Covariance matrix by Fisher Information Matrix via linearization

Source: R/saem_fit_aux.R

Get the covariance matrix of fixed effect estimates via calculating Fisher Information Matrix by linearization

calc.COV(fit0)

Arguments

fit0

saemFit fit

Value

standard error of fixed effects

References

Comets E, Lavenu A, Lavielle M. SAEMIX, an R version of the SAEM algorithm. 20th meeting of the Population Approach Group in Europe, Athens, Greece (2011), Abstr 2173.