
#> 2 0.9999604 forward cov_WT_cl 0.008872241
#>
#> $resFwd
#> $resFwd[[1]]
#> ── nlmixr FOCEi (outer: nlminb) fit ────────────────────────────────────────────
#>
#> OBJF AIC BIC Log-likelihood Condition Number
#> FOCEi 116.8035 373.4033 393.5829 -179.7016 68.42019
#>
#> ── Time (sec $time): ───────────────────────────────────────────────────────────
#>
#> setup optimize covariance table other
#> elapsed 0.386473 0.218991 0.218999 0.017 0.720537
#>
#> ── Population Parameters ($parFixed or $parFixedDf): ───────────────────────────
#>
#> Parameter Est. SE %RSE Back-transformed(95%CI) BSV(CV%) Shrink(SD)%
#> tka Log Ka 0.464 0.195 42.1 1.59 (1.08, 2.33) 70.4 1.81%
#> tcl Log Cl 1.01 0.0751 7.42 2.75 (2.37, 3.19) 26.8 3.87%
#> tv log V 3.46 0.0437 1.26 31.8 (29.2, 34.6) 13.9 10.3%
#> add.sd 0.695 0.695
#>
#> Covariance Type ($covMethod): r,s
#> Some strong fixed parameter correlations exist ($cor) :
#> cor:tcl,tka cor:tv,tka cor:tv,tcl
#> 0.158 0.422 0.744
#>
#>
#> No correlations in between subject variability (BSV) matrix
#> Full BSV covariance ($omega) or correlation ($omegaR; diagonals=SDs)
#> Distribution stats (mean/skewness/kurtosis/p-value) available in $shrink
#> Minimization message ($message):
#> relative convergence (4)
#>
#> ── Fit Data (object is a modified tibble): ─────────────────────────────────────
#> # A tibble: 132 × 20
#> ID TIME DV PRED RES WRES IPRED IRES IWRES CPRED CRES
#> <fct> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl>
#> 1 1 0 0.74 1.79e-15 0.740 1.07 0 0.74 1.07 -5.61e-16 0.740
#> 2 1 0.25 2.84 3.26e+ 0 -0.423 -0.225 3.85 -1.01 -1.45 3.22e+ 0 -0.379
#> 3 1 0.57 6.57 5.83e+ 0 0.740 0.297 6.78 -0.215 -0.309 5.77e+ 0 0.795
#> # … with 129 more rows, and 9 more variables: CWRES <dbl>, eta.ka <dbl>,
#> # eta.cl <dbl>, eta.v <dbl>, ka <dbl>, cl <dbl>, v <dbl>, tad <dbl>,
#> # dosenum <dbl>
#>
#> $resFwd[[2]]
#> step covar var objf deltObjf AIC BIC numParams qchisqr
#> 1 1 WT ka 116.8035 2.22349e-05 377.4032 403.3484 9 5.991465
#> 2 1 WT cl 116.8036 -7.923847e-05 377.4033 403.3485 9 5.991465
#> pchisqr included searchType covNames covarEffect
#> 1 1 forward cov_WT_ka 0.006727113
#> 2 0.9999604 forward cov_WT_cl 0.008872241
#>
#>
#> $resBck
#> $resBck[[1]]
#> ── nlmixr FOCEi (outer: nlminb) fit ────────────────────────────────────────────
#>
#> OBJF AIC BIC Log-likelihood Condition Number
#> FOCEi 116.8035 373.4033 393.5829 -179.7016 68.42019
#>
#> ── Time (sec $time): ───────────────────────────────────────────────────────────
#>
#> setup optimize covariance table other
#> elapsed 0.386473 0.218991 0.218999 0.017 0.720537
#>
#> ── Population Parameters ($parFixed or $parFixedDf): ───────────────────────────
#>
#> Parameter Est. SE %RSE Back-transformed(95%CI) BSV(CV%) Shrink(SD)%
#> tka Log Ka 0.464 0.195 42.1 1.59 (1.08, 2.33) 70.4 1.81%
#> tcl Log Cl 1.01 0.0751 7.42 2.75 (2.37, 3.19) 26.8 3.87%
#> tv log V 3.46 0.0437 1.26 31.8 (29.2, 34.6) 13.9 10.3%
#> add.sd 0.695 0.695
#>
#> Covariance Type ($covMethod): r,s
#> Some strong fixed parameter correlations exist ($cor) :
#> cor:tcl,tka cor:tv,tka cor:tv,tcl
#> 0.158 0.422 0.744
#>
#>
#> No correlations in between subject variability (BSV) matrix
#> Full BSV covariance ($omega) or correlation ($omegaR; diagonals=SDs)
#> Distribution stats (mean/skewness/kurtosis/p-value) available in $shrink
#> Minimization message ($message):
#> relative convergence (4)
#>
#> ── Fit Data (object is a modified tibble): ─────────────────────────────────────
#> # A tibble: 132 × 20
#> ID TIME DV PRED RES WRES IPRED IRES IWRES CPRED CRES
#> <fct> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl>
#> 1 1 0 0.74 1.79e-15 0.740 1.07 0 0.74 1.07 -5.61e-16 0.740
#> 2 1 0.25 2.84 3.26e+ 0 -0.423 -0.225 3.85 -1.01 -1.45 3.22e+ 0 -0.379
#> 3 1 0.57 6.57 5.83e+ 0 0.740 0.297 6.78 -0.215 -0.309 5.77e+ 0 0.795
#> # … with 129 more rows, and 9 more variables: CWRES <dbl>, eta.ka <dbl>,
#> # eta.cl <dbl>, eta.v <dbl>, ka <dbl>, cl <dbl>, v <dbl>, tad <dbl>,
#> # dosenum <dbl>
#>
#> $resBck[[2]]
#> NULL
#>
#>
## Note that this didn't include sex, add it to dataset and restart model
d <- theo_sd
d$SEX <-0
d$SEX[d$ID<=6] <-1
fit <- nlmixr(one.cmt, d, "focei")
#> ℹ parameter labels from comments will be replaced by 'label()'
#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
#> F: Forward difference gradient approximation
#> C: Central difference gradient approximation
#> M: Mixed forward and central difference gradient approximation
#> Unscaled parameters for Omegas=chol(solve(omega));
#> Diagonals are transformed, as specified by foceiControl(diagXform=)
#> |-----+---------------+-----------+-----------+-----------+-----------|
#> | #| Objective Fun | tka | tcl | tv | add.sd |
#> |.....................| o1 | o2 | o3 |...........|
#> | 1| 133.57512 | -1.000 | -0.6378 | 1.000 | -0.8333 |
#> |.....................| -0.5425 | -0.3992 | -0.1145 |...........|
#> | U| 133.57512 | 0.4500 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | X| 133.57512 | 1.568 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.136 | 1.351 | 1.778 |...........|
#> | G| Gill Diff. | -0.9310 | -1.614 | -3.052 | 1.541 |
#> |.....................| -11.80 | -35.24 | -34.65 |...........|
#> | 2| 122.59020 | -0.9817 | -0.6062 | 1.060 | -0.8636 |
#> |.....................| -0.3110 | 0.2924 | 0.5654 |...........|
#> | U| 122.5902 | 0.4683 | 1.025 | 3.510 | 0.6894 |
#> |.....................| 1.399 | 2.286 | 2.987 |...........|
#> | X| 122.5902 | 1.597 | 2.787 | 33.44 | 0.6894 |
#> |.....................| 1.399 | 2.286 | 2.987 |...........|
#> | F| Forward Diff. | -0.9193 | 14.79 | 70.12 | -4.948 |
#> |.....................| 14.22 | 16.76 | 13.93 |...........|
#> | 3| 691.01138 | -0.9592 | -0.7976 | 0.1049 | -0.8098 |
#> |.....................| -0.3897 | 0.4190 | 0.7258 |...........|
#> | U| 691.01138 | 0.4908 | 0.8335 | 2.555 | 0.7082 |
#> |.....................| 1.310 | 2.457 | 3.272 |...........|
#> | X| 691.01138 | 1.634 | 2.301 | 12.87 | 0.7082 |
#> |.....................| 1.310 | 2.457 | 3.272 |...........|
#> | 4| 121.02313 | -0.9805 | -0.6255 | 0.9681 | -0.8571 |
#> |.....................| -0.3296 | 0.2704 | 0.5472 |...........|
#> | U| 121.02313 | 0.4695 | 1.006 | 3.418 | 0.6917 |
#> |.....................| 1.378 | 2.256 | 2.955 |...........|
#> | X| 121.02313 | 1.599 | 2.733 | 30.51 | 0.6917 |
#> |.....................| 1.378 | 2.256 | 2.955 |...........|
#> | F| Forward Diff. | 2.644 | -6.902 | -53.13 | -3.008 |
#> |.....................| 13.05 | 15.51 | 9.450 |...........|
#> | 5| 118.40944 | -0.9856 | -0.6239 | 1.019 | -0.8463 |
#> |.....................| -0.3724 | 0.2115 | 0.5032 |...........|
#> | U| 118.40944 | 0.4644 | 1.007 | 3.469 | 0.6955 |
#> |.....................| 1.329 | 2.176 | 2.877 |...........|
#> | X| 118.40944 | 1.591 | 2.738 | 32.12 | 0.6955 |
#> |.....................| 1.329 | 2.176 | 2.877 |...........|
#> | F| Forward Diff. | 0.01257 | -0.06271 | 11.65 | -1.181 |
#> |.....................| 7.396 | 11.24 | 6.682 |...........|
#> | 6| 117.95102 | -0.9860 | -0.6177 | 0.9748 | -0.8413 |
#> |.....................| -0.4126 | 0.1437 | 0.4615 |...........|
#> | U| 117.95102 | 0.4640 | 1.013 | 3.425 | 0.6972 |
#> |.....................| 1.284 | 2.085 | 2.803 |...........|
#> | X| 117.95102 | 1.590 | 2.755 | 30.72 | 0.6972 |
#> |.....................| 1.284 | 2.085 | 2.803 |...........|
#> | F| Forward Diff. | 1.122 | -2.134 | -37.05 | 0.6672 |
#> |.....................| 3.102 | 7.185 | 4.243 |...........|
#> | 7| 117.01192 | -0.9844 | -0.6189 | 1.027 | -0.8580 |
#> |.....................| -0.4206 | 0.07306 | 0.4170 |...........|
#> | U| 117.01192 | 0.4656 | 1.012 | 3.477 | 0.6914 |
#> |.....................| 1.275 | 1.989 | 2.723 |...........|
#> | X| 117.01192 | 1.593 | 2.752 | 32.35 | 0.6914 |
#> |.....................| 1.275 | 1.989 | 2.723 |...........|
#> | F| Forward Diff. | -0.2405 | 1.324 | 17.06 | -1.389 |
#> |.....................| 1.899 | 2.064 | 1.794 |...........|
#> | 8| 117.12874 | -0.9866 | -0.6555 | 1.005 | -0.8409 |
#> |.....................| -0.4185 | 0.01390 | 0.3507 |...........|
#> | U| 117.12874 | 0.4634 | 0.9756 | 3.455 | 0.6973 |
#> |.....................| 1.277 | 1.909 | 2.606 |...........|
#> | X| 117.12874 | 1.590 | 2.653 | 31.66 | 0.6973 |
#> |.....................| 1.277 | 1.909 | 2.606 |...........|
#> | 9| 116.86111 | -0.9850 | -0.6329 | 1.006 | -0.8508 |
#> |.....................| -0.4213 | 0.05044 | 0.3921 |...........|
#> | U| 116.86111 | 0.4650 | 0.9982 | 3.456 | 0.6939 |
#> |.....................| 1.274 | 1.959 | 2.679 |...........|
#> | X| 116.86111 | 1.592 | 2.713 | 31.68 | 0.6939 |
#> |.....................| 1.274 | 1.959 | 2.679 |...........|
#> | F| Forward Diff. | 0.1372 | -4.279 | -4.745 | -0.1588 |
#> |.....................| 1.829 | 0.4197 | -0.2277 |...........|
#> | 10| 116.90243 | -0.9853 | -0.5936 | 1.006 | -0.8456 |
#> |.....................| -0.4367 | 0.04760 | 0.3910 |...........|
#> | U| 116.90243 | 0.4647 | 1.037 | 3.456 | 0.6957 |
#> |.....................| 1.256 | 1.955 | 2.677 |...........|
#> | X| 116.90243 | 1.592 | 2.822 | 31.68 | 0.6957 |
#> |.....................| 1.256 | 1.955 | 2.677 |...........|
#> | 11| 116.81300 | -0.9853 | -0.6177 | 1.012 | -0.8493 |
#> |.....................| -0.4275 | 0.04920 | 0.3921 |...........|
#> | U| 116.813 | 0.4647 | 1.013 | 3.462 | 0.6944 |
#> |.....................| 1.267 | 1.957 | 2.679 |...........|
#> | X| 116.813 | 1.592 | 2.755 | 31.88 | 0.6944 |
#> |.....................| 1.267 | 1.957 | 2.679 |...........|
#> | F| Forward Diff. | 0.04146 | 0.5982 | 2.027 | -0.1930 |
#> |.....................| 1.293 | 0.4341 | -0.1919 |...........|
#> | 12| 116.81643 | -0.9859 | -0.6188 | 1.005 | -0.8484 |
#> |.....................| -0.4420 | 0.04884 | 0.3991 |...........|
#> | U| 116.81643 | 0.4641 | 1.012 | 3.455 | 0.6947 |
#> |.....................| 1.250 | 1.957 | 2.692 |...........|
#> | X| 116.81643 | 1.591 | 2.752 | 31.66 | 0.6947 |
#> |.....................| 1.250 | 1.957 | 2.692 |...........|
#> | 13| 116.81366 | -0.9854 | -0.6194 | 1.006 | -0.8487 |
#> |.....................| -0.4322 | 0.04799 | 0.3932 |...........|
#> | U| 116.81366 | 0.4646 | 1.012 | 3.456 | 0.6946 |
#> |.....................| 1.262 | 1.955 | 2.681 |...........|
#> | X| 116.81366 | 1.591 | 2.750 | 31.69 | 0.6946 |
#> |.....................| 1.262 | 1.955 | 2.681 |...........|
#> | 14| 116.80890 | -0.9853 | -0.6186 | 1.009 | -0.8490 |
#> |.....................| -0.4295 | 0.04853 | 0.3924 |...........|
#> | U| 116.8089 | 0.4647 | 1.012 | 3.459 | 0.6945 |
#> |.....................| 1.265 | 1.956 | 2.680 |...........|
#> | X| 116.8089 | 1.592 | 2.752 | 31.78 | 0.6945 |
#> |.....................| 1.265 | 1.956 | 2.680 |...........|
#> | F| Forward Diff. | 0.09967 | 0.1293 | -0.9650 | 0.1356 |
#> |.....................| 1.065 | 0.2446 | -0.1725 |...........|
#> | 15| 116.80676 | -0.9856 | -0.6189 | 1.011 | -0.8494 |
#> |.....................| -0.4323 | 0.04789 | 0.3929 |...........|
#> | U| 116.80676 | 0.4644 | 1.012 | 3.461 | 0.6944 |
#> |.....................| 1.261 | 1.955 | 2.680 |...........|
#> | X| 116.80676 | 1.591 | 2.752 | 31.86 | 0.6944 |
#> |.....................| 1.261 | 1.955 | 2.680 |...........|
#> | F| Forward Diff. | 0.01623 | 0.1762 | 1.448 | 0.001944 |
#> |.....................| 0.8101 | 0.3560 | -0.1495 |...........|
#> | 16| 116.80511 | -0.9857 | -0.6196 | 1.009 | -0.8499 |
#> |.....................| -0.4347 | 0.04738 | 0.3939 |...........|
#> | U| 116.80511 | 0.4643 | 1.012 | 3.459 | 0.6942 |
#> |.....................| 1.259 | 1.955 | 2.682 |...........|
#> | X| 116.80511 | 1.591 | 2.750 | 31.77 | 0.6942 |
#> |.....................| 1.259 | 1.955 | 2.682 |...........|
#> | F| Forward Diff. | 0.06298 | -0.1883 | -1.085 | -0.05009 |
#> |.....................| 0.4485 | 0.2102 | -0.08332 |...........|
#> | 17| 116.80401 | -0.9859 | -0.6193 | 1.011 | -0.8500 |
#> |.....................| -0.4369 | 0.04655 | 0.3962 |...........|
#> | U| 116.80401 | 0.4641 | 1.012 | 3.461 | 0.6942 |
#> |.....................| 1.256 | 1.954 | 2.686 |...........|
#> | X| 116.80401 | 1.591 | 2.750 | 31.84 | 0.6942 |
#> |.....................| 1.256 | 1.954 | 2.686 |...........|
#> | F| Forward Diff. |-0.0009677 | 0.002269 | 0.9503 | -0.2533 |
#> |.....................| 0.1402 | 0.3095 | -0.009911 |...........|
#> | 18| 116.80364 | -0.9861 | -0.6189 | 1.010 | -0.8474 |
#> |.....................| -0.4369 | 0.04466 | 0.3982 |...........|
#> | U| 116.80364 | 0.4639 | 1.012 | 3.460 | 0.6951 |
#> |.....................| 1.256 | 1.951 | 2.690 |...........|
#> | X| 116.80364 | 1.590 | 2.752 | 31.81 | 0.6951 |
#> |.....................| 1.256 | 1.951 | 2.690 |...........|
#> | F| Forward Diff. | 0.01764 | 0.05231 | 0.02747 | 0.2443 |
#> |.....................| 0.1370 | 0.07969 | 0.09639 |...........|
#> | 19| 116.80372 | -0.9864 | -0.6195 | 1.009 | -0.8504 |
#> |.....................| -0.4386 | 0.04367 | 0.3970 |...........|
#> | U| 116.80372 | 0.4636 | 1.012 | 3.459 | 0.6940 |
#> |.....................| 1.254 | 1.950 | 2.688 |...........|
#> | X| 116.80372 | 1.590 | 2.750 | 31.80 | 0.6940 |
#> |.....................| 1.254 | 1.950 | 2.688 |...........|
#> | 20| 116.80348 | -0.9862 | -0.6192 | 1.010 | -0.8488 |
#> |.....................| -0.4377 | 0.04420 | 0.3976 |...........|
#> | U| 116.80348 | 0.4638 | 1.012 | 3.460 | 0.6946 |
#> |.....................| 1.255 | 1.950 | 2.689 |...........|
#> | X| 116.80348 | 1.590 | 2.751 | 31.80 | 0.6946 |
#> |.....................| 1.255 | 1.950 | 2.689 |...........|
#> | F| Forward Diff. | 0.01066 | -0.05164 | -0.1358 | 0.07351 |
#> |.....................| 0.1166 | 0.04721 | 0.07105 |...........|
#> | 21| 116.80394 | -0.9863 | -0.6188 | 1.011 | -0.8494 |
#> |.....................| -0.4387 | 0.04380 | 0.3970 |...........|
#> | U| 116.80394 | 0.4637 | 1.012 | 3.461 | 0.6944 |
#> |.....................| 1.254 | 1.950 | 2.688 |...........|
#> | X| 116.80394 | 1.590 | 2.752 | 31.84 | 0.6944 |
#> |.....................| 1.254 | 1.950 | 2.688 |...........|
#> | 22| 116.80348 | -0.9862 | -0.6192 | 1.010 | -0.8488 |
#> |.....................| -0.4377 | 0.04420 | 0.3976 |...........|
#> | U| 116.80348 | 0.4638 | 1.012 | 3.460 | 0.6946 |
#> |.....................| 1.255 | 1.950 | 2.689 |...........|
#> | X| 116.80348 | 1.590 | 2.751 | 31.80 | 0.6946 |
#> |.....................| 1.255 | 1.950 | 2.689 |...........|
#> calculating covariance matrix
#> done
#> Calculating residuals/tables
#> done
#> Warning: initial ETAs were nudged; (can control by foceiControl(etaNudge=., etaNudge2=))
#> Warning: ETAs were reset to zero during optimization; (Can control by foceiControl(resetEtaP=.))
#> Warning: last objective function was not at minimum, possible problems in optimization
#> Warning: gradient problems with initial estimate and covariance; see $scaleInfo
# This would restart if for some reason the search crashed:
RxODE::.rxWithWd(tempdir(), {# with temporary directory
covarSearchAuto(fit, varsVec = c("ka", "cl"), covarsVec = c("WT", "SEX"),
catCovariates = c("SEX"), restart = TRUE)
covarSearchAuto(fit, varsVec = c("ka", "cl"), covarsVec = c("WT", "SEX"),
catCovariates = c("SEX"), restart = TRUE,
searchType = "forward")
})
#>
#> ── starting forward search... ──────────────────────────────────────────────────
#> ✔ added centered_WT*cov_WT_ka to ka's equation in the model
#> ✔ updated value: ka<-exp(tka+centered_WT*cov_WT_ka+eta.ka)
#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
#> F: Forward difference gradient approximation
#> C: Central difference gradient approximation
#> M: Mixed forward and central difference gradient approximation
#> Unscaled parameters for Omegas=chol(solve(omega));
#> Diagonals are transformed, as specified by foceiControl(diagXform=)
#> |-----+---------------+-----------+-----------+-----------+-----------|
#> | #| Objective Fun | tka | tcl | tv | add.sd |
#> |.....................|centered_WT | cov_WT_ka | o1 | o2 |
#> |.....................| o3 |...........|...........|...........|
#> | 1| 133.57512 | -0.7391 | -0.4242 | 1.000 | -0.5942 |
#> |.....................| -0.4203 | -1.000 | -0.3413 | -0.2167 |
#> |.....................| 0.03089 |...........|...........|...........|
#> | U| 133.57512 | 0.4500 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.000 | 0.000 | 1.136 | 1.351 |
#> |.....................| 1.778 |...........|...........|...........|
#> | X| 133.57512 | 1.568 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 2.718 | 1.000 | 1.136 | 1.351 |
#> |.....................| 1.778 |...........|...........|...........|
#> | G| Gill Diff. | -0.9310 | -1.614 | -3.052 | 1.591 |
#> |.....................| -0.001938 | -0.9310 | -11.78 | -35.27 |
#> |.....................| -34.78 |...........|...........|...........|
#> | 2| 122.56663 | -0.7209 | -0.3926 | 1.060 | -0.6254 |
#> |.....................| -0.4201 | -0.9818 | -0.1106 | 0.4739 |
#> |.....................| 0.7118 |...........|...........|...........|
#> | U| 122.56663 | 0.4682 | 1.025 | 3.510 | 0.6891 |
#> |.....................| 1.000 | 0.01823 | 1.398 | 2.284 |
#> |.....................| 2.989 |...........|...........|...........|
#> | X| 122.56663 | 1.597 | 2.787 | 33.44 | 0.6891 |
#> |.....................| 2.719 | 1.018 | 1.398 | 2.284 |
#> |.....................| 2.989 |...........|...........|...........|
#> | F| Forward Diff. | 0.5883 | 14.89 | 69.34 | -5.082 |
#> |.....................| 0.01707 | 0.5885 | 14.10 | 16.71 |
#> |.....................| 13.90 |...........|...........|...........|
#> | 3| 690.01754 | -0.7198 | -0.5879 | 0.1045 | -0.5693 |
#> |.....................| -0.4204 | -0.9806 | -0.1910 | 0.5963 |
#> |.....................| 0.8691 |...........|...........|...........|
#> | U| 690.01754 | 0.4694 | 0.8295 | 2.554 | 0.7087 |
#> |.....................| 0.9999 | 0.01936 | 1.307 | 2.450 |
#> |.....................| 3.269 |...........|...........|...........|
#> | X| 690.01754 | 1.599 | 2.292 | 12.86 | 0.7087 |
#> |.....................| 2.718 | 1.020 | 1.307 | 2.450 |
#> |.....................| 3.269 |...........|...........|...........|
#> | 4| 121.05724 | -0.7217 | -0.4123 | 0.9681 | -0.6186 |
#> |.....................| -0.4202 | -0.9826 | -0.1293 | 0.4518 |
#> |.....................| 0.6935 |...........|...........|...........|
#> | U| 121.05724 | 0.4674 | 1.005 | 3.418 | 0.6914 |
#> |.....................| 1.000 | 0.01745 | 1.377 | 2.254 |
#> |.....................| 2.957 |...........|...........|...........|
#> | X| 121.05724 | 1.596 | 2.732 | 30.51 | 0.6914 |
#> |.....................| 2.719 | 1.018 | 1.377 | 2.254 |
#> |.....................| 2.957 |...........|...........|...........|
#> | F| Forward Diff. | 3.837 | -6.944 | -53.83 | -3.090 |
#> |.....................| 0.06934 | 3.838 | 13.37 | 15.43 |
#> |.....................| 9.539 |...........|...........|...........|
#> | 5| 118.41302 | -0.7303 | -0.4110 | 1.020 | -0.6076 |
#> |.....................| -0.4203 | -0.9912 | -0.1722 | 0.3939 |
#> |.....................| 0.6500 |...........|...........|...........|
#> | U| 118.41302 | 0.4588 | 1.007 | 3.470 | 0.6953 |
#> |.....................| 1.000 | 0.008841 | 1.328 | 2.176 |
#> |.....................| 2.879 |...........|...........|...........|
#> | X| 118.41302 | 1.582 | 2.736 | 32.12 | 0.6953 |
#> |.....................| 2.718 | 1.009 | 1.328 | 2.176 |
#> |.....................| 2.879 |...........|...........|...........|
#> | F| Forward Diff. | 0.2193 | -0.3076 | 11.77 | -1.219 |
#> |.....................|-0.0007891 | 0.2195 | 7.249 | 11.25 |
#> |.....................| 6.750 |...........|...........|...........|
#> | 6| 117.95957 | -0.7313 | -0.4033 | 0.9747 | -0.6024 |
#> |.....................| -0.4203 | -0.9922 | -0.2116 | 0.3262 |
#> |.....................| 0.6080 |...........|...........|...........|
#> | U| 117.95957 | 0.4578 | 1.014 | 3.425 | 0.6971 |
#> |.....................| 1.000 | 0.007833 | 1.284 | 2.085 |
#> |.....................| 2.805 |...........|...........|...........|
#> | X| 117.95957 | 1.581 | 2.757 | 30.71 | 0.6971 |
#> |.....................| 2.718 | 1.008 | 1.284 | 2.085 |
#> |.....................| 2.805 |...........|...........|...........|
#> | F| Forward Diff. | 1.235 | -1.853 | -37.21 | 0.1988 |
#> |.....................| 0.01043 | 1.235 | 3.123 | 7.245 |
#> |.....................| 4.285 |...........|...........|...........|
#> | 7| 117.01527 | -0.7254 | -0.4049 | 1.027 | -0.6142 |
#> |.....................| -0.4200 | -0.9862 | -0.2186 | 0.2552 |
#> |.....................| 0.5634 |...........|...........|...........|
#> | U| 117.01527 | 0.4638 | 1.013 | 3.477 | 0.6930 |
#> |.....................| 1.000 | 0.01375 | 1.276 | 1.989 |
#> |.....................| 2.725 |...........|...........|...........|
#> | X| 117.01527 | 1.590 | 2.753 | 32.36 | 0.6930 |
#> |.....................| 2.719 | 1.014 | 1.276 | 1.989 |
#> |.....................| 2.725 |...........|...........|...........|
#> | F| Forward Diff. | 0.4612 | 1.530 | 17.00 | -0.8240 |
#> |.....................| 0.009037 | 0.4613 | 2.046 | 2.040 |
#> |.....................| 1.907 |...........|...........|...........|
#> | 8| 117.25439 | -0.7495 | -0.4529 | 1.005 | -0.6159 |
#> |.....................| -0.4203 | -1.010 | -0.2219 | 0.2056 |
#> |.....................| 0.5036 |...........|...........|...........|
#> | U| 117.25439 | 0.4396 | 0.9646 | 3.455 | 0.6924 |
#> |.....................| 1.000 | -0.01039 | 1.272 | 1.922 |
#> |.....................| 2.619 |...........|...........|...........|
#> | X| 117.25439 | 1.552 | 2.624 | 31.67 | 0.6924 |
#> |.....................| 2.718 | 0.9897 | 1.272 | 1.922 |
#> |.....................| 2.619 |...........|...........|...........|
#> | 9| 116.86499 | -0.7327 | -0.4199 | 1.006 | -0.6140 |
#> |.....................| -0.4201 | -0.9935 | -0.2213 | 0.2393 |
#> |.....................| 0.5447 |...........|...........|...........|
#> | U| 116.86499 | 0.4565 | 0.9976 | 3.456 | 0.6931 |
#> |.....................| 1.000 | 0.006478 | 1.273 | 1.967 |
#> |.....................| 2.692 |...........|...........|...........|
#> | X| 116.86499 | 1.579 | 2.712 | 31.69 | 0.6931 |
#> |.....................| 2.719 | 1.006 | 1.273 | 1.967 |
#> |.....................| 2.692 |...........|...........|...........|
#> | F| Forward Diff. | 0.01173 | -4.519 | -4.436 | -0.4241 |
#> |.....................| 0.002109 | 0.01176 | 1.833 | 0.9175 |
#> |.....................| 0.1786 |...........|...........|...........|
#> | 10| 116.86782 | -0.7345 | -0.3853 | 1.007 | -0.6104 |
#> |.....................| -0.4202 | -0.9954 | -0.2332 | 0.2360 |
#> |.....................| 0.5422 |...........|...........|...........|
#> | U| 116.86782 | 0.4546 | 1.032 | 3.457 | 0.6943 |
#> |.....................| 1.000 | 0.004634 | 1.259 | 1.963 |
#> |.....................| 2.688 |...........|...........|...........|
#> | X| 116.86782 | 1.576 | 2.807 | 31.71 | 0.6943 |
#> |.....................| 2.719 | 1.005 | 1.259 | 1.963 |
#> |.....................| 2.688 |...........|...........|...........|
#> | 11| 116.81520 | -0.7332 | -0.4038 | 1.012 | -0.6124 |
#> |.....................| -0.4201 | -0.9941 | -0.2272 | 0.2372 |
#> |.....................| 0.5438 |...........|...........|...........|
#> | U| 116.8152 | 0.4559 | 1.014 | 3.462 | 0.6936 |
#> |.....................| 1.000 | 0.005913 | 1.266 | 1.964 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.8152 | 1.578 | 2.756 | 31.88 | 0.6936 |
#> |.....................| 2.719 | 1.006 | 1.266 | 1.964 |
#> |.....................| 2.690 |...........|...........|...........|
#> | F| Forward Diff. | -0.1208 | 0.6475 | 2.176 | -0.4241 |
#> |.....................| -0.002311 | -0.1208 | 1.132 | 0.7265 |
#> |.....................| 0.2261 |...........|...........|...........|
#> | 12| 116.82949 | -0.7297 | -0.4041 | 1.003 | -0.6069 |
#> |.....................| -0.4201 | -0.9905 | -0.2406 | 0.2349 |
#> |.....................| 0.5478 |...........|...........|...........|
#> | U| 116.82949 | 0.4595 | 1.013 | 3.453 | 0.6956 |
#> |.....................| 1.000 | 0.009473 | 1.251 | 1.961 |
#> |.....................| 2.697 |...........|...........|...........|
#> | X| 116.82949 | 1.583 | 2.755 | 31.60 | 0.6956 |
#> |.....................| 2.719 | 1.010 | 1.251 | 1.961 |
#> |.....................| 2.697 |...........|...........|...........|
#> | 13| 116.81371 | -0.7329 | -0.4054 | 1.006 | -0.6114 |
#> |.....................| -0.4201 | -0.9938 | -0.2300 | 0.2354 |
#> |.....................| 0.5432 |...........|...........|...........|
#> | U| 116.81371 | 0.4562 | 1.012 | 3.456 | 0.6940 |
#> |.....................| 1.000 | 0.006211 | 1.263 | 1.962 |
#> |.....................| 2.689 |...........|...........|...........|
#> | X| 116.81371 | 1.578 | 2.751 | 31.70 | 0.6940 |
#> |.....................| 2.719 | 1.006 | 1.263 | 1.962 |
#> |.....................| 2.689 |...........|...........|...........|
#> | F| Forward Diff. | 0.02145 | -0.1768 | -3.058 | -0.3040 |
#> |.....................| -0.001671 | 0.02153 | 0.8004 | 0.6029 |
#> |.....................| 0.05288 |...........|...........|...........|
#> | 14| 116.80660 | -0.7322 | -0.4068 | 1.011 | -0.6095 |
#> |.....................| -0.4201 | -0.9930 | -0.2339 | 0.2343 |
#> |.....................| 0.5446 |...........|...........|...........|
#> | U| 116.8066 | 0.4570 | 1.011 | 3.461 | 0.6947 |
#> |.....................| 1.000 | 0.006954 | 1.258 | 1.961 |
#> |.....................| 2.692 |...........|...........|...........|
#> | X| 116.8066 | 1.579 | 2.747 | 31.84 | 0.6947 |
#> |.....................| 2.719 | 1.007 | 1.258 | 1.961 |
#> |.....................| 2.692 |...........|...........|...........|
#> | F| Forward Diff. | -0.01093 | -0.3104 | 1.002 | -0.06813 |
#> |.....................| -0.001589 | -0.01078 | -0.05248 | 0.5435 |
#> |.....................| 0.2242 |...........|...........|...........|
#> | 15| 116.80565 | -0.7313 | -0.4052 | 1.010 | -0.6079 |
#> |.....................| -0.4200 | -0.9922 | -0.2311 | 0.2290 |
#> |.....................| 0.5449 |...........|...........|...........|
#> | U| 116.80565 | 0.4579 | 1.012 | 3.460 | 0.6952 |
#> |.....................| 1.000 | 0.007846 | 1.261 | 1.953 |
#> |.....................| 2.692 |...........|...........|...........|
#> | X| 116.80565 | 1.581 | 2.752 | 31.80 | 0.6952 |
#> |.....................| 2.719 | 1.008 | 1.261 | 1.953 |
#> |.....................| 2.692 |...........|...........|...........|
#> | F| Forward Diff. | 0.1391 | 0.07373 | -0.1581 | 0.1321 |
#> |.....................| 0.002361 | 0.1391 | 0.6135 | 0.2208 |
#> |.....................| 0.1250 |...........|...........|...........|
#> | 16| 116.80376 | -0.7328 | -0.4058 | 1.010 | -0.6099 |
#> |.....................| -0.4201 | -0.9936 | -0.2364 | 0.2264 |
#> |.....................| 0.5442 |...........|...........|...........|
#> | U| 116.80376 | 0.4564 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.000 | 0.006367 | 1.255 | 1.950 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 116.80376 | 1.578 | 2.750 | 31.83 | 0.6945 |
#> |.....................| 2.719 | 1.006 | 1.255 | 1.950 |
#> |.....................| 2.691 |...........|...........|...........|
#> | F| Forward Diff. | -0.06478 | -0.07166 | 0.6997 | -0.09342 |
#> |.....................| -0.001903 | -0.06475 | -0.03712 | 0.005775 |
#> |.....................| 0.09210 |...........|...........|...........|
#> | 17| 116.81449 | -0.7316 | -0.4055 | 1.005 | -0.6086 |
#> |.....................| -0.4200 | -0.9925 | -0.2394 | 0.2273 |
#> |.....................| 0.5426 |...........|...........|...........|
#> | U| 116.81449 | 0.4575 | 1.012 | 3.455 | 0.6950 |
#> |.....................| 1.000 | 0.007498 | 1.252 | 1.951 |
#> |.....................| 2.688 |...........|...........|...........|
#> | X| 116.81449 | 1.580 | 2.751 | 31.66 | 0.6950 |
#> |.....................| 2.719 | 1.008 | 1.252 | 1.951 |
#> |.....................| 2.688 |...........|...........|...........|
#> | 18| 116.80356 | -0.7327 | -0.4057 | 1.009 | -0.6098 |
#> |.....................| -0.4201 | -0.9936 | -0.2364 | 0.2264 |
#> |.....................| 0.5441 |...........|...........|...........|
#> | U| 116.80356 | 0.4565 | 1.012 | 3.459 | 0.6946 |
#> |.....................| 1.000 | 0.006447 | 1.255 | 1.950 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 116.80356 | 1.578 | 2.750 | 31.80 | 0.6946 |
#> |.....................| 2.719 | 1.006 | 1.255 | 1.950 |
#> |.....................| 2.691 |...........|...........|...........|
#> | F| Forward Diff. | -0.03566 | -0.09869 | -0.1316 | -0.02313 |
#> |.....................| -0.001623 | -0.03572 | -0.02324 | 0.01337 |
#> |.....................| 0.06508 |...........|...........|...........|
#> | 19| 116.80346 | -0.7324 | -0.4054 | 1.010 | -0.6097 |
#> |.....................| -0.4200 | -0.9933 | -0.2364 | 0.2266 |
#> |.....................| 0.5435 |...........|...........|...........|
#> | U| 116.80346 | 0.4567 | 1.012 | 3.460 | 0.6946 |
#> |.....................| 1.000 | 0.006727 | 1.255 | 1.950 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80346 | 1.579 | 2.751 | 31.81 | 0.6946 |
#> |.....................| 2.719 | 1.007 | 1.255 | 1.950 |
#> |.....................| 2.690 |...........|...........|...........|
#> | C| Central Diff. | -0.02335 | -0.01419 | 0.08010 | 0.1344 |
#> |.....................| 0.03695 | -0.02340 | -0.1781 | 0.03927 |
#> |.....................| 0.05723 |...........|...........|...........|
#> | 20| 116.80346 | -0.7324 | -0.4054 | 1.010 | -0.6097 |
#> |.....................| -0.4200 | -0.9933 | -0.2364 | 0.2266 |
#> |.....................| 0.5435 |...........|...........|...........|
#> | U| 116.80346 | 0.4567 | 1.012 | 3.460 | 0.6946 |
#> |.....................| 1.000 | 0.006727 | 1.255 | 1.950 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80346 | 1.579 | 2.751 | 31.81 | 0.6946 |
#> |.....................| 2.719 | 1.007 | 1.255 | 1.950 |
#> |.....................| 2.690 |...........|...........|...........|
#> calculating covariance matrix
#> done
#> Calculating residuals/tables
#> done
#> ✔ added centered_WT*cov_WT_cl to cl's equation in the model
#> ✔ updated value: cl<-exp(tcl+centered_WT*cov_WT_cl+eta.cl)
#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
#> F: Forward difference gradient approximation
#> C: Central difference gradient approximation
#> M: Mixed forward and central difference gradient approximation
#> Unscaled parameters for Omegas=chol(solve(omega));
#> Diagonals are transformed, as specified by foceiControl(diagXform=)
#> |-----+---------------+-----------+-----------+-----------+-----------|
#> | #| Objective Fun | tka | tcl | tv | add.sd |
#> |.....................|centered_WT | cov_WT_cl | o1 | o2 |
#> |.....................| o3 |...........|...........|...........|
#> | 1| 133.57512 | -0.7391 | -0.4242 | 1.000 | -0.5942 |
#> |.....................| -0.4203 | -1.000 | -0.3413 | -0.2167 |
#> |.....................| 0.03089 |...........|...........|...........|
#> | U| 133.57512 | 0.4500 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.000 | 0.000 | 1.136 | 1.351 |
#> |.....................| 1.778 |...........|...........|...........|
#> | X| 133.57512 | 1.568 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 2.718 | 1.000 | 1.136 | 1.351 |
#> |.....................| 1.778 |...........|...........|...........|
#> | G| Gill Diff. | -0.9310 | -1.614 | -3.052 | 1.589 |
#> |.....................| -0.001457 | -1.614 | -11.78 | -35.27 |
#> |.....................| -34.78 |...........|...........|...........|
#> | 2| 123.26516 | -0.7209 | -0.3926 | 1.060 | -0.6253 |
#> |.....................| -0.4201 | -0.9684 | -0.1107 | 0.4736 |
#> |.....................| 0.7116 |...........|...........|...........|
#> | U| 123.26516 | 0.4682 | 1.025 | 3.510 | 0.6891 |
#> |.....................| 1.000 | 0.03159 | 1.398 | 2.284 |
#> |.....................| 2.989 |...........|...........|...........|
#> | X| 123.26516 | 1.597 | 2.787 | 33.44 | 0.6891 |
#> |.....................| 2.719 | 1.032 | 1.398 | 2.284 |
#> |.....................| 2.989 |...........|...........|...........|
#> | F| Forward Diff. | -0.5868 | 30.11 | 74.23 | -5.071 |
#> |.....................| 0.5706 | 29.86 | 14.13 | 18.23 |
#> |.....................| 14.14 |...........|...........|...........|
#> | 3| 859.85007 | -0.7037 | -0.7267 | 0.2257 | -0.5836 |
#> |.....................| -0.4268 | -1.300 | -0.1453 | 0.6512 |
#> |.....................| 0.9315 |...........|...........|...........|
#> | U| 859.85007 | 0.4854 | 0.6908 | 2.676 | 0.7037 |
#> |.....................| 0.9935 | -0.2996 | 1.359 | 2.524 |
#> |.....................| 3.380 |...........|...........|...........|
#> | X| 859.85007 | 1.625 | 1.995 | 14.52 | 0.7037 |
#> |.....................| 2.701 | 0.7411 | 1.359 | 2.524 |
#> |.....................| 3.380 |...........|...........|...........|
#> | 4| 120.81610 | -0.7203 | -0.4261 | 0.9771 | -0.6196 |
#> |.....................| -0.4208 | -1.002 | -0.1264 | 0.4533 |
#> |.....................| 0.6959 |...........|...........|...........|
#> | U| 120.8161 | 0.4689 | 0.9913 | 3.427 | 0.6911 |
#> |.....................| 0.9995 | -0.001655 | 1.380 | 2.257 |
#> |.....................| 2.961 |...........|...........|...........|
#> | X| 120.8161 | 1.598 | 2.695 | 30.79 | 0.6911 |
#> |.....................| 2.717 | 0.9983 | 1.380 | 2.257 |
#> |.....................| 2.961 |...........|...........|...........|
#> | F| Forward Diff. | 2.099 | -13.28 | -43.93 | -3.395 |
#> |.....................| -0.1107 | -13.26 | 13.28 | 15.66 |
#> |.....................| 9.277 |...........|...........|...........|
#> | 5| 118.45977 | -0.7247 | -0.4172 | 1.022 | -0.6089 |
#> |.....................| -0.4209 | -0.9926 | -0.1681 | 0.3917 |
#> |.....................| 0.6499 |...........|...........|...........|
#> | U| 118.45977 | 0.4644 | 1.000 | 3.472 | 0.6948 |
#> |.....................| 0.9994 | 0.007380 | 1.333 | 2.173 |
#> |.....................| 2.879 |...........|...........|...........|
#> | X| 118.45977 | 1.591 | 2.719 | 32.22 | 0.6948 |
#> |.....................| 2.717 | 1.007 | 1.333 | 2.173 |
#> |.....................| 2.879 |...........|...........|...........|
#> | F| Forward Diff. | -0.07409 | 0.4343 | 15.45 | -1.363 |
#> |.....................| -1.321 | 0.4540 | 7.766 | 11.18 |
#> |.....................| 6.887 |...........|...........|...........|
#> | 6| 118.07299 | -0.7248 | -0.4061 | 0.9729 | -0.6038 |
#> |.....................| -0.4136 | -0.9817 | -0.2060 | 0.3287 |
#> |.....................| 0.6073 |...........|...........|...........|
#> | U| 118.07299 | 0.4643 | 1.011 | 3.423 | 0.6966 |
#> |.....................| 1.007 | 0.01828 | 1.290 | 2.088 |
#> |.....................| 2.803 |...........|...........|...........|
#> | X| 118.07299 | 1.591 | 2.749 | 30.66 | 0.6966 |
#> |.....................| 2.737 | 1.018 | 1.290 | 2.088 |
#> |.....................| 2.803 |...........|...........|...........|
#> | F| Forward Diff. | 1.344 | 3.736 | -37.78 | -0.04684 |
#> |.....................| 0.06989 | 3.762 | 3.849 | 7.447 |
#> |.....................| 4.174 |...........|...........|...........|
#> | 7| 117.26519 | -0.7264 | -0.4374 | 1.022 | -0.6094 |
#> |.....................| -0.4061 | -1.014 | -0.2254 | 0.2693 |
#> |.....................| 0.5676 |...........|...........|...........|
#> | U| 117.26519 | 0.4628 | 0.9800 | 3.472 | 0.6947 |
#> |.....................| 1.014 | -0.01353 | 1.268 | 2.008 |
#> |.....................| 2.733 |...........|...........|...........|
#> | X| 117.26519 | 1.588 | 2.664 | 32.21 | 0.6947 |
#> |.....................| 2.757 | 0.9866 | 1.268 | 2.008 |
#> |.....................| 2.733 |...........|...........|...........|
#> | F| Forward Diff. | -0.5664 | -13.66 | 9.555 | -0.2750 |
#> |.....................| -0.9035 | -13.85 | 1.175 | 3.410 |
#> |.....................| 2.098 |...........|...........|...........|
#> | 8| 118.05686 | -0.7225 | -0.3748 | 1.025 | -0.6188 |
#> |.....................| -0.3985 | -0.9492 | -0.2153 | 0.2362 |
#> |.....................| 0.5439 |...........|...........|...........|
#> | U| 118.05686 | 0.4666 | 1.043 | 3.475 | 0.6914 |
#> |.....................| 1.022 | 0.05084 | 1.279 | 1.963 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 118.05686 | 1.595 | 2.837 | 32.31 | 0.6914 |
#> |.....................| 2.778 | 1.052 | 1.279 | 1.963 |
#> |.....................| 2.691 |...........|...........|...........|
#> | 9| 116.87529 | -0.7255 | -0.4157 | 1.007 | -0.6090 |
#> |.....................| -0.4046 | -0.9915 | -0.2273 | 0.2638 |
#> |.....................| 0.5643 |...........|...........|...........|
#> | U| 116.87529 | 0.4637 | 1.002 | 3.457 | 0.6948 |
#> |.....................| 1.016 | 0.008506 | 1.266 | 2.000 |
#> |.....................| 2.727 |...........|...........|...........|
#> | X| 116.87529 | 1.590 | 2.723 | 31.72 | 0.6948 |
#> |.....................| 2.761 | 1.009 | 1.266 | 2.000 |
#> |.....................| 2.727 |...........|...........|...........|
#> | F| Forward Diff. | 0.09718 | -0.5758 | -2.570 | -0.1384 |
#> |.....................| -1.067 | -0.5840 | 1.029 | 2.643 |
#> |.....................| 1.329 |...........|...........|...........|
#> | 10| 117.00331 | -0.7263 | -0.4110 | 1.028 | -0.6079 |
#> |.....................| -0.3959 | -0.9867 | -0.2358 | 0.2421 |
#> |.....................| 0.5533 |...........|...........|...........|
#> | U| 117.00331 | 0.4629 | 1.006 | 3.478 | 0.6952 |
#> |.....................| 1.024 | 0.01331 | 1.256 | 1.971 |
#> |.....................| 2.707 |...........|...........|...........|
#> | X| 117.00331 | 1.589 | 2.736 | 32.40 | 0.6952 |
#> |.....................| 2.785 | 1.013 | 1.256 | 1.971 |
#> |.....................| 2.707 |...........|...........|...........|
#> | 11| 116.85677 | -0.7257 | -0.4144 | 1.013 | -0.6087 |
#> |.....................| -0.4023 | -0.9902 | -0.2296 | 0.2580 |
#> |.....................| 0.5613 |...........|...........|...........|
#> | U| 116.85677 | 0.4634 | 1.003 | 3.463 | 0.6949 |
#> |.....................| 1.018 | 0.009803 | 1.263 | 1.993 |
#> |.....................| 2.722 |...........|...........|...........|
#> | X| 116.85677 | 1.590 | 2.726 | 31.90 | 0.6949 |
#> |.....................| 2.768 | 1.010 | 1.263 | 1.993 |
#> |.....................| 2.722 |...........|...........|...........|
#> | F| Forward Diff. | -0.04765 | 0.6256 | 3.274 | -0.04788 |
#> |.....................| -1.060 | 0.6378 | 0.7205 | 2.183 |
#> |.....................| 1.251 |...........|...........|...........|
#> | 12| 116.84445 | -0.7256 | -0.4158 | 1.006 | -0.6086 |
#> |.....................| -0.3997 | -0.9916 | -0.2310 | 0.2530 |
#> |.....................| 0.5585 |...........|...........|...........|
#> | U| 116.84445 | 0.4635 | 1.002 | 3.456 | 0.6949 |
#> |.....................| 1.021 | 0.008432 | 1.262 | 1.986 |
#> |.....................| 2.716 |...........|...........|...........|
#> | X| 116.84445 | 1.590 | 2.723 | 31.69 | 0.6949 |
#> |.....................| 2.775 | 1.008 | 1.262 | 1.986 |
#> |.....................| 2.716 |...........|...........|...........|
#> | F| Forward Diff. | 0.09730 | -0.6994 | -3.538 | -0.03650 |
#> |.....................| -1.064 | -0.7129 | 0.6224 | 1.894 |
#> |.....................| 0.9409 |...........|...........|...........|
#> | 13| 116.82752 | -0.7257 | -0.4150 | 1.012 | -0.6089 |
#> |.....................| -0.3958 | -0.9907 | -0.2318 | 0.2475 |
#> |.....................| 0.5555 |...........|...........|...........|
#> | U| 116.82752 | 0.4634 | 1.002 | 3.462 | 0.6948 |
#> |.....................| 1.024 | 0.009266 | 1.261 | 1.978 |
#> |.....................| 2.711 |...........|...........|...........|
#> | X| 116.82752 | 1.589 | 2.725 | 31.88 | 0.6948 |
#> |.....................| 2.786 | 1.009 | 1.261 | 1.978 |
#> |.....................| 2.711 |...........|...........|...........|
#> | F| Forward Diff. | -0.04193 | 0.2040 | 2.262 | -0.1521 |
#> |.....................| -1.050 | 0.2102 | 0.4967 | 1.488 |
#> |.....................| 0.8587 |...........|...........|...........|
#> | 14| 116.81980 | -0.7256 | -0.4157 | 1.007 | -0.6086 |
#> |.....................| -0.3905 | -0.9915 | -0.2326 | 0.2422 |
#> |.....................| 0.5525 |...........|...........|...........|
#> | U| 116.8198 | 0.4635 | 1.002 | 3.457 | 0.6950 |
#> |.....................| 1.030 | 0.008500 | 1.260 | 1.971 |
#> |.....................| 2.706 |...........|...........|...........|
#> | X| 116.8198 | 1.590 | 2.723 | 31.72 | 0.6950 |
#> |.....................| 2.800 | 1.009 | 1.260 | 1.971 |
#> |.....................| 2.706 |...........|...........|...........|
#> | F| Forward Diff. | 0.06676 | -0.5802 | -2.545 | 0.01398 |
#> |.....................| -1.040 | -0.5962 | 0.01321 | 1.186 |
#> |.....................| 0.5819 |...........|...........|...........|
#> | 15| 116.81249 | -0.7257 | -0.4151 | 1.011 | -0.6086 |
#> |.....................| -0.3839 | -0.9908 | -0.2308 | 0.2379 |
#> |.....................| 0.5500 |...........|...........|...........|
#> | U| 116.81249 | 0.4634 | 1.002 | 3.461 | 0.6950 |
#> |.....................| 1.036 | 0.009190 | 1.262 | 1.965 |
#> |.....................| 2.701 |...........|...........|...........|
#> | X| 116.81249 | 1.590 | 2.725 | 31.86 | 0.6950 |
#> |.....................| 2.819 | 1.009 | 1.262 | 1.965 |
#> |.....................| 2.701 |...........|...........|...........|
#> | F| Forward Diff. | -0.02431 | 0.1156 | 1.592 | 0.04944 |
#> |.....................| -1.010 | 0.1201 | 0.6380 | 0.8200 |
#> |.....................| 0.4831 |...........|...........|...........|
#> | 16| 116.80960 | -0.7257 | -0.4154 | 1.008 | -0.6098 |
#> |.....................| -0.3758 | -0.9912 | -0.2330 | 0.2357 |
#> |.....................| 0.5487 |...........|...........|...........|
#> | U| 116.8096 | 0.4634 | 1.002 | 3.458 | 0.6946 |
#> |.....................| 1.045 | 0.008808 | 1.259 | 1.962 |
#> |.....................| 2.699 |...........|...........|...........|
#> | X| 116.8096 | 1.590 | 2.724 | 31.75 | 0.6946 |
#> |.....................| 2.842 | 1.009 | 1.259 | 1.962 |
#> |.....................| 2.699 |...........|...........|...........|
#> | F| Forward Diff. | 0.03766 | -0.3156 | -1.557 | 0.01295 |
#> |.....................| -0.9931 | -0.3284 | 0.4427 | 0.6703 |
#> |.....................| 0.3523 |...........|...........|...........|
#> | 17| 116.80820 | -0.7258 | -0.4149 | 1.011 | -0.6104 |
#> |.....................| -0.3679 | -0.9906 | -0.2371 | 0.2351 |
#> |.....................| 0.5484 |...........|...........|...........|
#> | U| 116.8082 | 0.4634 | 1.003 | 3.461 | 0.6943 |
#> |.....................| 1.052 | 0.009444 | 1.255 | 1.962 |
#> |.....................| 2.698 |...........|...........|...........|
#> | X| 116.8082 | 1.589 | 2.725 | 31.85 | 0.6943 |
#> |.....................| 2.865 | 1.009 | 1.255 | 1.962 |
#> |.....................| 2.698 |...........|...........|...........|
#> | F| Forward Diff. | -0.04468 | 0.2690 | 1.586 | -0.07671 |
#> |.....................| -0.9719 | 0.2856 | -0.09668 | 0.6631 |
#> |.....................| 0.4284 |...........|...........|...........|
#> | 18| 116.80691 | -0.7255 | -0.4153 | 1.008 | -0.6096 |
#> |.....................| -0.3590 | -0.9911 | -0.2364 | 0.2342 |
#> |.....................| 0.5472 |...........|...........|...........|
#> | U| 116.80691 | 0.4636 | 1.002 | 3.458 | 0.6946 |
#> |.....................| 1.061 | 0.008942 | 1.255 | 1.960 |
#> |.....................| 2.696 |...........|...........|...........|
#> | X| 116.80691 | 1.590 | 2.724 | 31.77 | 0.6946 |
#> |.....................| 2.890 | 1.009 | 1.255 | 1.960 |
#> |.....................| 2.696 |...........|...........|...........|
#> | F| Forward Diff. | 0.02779 | -0.1677 | -1.124 | -0.002516 |
#> |.....................| -0.9417 | -0.1689 |-0.0008595 | 0.5422 |
#> |.....................| 0.2791 |...........|...........|...........|
#> | 19| 116.80628 | -0.7255 | -0.4148 | 1.011 | -0.6090 |
#> |.....................| -0.3504 | -0.9906 | -0.2343 | 0.2327 |
#> |.....................| 0.5460 |...........|...........|...........|
#> | U| 116.80628 | 0.4636 | 1.003 | 3.461 | 0.6948 |
#> |.....................| 1.070 | 0.009366 | 1.258 | 1.958 |
#> |.....................| 2.694 |...........|...........|...........|
#> | X| 116.80628 | 1.590 | 2.726 | 31.85 | 0.6948 |
#> |.....................| 2.915 | 1.009 | 1.258 | 1.958 |
#> |.....................| 2.694 |...........|...........|...........|
#> | F| Forward Diff. | -0.02227 | 0.3104 | 1.408 | -0.07037 |
#> |.....................| -0.9140 | 0.3418 | 0.2318 | 0.4631 |
#> |.....................| 0.2483 |...........|...........|...........|
#> | 20| 116.80562 | -0.7255 | -0.4152 | 1.009 | -0.6085 |
#> |.....................| -0.3464 | -0.9912 | -0.2348 | 0.2322 |
#> |.....................| 0.5459 |...........|...........|...........|
#> | U| 116.80562 | 0.4636 | 1.002 | 3.459 | 0.6950 |
#> |.....................| 1.074 | 0.008778 | 1.257 | 1.958 |
#> |.....................| 2.694 |...........|...........|...........|
#> | X| 116.80562 | 1.590 | 2.724 | 31.77 | 0.6950 |
#> |.....................| 2.927 | 1.009 | 1.257 | 1.958 |
#> |.....................| 2.694 |...........|...........|...........|
#> | F| Forward Diff. | 0.02645 | -0.1435 | -0.9284 | 0.06898 |
#> |.....................| -0.9008 | -0.1445 | 0.2245 | 0.4178 |
#> |.....................| 0.2078 |...........|...........|...........|
#> | 21| 116.80523 | -0.7256 | -0.4148 | 1.011 | -0.6086 |
#> |.....................| -0.3424 | -0.9909 | -0.2356 | 0.2314 |
#> |.....................| 0.5457 |...........|...........|...........|
#> | U| 116.80523 | 0.4635 | 1.003 | 3.461 | 0.6950 |
#> |.....................| 1.078 | 0.009104 | 1.256 | 1.957 |
#> |.....................| 2.694 |...........|...........|...........|
#> | X| 116.80523 | 1.590 | 2.726 | 31.84 | 0.6950 |
#> |.....................| 2.939 | 1.009 | 1.256 | 1.957 |
#> |.....................| 2.694 |...........|...........|...........|
#> | F| Forward Diff. | -0.02893 | 0.2145 | 1.146 | 0.01324 |
#> |.....................| -0.9001 | 0.2420 | 0.06451 | 0.3671 |
#> |.....................| 0.2252 |...........|...........|...........|
#> | 22| 116.80465 | -0.7256 | -0.4151 | 1.009 | -0.6086 |
#> |.....................| -0.3410 | -0.9913 | -0.2357 | 0.2309 |
#> |.....................| 0.5453 |...........|...........|...........|
#> | U| 116.80465 | 0.4635 | 1.002 | 3.459 | 0.6950 |
#> |.....................| 1.079 | 0.008735 | 1.256 | 1.956 |
#> |.....................| 2.693 |...........|...........|...........|
#> | X| 116.80465 | 1.590 | 2.725 | 31.79 | 0.6950 |
#> |.....................| 2.943 | 1.009 | 1.256 | 1.956 |
#> |.....................| 2.693 |...........|...........|...........|
#> | F| Forward Diff. | 0.01212 | -0.1039 | -0.5735 | 0.06024 |
#> |.....................| -0.8870 | -0.1020 | 0.05391 | 0.3428 |
#> |.....................| 0.1724 |...........|...........|...........|
#> | 23| 116.80425 | -0.7256 | -0.4149 | 1.010 | -0.6088 |
#> |.....................| -0.3391 | -0.9911 | -0.2359 | 0.2302 |
#> |.....................| 0.5450 |...........|...........|...........|
#> | U| 116.80425 | 0.4635 | 1.003 | 3.460 | 0.6949 |
#> |.....................| 1.081 | 0.008948 | 1.256 | 1.955 |
#> |.....................| 2.692 |...........|...........|...........|
#> | X| 116.80425 | 1.590 | 2.725 | 31.82 | 0.6949 |
#> |.....................| 2.948 | 1.009 | 1.256 | 1.955 |
#> |.....................| 2.692 |...........|...........|...........|
#> | F| Forward Diff. | -0.01639 | 0.1037 | 0.5987 | 0.02830 |
#> |.....................| -0.8864 | 0.1225 | 0.04883 | 0.2777 |
#> |.....................| 0.1680 |...........|...........|...........|
#> | 24| 116.80424 | -0.7256 | -0.4151 | 1.009 | -0.6088 |
#> |.....................| -0.3373 | -0.9913 | -0.2360 | 0.2296 |
#> |.....................| 0.5446 |...........|...........|...........|
#> | U| 116.80424 | 0.4635 | 1.002 | 3.459 | 0.6949 |
#> |.....................| 1.083 | 0.008691 | 1.256 | 1.954 |
#> |.....................| 2.692 |...........|...........|...........|
#> | X| 116.80424 | 1.590 | 2.725 | 31.78 | 0.6949 |
#> |.....................| 2.954 | 1.009 | 1.256 | 1.954 |
#> |.....................| 2.692 |...........|...........|...........|
#> | C| Central Diff. |-0.0001167 | -0.1557 | -0.7359 | 0.05313 |
#> |.....................| 0.4682 | -0.1686 | -0.1753 | 0.2650 |
#> |.....................| 0.1198 |...........|...........|...........|
#> | 25| 116.80386 | -0.7256 | -0.4149 | 1.010 | -0.6089 |
#> |.....................| -0.3379 | -0.9911 | -0.2357 | 0.2293 |
#> |.....................| 0.5445 |...........|...........|...........|
#> | U| 116.80386 | 0.4635 | 1.003 | 3.460 | 0.6949 |
#> |.....................| 1.082 | 0.008898 | 1.256 | 1.954 |
#> |.....................| 2.692 |...........|...........|...........|
#> | X| 116.80386 | 1.590 | 2.725 | 31.81 | 0.6949 |
#> |.....................| 2.952 | 1.009 | 1.256 | 1.954 |
#> |.....................| 2.692 |...........|...........|...........|
#> | F| Forward Diff. | -0.005283 | 0.06096 | 0.2574 | 0.03751 |
#> |.....................| -0.8770 | 0.07625 | 0.05273 | 0.2261 |
#> |.....................| 0.1359 |...........|...........|...........|
#> | 26| 116.80382 | -0.7255 | -0.4149 | 1.010 | -0.6093 |
#> |.....................| -0.3369 | -0.9911 | -0.2353 | 0.2290 |
#> |.....................| 0.5444 |...........|...........|...........|
#> | U| 116.80382 | 0.4636 | 1.003 | 3.460 | 0.6947 |
#> |.....................| 1.083 | 0.008879 | 1.257 | 1.953 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 116.80382 | 1.590 | 2.725 | 31.82 | 0.6947 |
#> |.....................| 2.955 | 1.009 | 1.257 | 1.953 |
#> |.....................| 2.691 |...........|...........|...........|
#> | C| Central Diff. | -0.01642 | 0.03867 | 0.2678 | 0.03984 |
#> |.....................| 0.4930 | 0.04192 | -0.02741 | 0.2097 |
#> |.....................| 0.1227 |...........|...........|...........|
#> | 27| 116.80374 | -0.7255 | -0.4149 | 1.010 | -0.6093 |
#> |.....................| -0.3374 | -0.9912 | -0.2353 | 0.2288 |
#> |.....................| 0.5442 |...........|...........|...........|
#> | U| 116.80374 | 0.4636 | 1.003 | 3.460 | 0.6947 |
#> |.....................| 1.083 | 0.008839 | 1.257 | 1.953 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 116.80374 | 1.590 | 2.725 | 31.81 | 0.6947 |
#> |.....................| 2.953 | 1.009 | 1.257 | 1.953 |
#> |.....................| 2.691 |...........|...........|...........|
#> | C| Central Diff. | -0.01008 | -0.002947 | 0.01119 | -0.003481 |
#> |.....................| 0.4506 | -0.003364 | -0.06411 | 0.2096 |
#> |.....................| 0.1102 |...........|...........|...........|
#> | 28| 116.80370 | -0.7255 | -0.4149 | 1.010 | -0.6093 |
#> |.....................| -0.3379 | -0.9912 | -0.2352 | 0.2286 |
#> |.....................| 0.5441 |...........|...........|...........|
#> | U| 116.8037 | 0.4636 | 1.003 | 3.460 | 0.6947 |
#> |.....................| 1.082 | 0.008843 | 1.257 | 1.953 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 116.8037 | 1.590 | 2.725 | 31.81 | 0.6947 |
#> |.....................| 2.952 | 1.009 | 1.257 | 1.953 |
#> |.....................| 2.691 |...........|...........|...........|
#> | C| Central Diff. | -0.008927 | -0.003530 | -0.002543 | 0.03935 |
#> |.....................| 0.4491 | -0.003826 | -0.05456 | 0.1732 |
#> |.....................| 0.09266 |...........|...........|...........|
#> | 29| 116.80365 | -0.7255 | -0.4149 | 1.010 | -0.6094 |
#> |.....................| -0.3390 | -0.9911 | -0.2351 | 0.2282 |
#> |.....................| 0.5439 |...........|...........|...........|
#> | U| 116.80365 | 0.4637 | 1.003 | 3.460 | 0.6947 |
#> |.....................| 1.081 | 0.008852 | 1.257 | 1.952 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 116.80365 | 1.590 | 2.725 | 31.81 | 0.6947 |
#> |.....................| 2.949 | 1.009 | 1.257 | 1.952 |
#> |.....................| 2.691 |...........|...........|...........|
#> | C| Central Diff. | -0.007599 | -0.001520 | 0.0005778 | 0.02794 |
#> |.....................| 0.4720 | -0.001619 | -0.02704 | 0.1464 |
#> |.....................| 0.07022 |...........|...........|...........|
#> | 30| 116.80358 | -0.7254 | -0.4149 | 1.010 | -0.6096 |
#> |.....................| -0.3412 | -0.9911 | -0.2350 | 0.2275 |
#> |.....................| 0.5436 |...........|...........|...........|
#> | U| 116.80358 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.079 | 0.008860 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80358 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.942 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | C| Central Diff. | -0.005416 | -0.004754 | 0.003477 | 0.06070 |
#> |.....................| 0.4775 | -0.005155 | -0.009362 | 0.09563 |
#> |.....................| 0.04744 |...........|...........|...........|
#> | 31| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3423 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | C| Central Diff. | -0.004504 | -0.001809 | -0.007112 | -0.08529 |
#> |.....................| 0.4776 | -0.001961 | -0.04002 | 0.07330 |
#> |.....................| 0.05623 |...........|...........|...........|
#> | 32| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6096 |
#> |.....................| -0.3429 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.077 | 0.008874 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.937 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 33| 116.80362 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3426 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80362 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008873 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80362 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.938 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 34| 116.80362 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80362 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008873 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80362 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.938 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 35| 116.80355 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80355 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80355 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | C| Central Diff. | -0.004420 | -0.001815 | -0.01189 | -0.1646 |
#> |.....................| 0.5141 | -0.001996 | 0.02918 | 0.09605 |
#> |.....................| 0.03007 |...........|...........|...........|
#> | 36| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.938 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 37| 116.80358 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80358 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80358 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 38| 116.80358 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80358 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80358 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 39| 116.80357 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80357 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80357 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 40| 116.80357 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80357 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80357 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 41| 116.80357 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80357 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80357 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 42| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 43| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 44| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 45| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 46| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 47| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> calculating covariance matrix
#> done
#> Calculating residuals/tables
#> done
#> ✔ added categorical_SEX_0*cov_SEX_0_ka to ka's equation in the model
#> ✔ updated value: ka<-exp(tka+categorical_SEX_0*cov_SEX_0_ka+eta.ka)
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → calculate jacobian
#>
#> → calculate ∂(f)/∂(η)
#>
#> → calculate ∂(R²)/∂(η)
#>
#> → finding duplicate expressions in inner model...
#>
#> → optimizing duplicate expressions in inner model...
#>
#> → finding duplicate expressions in EBE model...
#>
#> → optimizing duplicate expressions in EBE model...
#>
#> → compiling inner model...
#>
#> ✔ done
#> → finding duplicate expressions in FD model...
#>
#> → compiling EBE model...
#>
#> ✔ done
#> → compiling events FD model...
#>
#> ✔ done
#> Needed Covariates:
#> [1] "categorical_SEX_0"
#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
#> F: Forward difference gradient approximation
#> C: Central difference gradient approximation
#> M: Mixed forward and central difference gradient approximation
#> Unscaled parameters for Omegas=chol(solve(omega));
#> Diagonals are transformed, as specified by foceiControl(diagXform=)
#> |-----+---------------+-----------+-----------+-----------+-----------|
#> | #| Objective Fun | tka | tcl | tv | add.sd |
#> |.....................|cov_SEX_0_ka | o1 | o2 | o3 |
#> | 1| 133.57512 | -0.7391 | -0.4242 | 1.000 | -0.5942 |
#> |.....................| -1.000 | -0.3413 | -0.2167 | 0.03089 |
#> | U| 133.57512 | 0.4500 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 0.000 | 1.136 | 1.351 | 1.778 |
#> | X| 133.57512 | 1.568 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.000 | 1.136 | 1.351 | 1.778 |
#> | G| Gill Diff. | -0.9310 | -1.614 | -3.052 | 1.589 |
#> |.....................| -0.3833 | -11.78 | -35.27 | -34.78 |
#> | 2| 122.57176 | -0.7209 | -0.3926 | 1.060 | -0.6253 |
#> |.....................| -0.9925 | -0.1106 | 0.4740 | 0.7119 |
#> | U| 122.57176 | 0.4682 | 1.025 | 3.510 | 0.6891 |
#> |.....................| 0.007504 | 1.398 | 2.284 | 2.989 |
#> | X| 122.57176 | 1.597 | 2.787 | 33.44 | 0.6891 |
#> |.....................| 1.008 | 1.398 | 2.284 | 2.989 |
#> | F| Forward Diff. | -0.6138 | 14.75 | 69.97 | -5.068 |
#> |.....................| -0.1255 | 14.08 | 16.75 | 13.96 |
#> | 3| 691.05960 | -0.7027 | -0.5840 | 0.1043 | -0.5701 |
#> |.....................| -0.9868 | -0.1885 | 0.5987 | 0.8711 |
#> | U| 691.0596 | 0.4864 | 0.8334 | 2.554 | 0.7084 |
#> |.....................| 0.01320 | 1.310 | 2.453 | 3.272 |
#> | X| 691.0596 | 1.626 | 2.301 | 12.86 | 0.7084 |
#> |.....................| 1.013 | 1.310 | 2.453 | 3.272 |
#> | 4| 121.03067 | -0.7201 | -0.4119 | 0.9680 | -0.6187 |
#> |.....................| -0.9923 | -0.1291 | 0.4520 | 0.6936 |
#> | U| 121.03067 | 0.4690 | 1.006 | 3.418 | 0.6914 |
#> |.....................| 0.007669 | 1.377 | 2.255 | 2.957 |
#> | X| 121.03067 | 1.598 | 2.733 | 30.51 | 0.6914 |
#> |.....................| 1.008 | 1.377 | 2.255 | 2.957 |
#> | F| Forward Diff. | 2.906 | -6.927 | -53.50 | -3.168 |
#> |.....................| 1.742 | 13.24 | 15.45 | 9.487 |
#> | 5| 118.40376 | -0.7259 | -0.4104 | 1.019 | -0.6075 |
#> |.....................| -0.9959 | -0.1720 | 0.3935 | 0.6497 |
#> | U| 118.40376 | 0.4632 | 1.007 | 3.469 | 0.6954 |
#> |.....................| 0.004068 | 1.329 | 2.176 | 2.879 |
#> | X| 118.40376 | 1.589 | 2.738 | 32.11 | 0.6954 |
#> |.....................| 1.004 | 1.329 | 2.176 | 2.879 |
#> | F| Forward Diff. | 0.06943 | -0.1210 | 11.55 | -1.206 |
#> |.....................| 0.1265 | 7.334 | 11.27 | 6.739 |
#> | 6| 117.96347 | -0.7265 | -0.4041 | 0.9745 | -0.6023 |
#> |.....................| -0.9967 | -0.2119 | 0.3257 | 0.6079 |
#> | U| 117.96347 | 0.4626 | 1.013 | 3.425 | 0.6972 |
#> |.....................| 0.003313 | 1.283 | 2.084 | 2.804 |
#> | X| 117.96347 | 1.588 | 2.755 | 30.71 | 0.6972 |
#> |.....................| 1.003 | 1.283 | 2.084 | 2.804 |
#> | F| Forward Diff. | 1.151 | -2.174 | -37.47 | 0.1929 |
#> |.....................| 0.6283 | 3.090 | 7.222 | 4.287 |
#> | 7| 117.01052 | -0.7240 | -0.4046 | 1.027 | -0.6151 |
#> |.....................| -0.9949 | -0.2188 | 0.2547 | 0.5630 |
#> | U| 117.01052 | 0.4651 | 1.013 | 3.477 | 0.6927 |
#> |.....................| 0.005105 | 1.275 | 1.988 | 2.725 |
#> | X| 117.01052 | 1.592 | 2.754 | 32.35 | 0.6927 |
#> |.....................| 1.005 | 1.275 | 1.988 | 2.725 |
#> | F| Forward Diff. | -0.1135 | 1.555 | 17.12 | -0.7676 |
#> |.....................| 0.04685 | 2.022 | 2.107 | 1.858 |
#> | 8| 117.19994 | -0.7301 | -0.4496 | 1.005 | -0.6190 |
#> |.....................| -1.001 | -0.2216 | 0.1978 | 0.4985 |
#> | U| 117.19994 | 0.4590 | 0.9679 | 3.455 | 0.6913 |
#> |.....................| -0.001212 | 1.272 | 1.911 | 2.610 |
#> | X| 117.19994 | 1.583 | 2.632 | 31.67 | 0.6913 |
#> |.....................| 0.9988 | 1.272 | 1.911 | 2.610 |
#> | 9| 116.86330 | -0.7258 | -0.4199 | 1.006 | -0.6157 |
#> |.....................| -0.9969 | -0.2213 | 0.2352 | 0.5414 |
#> | U| 116.8633 | 0.4633 | 0.9976 | 3.456 | 0.6925 |
#> |.....................| 0.003095 | 1.273 | 1.962 | 2.686 |
#> | X| 116.8633 | 1.589 | 2.712 | 31.69 | 0.6925 |
#> |.....................| 1.003 | 1.273 | 1.962 | 2.686 |
#> | F| Forward Diff. | 0.1191 | -4.492 | -4.573 | -0.6919 |
#> |.....................| 0.1224 | 1.886 | 0.6391 | -0.004244 |
#> | 10| 116.87411 | -0.7264 | -0.3840 | 1.006 | -0.6094 |
#> |.....................| -0.9982 | -0.2350 | 0.2323 | 0.5392 |
#> | U| 116.87411 | 0.4628 | 1.033 | 3.456 | 0.6947 |
#> |.....................| 0.001768 | 1.257 | 1.958 | 2.682 |
#> | X| 116.87411 | 1.588 | 2.811 | 31.69 | 0.6947 |
#> |.....................| 1.002 | 1.257 | 1.958 | 2.682 |
#> | 11| 116.81210 | -0.7261 | -0.4038 | 1.012 | -0.6130 |
#> |.....................| -0.9974 | -0.2277 | 0.2336 | 0.5407 |
#> | U| 116.8121 | 0.4630 | 1.014 | 3.462 | 0.6934 |
#> |.....................| 0.002554 | 1.265 | 1.960 | 2.685 |
#> | X| 116.8121 | 1.589 | 2.756 | 31.87 | 0.6934 |
#> |.....................| 1.003 | 1.265 | 1.960 | 2.685 |
#> | F| Forward Diff. | 0.01717 | 0.6550 | 1.923 | -0.2624 |
#> |.....................| 0.03243 | 1.074 | 0.4303 | 0.02936 |
#> | 12| 116.82346 | -0.7263 | -0.4053 | 1.004 | -0.6092 |
#> |.....................| -0.9979 | -0.2429 | 0.2340 | 0.5468 |
#> | U| 116.82346 | 0.4629 | 1.012 | 3.454 | 0.6948 |
#> |.....................| 0.002061 | 1.248 | 1.960 | 2.696 |
#> | X| 116.82346 | 1.589 | 2.751 | 31.63 | 0.6948 |
#> |.....................| 1.002 | 1.248 | 1.960 | 2.696 |
#> | 13| 116.81327 | -0.7262 | -0.4057 | 1.006 | -0.6122 |
#> |.....................| -0.9975 | -0.2308 | 0.2323 | 0.5406 |
#> | U| 116.81327 | 0.4629 | 1.012 | 3.456 | 0.6937 |
#> |.....................| 0.002459 | 1.262 | 1.958 | 2.685 |
#> | X| 116.81327 | 1.589 | 2.750 | 31.69 | 0.6937 |
#> |.....................| 1.002 | 1.262 | 1.958 | 2.685 |
#> | 14| 116.80847 | -0.7262 | -0.4047 | 1.009 | -0.6126 |
#> |.....................| -0.9975 | -0.2291 | 0.2330 | 0.5407 |
#> | U| 116.80847 | 0.4630 | 1.013 | 3.459 | 0.6935 |
#> |.....................| 0.002510 | 1.264 | 1.959 | 2.685 |
#> | X| 116.80847 | 1.589 | 2.753 | 31.79 | 0.6935 |
#> |.....................| 1.003 | 1.264 | 1.959 | 2.685 |
#> | F| Forward Diff. | 0.06602 | 0.2217 | -0.6063 | -0.2064 |
#> |.....................| 0.07349 | 0.9058 | 0.4319 | -0.02269 |
#> | 15| 116.80615 | -0.7263 | -0.4053 | 1.011 | -0.6121 |
#> |.....................| -0.9977 | -0.2315 | 0.2318 | 0.5407 |
#> | U| 116.80615 | 0.4628 | 1.012 | 3.461 | 0.6937 |
#> |.....................| 0.002316 | 1.261 | 1.957 | 2.685 |
#> | X| 116.80615 | 1.589 | 2.752 | 31.84 | 0.6937 |
#> |.....................| 1.002 | 1.261 | 1.957 | 2.685 |
#> | F| Forward Diff. | 0.004366 | 0.1398 | 0.8989 | -0.2182 |
#> |.....................| 0.03171 | 0.5977 | 0.3486 | 0.01430 |
#> | 16| 116.80588 | -0.7263 | -0.4056 | 1.008 | -0.6115 |
#> |.....................| -0.9978 | -0.2332 | 0.2309 | 0.5407 |
#> | U| 116.80588 | 0.4628 | 1.012 | 3.458 | 0.6939 |
#> |.....................| 0.002229 | 1.259 | 1.956 | 2.685 |
#> | X| 116.80588 | 1.588 | 2.751 | 31.76 | 0.6939 |
#> |.....................| 1.002 | 1.259 | 1.956 | 2.685 |
#> | F| Forward Diff. | 0.05136 | -0.1335 | -1.458 | -0.1218 |
#> |.....................| 0.03459 | 0.4392 | 0.3226 | -0.05937 |
#> | 17| 116.80398 | -0.7262 | -0.4054 | 1.010 | -0.6102 |
#> |.....................| -0.9978 | -0.2340 | 0.2296 | 0.5424 |
#> | U| 116.80398 | 0.4629 | 1.012 | 3.460 | 0.6944 |
#> |.....................| 0.002171 | 1.258 | 1.954 | 2.688 |
#> | X| 116.80398 | 1.589 | 2.751 | 31.82 | 0.6944 |
#> |.....................| 1.002 | 1.258 | 1.954 | 2.688 |
#> | F| Forward Diff. | 0.01698 | 0.05928 | 0.3320 | 0.04971 |
#> |.....................| 0.03278 | 0.2857 | 0.2292 | 0.04921 |
#> | 18| 116.80390 | -0.7263 | -0.4052 | 1.009 | -0.6120 |
#> |.....................| -0.9982 | -0.2351 | 0.2276 | 0.5433 |
#> | U| 116.8039 | 0.4628 | 1.012 | 3.459 | 0.6938 |
#> |.....................| 0.001752 | 1.257 | 1.952 | 2.689 |
#> | X| 116.8039 | 1.589 | 2.752 | 31.79 | 0.6938 |
#> |.....................| 1.002 | 1.257 | 1.952 | 2.689 |
#> | C| Central Diff. | 0.006937 | 0.0002783 | -0.6092 | -0.1246 |
#> |.....................| -0.005878 | 0.1261 | 0.1405 | 0.04195 |
#> | 19| 116.80390 | -0.7263 | -0.4052 | 1.009 | -0.6120 |
#> |.....................| -0.9982 | -0.2351 | 0.2276 | 0.5433 |
#> | U| 116.8039 | 0.4628 | 1.012 | 3.459 | 0.6938 |
#> |.....................| 0.001752 | 1.257 | 1.952 | 2.689 |
#> | X| 116.8039 | 1.589 | 2.752 | 31.79 | 0.6938 |
#> |.....................| 1.002 | 1.257 | 1.952 | 2.689 |
#> calculating covariance matrix
#> done
#> Calculating residuals/tables
#> done
#> ✔ added categorical_SEX_0*cov_SEX_0_cl to cl's equation in the model
#> ✔ updated value: cl<-exp(tcl+categorical_SEX_0*cov_SEX_0_cl+eta.cl)
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → creating full model...
#> → pruning branches (`if`/`else`)...
#> ✔ done
#> → loading into symengine environment...
#> ✔ done
#> → calculate jacobian
#>
#> → calculate ∂(f)/∂(η)
#>
#> → calculate ∂(R²)/∂(η)
#>
#> → finding duplicate expressions in inner model...
#>
#> → optimizing duplicate expressions in inner model...
#>
#> → finding duplicate expressions in EBE model...
#>
#> → optimizing duplicate expressions in EBE model...
#>
#> → compiling inner model...
#>
#> ✔ done
#> → finding duplicate expressions in FD model...
#>
#> → compiling EBE model...
#>
#> ✔ done
#> → compiling events FD model...
#>
#> ✔ done
#> Needed Covariates:
#> [1] "categorical_SEX_0"
#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
#> F: Forward difference gradient approximation
#> C: Central difference gradient approximation
#> M: Mixed forward and central difference gradient approximation
#> Unscaled parameters for Omegas=chol(solve(omega));
#> Diagonals are transformed, as specified by foceiControl(diagXform=)
#> |-----+---------------+-----------+-----------+-----------+-----------|
#> | #| Objective Fun | tka | tcl | tv | add.sd |
#> |.....................|cov_SEX_0_cl | o1 | o2 | o3 |
#> | 1| 133.57512 | -0.7391 | -0.4242 | 1.000 | -0.5942 |
#> |.....................| -1.000 | -0.3413 | -0.2167 | 0.03089 |
#> | U| 133.57512 | 0.4500 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 0.000 | 1.136 | 1.351 | 1.778 |
#> | X| 133.57512 | 1.568 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.000 | 1.136 | 1.351 | 1.778 |
#> | G| Gill Diff. | -0.9310 | -1.614 | -3.052 | 1.589 |
#> |.....................| -1.864 | -11.78 | -35.27 | -34.78 |
#> | 2| 122.79252 | -0.7209 | -0.3926 | 1.060 | -0.6253 |
#> |.....................| -0.9635 | -0.1107 | 0.4735 | 0.7115 |
#> | U| 122.79252 | 0.4682 | 1.025 | 3.510 | 0.6891 |
#> |.....................| 0.03648 | 1.398 | 2.284 | 2.989 |
#> | X| 122.79252 | 1.597 | 2.787 | 33.44 | 0.6891 |
#> |.....................| 1.037 | 1.398 | 2.284 | 2.989 |
#> | F| Forward Diff. | -0.7224 | 23.53 | 72.49 | -4.846 |
#> |.....................| 11.03 | 14.22 | 17.29 | 14.16 |
#> | 3| 736.39476 | -0.7016 | -0.6833 | 0.1439 | -0.5787 |
#> |.....................| -1.088 | -0.1720 | 0.6205 | 0.8942 |
#> | U| 736.39476 | 0.4875 | 0.7342 | 2.594 | 0.7054 |
#> |.....................| -0.08802 | 1.329 | 2.482 | 3.313 |
#> | X| 736.39476 | 1.628 | 2.084 | 13.38 | 0.7054 |
#> |.....................| 0.9157 | 1.329 | 2.482 | 3.313 |
#> | 4| 120.79421 | -0.7200 | -0.4215 | 0.9709 | -0.6194 |
#> |.....................| -0.9770 | -0.1282 | 0.4523 | 0.6941 |
#> | U| 120.79421 | 0.4691 | 0.9960 | 3.421 | 0.6912 |
#> |.....................| 0.02296 | 1.378 | 2.255 | 2.958 |
#> | X| 120.79421 | 1.599 | 2.707 | 30.60 | 0.6912 |
#> |.....................| 1.023 | 1.378 | 2.255 | 2.958 |
#> | F| Forward Diff. | 2.534 | -5.692 | -49.42 | -3.130 |
#> |.....................| -5.302 | 13.05 | 15.32 | 9.338 |
#> | 5| 118.38422 | -0.7252 | -0.4264 | 1.023 | -0.6089 |
#> |.....................| -0.9744 | -0.1700 | 0.3935 | 0.6501 |
#> | U| 118.38422 | 0.4639 | 0.9910 | 3.473 | 0.6949 |
#> |.....................| 0.02562 | 1.331 | 2.176 | 2.879 |
#> | X| 118.38422 | 1.590 | 2.694 | 32.22 | 0.6949 |
#> |.....................| 1.026 | 1.331 | 2.176 | 2.879 |
#> | F| Forward Diff. | -0.1463 | -1.154 | 15.21 | -1.138 |
#> |.....................| -2.496 | 7.504 | 11.07 | 6.962 |
#> | 6| 117.77043 | -0.7253 | -0.4088 | 0.9789 | -0.6044 |
#> |.....................| -0.9558 | -0.2082 | 0.3294 | 0.6070 |
#> | U| 117.77043 | 0.4639 | 1.009 | 3.429 | 0.6964 |
#> |.....................| 0.04417 | 1.287 | 2.089 | 2.803 |
#> | X| 117.77043 | 1.590 | 2.742 | 30.84 | 0.6964 |
#> |.....................| 1.045 | 1.287 | 2.089 | 2.803 |
#> | F| Forward Diff. | 1.141 | 4.597 | -31.16 | 0.08457 |
#> |.....................| 2.182 | 3.543 | 7.253 | 4.044 |
#> | 7| 116.96098 | -0.7250 | -0.4401 | 1.025 | -0.6153 |
#> |.....................| -0.9703 | -0.2219 | 0.2619 | 0.5643 |
#> | U| 116.96098 | 0.4641 | 0.9773 | 3.475 | 0.6926 |
#> |.....................| 0.02969 | 1.272 | 1.998 | 2.727 |
#> | X| 116.96098 | 1.591 | 2.657 | 32.30 | 0.6926 |
#> |.....................| 1.030 | 1.272 | 1.998 | 2.727 |
#> | F| Forward Diff. | -0.3967 | -5.118 | 14.10 | -0.8944 |
#> |.....................| -3.807 | 1.589 | 2.347 | 1.916 |
#> | 8| 117.38482 | -0.7213 | -0.3814 | 1.017 | -0.6133 |
#> |.....................| -0.9268 | -0.2089 | 0.2126 | 0.5200 |
#> | U| 117.38482 | 0.4678 | 1.036 | 3.467 | 0.6933 |
#> |.....................| 0.07318 | 1.287 | 1.931 | 2.648 |
#> | X| 117.38482 | 1.596 | 2.818 | 32.04 | 0.6933 |
#> |.....................| 1.076 | 1.287 | 1.931 | 2.648 |
#> | 9| 116.76698 | -0.7239 | -0.4235 | 1.006 | -0.6138 |
#> |.....................| -0.9580 | -0.2216 | 0.2504 | 0.5542 |
#> | U| 116.76698 | 0.4653 | 0.9940 | 3.456 | 0.6931 |
#> |.....................| 0.04202 | 1.272 | 1.982 | 2.709 |
#> | X| 116.76698 | 1.592 | 2.702 | 31.69 | 0.6931 |
#> |.....................| 1.043 | 1.272 | 1.982 | 2.709 |
#> | F| Forward Diff. | 0.2564 | 0.7371 | -3.485 | -0.5046 |
#> |.....................| 0.05455 | 1.833 | 1.505 | 0.7553 |
#> | 10| 116.77116 | -0.7265 | -0.4240 | 1.015 | -0.6009 |
#> |.....................| -0.9497 | -0.2474 | 0.2438 | 0.5530 |
#> | U| 116.77116 | 0.4627 | 0.9935 | 3.465 | 0.6977 |
#> |.....................| 0.05029 | 1.243 | 1.973 | 2.707 |
#> | X| 116.77116 | 1.588 | 2.701 | 31.97 | 0.6977 |
#> |.....................| 1.052 | 1.243 | 1.973 | 2.707 |
#> | 11| 116.75064 | -0.7251 | -0.4249 | 1.014 | -0.6092 |
#> |.....................| -0.9556 | -0.2323 | 0.2460 | 0.5526 |
#> | U| 116.75064 | 0.4641 | 0.9926 | 3.464 | 0.6948 |
#> |.....................| 0.04440 | 1.260 | 1.976 | 2.706 |
#> | X| 116.75064 | 1.591 | 2.698 | 31.95 | 0.6948 |
#> |.....................| 1.045 | 1.260 | 1.976 | 2.706 |
#> | F| Forward Diff. | -0.04480 | 1.210 | 4.754 | 0.06853 |
#> |.....................| 0.4846 | 0.4376 | 1.181 | 0.8815 |
#> | 12| 116.74781 | -0.7258 | -0.4344 | 1.007 | -0.6080 |
#> |.....................| -0.9590 | -0.2378 | 0.2402 | 0.5490 |
#> | U| 116.74781 | 0.4633 | 0.9830 | 3.457 | 0.6952 |
#> |.....................| 0.04096 | 1.254 | 1.969 | 2.700 |
#> | X| 116.74781 | 1.589 | 2.673 | 31.71 | 0.6952 |
#> |.....................| 1.042 | 1.254 | 1.969 | 2.700 |
#> | F| Forward Diff. | 0.008017 | -2.721 | -3.222 | 0.2572 |
#> |.....................| -1.739 | -0.1191 | 0.7926 | 0.4858 |
#> | 13| 116.72996 | -0.7258 | -0.4301 | 1.011 | -0.6094 |
#> |.....................| -0.9561 | -0.2367 | 0.2380 | 0.5475 |
#> | U| 116.72996 | 0.4633 | 0.9874 | 3.461 | 0.6947 |
#> |.....................| 0.04388 | 1.255 | 1.966 | 2.697 |
#> | X| 116.72996 | 1.589 | 2.684 | 31.86 | 0.6947 |
#> |.....................| 1.045 | 1.255 | 1.966 | 2.697 |
#> | F| Forward Diff. | -0.06375 | -0.6705 | 1.584 | 0.1387 |
#> |.....................| -0.4893 | 0.1923 | 0.6005 | 0.5040 |
#> | 14| 116.73508 | -0.7256 | -0.4274 | 1.005 | -0.6099 |
#> |.....................| -0.9542 | -0.2374 | 0.2357 | 0.5455 |
#> | U| 116.73508 | 0.4636 | 0.9900 | 3.455 | 0.6945 |
#> |.....................| 0.04579 | 1.254 | 1.962 | 2.693 |
#> | X| 116.73508 | 1.590 | 2.691 | 31.66 | 0.6945 |
#> |.....................| 1.047 | 1.254 | 1.962 | 2.693 |
#> | 15| 116.72731 | -0.7257 | -0.4291 | 1.009 | -0.6096 |
#> |.....................| -0.9554 | -0.2370 | 0.2371 | 0.5467 |
#> | U| 116.72731 | 0.4634 | 0.9884 | 3.459 | 0.6946 |
#> |.....................| 0.04459 | 1.255 | 1.964 | 2.696 |
#> | X| 116.72731 | 1.589 | 2.687 | 31.79 | 0.6946 |
#> |.....................| 1.046 | 1.255 | 1.964 | 2.696 |
#> | F| Forward Diff. | -0.001385 | -0.4217 | -0.5690 | 0.09627 |
#> |.....................| -0.3311 | -0.07777 | 0.5526 | 0.3931 |
#> | 16| 116.72600 | -0.7257 | -0.4279 | 1.011 | -0.6098 |
#> |.....................| -0.9545 | -0.2367 | 0.2356 | 0.5456 |
#> | U| 116.726 | 0.4634 | 0.9895 | 3.461 | 0.6945 |
#> |.....................| 0.04551 | 1.255 | 1.962 | 2.694 |
#> | X| 116.726 | 1.589 | 2.690 | 31.84 | 0.6945 |
#> |.....................| 1.047 | 1.255 | 1.962 | 2.694 |
#> | F| Forward Diff. | -0.02870 | 0.1595 | 1.032 | 0.03261 |
#> |.....................| 0.01310 | 0.2993 | 0.4131 | 0.3464 |
#> | 17| 116.72495 | -0.7256 | -0.4286 | 1.009 | -0.6103 |
#> |.....................| -0.9546 | -0.2366 | 0.2341 | 0.5442 |
#> | U| 116.72495 | 0.4635 | 0.9889 | 3.459 | 0.6944 |
#> |.....................| 0.04540 | 1.255 | 1.960 | 2.691 |
#> | X| 116.72495 | 1.590 | 2.688 | 31.78 | 0.6944 |
#> |.....................| 1.046 | 1.255 | 1.960 | 2.691 |
#> | F| Forward Diff. | 0.01431 | -0.1674 | -0.7009 | 0.02858 |
#> |.....................| -0.1371 | -0.01406 | 0.3322 | 0.2395 |
#> | 18| 116.72404 | -0.7254 | -0.4289 | 1.010 | -0.6110 |
#> |.....................| -0.9547 | -0.2360 | 0.2325 | 0.5423 |
#> | U| 116.72404 | 0.4637 | 0.9886 | 3.460 | 0.6941 |
#> |.....................| 0.04533 | 1.256 | 1.958 | 2.688 |
#> | X| 116.72404 | 1.590 | 2.687 | 31.82 | 0.6941 |
#> |.....................| 1.046 | 1.256 | 1.958 | 2.688 |
#> | F| Forward Diff. | -0.007771 | -0.2005 | 0.4020 | -0.07016 |
#> |.....................| -0.1716 | 0.3784 | 0.2054 | 0.1653 |
#> | 19| 116.72395 | -0.7252 | -0.4284 | 1.010 | -0.6107 |
#> |.....................| -0.9543 | -0.2386 | 0.2322 | 0.5412 |
#> | U| 116.72395 | 0.4639 | 0.9890 | 3.460 | 0.6942 |
#> |.....................| 0.04566 | 1.253 | 1.958 | 2.686 |
#> | X| 116.72395 | 1.590 | 2.689 | 31.81 | 0.6942 |
#> |.....................| 1.047 | 1.253 | 1.958 | 2.686 |
#> | C| Central Diff. | -0.009444 | -0.08092 | 0.1143 | 0.002471 |
#> |.....................| -0.1244 | -0.2495 | 0.1646 | 0.1098 |
#> | 20| 116.72365 | -0.7252 | -0.4281 | 1.009 | -0.6107 |
#> |.....................| -0.9539 | -0.2376 | 0.2315 | 0.5408 |
#> | U| 116.72365 | 0.4639 | 0.9893 | 3.459 | 0.6942 |
#> |.....................| 0.04614 | 1.254 | 1.957 | 2.685 |
#> | X| 116.72365 | 1.590 | 2.689 | 31.80 | 0.6942 |
#> |.....................| 1.047 | 1.254 | 1.957 | 2.685 |
#> | F| Forward Diff. | 0.02096 | 0.1041 | -0.1935 | -0.01028 |
#> |.....................| 0.04643 | 0.2440 | 0.1311 | 0.07417 |
#> | 21| 116.72365 | -0.7252 | -0.4281 | 1.009 | -0.6107 |
#> |.....................| -0.9539 | -0.2376 | 0.2315 | 0.5408 |
#> | U| 116.72365 | 0.4639 | 0.9893 | 3.459 | 0.6942 |
#> |.....................| 0.04614 | 1.254 | 1.957 | 2.685 |
#> | X| 116.72365 | 1.590 | 2.689 | 31.80 | 0.6942 |
#> |.....................| 1.047 | 1.254 | 1.957 | 2.685 |
#> calculating covariance matrix
#> done
#> Calculating residuals/tables
#> done
#>
#> ── objf value did not improve, exiting the search ... ──────────────────────────
#>
#> ── forward search complete ──
#>
#> ── starting backward search... ─────────────────────────────────────────────────
#> ! no covariates added in the forward search, skipping backward search
#>
#> ── starting forward search... ──────────────────────────────────────────────────
#> ✔ added centered_WT*cov_WT_ka to ka's equation in the model
#> ✔ updated value: ka<-exp(tka+centered_WT*cov_WT_ka+eta.ka)
#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
#> F: Forward difference gradient approximation
#> C: Central difference gradient approximation
#> M: Mixed forward and central difference gradient approximation
#> Unscaled parameters for Omegas=chol(solve(omega));
#> Diagonals are transformed, as specified by foceiControl(diagXform=)
#> |-----+---------------+-----------+-----------+-----------+-----------|
#> | #| Objective Fun | tka | tcl | tv | add.sd |
#> |.....................|centered_WT | cov_WT_ka | o1 | o2 |
#> |.....................| o3 |...........|...........|...........|
#> | 1| 133.57512 | -0.7391 | -0.4242 | 1.000 | -0.5942 |
#> |.....................| -0.4203 | -1.000 | -0.3413 | -0.2167 |
#> |.....................| 0.03089 |...........|...........|...........|
#> | U| 133.57512 | 0.4500 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.000 | 0.000 | 1.136 | 1.351 |
#> |.....................| 1.778 |...........|...........|...........|
#> | X| 133.57512 | 1.568 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 2.718 | 1.000 | 1.136 | 1.351 |
#> |.....................| 1.778 |...........|...........|...........|
#> | G| Gill Diff. | -0.9310 | -1.614 | -3.052 | 1.591 |
#> |.....................| -0.001938 | -0.9310 | -11.78 | -35.27 |
#> |.....................| -34.78 |...........|...........|...........|
#> | 2| 122.56663 | -0.7209 | -0.3926 | 1.060 | -0.6254 |
#> |.....................| -0.4201 | -0.9818 | -0.1106 | 0.4739 |
#> |.....................| 0.7118 |...........|...........|...........|
#> | U| 122.56663 | 0.4682 | 1.025 | 3.510 | 0.6891 |
#> |.....................| 1.000 | 0.01823 | 1.398 | 2.284 |
#> |.....................| 2.989 |...........|...........|...........|
#> | X| 122.56663 | 1.597 | 2.787 | 33.44 | 0.6891 |
#> |.....................| 2.719 | 1.018 | 1.398 | 2.284 |
#> |.....................| 2.989 |...........|...........|...........|
#> | F| Forward Diff. | 0.5883 | 14.89 | 69.34 | -5.082 |
#> |.....................| 0.01707 | 0.5885 | 14.10 | 16.71 |
#> |.....................| 13.90 |...........|...........|...........|
#> | 3| 690.01754 | -0.7198 | -0.5879 | 0.1045 | -0.5693 |
#> |.....................| -0.4204 | -0.9806 | -0.1910 | 0.5963 |
#> |.....................| 0.8691 |...........|...........|...........|
#> | U| 690.01754 | 0.4694 | 0.8295 | 2.554 | 0.7087 |
#> |.....................| 0.9999 | 0.01936 | 1.307 | 2.450 |
#> |.....................| 3.269 |...........|...........|...........|
#> | X| 690.01754 | 1.599 | 2.292 | 12.86 | 0.7087 |
#> |.....................| 2.718 | 1.020 | 1.307 | 2.450 |
#> |.....................| 3.269 |...........|...........|...........|
#> | 4| 121.05724 | -0.7217 | -0.4123 | 0.9681 | -0.6186 |
#> |.....................| -0.4202 | -0.9826 | -0.1293 | 0.4518 |
#> |.....................| 0.6935 |...........|...........|...........|
#> | U| 121.05724 | 0.4674 | 1.005 | 3.418 | 0.6914 |
#> |.....................| 1.000 | 0.01745 | 1.377 | 2.254 |
#> |.....................| 2.957 |...........|...........|...........|
#> | X| 121.05724 | 1.596 | 2.732 | 30.51 | 0.6914 |
#> |.....................| 2.719 | 1.018 | 1.377 | 2.254 |
#> |.....................| 2.957 |...........|...........|...........|
#> | F| Forward Diff. | 3.837 | -6.944 | -53.83 | -3.090 |
#> |.....................| 0.06934 | 3.838 | 13.37 | 15.43 |
#> |.....................| 9.539 |...........|...........|...........|
#> | 5| 118.41302 | -0.7303 | -0.4110 | 1.020 | -0.6076 |
#> |.....................| -0.4203 | -0.9912 | -0.1722 | 0.3939 |
#> |.....................| 0.6500 |...........|...........|...........|
#> | U| 118.41302 | 0.4588 | 1.007 | 3.470 | 0.6953 |
#> |.....................| 1.000 | 0.008841 | 1.328 | 2.176 |
#> |.....................| 2.879 |...........|...........|...........|
#> | X| 118.41302 | 1.582 | 2.736 | 32.12 | 0.6953 |
#> |.....................| 2.718 | 1.009 | 1.328 | 2.176 |
#> |.....................| 2.879 |...........|...........|...........|
#> | F| Forward Diff. | 0.2193 | -0.3076 | 11.77 | -1.219 |
#> |.....................|-0.0007891 | 0.2195 | 7.249 | 11.25 |
#> |.....................| 6.750 |...........|...........|...........|
#> | 6| 117.95957 | -0.7313 | -0.4033 | 0.9747 | -0.6024 |
#> |.....................| -0.4203 | -0.9922 | -0.2116 | 0.3262 |
#> |.....................| 0.6080 |...........|...........|...........|
#> | U| 117.95957 | 0.4578 | 1.014 | 3.425 | 0.6971 |
#> |.....................| 1.000 | 0.007833 | 1.284 | 2.085 |
#> |.....................| 2.805 |...........|...........|...........|
#> | X| 117.95957 | 1.581 | 2.757 | 30.71 | 0.6971 |
#> |.....................| 2.718 | 1.008 | 1.284 | 2.085 |
#> |.....................| 2.805 |...........|...........|...........|
#> | F| Forward Diff. | 1.235 | -1.853 | -37.21 | 0.1988 |
#> |.....................| 0.01043 | 1.235 | 3.123 | 7.245 |
#> |.....................| 4.285 |...........|...........|...........|
#> | 7| 117.01527 | -0.7254 | -0.4049 | 1.027 | -0.6142 |
#> |.....................| -0.4200 | -0.9862 | -0.2186 | 0.2552 |
#> |.....................| 0.5634 |...........|...........|...........|
#> | U| 117.01527 | 0.4638 | 1.013 | 3.477 | 0.6930 |
#> |.....................| 1.000 | 0.01375 | 1.276 | 1.989 |
#> |.....................| 2.725 |...........|...........|...........|
#> | X| 117.01527 | 1.590 | 2.753 | 32.36 | 0.6930 |
#> |.....................| 2.719 | 1.014 | 1.276 | 1.989 |
#> |.....................| 2.725 |...........|...........|...........|
#> | F| Forward Diff. | 0.4612 | 1.530 | 17.00 | -0.8240 |
#> |.....................| 0.009037 | 0.4613 | 2.046 | 2.040 |
#> |.....................| 1.907 |...........|...........|...........|
#> | 8| 117.25439 | -0.7495 | -0.4529 | 1.005 | -0.6159 |
#> |.....................| -0.4203 | -1.010 | -0.2219 | 0.2056 |
#> |.....................| 0.5036 |...........|...........|...........|
#> | U| 117.25439 | 0.4396 | 0.9646 | 3.455 | 0.6924 |
#> |.....................| 1.000 | -0.01039 | 1.272 | 1.922 |
#> |.....................| 2.619 |...........|...........|...........|
#> | X| 117.25439 | 1.552 | 2.624 | 31.67 | 0.6924 |
#> |.....................| 2.718 | 0.9897 | 1.272 | 1.922 |
#> |.....................| 2.619 |...........|...........|...........|
#> | 9| 116.86499 | -0.7327 | -0.4199 | 1.006 | -0.6140 |
#> |.....................| -0.4201 | -0.9935 | -0.2213 | 0.2393 |
#> |.....................| 0.5447 |...........|...........|...........|
#> | U| 116.86499 | 0.4565 | 0.9976 | 3.456 | 0.6931 |
#> |.....................| 1.000 | 0.006478 | 1.273 | 1.967 |
#> |.....................| 2.692 |...........|...........|...........|
#> | X| 116.86499 | 1.579 | 2.712 | 31.69 | 0.6931 |
#> |.....................| 2.719 | 1.006 | 1.273 | 1.967 |
#> |.....................| 2.692 |...........|...........|...........|
#> | F| Forward Diff. | 0.01173 | -4.519 | -4.436 | -0.4241 |
#> |.....................| 0.002109 | 0.01176 | 1.833 | 0.9175 |
#> |.....................| 0.1786 |...........|...........|...........|
#> | 10| 116.86782 | -0.7345 | -0.3853 | 1.007 | -0.6104 |
#> |.....................| -0.4202 | -0.9954 | -0.2332 | 0.2360 |
#> |.....................| 0.5422 |...........|...........|...........|
#> | U| 116.86782 | 0.4546 | 1.032 | 3.457 | 0.6943 |
#> |.....................| 1.000 | 0.004634 | 1.259 | 1.963 |
#> |.....................| 2.688 |...........|...........|...........|
#> | X| 116.86782 | 1.576 | 2.807 | 31.71 | 0.6943 |
#> |.....................| 2.719 | 1.005 | 1.259 | 1.963 |
#> |.....................| 2.688 |...........|...........|...........|
#> | 11| 116.81520 | -0.7332 | -0.4038 | 1.012 | -0.6124 |
#> |.....................| -0.4201 | -0.9941 | -0.2272 | 0.2372 |
#> |.....................| 0.5438 |...........|...........|...........|
#> | U| 116.8152 | 0.4559 | 1.014 | 3.462 | 0.6936 |
#> |.....................| 1.000 | 0.005913 | 1.266 | 1.964 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.8152 | 1.578 | 2.756 | 31.88 | 0.6936 |
#> |.....................| 2.719 | 1.006 | 1.266 | 1.964 |
#> |.....................| 2.690 |...........|...........|...........|
#> | F| Forward Diff. | -0.1208 | 0.6475 | 2.176 | -0.4241 |
#> |.....................| -0.002311 | -0.1208 | 1.132 | 0.7265 |
#> |.....................| 0.2261 |...........|...........|...........|
#> | 12| 116.82949 | -0.7297 | -0.4041 | 1.003 | -0.6069 |
#> |.....................| -0.4201 | -0.9905 | -0.2406 | 0.2349 |
#> |.....................| 0.5478 |...........|...........|...........|
#> | U| 116.82949 | 0.4595 | 1.013 | 3.453 | 0.6956 |
#> |.....................| 1.000 | 0.009473 | 1.251 | 1.961 |
#> |.....................| 2.697 |...........|...........|...........|
#> | X| 116.82949 | 1.583 | 2.755 | 31.60 | 0.6956 |
#> |.....................| 2.719 | 1.010 | 1.251 | 1.961 |
#> |.....................| 2.697 |...........|...........|...........|
#> | 13| 116.81371 | -0.7329 | -0.4054 | 1.006 | -0.6114 |
#> |.....................| -0.4201 | -0.9938 | -0.2300 | 0.2354 |
#> |.....................| 0.5432 |...........|...........|...........|
#> | U| 116.81371 | 0.4562 | 1.012 | 3.456 | 0.6940 |
#> |.....................| 1.000 | 0.006211 | 1.263 | 1.962 |
#> |.....................| 2.689 |...........|...........|...........|
#> | X| 116.81371 | 1.578 | 2.751 | 31.70 | 0.6940 |
#> |.....................| 2.719 | 1.006 | 1.263 | 1.962 |
#> |.....................| 2.689 |...........|...........|...........|
#> | F| Forward Diff. | 0.02145 | -0.1768 | -3.058 | -0.3040 |
#> |.....................| -0.001671 | 0.02153 | 0.8004 | 0.6029 |
#> |.....................| 0.05288 |...........|...........|...........|
#> | 14| 116.80660 | -0.7322 | -0.4068 | 1.011 | -0.6095 |
#> |.....................| -0.4201 | -0.9930 | -0.2339 | 0.2343 |
#> |.....................| 0.5446 |...........|...........|...........|
#> | U| 116.8066 | 0.4570 | 1.011 | 3.461 | 0.6947 |
#> |.....................| 1.000 | 0.006954 | 1.258 | 1.961 |
#> |.....................| 2.692 |...........|...........|...........|
#> | X| 116.8066 | 1.579 | 2.747 | 31.84 | 0.6947 |
#> |.....................| 2.719 | 1.007 | 1.258 | 1.961 |
#> |.....................| 2.692 |...........|...........|...........|
#> | F| Forward Diff. | -0.01093 | -0.3104 | 1.002 | -0.06813 |
#> |.....................| -0.001589 | -0.01078 | -0.05248 | 0.5435 |
#> |.....................| 0.2242 |...........|...........|...........|
#> | 15| 116.80565 | -0.7313 | -0.4052 | 1.010 | -0.6079 |
#> |.....................| -0.4200 | -0.9922 | -0.2311 | 0.2290 |
#> |.....................| 0.5449 |...........|...........|...........|
#> | U| 116.80565 | 0.4579 | 1.012 | 3.460 | 0.6952 |
#> |.....................| 1.000 | 0.007846 | 1.261 | 1.953 |
#> |.....................| 2.692 |...........|...........|...........|
#> | X| 116.80565 | 1.581 | 2.752 | 31.80 | 0.6952 |
#> |.....................| 2.719 | 1.008 | 1.261 | 1.953 |
#> |.....................| 2.692 |...........|...........|...........|
#> | F| Forward Diff. | 0.1391 | 0.07373 | -0.1581 | 0.1321 |
#> |.....................| 0.002361 | 0.1391 | 0.6135 | 0.2208 |
#> |.....................| 0.1250 |...........|...........|...........|
#> | 16| 116.80376 | -0.7328 | -0.4058 | 1.010 | -0.6099 |
#> |.....................| -0.4201 | -0.9936 | -0.2364 | 0.2264 |
#> |.....................| 0.5442 |...........|...........|...........|
#> | U| 116.80376 | 0.4564 | 1.012 | 3.460 | 0.6945 |
#> |.....................| 1.000 | 0.006367 | 1.255 | 1.950 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 116.80376 | 1.578 | 2.750 | 31.83 | 0.6945 |
#> |.....................| 2.719 | 1.006 | 1.255 | 1.950 |
#> |.....................| 2.691 |...........|...........|...........|
#> | F| Forward Diff. | -0.06478 | -0.07166 | 0.6997 | -0.09342 |
#> |.....................| -0.001903 | -0.06475 | -0.03712 | 0.005775 |
#> |.....................| 0.09210 |...........|...........|...........|
#> | 17| 116.81449 | -0.7316 | -0.4055 | 1.005 | -0.6086 |
#> |.....................| -0.4200 | -0.9925 | -0.2394 | 0.2273 |
#> |.....................| 0.5426 |...........|...........|...........|
#> | U| 116.81449 | 0.4575 | 1.012 | 3.455 | 0.6950 |
#> |.....................| 1.000 | 0.007498 | 1.252 | 1.951 |
#> |.....................| 2.688 |...........|...........|...........|
#> | X| 116.81449 | 1.580 | 2.751 | 31.66 | 0.6950 |
#> |.....................| 2.719 | 1.008 | 1.252 | 1.951 |
#> |.....................| 2.688 |...........|...........|...........|
#> | 18| 116.80356 | -0.7327 | -0.4057 | 1.009 | -0.6098 |
#> |.....................| -0.4201 | -0.9936 | -0.2364 | 0.2264 |
#> |.....................| 0.5441 |...........|...........|...........|
#> | U| 116.80356 | 0.4565 | 1.012 | 3.459 | 0.6946 |
#> |.....................| 1.000 | 0.006447 | 1.255 | 1.950 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 116.80356 | 1.578 | 2.750 | 31.80 | 0.6946 |
#> |.....................| 2.719 | 1.006 | 1.255 | 1.950 |
#> |.....................| 2.691 |...........|...........|...........|
#> | F| Forward Diff. | -0.03566 | -0.09869 | -0.1316 | -0.02313 |
#> |.....................| -0.001623 | -0.03572 | -0.02324 | 0.01337 |
#> |.....................| 0.06508 |...........|...........|...........|
#> | 19| 116.80346 | -0.7324 | -0.4054 | 1.010 | -0.6097 |
#> |.....................| -0.4200 | -0.9933 | -0.2364 | 0.2266 |
#> |.....................| 0.5435 |...........|...........|...........|
#> | U| 116.80346 | 0.4567 | 1.012 | 3.460 | 0.6946 |
#> |.....................| 1.000 | 0.006727 | 1.255 | 1.950 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80346 | 1.579 | 2.751 | 31.81 | 0.6946 |
#> |.....................| 2.719 | 1.007 | 1.255 | 1.950 |
#> |.....................| 2.690 |...........|...........|...........|
#> | C| Central Diff. | -0.02335 | -0.01419 | 0.08010 | 0.1344 |
#> |.....................| 0.03695 | -0.02340 | -0.1781 | 0.03927 |
#> |.....................| 0.05723 |...........|...........|...........|
#> | 20| 116.80346 | -0.7324 | -0.4054 | 1.010 | -0.6097 |
#> |.....................| -0.4200 | -0.9933 | -0.2364 | 0.2266 |
#> |.....................| 0.5435 |...........|...........|...........|
#> | U| 116.80346 | 0.4567 | 1.012 | 3.460 | 0.6946 |
#> |.....................| 1.000 | 0.006727 | 1.255 | 1.950 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80346 | 1.579 | 2.751 | 31.81 | 0.6946 |
#> |.....................| 2.719 | 1.007 | 1.255 | 1.950 |
#> |.....................| 2.690 |...........|...........|...........|
#> calculating covariance matrix
#> done
#> Calculating residuals/tables
#> done
#> ✔ added centered_WT*cov_WT_cl to cl's equation in the model
#> ✔ updated value: cl<-exp(tcl+centered_WT*cov_WT_cl+eta.cl)
#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
#> F: Forward difference gradient approximation
#> C: Central difference gradient approximation
#> M: Mixed forward and central difference gradient approximation
#> Unscaled parameters for Omegas=chol(solve(omega));
#> Diagonals are transformed, as specified by foceiControl(diagXform=)
#> |-----+---------------+-----------+-----------+-----------+-----------|
#> | #| Objective Fun | tka | tcl | tv | add.sd |
#> |.....................|centered_WT | cov_WT_cl | o1 | o2 |
#> |.....................| o3 |...........|...........|...........|
#> | 1| 133.57512 | -0.7391 | -0.4242 | 1.000 | -0.5942 |
#> |.....................| -0.4203 | -1.000 | -0.3413 | -0.2167 |
#> |.....................| 0.03089 |...........|...........|...........|
#> | U| 133.57512 | 0.4500 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 1.000 | 0.000 | 1.136 | 1.351 |
#> |.....................| 1.778 |...........|...........|...........|
#> | X| 133.57512 | 1.568 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 2.718 | 1.000 | 1.136 | 1.351 |
#> |.....................| 1.778 |...........|...........|...........|
#> | G| Gill Diff. | -0.9310 | -1.614 | -3.052 | 1.589 |
#> |.....................| -0.001457 | -1.614 | -11.78 | -35.27 |
#> |.....................| -34.78 |...........|...........|...........|
#> | 2| 123.26516 | -0.7209 | -0.3926 | 1.060 | -0.6253 |
#> |.....................| -0.4201 | -0.9684 | -0.1107 | 0.4736 |
#> |.....................| 0.7116 |...........|...........|...........|
#> | U| 123.26516 | 0.4682 | 1.025 | 3.510 | 0.6891 |
#> |.....................| 1.000 | 0.03159 | 1.398 | 2.284 |
#> |.....................| 2.989 |...........|...........|...........|
#> | X| 123.26516 | 1.597 | 2.787 | 33.44 | 0.6891 |
#> |.....................| 2.719 | 1.032 | 1.398 | 2.284 |
#> |.....................| 2.989 |...........|...........|...........|
#> | F| Forward Diff. | -0.5868 | 30.11 | 74.23 | -5.071 |
#> |.....................| 0.5706 | 29.86 | 14.13 | 18.23 |
#> |.....................| 14.14 |...........|...........|...........|
#> | 3| 859.85007 | -0.7037 | -0.7267 | 0.2257 | -0.5836 |
#> |.....................| -0.4268 | -1.300 | -0.1453 | 0.6512 |
#> |.....................| 0.9315 |...........|...........|...........|
#> | U| 859.85007 | 0.4854 | 0.6908 | 2.676 | 0.7037 |
#> |.....................| 0.9935 | -0.2996 | 1.359 | 2.524 |
#> |.....................| 3.380 |...........|...........|...........|
#> | X| 859.85007 | 1.625 | 1.995 | 14.52 | 0.7037 |
#> |.....................| 2.701 | 0.7411 | 1.359 | 2.524 |
#> |.....................| 3.380 |...........|...........|...........|
#> | 4| 120.81610 | -0.7203 | -0.4261 | 0.9771 | -0.6196 |
#> |.....................| -0.4208 | -1.002 | -0.1264 | 0.4533 |
#> |.....................| 0.6959 |...........|...........|...........|
#> | U| 120.8161 | 0.4689 | 0.9913 | 3.427 | 0.6911 |
#> |.....................| 0.9995 | -0.001655 | 1.380 | 2.257 |
#> |.....................| 2.961 |...........|...........|...........|
#> | X| 120.8161 | 1.598 | 2.695 | 30.79 | 0.6911 |
#> |.....................| 2.717 | 0.9983 | 1.380 | 2.257 |
#> |.....................| 2.961 |...........|...........|...........|
#> | F| Forward Diff. | 2.099 | -13.28 | -43.93 | -3.395 |
#> |.....................| -0.1107 | -13.26 | 13.28 | 15.66 |
#> |.....................| 9.277 |...........|...........|...........|
#> | 5| 118.45977 | -0.7247 | -0.4172 | 1.022 | -0.6089 |
#> |.....................| -0.4209 | -0.9926 | -0.1681 | 0.3917 |
#> |.....................| 0.6499 |...........|...........|...........|
#> | U| 118.45977 | 0.4644 | 1.000 | 3.472 | 0.6948 |
#> |.....................| 0.9994 | 0.007380 | 1.333 | 2.173 |
#> |.....................| 2.879 |...........|...........|...........|
#> | X| 118.45977 | 1.591 | 2.719 | 32.22 | 0.6948 |
#> |.....................| 2.717 | 1.007 | 1.333 | 2.173 |
#> |.....................| 2.879 |...........|...........|...........|
#> | F| Forward Diff. | -0.07409 | 0.4343 | 15.45 | -1.363 |
#> |.....................| -1.321 | 0.4540 | 7.766 | 11.18 |
#> |.....................| 6.887 |...........|...........|...........|
#> | 6| 118.07299 | -0.7248 | -0.4061 | 0.9729 | -0.6038 |
#> |.....................| -0.4136 | -0.9817 | -0.2060 | 0.3287 |
#> |.....................| 0.6073 |...........|...........|...........|
#> | U| 118.07299 | 0.4643 | 1.011 | 3.423 | 0.6966 |
#> |.....................| 1.007 | 0.01828 | 1.290 | 2.088 |
#> |.....................| 2.803 |...........|...........|...........|
#> | X| 118.07299 | 1.591 | 2.749 | 30.66 | 0.6966 |
#> |.....................| 2.737 | 1.018 | 1.290 | 2.088 |
#> |.....................| 2.803 |...........|...........|...........|
#> | F| Forward Diff. | 1.344 | 3.736 | -37.78 | -0.04684 |
#> |.....................| 0.06989 | 3.762 | 3.849 | 7.447 |
#> |.....................| 4.174 |...........|...........|...........|
#> | 7| 117.26519 | -0.7264 | -0.4374 | 1.022 | -0.6094 |
#> |.....................| -0.4061 | -1.014 | -0.2254 | 0.2693 |
#> |.....................| 0.5676 |...........|...........|...........|
#> | U| 117.26519 | 0.4628 | 0.9800 | 3.472 | 0.6947 |
#> |.....................| 1.014 | -0.01353 | 1.268 | 2.008 |
#> |.....................| 2.733 |...........|...........|...........|
#> | X| 117.26519 | 1.588 | 2.664 | 32.21 | 0.6947 |
#> |.....................| 2.757 | 0.9866 | 1.268 | 2.008 |
#> |.....................| 2.733 |...........|...........|...........|
#> | F| Forward Diff. | -0.5664 | -13.66 | 9.555 | -0.2750 |
#> |.....................| -0.9035 | -13.85 | 1.175 | 3.410 |
#> |.....................| 2.098 |...........|...........|...........|
#> | 8| 118.05686 | -0.7225 | -0.3748 | 1.025 | -0.6188 |
#> |.....................| -0.3985 | -0.9492 | -0.2153 | 0.2362 |
#> |.....................| 0.5439 |...........|...........|...........|
#> | U| 118.05686 | 0.4666 | 1.043 | 3.475 | 0.6914 |
#> |.....................| 1.022 | 0.05084 | 1.279 | 1.963 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 118.05686 | 1.595 | 2.837 | 32.31 | 0.6914 |
#> |.....................| 2.778 | 1.052 | 1.279 | 1.963 |
#> |.....................| 2.691 |...........|...........|...........|
#> | 9| 116.87529 | -0.7255 | -0.4157 | 1.007 | -0.6090 |
#> |.....................| -0.4046 | -0.9915 | -0.2273 | 0.2638 |
#> |.....................| 0.5643 |...........|...........|...........|
#> | U| 116.87529 | 0.4637 | 1.002 | 3.457 | 0.6948 |
#> |.....................| 1.016 | 0.008506 | 1.266 | 2.000 |
#> |.....................| 2.727 |...........|...........|...........|
#> | X| 116.87529 | 1.590 | 2.723 | 31.72 | 0.6948 |
#> |.....................| 2.761 | 1.009 | 1.266 | 2.000 |
#> |.....................| 2.727 |...........|...........|...........|
#> | F| Forward Diff. | 0.09718 | -0.5758 | -2.570 | -0.1384 |
#> |.....................| -1.067 | -0.5840 | 1.029 | 2.643 |
#> |.....................| 1.329 |...........|...........|...........|
#> | 10| 117.00331 | -0.7263 | -0.4110 | 1.028 | -0.6079 |
#> |.....................| -0.3959 | -0.9867 | -0.2358 | 0.2421 |
#> |.....................| 0.5533 |...........|...........|...........|
#> | U| 117.00331 | 0.4629 | 1.006 | 3.478 | 0.6952 |
#> |.....................| 1.024 | 0.01331 | 1.256 | 1.971 |
#> |.....................| 2.707 |...........|...........|...........|
#> | X| 117.00331 | 1.589 | 2.736 | 32.40 | 0.6952 |
#> |.....................| 2.785 | 1.013 | 1.256 | 1.971 |
#> |.....................| 2.707 |...........|...........|...........|
#> | 11| 116.85677 | -0.7257 | -0.4144 | 1.013 | -0.6087 |
#> |.....................| -0.4023 | -0.9902 | -0.2296 | 0.2580 |
#> |.....................| 0.5613 |...........|...........|...........|
#> | U| 116.85677 | 0.4634 | 1.003 | 3.463 | 0.6949 |
#> |.....................| 1.018 | 0.009803 | 1.263 | 1.993 |
#> |.....................| 2.722 |...........|...........|...........|
#> | X| 116.85677 | 1.590 | 2.726 | 31.90 | 0.6949 |
#> |.....................| 2.768 | 1.010 | 1.263 | 1.993 |
#> |.....................| 2.722 |...........|...........|...........|
#> | F| Forward Diff. | -0.04765 | 0.6256 | 3.274 | -0.04788 |
#> |.....................| -1.060 | 0.6378 | 0.7205 | 2.183 |
#> |.....................| 1.251 |...........|...........|...........|
#> | 12| 116.84445 | -0.7256 | -0.4158 | 1.006 | -0.6086 |
#> |.....................| -0.3997 | -0.9916 | -0.2310 | 0.2530 |
#> |.....................| 0.5585 |...........|...........|...........|
#> | U| 116.84445 | 0.4635 | 1.002 | 3.456 | 0.6949 |
#> |.....................| 1.021 | 0.008432 | 1.262 | 1.986 |
#> |.....................| 2.716 |...........|...........|...........|
#> | X| 116.84445 | 1.590 | 2.723 | 31.69 | 0.6949 |
#> |.....................| 2.775 | 1.008 | 1.262 | 1.986 |
#> |.....................| 2.716 |...........|...........|...........|
#> | F| Forward Diff. | 0.09730 | -0.6994 | -3.538 | -0.03650 |
#> |.....................| -1.064 | -0.7129 | 0.6224 | 1.894 |
#> |.....................| 0.9409 |...........|...........|...........|
#> | 13| 116.82752 | -0.7257 | -0.4150 | 1.012 | -0.6089 |
#> |.....................| -0.3958 | -0.9907 | -0.2318 | 0.2475 |
#> |.....................| 0.5555 |...........|...........|...........|
#> | U| 116.82752 | 0.4634 | 1.002 | 3.462 | 0.6948 |
#> |.....................| 1.024 | 0.009266 | 1.261 | 1.978 |
#> |.....................| 2.711 |...........|...........|...........|
#> | X| 116.82752 | 1.589 | 2.725 | 31.88 | 0.6948 |
#> |.....................| 2.786 | 1.009 | 1.261 | 1.978 |
#> |.....................| 2.711 |...........|...........|...........|
#> | F| Forward Diff. | -0.04193 | 0.2040 | 2.262 | -0.1521 |
#> |.....................| -1.050 | 0.2102 | 0.4967 | 1.488 |
#> |.....................| 0.8587 |...........|...........|...........|
#> | 14| 116.81980 | -0.7256 | -0.4157 | 1.007 | -0.6086 |
#> |.....................| -0.3905 | -0.9915 | -0.2326 | 0.2422 |
#> |.....................| 0.5525 |...........|...........|...........|
#> | U| 116.8198 | 0.4635 | 1.002 | 3.457 | 0.6950 |
#> |.....................| 1.030 | 0.008500 | 1.260 | 1.971 |
#> |.....................| 2.706 |...........|...........|...........|
#> | X| 116.8198 | 1.590 | 2.723 | 31.72 | 0.6950 |
#> |.....................| 2.800 | 1.009 | 1.260 | 1.971 |
#> |.....................| 2.706 |...........|...........|...........|
#> | F| Forward Diff. | 0.06676 | -0.5802 | -2.545 | 0.01398 |
#> |.....................| -1.040 | -0.5962 | 0.01321 | 1.186 |
#> |.....................| 0.5819 |...........|...........|...........|
#> | 15| 116.81249 | -0.7257 | -0.4151 | 1.011 | -0.6086 |
#> |.....................| -0.3839 | -0.9908 | -0.2308 | 0.2379 |
#> |.....................| 0.5500 |...........|...........|...........|
#> | U| 116.81249 | 0.4634 | 1.002 | 3.461 | 0.6950 |
#> |.....................| 1.036 | 0.009190 | 1.262 | 1.965 |
#> |.....................| 2.701 |...........|...........|...........|
#> | X| 116.81249 | 1.590 | 2.725 | 31.86 | 0.6950 |
#> |.....................| 2.819 | 1.009 | 1.262 | 1.965 |
#> |.....................| 2.701 |...........|...........|...........|
#> | F| Forward Diff. | -0.02431 | 0.1156 | 1.592 | 0.04944 |
#> |.....................| -1.010 | 0.1201 | 0.6380 | 0.8200 |
#> |.....................| 0.4831 |...........|...........|...........|
#> | 16| 116.80960 | -0.7257 | -0.4154 | 1.008 | -0.6098 |
#> |.....................| -0.3758 | -0.9912 | -0.2330 | 0.2357 |
#> |.....................| 0.5487 |...........|...........|...........|
#> | U| 116.8096 | 0.4634 | 1.002 | 3.458 | 0.6946 |
#> |.....................| 1.045 | 0.008808 | 1.259 | 1.962 |
#> |.....................| 2.699 |...........|...........|...........|
#> | X| 116.8096 | 1.590 | 2.724 | 31.75 | 0.6946 |
#> |.....................| 2.842 | 1.009 | 1.259 | 1.962 |
#> |.....................| 2.699 |...........|...........|...........|
#> | F| Forward Diff. | 0.03766 | -0.3156 | -1.557 | 0.01295 |
#> |.....................| -0.9931 | -0.3284 | 0.4427 | 0.6703 |
#> |.....................| 0.3523 |...........|...........|...........|
#> | 17| 116.80820 | -0.7258 | -0.4149 | 1.011 | -0.6104 |
#> |.....................| -0.3679 | -0.9906 | -0.2371 | 0.2351 |
#> |.....................| 0.5484 |...........|...........|...........|
#> | U| 116.8082 | 0.4634 | 1.003 | 3.461 | 0.6943 |
#> |.....................| 1.052 | 0.009444 | 1.255 | 1.962 |
#> |.....................| 2.698 |...........|...........|...........|
#> | X| 116.8082 | 1.589 | 2.725 | 31.85 | 0.6943 |
#> |.....................| 2.865 | 1.009 | 1.255 | 1.962 |
#> |.....................| 2.698 |...........|...........|...........|
#> | F| Forward Diff. | -0.04468 | 0.2690 | 1.586 | -0.07671 |
#> |.....................| -0.9719 | 0.2856 | -0.09668 | 0.6631 |
#> |.....................| 0.4284 |...........|...........|...........|
#> | 18| 116.80691 | -0.7255 | -0.4153 | 1.008 | -0.6096 |
#> |.....................| -0.3590 | -0.9911 | -0.2364 | 0.2342 |
#> |.....................| 0.5472 |...........|...........|...........|
#> | U| 116.80691 | 0.4636 | 1.002 | 3.458 | 0.6946 |
#> |.....................| 1.061 | 0.008942 | 1.255 | 1.960 |
#> |.....................| 2.696 |...........|...........|...........|
#> | X| 116.80691 | 1.590 | 2.724 | 31.77 | 0.6946 |
#> |.....................| 2.890 | 1.009 | 1.255 | 1.960 |
#> |.....................| 2.696 |...........|...........|...........|
#> | F| Forward Diff. | 0.02779 | -0.1677 | -1.124 | -0.002516 |
#> |.....................| -0.9417 | -0.1689 |-0.0008595 | 0.5422 |
#> |.....................| 0.2791 |...........|...........|...........|
#> | 19| 116.80628 | -0.7255 | -0.4148 | 1.011 | -0.6090 |
#> |.....................| -0.3504 | -0.9906 | -0.2343 | 0.2327 |
#> |.....................| 0.5460 |...........|...........|...........|
#> | U| 116.80628 | 0.4636 | 1.003 | 3.461 | 0.6948 |
#> |.....................| 1.070 | 0.009366 | 1.258 | 1.958 |
#> |.....................| 2.694 |...........|...........|...........|
#> | X| 116.80628 | 1.590 | 2.726 | 31.85 | 0.6948 |
#> |.....................| 2.915 | 1.009 | 1.258 | 1.958 |
#> |.....................| 2.694 |...........|...........|...........|
#> | F| Forward Diff. | -0.02227 | 0.3104 | 1.408 | -0.07037 |
#> |.....................| -0.9140 | 0.3418 | 0.2318 | 0.4631 |
#> |.....................| 0.2483 |...........|...........|...........|
#> | 20| 116.80562 | -0.7255 | -0.4152 | 1.009 | -0.6085 |
#> |.....................| -0.3464 | -0.9912 | -0.2348 | 0.2322 |
#> |.....................| 0.5459 |...........|...........|...........|
#> | U| 116.80562 | 0.4636 | 1.002 | 3.459 | 0.6950 |
#> |.....................| 1.074 | 0.008778 | 1.257 | 1.958 |
#> |.....................| 2.694 |...........|...........|...........|
#> | X| 116.80562 | 1.590 | 2.724 | 31.77 | 0.6950 |
#> |.....................| 2.927 | 1.009 | 1.257 | 1.958 |
#> |.....................| 2.694 |...........|...........|...........|
#> | F| Forward Diff. | 0.02645 | -0.1435 | -0.9284 | 0.06898 |
#> |.....................| -0.9008 | -0.1445 | 0.2245 | 0.4178 |
#> |.....................| 0.2078 |...........|...........|...........|
#> | 21| 116.80523 | -0.7256 | -0.4148 | 1.011 | -0.6086 |
#> |.....................| -0.3424 | -0.9909 | -0.2356 | 0.2314 |
#> |.....................| 0.5457 |...........|...........|...........|
#> | U| 116.80523 | 0.4635 | 1.003 | 3.461 | 0.6950 |
#> |.....................| 1.078 | 0.009104 | 1.256 | 1.957 |
#> |.....................| 2.694 |...........|...........|...........|
#> | X| 116.80523 | 1.590 | 2.726 | 31.84 | 0.6950 |
#> |.....................| 2.939 | 1.009 | 1.256 | 1.957 |
#> |.....................| 2.694 |...........|...........|...........|
#> | F| Forward Diff. | -0.02893 | 0.2145 | 1.146 | 0.01324 |
#> |.....................| -0.9001 | 0.2420 | 0.06451 | 0.3671 |
#> |.....................| 0.2252 |...........|...........|...........|
#> | 22| 116.80465 | -0.7256 | -0.4151 | 1.009 | -0.6086 |
#> |.....................| -0.3410 | -0.9913 | -0.2357 | 0.2309 |
#> |.....................| 0.5453 |...........|...........|...........|
#> | U| 116.80465 | 0.4635 | 1.002 | 3.459 | 0.6950 |
#> |.....................| 1.079 | 0.008735 | 1.256 | 1.956 |
#> |.....................| 2.693 |...........|...........|...........|
#> | X| 116.80465 | 1.590 | 2.725 | 31.79 | 0.6950 |
#> |.....................| 2.943 | 1.009 | 1.256 | 1.956 |
#> |.....................| 2.693 |...........|...........|...........|
#> | F| Forward Diff. | 0.01212 | -0.1039 | -0.5735 | 0.06024 |
#> |.....................| -0.8870 | -0.1020 | 0.05391 | 0.3428 |
#> |.....................| 0.1724 |...........|...........|...........|
#> | 23| 116.80425 | -0.7256 | -0.4149 | 1.010 | -0.6088 |
#> |.....................| -0.3391 | -0.9911 | -0.2359 | 0.2302 |
#> |.....................| 0.5450 |...........|...........|...........|
#> | U| 116.80425 | 0.4635 | 1.003 | 3.460 | 0.6949 |
#> |.....................| 1.081 | 0.008948 | 1.256 | 1.955 |
#> |.....................| 2.692 |...........|...........|...........|
#> | X| 116.80425 | 1.590 | 2.725 | 31.82 | 0.6949 |
#> |.....................| 2.948 | 1.009 | 1.256 | 1.955 |
#> |.....................| 2.692 |...........|...........|...........|
#> | F| Forward Diff. | -0.01639 | 0.1037 | 0.5987 | 0.02830 |
#> |.....................| -0.8864 | 0.1225 | 0.04883 | 0.2777 |
#> |.....................| 0.1680 |...........|...........|...........|
#> | 24| 116.80424 | -0.7256 | -0.4151 | 1.009 | -0.6088 |
#> |.....................| -0.3373 | -0.9913 | -0.2360 | 0.2296 |
#> |.....................| 0.5446 |...........|...........|...........|
#> | U| 116.80424 | 0.4635 | 1.002 | 3.459 | 0.6949 |
#> |.....................| 1.083 | 0.008691 | 1.256 | 1.954 |
#> |.....................| 2.692 |...........|...........|...........|
#> | X| 116.80424 | 1.590 | 2.725 | 31.78 | 0.6949 |
#> |.....................| 2.954 | 1.009 | 1.256 | 1.954 |
#> |.....................| 2.692 |...........|...........|...........|
#> | C| Central Diff. |-0.0001167 | -0.1557 | -0.7359 | 0.05313 |
#> |.....................| 0.4682 | -0.1686 | -0.1753 | 0.2650 |
#> |.....................| 0.1198 |...........|...........|...........|
#> | 25| 116.80386 | -0.7256 | -0.4149 | 1.010 | -0.6089 |
#> |.....................| -0.3379 | -0.9911 | -0.2357 | 0.2293 |
#> |.....................| 0.5445 |...........|...........|...........|
#> | U| 116.80386 | 0.4635 | 1.003 | 3.460 | 0.6949 |
#> |.....................| 1.082 | 0.008898 | 1.256 | 1.954 |
#> |.....................| 2.692 |...........|...........|...........|
#> | X| 116.80386 | 1.590 | 2.725 | 31.81 | 0.6949 |
#> |.....................| 2.952 | 1.009 | 1.256 | 1.954 |
#> |.....................| 2.692 |...........|...........|...........|
#> | F| Forward Diff. | -0.005283 | 0.06096 | 0.2574 | 0.03751 |
#> |.....................| -0.8770 | 0.07625 | 0.05273 | 0.2261 |
#> |.....................| 0.1359 |...........|...........|...........|
#> | 26| 116.80382 | -0.7255 | -0.4149 | 1.010 | -0.6093 |
#> |.....................| -0.3369 | -0.9911 | -0.2353 | 0.2290 |
#> |.....................| 0.5444 |...........|...........|...........|
#> | U| 116.80382 | 0.4636 | 1.003 | 3.460 | 0.6947 |
#> |.....................| 1.083 | 0.008879 | 1.257 | 1.953 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 116.80382 | 1.590 | 2.725 | 31.82 | 0.6947 |
#> |.....................| 2.955 | 1.009 | 1.257 | 1.953 |
#> |.....................| 2.691 |...........|...........|...........|
#> | C| Central Diff. | -0.01642 | 0.03867 | 0.2678 | 0.03984 |
#> |.....................| 0.4930 | 0.04192 | -0.02741 | 0.2097 |
#> |.....................| 0.1227 |...........|...........|...........|
#> | 27| 116.80374 | -0.7255 | -0.4149 | 1.010 | -0.6093 |
#> |.....................| -0.3374 | -0.9912 | -0.2353 | 0.2288 |
#> |.....................| 0.5442 |...........|...........|...........|
#> | U| 116.80374 | 0.4636 | 1.003 | 3.460 | 0.6947 |
#> |.....................| 1.083 | 0.008839 | 1.257 | 1.953 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 116.80374 | 1.590 | 2.725 | 31.81 | 0.6947 |
#> |.....................| 2.953 | 1.009 | 1.257 | 1.953 |
#> |.....................| 2.691 |...........|...........|...........|
#> | C| Central Diff. | -0.01008 | -0.002947 | 0.01119 | -0.003481 |
#> |.....................| 0.4506 | -0.003364 | -0.06411 | 0.2096 |
#> |.....................| 0.1102 |...........|...........|...........|
#> | 28| 116.80370 | -0.7255 | -0.4149 | 1.010 | -0.6093 |
#> |.....................| -0.3379 | -0.9912 | -0.2352 | 0.2286 |
#> |.....................| 0.5441 |...........|...........|...........|
#> | U| 116.8037 | 0.4636 | 1.003 | 3.460 | 0.6947 |
#> |.....................| 1.082 | 0.008843 | 1.257 | 1.953 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 116.8037 | 1.590 | 2.725 | 31.81 | 0.6947 |
#> |.....................| 2.952 | 1.009 | 1.257 | 1.953 |
#> |.....................| 2.691 |...........|...........|...........|
#> | C| Central Diff. | -0.008927 | -0.003530 | -0.002543 | 0.03935 |
#> |.....................| 0.4491 | -0.003826 | -0.05456 | 0.1732 |
#> |.....................| 0.09266 |...........|...........|...........|
#> | 29| 116.80365 | -0.7255 | -0.4149 | 1.010 | -0.6094 |
#> |.....................| -0.3390 | -0.9911 | -0.2351 | 0.2282 |
#> |.....................| 0.5439 |...........|...........|...........|
#> | U| 116.80365 | 0.4637 | 1.003 | 3.460 | 0.6947 |
#> |.....................| 1.081 | 0.008852 | 1.257 | 1.952 |
#> |.....................| 2.691 |...........|...........|...........|
#> | X| 116.80365 | 1.590 | 2.725 | 31.81 | 0.6947 |
#> |.....................| 2.949 | 1.009 | 1.257 | 1.952 |
#> |.....................| 2.691 |...........|...........|...........|
#> | C| Central Diff. | -0.007599 | -0.001520 | 0.0005778 | 0.02794 |
#> |.....................| 0.4720 | -0.001619 | -0.02704 | 0.1464 |
#> |.....................| 0.07022 |...........|...........|...........|
#> | 30| 116.80358 | -0.7254 | -0.4149 | 1.010 | -0.6096 |
#> |.....................| -0.3412 | -0.9911 | -0.2350 | 0.2275 |
#> |.....................| 0.5436 |...........|...........|...........|
#> | U| 116.80358 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.079 | 0.008860 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80358 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.942 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | C| Central Diff. | -0.005416 | -0.004754 | 0.003477 | 0.06070 |
#> |.....................| 0.4775 | -0.005155 | -0.009362 | 0.09563 |
#> |.....................| 0.04744 |...........|...........|...........|
#> | 31| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3423 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | C| Central Diff. | -0.004504 | -0.001809 | -0.007112 | -0.08529 |
#> |.....................| 0.4776 | -0.001961 | -0.04002 | 0.07330 |
#> |.....................| 0.05623 |...........|...........|...........|
#> | 32| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6096 |
#> |.....................| -0.3429 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.077 | 0.008874 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.937 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 33| 116.80362 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3426 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80362 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008873 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80362 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.938 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 34| 116.80362 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80362 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008873 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80362 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.938 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 35| 116.80355 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80355 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80355 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | C| Central Diff. | -0.004420 | -0.001815 | -0.01189 | -0.1646 |
#> |.....................| 0.5141 | -0.001996 | 0.02918 | 0.09605 |
#> |.....................| 0.03007 |...........|...........|...........|
#> | 36| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.938 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 37| 116.80358 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80358 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80358 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 38| 116.80358 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80358 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80358 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 39| 116.80357 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80357 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80357 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 40| 116.80357 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80357 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80357 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 41| 116.80357 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80357 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80357 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 42| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 43| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 44| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 45| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 46| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | 47| 116.80356 | -0.7254 | -0.4149 | 1.010 | -0.6097 |
#> |.....................| -0.3424 | -0.9911 | -0.2349 | 0.2272 |
#> |.....................| 0.5434 |...........|...........|...........|
#> | U| 116.80356 | 0.4637 | 1.003 | 3.460 | 0.6946 |
#> |.....................| 1.078 | 0.008872 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> | X| 116.80356 | 1.590 | 2.725 | 31.81 | 0.6946 |
#> |.....................| 2.939 | 1.009 | 1.257 | 1.951 |
#> |.....................| 2.690 |...........|...........|...........|
#> calculating covariance matrix
#> done
#> Calculating residuals/tables
#> done
#> ✔ added categorical_SEX_0*cov_SEX_0_ka to ka's equation in the model
#> ✔ updated value: ka<-exp(tka+categorical_SEX_0*cov_SEX_0_ka+eta.ka)
#> Needed Covariates:
#> [1] "categorical_SEX_0"
#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
#> F: Forward difference gradient approximation
#> C: Central difference gradient approximation
#> M: Mixed forward and central difference gradient approximation
#> Unscaled parameters for Omegas=chol(solve(omega));
#> Diagonals are transformed, as specified by foceiControl(diagXform=)
#> |-----+---------------+-----------+-----------+-----------+-----------|
#> | #| Objective Fun | tka | tcl | tv | add.sd |
#> |.....................|cov_SEX_0_ka | o1 | o2 | o3 |
#> | 1| 133.57512 | -0.7391 | -0.4242 | 1.000 | -0.5942 |
#> |.....................| -1.000 | -0.3413 | -0.2167 | 0.03089 |
#> | U| 133.57512 | 0.4500 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 0.000 | 1.136 | 1.351 | 1.778 |
#> | X| 133.57512 | 1.568 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.000 | 1.136 | 1.351 | 1.778 |
#> | G| Gill Diff. | -0.9310 | -1.614 | -3.052 | 1.589 |
#> |.....................| -0.3833 | -11.78 | -35.27 | -34.78 |
#> | 2| 122.57176 | -0.7209 | -0.3926 | 1.060 | -0.6253 |
#> |.....................| -0.9925 | -0.1106 | 0.4740 | 0.7119 |
#> | U| 122.57176 | 0.4682 | 1.025 | 3.510 | 0.6891 |
#> |.....................| 0.007504 | 1.398 | 2.284 | 2.989 |
#> | X| 122.57176 | 1.597 | 2.787 | 33.44 | 0.6891 |
#> |.....................| 1.008 | 1.398 | 2.284 | 2.989 |
#> | F| Forward Diff. | -0.6138 | 14.75 | 69.97 | -5.068 |
#> |.....................| -0.1255 | 14.08 | 16.75 | 13.96 |
#> | 3| 691.05960 | -0.7027 | -0.5840 | 0.1043 | -0.5701 |
#> |.....................| -0.9868 | -0.1885 | 0.5987 | 0.8711 |
#> | U| 691.0596 | 0.4864 | 0.8334 | 2.554 | 0.7084 |
#> |.....................| 0.01320 | 1.310 | 2.453 | 3.272 |
#> | X| 691.0596 | 1.626 | 2.301 | 12.86 | 0.7084 |
#> |.....................| 1.013 | 1.310 | 2.453 | 3.272 |
#> | 4| 121.03067 | -0.7201 | -0.4119 | 0.9680 | -0.6187 |
#> |.....................| -0.9923 | -0.1291 | 0.4520 | 0.6936 |
#> | U| 121.03067 | 0.4690 | 1.006 | 3.418 | 0.6914 |
#> |.....................| 0.007669 | 1.377 | 2.255 | 2.957 |
#> | X| 121.03067 | 1.598 | 2.733 | 30.51 | 0.6914 |
#> |.....................| 1.008 | 1.377 | 2.255 | 2.957 |
#> | F| Forward Diff. | 2.906 | -6.927 | -53.50 | -3.168 |
#> |.....................| 1.742 | 13.24 | 15.45 | 9.487 |
#> | 5| 118.40376 | -0.7259 | -0.4104 | 1.019 | -0.6075 |
#> |.....................| -0.9959 | -0.1720 | 0.3935 | 0.6497 |
#> | U| 118.40376 | 0.4632 | 1.007 | 3.469 | 0.6954 |
#> |.....................| 0.004068 | 1.329 | 2.176 | 2.879 |
#> | X| 118.40376 | 1.589 | 2.738 | 32.11 | 0.6954 |
#> |.....................| 1.004 | 1.329 | 2.176 | 2.879 |
#> | F| Forward Diff. | 0.06943 | -0.1210 | 11.55 | -1.206 |
#> |.....................| 0.1265 | 7.334 | 11.27 | 6.739 |
#> | 6| 117.96347 | -0.7265 | -0.4041 | 0.9745 | -0.6023 |
#> |.....................| -0.9967 | -0.2119 | 0.3257 | 0.6079 |
#> | U| 117.96347 | 0.4626 | 1.013 | 3.425 | 0.6972 |
#> |.....................| 0.003313 | 1.283 | 2.084 | 2.804 |
#> | X| 117.96347 | 1.588 | 2.755 | 30.71 | 0.6972 |
#> |.....................| 1.003 | 1.283 | 2.084 | 2.804 |
#> | F| Forward Diff. | 1.151 | -2.174 | -37.47 | 0.1929 |
#> |.....................| 0.6283 | 3.090 | 7.222 | 4.287 |
#> | 7| 117.01052 | -0.7240 | -0.4046 | 1.027 | -0.6151 |
#> |.....................| -0.9949 | -0.2188 | 0.2547 | 0.5630 |
#> | U| 117.01052 | 0.4651 | 1.013 | 3.477 | 0.6927 |
#> |.....................| 0.005105 | 1.275 | 1.988 | 2.725 |
#> | X| 117.01052 | 1.592 | 2.754 | 32.35 | 0.6927 |
#> |.....................| 1.005 | 1.275 | 1.988 | 2.725 |
#> | F| Forward Diff. | -0.1135 | 1.555 | 17.12 | -0.7676 |
#> |.....................| 0.04685 | 2.022 | 2.107 | 1.858 |
#> | 8| 117.19994 | -0.7301 | -0.4496 | 1.005 | -0.6190 |
#> |.....................| -1.001 | -0.2216 | 0.1978 | 0.4985 |
#> | U| 117.19994 | 0.4590 | 0.9679 | 3.455 | 0.6913 |
#> |.....................| -0.001212 | 1.272 | 1.911 | 2.610 |
#> | X| 117.19994 | 1.583 | 2.632 | 31.67 | 0.6913 |
#> |.....................| 0.9988 | 1.272 | 1.911 | 2.610 |
#> | 9| 116.86330 | -0.7258 | -0.4199 | 1.006 | -0.6157 |
#> |.....................| -0.9969 | -0.2213 | 0.2352 | 0.5414 |
#> | U| 116.8633 | 0.4633 | 0.9976 | 3.456 | 0.6925 |
#> |.....................| 0.003095 | 1.273 | 1.962 | 2.686 |
#> | X| 116.8633 | 1.589 | 2.712 | 31.69 | 0.6925 |
#> |.....................| 1.003 | 1.273 | 1.962 | 2.686 |
#> | F| Forward Diff. | 0.1191 | -4.492 | -4.573 | -0.6919 |
#> |.....................| 0.1224 | 1.886 | 0.6391 | -0.004244 |
#> | 10| 116.87411 | -0.7264 | -0.3840 | 1.006 | -0.6094 |
#> |.....................| -0.9982 | -0.2350 | 0.2323 | 0.5392 |
#> | U| 116.87411 | 0.4628 | 1.033 | 3.456 | 0.6947 |
#> |.....................| 0.001768 | 1.257 | 1.958 | 2.682 |
#> | X| 116.87411 | 1.588 | 2.811 | 31.69 | 0.6947 |
#> |.....................| 1.002 | 1.257 | 1.958 | 2.682 |
#> | 11| 116.81210 | -0.7261 | -0.4038 | 1.012 | -0.6130 |
#> |.....................| -0.9974 | -0.2277 | 0.2336 | 0.5407 |
#> | U| 116.8121 | 0.4630 | 1.014 | 3.462 | 0.6934 |
#> |.....................| 0.002554 | 1.265 | 1.960 | 2.685 |
#> | X| 116.8121 | 1.589 | 2.756 | 31.87 | 0.6934 |
#> |.....................| 1.003 | 1.265 | 1.960 | 2.685 |
#> | F| Forward Diff. | 0.01717 | 0.6550 | 1.923 | -0.2624 |
#> |.....................| 0.03243 | 1.074 | 0.4303 | 0.02936 |
#> | 12| 116.82346 | -0.7263 | -0.4053 | 1.004 | -0.6092 |
#> |.....................| -0.9979 | -0.2429 | 0.2340 | 0.5468 |
#> | U| 116.82346 | 0.4629 | 1.012 | 3.454 | 0.6948 |
#> |.....................| 0.002061 | 1.248 | 1.960 | 2.696 |
#> | X| 116.82346 | 1.589 | 2.751 | 31.63 | 0.6948 |
#> |.....................| 1.002 | 1.248 | 1.960 | 2.696 |
#> | 13| 116.81327 | -0.7262 | -0.4057 | 1.006 | -0.6122 |
#> |.....................| -0.9975 | -0.2308 | 0.2323 | 0.5406 |
#> | U| 116.81327 | 0.4629 | 1.012 | 3.456 | 0.6937 |
#> |.....................| 0.002459 | 1.262 | 1.958 | 2.685 |
#> | X| 116.81327 | 1.589 | 2.750 | 31.69 | 0.6937 |
#> |.....................| 1.002 | 1.262 | 1.958 | 2.685 |
#> | 14| 116.80847 | -0.7262 | -0.4047 | 1.009 | -0.6126 |
#> |.....................| -0.9975 | -0.2291 | 0.2330 | 0.5407 |
#> | U| 116.80847 | 0.4630 | 1.013 | 3.459 | 0.6935 |
#> |.....................| 0.002510 | 1.264 | 1.959 | 2.685 |
#> | X| 116.80847 | 1.589 | 2.753 | 31.79 | 0.6935 |
#> |.....................| 1.003 | 1.264 | 1.959 | 2.685 |
#> | F| Forward Diff. | 0.06602 | 0.2217 | -0.6063 | -0.2064 |
#> |.....................| 0.07349 | 0.9058 | 0.4319 | -0.02269 |
#> | 15| 116.80615 | -0.7263 | -0.4053 | 1.011 | -0.6121 |
#> |.....................| -0.9977 | -0.2315 | 0.2318 | 0.5407 |
#> | U| 116.80615 | 0.4628 | 1.012 | 3.461 | 0.6937 |
#> |.....................| 0.002316 | 1.261 | 1.957 | 2.685 |
#> | X| 116.80615 | 1.589 | 2.752 | 31.84 | 0.6937 |
#> |.....................| 1.002 | 1.261 | 1.957 | 2.685 |
#> | F| Forward Diff. | 0.004366 | 0.1398 | 0.8989 | -0.2182 |
#> |.....................| 0.03171 | 0.5977 | 0.3486 | 0.01430 |
#> | 16| 116.80588 | -0.7263 | -0.4056 | 1.008 | -0.6115 |
#> |.....................| -0.9978 | -0.2332 | 0.2309 | 0.5407 |
#> | U| 116.80588 | 0.4628 | 1.012 | 3.458 | 0.6939 |
#> |.....................| 0.002229 | 1.259 | 1.956 | 2.685 |
#> | X| 116.80588 | 1.588 | 2.751 | 31.76 | 0.6939 |
#> |.....................| 1.002 | 1.259 | 1.956 | 2.685 |
#> | F| Forward Diff. | 0.05136 | -0.1335 | -1.458 | -0.1218 |
#> |.....................| 0.03459 | 0.4392 | 0.3226 | -0.05937 |
#> | 17| 116.80398 | -0.7262 | -0.4054 | 1.010 | -0.6102 |
#> |.....................| -0.9978 | -0.2340 | 0.2296 | 0.5424 |
#> | U| 116.80398 | 0.4629 | 1.012 | 3.460 | 0.6944 |
#> |.....................| 0.002171 | 1.258 | 1.954 | 2.688 |
#> | X| 116.80398 | 1.589 | 2.751 | 31.82 | 0.6944 |
#> |.....................| 1.002 | 1.258 | 1.954 | 2.688 |
#> | F| Forward Diff. | 0.01698 | 0.05928 | 0.3320 | 0.04971 |
#> |.....................| 0.03278 | 0.2857 | 0.2292 | 0.04921 |
#> | 18| 116.80390 | -0.7263 | -0.4052 | 1.009 | -0.6120 |
#> |.....................| -0.9982 | -0.2351 | 0.2276 | 0.5433 |
#> | U| 116.8039 | 0.4628 | 1.012 | 3.459 | 0.6938 |
#> |.....................| 0.001752 | 1.257 | 1.952 | 2.689 |
#> | X| 116.8039 | 1.589 | 2.752 | 31.79 | 0.6938 |
#> |.....................| 1.002 | 1.257 | 1.952 | 2.689 |
#> | C| Central Diff. | 0.006937 | 0.0002783 | -0.6092 | -0.1246 |
#> |.....................| -0.005878 | 0.1261 | 0.1405 | 0.04195 |
#> | 19| 116.80390 | -0.7263 | -0.4052 | 1.009 | -0.6120 |
#> |.....................| -0.9982 | -0.2351 | 0.2276 | 0.5433 |
#> | U| 116.8039 | 0.4628 | 1.012 | 3.459 | 0.6938 |
#> |.....................| 0.001752 | 1.257 | 1.952 | 2.689 |
#> | X| 116.8039 | 1.589 | 2.752 | 31.79 | 0.6938 |
#> |.....................| 1.002 | 1.257 | 1.952 | 2.689 |
#> calculating covariance matrix
#> done
#> Calculating residuals/tables
#> done
#> ✔ added categorical_SEX_0*cov_SEX_0_cl to cl's equation in the model
#> ✔ updated value: cl<-exp(tcl+categorical_SEX_0*cov_SEX_0_cl+eta.cl)
#> Needed Covariates:
#> [1] "categorical_SEX_0"
#> Key: U: Unscaled Parameters; X: Back-transformed parameters; G: Gill difference gradient approximation
#> F: Forward difference gradient approximation
#> C: Central difference gradient approximation
#> M: Mixed forward and central difference gradient approximation
#> Unscaled parameters for Omegas=chol(solve(omega));
#> Diagonals are transformed, as specified by foceiControl(diagXform=)
#> |-----+---------------+-----------+-----------+-----------+-----------|
#> | #| Objective Fun | tka | tcl | tv | add.sd |
#> |.....................|cov_SEX_0_cl | o1 | o2 | o3 |
#> | 1| 133.57512 | -0.7391 | -0.4242 | 1.000 | -0.5942 |
#> |.....................| -1.000 | -0.3413 | -0.2167 | 0.03089 |
#> | U| 133.57512 | 0.4500 | 0.9933 | 3.450 | 0.7000 |
#> |.....................| 0.000 | 1.136 | 1.351 | 1.778 |
#> | X| 133.57512 | 1.568 | 2.700 | 31.50 | 0.7000 |
#> |.....................| 1.000 | 1.136 | 1.351 | 1.778 |
#> | G| Gill Diff. | -0.9310 | -1.614 | -3.052 | 1.589 |
#> |.....................| -1.864 | -11.78 | -35.27 | -34.78 |
#> | 2| 122.79252 | -0.7209 | -0.3926 | 1.060 | -0.6253 |
#> |.....................| -0.9635 | -0.1107 | 0.4735 | 0.7115 |
#> | U| 122.79252 | 0.4682 | 1.025 | 3.510 | 0.6891 |
#> |.....................| 0.03648 | 1.398 | 2.284 | 2.989 |
#> | X| 122.79252 | 1.597 | 2.787 | 33.44 | 0.6891 |
#> |.....................| 1.037 | 1.398 | 2.284 | 2.989 |
#> | F| Forward Diff. | -0.7224 | 23.53 | 72.49 | -4.846 |
#> |.....................| 11.03 | 14.22 | 17.29 | 14.16 |
#> | 3| 736.39476 | -0.7016 | -0.6833 | 0.1439 | -0.5787 |
#> |.....................| -1.088 | -0.1720 | 0.6205 | 0.8942 |
#> | U| 736.39476 | 0.4875 | 0.7342 | 2.594 | 0.7054 |
#> |.....................| -0.08802 | 1.329 | 2.482 | 3.313 |
#> | X| 736.39476 | 1.628 | 2.084 | 13.38 | 0.7054 |
#> |.....................| 0.9157 | 1.329 | 2.482 | 3.313 |
#> | 4| 120.79421 | -0.7200 | -0.4215 | 0.9709 | -0.6194 |
#> |.....................| -0.9770 | -0.1282 | 0.4523 | 0.6941 |
#> | U| 120.79421 | 0.4691 | 0.9960 | 3.421 | 0.6912 |
#> |.....................| 0.02296 | 1.378 | 2.255 | 2.958 |
#> | X| 120.79421 | 1.599 | 2.707 | 30.60 | 0.6912 |
#> |.....................| 1.023 | 1.378 | 2.255 | 2.958 |
#> | F| Forward Diff. | 2.534 | -5.692 | -49.42 | -3.130 |
#> |.....................| -5.302 | 13.05 | 15.32 | 9.338 |
#> | 5| 118.38422 | -0.7252 | -0.4264 | 1.023 | -0.6089 |
#> |.....................| -0.9744 | -0.1700 | 0.3935 | 0.6501 |
#> | U| 118.38422 | 0.4639 | 0.9910 | 3.473 | 0.6949 |
#> |.....................| 0.02562 | 1.331 | 2.176 | 2.879 |
#> | X| 118.38422 | 1.590 | 2.694 | 32.22 | 0.6949 |
#> |.....................| 1.026 | 1.331 | 2.176 | 2.879 |
#> | F| Forward Diff. | -0.1463 | -1.154 | 15.21 | -1.138 |
#> |.....................| -2.496 | 7.504 | 11.07 | 6.962 |
#> | 6| 117.77043 | -0.7253 | -0.4088 | 0.9789 | -0.6044 |
#> |.....................| -0.9558 | -0.2082 | 0.3294 | 0.6070 |
#> | U| 117.77043 | 0.4639 | 1.009 | 3.429 | 0.6964 |
#> |.....................| 0.04417 | 1.287 | 2.089 | 2.803 |
#> | X| 117.77043 | 1.590 | 2.742 | 30.84 | 0.6964 |
#> |.....................| 1.045 | 1.287 | 2.089 | 2.803 |
#> | F| Forward Diff. | 1.141 | 4.597 | -31.16 | 0.08457 |
#> |.....................| 2.182 | 3.543 | 7.253 | 4.044 |
#> | 7| 116.96098 | -0.7250 | -0.4401 | 1.025 | -0.6153 |
#> |.....................| -0.9703 | -0.2219 | 0.2619 | 0.5643 |
#> | U| 116.96098 | 0.4641 | 0.9773 | 3.475 | 0.6926 |
#> |.....................| 0.02969 | 1.272 | 1.998 | 2.727 |
#> | X| 116.96098 | 1.591 | 2.657 | 32.30 | 0.6926 |
#> |.....................| 1.030 | 1.272 | 1.998 | 2.727 |
#> | F| Forward Diff. | -0.3967 | -5.118 | 14.10 | -0.8944 |
#> |.....................| -3.807 | 1.589 | 2.347 | 1.916 |
#> | 8| 117.38482 | -0.7213 | -0.3814 | 1.017 | -0.6133 |
#> |.....................| -0.9268 | -0.2089 | 0.2126 | 0.5200 |
#> | U| 117.38482 | 0.4678 | 1.036 | 3.467 | 0.6933 |
#> |.....................| 0.07318 | 1.287 | 1.931 | 2.648 |
#> | X| 117.38482 | 1.596 | 2.818 | 32.04 | 0.6933 |
#> |.....................| 1.076 | 1.287 | 1.931 | 2.648 |
#> | 9| 116.76698 | -0.7239 | -0.4235 | 1.006 | -0.6138 |
#> |.....................| -0.9580 | -0.2216 | 0.2504 | 0.5542 |
#> | U| 116.76698 | 0.4653 | 0.9940 | 3.456 | 0.6931 |
#> |.....................| 0.04202 | 1.272 | 1.982 | 2.709 |
#> | X| 116.76698 | 1.592 | 2.702 | 31.69 | 0.6931 |
#> |.....................| 1.043 | 1.272 | 1.982 | 2.709 |
#> | F| Forward Diff. | 0.2564 | 0.7371 | -3.485 | -0.5046 |
#> |.....................| 0.05455 | 1.833 | 1.505 | 0.7553 |
#> | 10| 116.77116 | -0.7265 | -0.4240 | 1.015 | -0.6009 |
#> |.....................| -0.9497 | -0.2474 | 0.2438 | 0.5530 |
#> | U| 116.77116 | 0.4627 | 0.9935 | 3.465 | 0.6977 |
#> |.....................| 0.05029 | 1.243 | 1.973 | 2.707 |
#> | X| 116.77116 | 1.588 | 2.701 | 31.97 | 0.6977 |
#> |.....................| 1.052 | 1.243 | 1.973 | 2.707 |
#> | 11| 116.75064 | -0.7251 | -0.4249 | 1.014 | -0.6092 |
#> |.....................| -0.9556 | -0.2323 | 0.2460 | 0.5526 |
#> | U| 116.75064 | 0.4641 | 0.9926 | 3.464 | 0.6948 |
#> |.....................| 0.04440 | 1.260 | 1.976 | 2.706 |
#> | X| 116.75064 | 1.591 | 2.698 | 31.95 | 0.6948 |
#> |.....................| 1.045 | 1.260 | 1.976 | 2.706 |
#> | F| Forward Diff. | -0.04480 | 1.210 | 4.754 | 0.06853 |
#> |.....................| 0.4846 | 0.4376 | 1.181 | 0.8815 |
#> | 12| 116.74781 | -0.7258 | -0.4344 | 1.007 | -0.6080 |
#> |.....................| -0.9590 | -0.2378 | 0.2402 | 0.5490 |
#> | U| 116.74781 | 0.4633 | 0.9830 | 3.457 | 0.6952 |
#> |.....................| 0.04096 | 1.254 | 1.969 | 2.700 |
#> | X| 116.74781 | 1.589 | 2.673 | 31.71 | 0.6952 |
#> |.....................| 1.042 | 1.254 | 1.969 | 2.700 |
#> | F| Forward Diff. | 0.008017 | -2.721 | -3.222 | 0.2572 |
#> |.....................| -1.739 | -0.1191 | 0.7926 | 0.4858 |
#> | 13| 116.72996 | -0.7258 | -0.4301 | 1.011 | -0.6094 |
#> |.....................| -0.9561 | -0.2367 | 0.2380 | 0.5475 |
#> | U| 116.72996 | 0.4633 | 0.9874 | 3.461 | 0.6947 |
#> |.....................| 0.04388 | 1.255 | 1.966 | 2.697 |
#> | X| 116.72996 | 1.589 | 2.684 | 31.86 | 0.6947 |
#> |.....................| 1.045 | 1.255 | 1.966 | 2.697 |
#> | F| Forward Diff. | -0.06375 | -0.6705 | 1.584 | 0.1387 |
#> |.....................| -0.4893 | 0.1923 | 0.6005 | 0.5040 |
#> | 14| 116.73508 | -0.7256 | -0.4274 | 1.005 | -0.6099 |
#> |.....................| -0.9542 | -0.2374 | 0.2357 | 0.5455 |
#> | U| 116.73508 | 0.4636 | 0.9900 | 3.455 | 0.6945 |
#> |.....................| 0.04579 | 1.254 | 1.962 | 2.693 |
#> | X| 116.73508 | 1.590 | 2.691 | 31.66 | 0.6945 |
#> |.....................| 1.047 | 1.254 | 1.962 | 2.693 |
#> | 15| 116.72731 | -0.7257 | -0.4291 | 1.009 | -0.6096 |
#> |.....................| -0.9554 | -0.2370 | 0.2371 | 0.5467 |
#> | U| 116.72731 | 0.4634 | 0.9884 | 3.459 | 0.6946 |
#> |.....................| 0.04459 | 1.255 | 1.964 | 2.696 |
#> | X| 116.72731 | 1.589 | 2.687 | 31.79 | 0.6946 |
#> |.....................| 1.046 | 1.255 | 1.964 | 2.696 |
#> | F| Forward Diff. | -0.001385 | -0.4217 | -0.5690 | 0.09627 |
#> |.....................| -0.3311 | -0.07777 | 0.5526 | 0.3931 |
#> | 16| 116.72600 | -0.7257 | -0.4279 | 1.011 | -0.6098 |
#> |.....................| -0.9545 | -0.2367 | 0.2356 | 0.5456 |
#> | U| 116.726 | 0.4634 | 0.9895 | 3.461 | 0.6945 |
#> |.....................| 0.04551 | 1.255 | 1.962 | 2.694 |
#> | X| 116.726 | 1.589 | 2.690 | 31.84 | 0.6945 |
#> |.....................| 1.047 | 1.255 | 1.962 | 2.694 |
#> | F| Forward Diff. | -0.02870 | 0.1595 | 1.032 | 0.03261 |
#> |.....................| 0.01310 | 0.2993 | 0.4131 | 0.3464 |
#> | 17| 116.72495 | -0.7256 | -0.4286 | 1.009 | -0.6103 |
#> |.....................| -0.9546 | -0.2366 | 0.2341 | 0.5442 |
#> | U| 116.72495 | 0.4635 | 0.9889 | 3.459 | 0.6944 |
#> |.....................| 0.04540 | 1.255 | 1.960 | 2.691 |
#> | X| 116.72495 | 1.590 | 2.688 | 31.78 | 0.6944 |
#> |.....................| 1.046 | 1.255 | 1.960 | 2.691 |
#> | F| Forward Diff. | 0.01431 | -0.1674 | -0.7009 | 0.02858 |
#> |.....................| -0.1371 | -0.01406 | 0.3322 | 0.2395 |
#> | 18| 116.72404 | -0.7254 | -0.4289 | 1.010 | -0.6110 |
#> |.....................| -0.9547 | -0.2360 | 0.2325 | 0.5423 |
#> | U| 116.72404 | 0.4637 | 0.9886 | 3.460 | 0.6941 |
#> |.....................| 0.04533 | 1.256 | 1.958 | 2.688 |
#> | X| 116.72404 | 1.590 | 2.687 | 31.82 | 0.6941 |
#> |.....................| 1.046 | 1.256 | 1.958 | 2.688 |
#> | F| Forward Diff. | -0.007771 | -0.2005 | 0.4020 | -0.07016 |
#> |.....................| -0.1716 | 0.3784 | 0.2054 | 0.1653 |
#> | 19| 116.72395 | -0.7252 | -0.4284 | 1.010 | -0.6107 |
#> |.....................| -0.9543 | -0.2386 | 0.2322 | 0.5412 |
#> | U| 116.72395 | 0.4639 | 0.9890 | 3.460 | 0.6942 |
#> |.....................| 0.04566 | 1.253 | 1.958 | 2.686 |
#> | X| 116.72395 | 1.590 | 2.689 | 31.81 | 0.6942 |
#> |.....................| 1.047 | 1.253 | 1.958 | 2.686 |
#> | C| Central Diff. | -0.009444 | -0.08092 | 0.1143 | 0.002471 |
#> |.....................| -0.1244 | -0.2495 | 0.1646 | 0.1098 |
#> | 20| 116.72365 | -0.7252 | -0.4281 | 1.009 | -0.6107 |
#> |.....................| -0.9539 | -0.2376 | 0.2315 | 0.5408 |
#> | U| 116.72365 | 0.4639 | 0.9893 | 3.459 | 0.6942 |
#> |.....................| 0.04614 | 1.254 | 1.957 | 2.685 |
#> | X| 116.72365 | 1.590 | 2.689 | 31.80 | 0.6942 |
#> |.....................| 1.047 | 1.254 | 1.957 | 2.685 |
#> | F| Forward Diff. | 0.02096 | 0.1041 | -0.1935 | -0.01028 |
#> |.....................| 0.04643 | 0.2440 | 0.1311 | 0.07417 |
#> | 21| 116.72365 | -0.7252 | -0.4281 | 1.009 | -0.6107 |
#> |.....................| -0.9539 | -0.2376 | 0.2315 | 0.5408 |
#> | U| 116.72365 | 0.4639 | 0.9893 | 3.459 | 0.6942 |
#> |.....................| 0.04614 | 1.254 | 1.957 | 2.685 |
#> | X| 116.72365 | 1.590 | 2.689 | 31.80 | 0.6942 |
#> |.....................| 1.047 | 1.254 | 1.957 | 2.685 |
#> calculating covariance matrix
#> done
#> Calculating residuals/tables
#> done
#>
#> ── objf value did not improve, exiting the search ... ──────────────────────────
#>
#> ── forward search complete ──
#>
#> $summaryTable
#> step covar var objf deltObjf AIC BIC numParams qchisqr
#> 1 1 WT ka 116.8035 2.22349e-05 377.4032 403.3484 9 5.991465
#> 2 1 WT cl 116.8036 -7.923847e-05 377.4033 403.3485 9 5.991465
#> 3 1 SEX ka 116.8039 -0.000418987 375.4037 398.4661 8 3.841459
#> 4 1 SEX cl 116.7237 0.07982507 375.3234 398.3858 8 3.841459
#> pchisqr included searchType covNames covarEffect
#> 1 1 forward cov_WT_ka 0.006727113
#> 2 0.9999604 forward cov_WT_cl 0.008872241
#> 3 0.9836691 forward cov_SEX_0_ka 0.001751534
#> 4 1 forward cov_SEX_0_cl 0.04614348
#>
#> $resFwd
#> $resFwd[[1]]
#> ── nlmixr FOCEi (outer: nlminb) fit ────────────────────────────────────────────
#>
#> OBJF AIC BIC Log-likelihood Condition Number
#> FOCEi 116.8035 373.4033 393.5829 -179.7016 68.42019
#>
#> ── Time (sec $time): ───────────────────────────────────────────────────────────
#>
#> setup optimize covariance table other
#> elapsed 0.370314 0.188871 0.188878 0.015 0.671937
#>
#> ── Population Parameters ($parFixed or $parFixedDf): ───────────────────────────
#>
#> Parameter Est. SE %RSE Back-transformed(95%CI) BSV(CV%) Shrink(SD)%
#> tka Log Ka 0.464 0.195 42.1 1.59 (1.08, 2.33) 70.4 1.81%
#> tcl Log Cl 1.01 0.0751 7.42 2.75 (2.37, 3.19) 26.8 3.87%
#> tv log V 3.46 0.0437 1.26 31.8 (29.2, 34.6) 13.9 10.3%
#> add.sd 0.695 0.695
#>
#> Covariance Type ($covMethod): r,s
#> Some strong fixed parameter correlations exist ($cor) :
#> cor:tcl,tka cor:tv,tka cor:tv,tcl
#> 0.158 0.422 0.744
#>
#>
#> No correlations in between subject variability (BSV) matrix
#> Full BSV covariance ($omega) or correlation ($omegaR; diagonals=SDs)
#> Distribution stats (mean/skewness/kurtosis/p-value) available in $shrink
#> Minimization message ($message):
#> relative convergence (4)
#>
#> ── Fit Data (object is a modified tibble): ─────────────────────────────────────
#> # A tibble: 132 × 20
#> ID TIME DV PRED RES WRES IPRED IRES IWRES CPRED CRES
#> <fct> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl>
#> 1 1 0 0.74 1.79e-15 0.740 1.07 0 0.74 1.07 -5.61e-16 0.740
#> 2 1 0.25 2.84 3.26e+ 0 -0.423 -0.225 3.85 -1.01 -1.45 3.22e+ 0 -0.379
#> 3 1 0.57 6.57 5.83e+ 0 0.740 0.297 6.78 -0.215 -0.309 5.77e+ 0 0.795
#> # … with 129 more rows, and 9 more variables: CWRES <dbl>, eta.ka <dbl>,
#> # eta.cl <dbl>, eta.v <dbl>, ka <dbl>, cl <dbl>, v <dbl>, tad <dbl>,
#> # dosenum <dbl>
#>
#> $resFwd[[2]]
#> step covar var objf deltObjf AIC BIC numParams qchisqr
#> 1 1 WT ka 116.8035 2.22349e-05 377.4032 403.3484 9 5.991465
#> 2 1 WT cl 116.8036 -7.923847e-05 377.4033 403.3485 9 5.991465
#> 3 1 SEX ka 116.8039 -0.000418987 375.4037 398.4661 8 3.841459
#> 4 1 SEX cl 116.7237 0.07982507 375.3234 398.3858 8 3.841459
#> pchisqr included searchType covNames covarEffect
#> 1 1 forward cov_WT_ka 0.006727113
#> 2 0.9999604 forward cov_WT_cl 0.008872241
#> 3 0.9836691 forward cov_SEX_0_ka 0.001751534
#> 4 1 forward cov_SEX_0_cl 0.04614348
#>
#>
#> $resBck
#> NULL
#>
# }